Desmoid tumor risk factors: Difference between revisions
Jump to navigation
Jump to search
Sara Mohsin (talk | contribs) No edit summary |
Sara Mohsin (talk | contribs) |
||
Line 7: | Line 7: | ||
==Risk Factors== | ==Risk Factors== | ||
Common risk factors for the development of desmoid tumor include:<ref name="JenayahBettaieb2015">{{cite journal|last1=Jenayah|first1=Amel Achour|last2=Bettaieb|first2=Hajer|last3=Saoudi|first3=Sarra|last4=Gharsa|first4=Anissa|last5=Sfar|first5=Ezzeddine|last6=Boudaya|first6=Fethia|last7=Chelli|first7=Dalenda|title=Desmoid tumors: clinical features and treatment options: a case report and a review of literature|journal=Pan African Medical Journal|volume=21|year=2015|issn=1937-8688|doi=10.11604/pamj.2015.21.93.7037}}</ref> | Common risk factors for the development of desmoid tumor include:<ref name="JenayahBettaieb2015">{{cite journal|last1=Jenayah|first1=Amel Achour|last2=Bettaieb|first2=Hajer|last3=Saoudi|first3=Sarra|last4=Gharsa|first4=Anissa|last5=Sfar|first5=Ezzeddine|last6=Boudaya|first6=Fethia|last7=Chelli|first7=Dalenda|title=Desmoid tumors: clinical features and treatment options: a case report and a review of literature|journal=Pan African Medical Journal|volume=21|year=2015|issn=1937-8688|doi=10.11604/pamj.2015.21.93.7037}}</ref> | ||
{| class="wikitable" | |||
|+Common risk factors for development of desmoid tumor | |||
!Risk factors | |||
! | |||
|- | |||
|Familial adenomatous polyposis (FAP) (10-20%) | |||
| | |||
* 852 times elevated risk of developing desmoids in FAP patients as compared to general population | |||
* Mostly desmoids in FAP are intra-abdominal or involve abdominal wall | |||
* Most of these desmoids are unresectable associated with diffuse infiltration of mesentery | |||
* FAP is associated with mutations in the ''APC'' (adenomatous polyposis coli) gene, located on chromosome 5q21-q22 | |||
* Sometimes, only manifestation of APC mutation is desmoid | |||
* FAP screening recommended in patients with multiple intraabdominal or truncal desmoid tumors | |||
* Risk of finding FAP in patients who develop a desmoid without a prior history of FAP is relatively low (4.8% only) | |||
|- | |||
|Gardner syndrome | |||
| | |||
|- | |||
|Specific location of APC (adenomatous polyposis coli) gene mutation i.e. 3' of codon 1444 | |||
| | |||
|- | |||
|Family history of desmoid tumor | |||
| | |||
|- | |||
|Pregnancy | |||
| | |||
|- | |||
|History of antecedent trauma at the tumor site (30%) | |||
| | |||
* Previous abdominal surgery in patients with FAP | |||
* In one-half patients, desmoids can develop within first five years post-surgery | |||
|- | |||
|Female gender | |||
| | |||
|} | |||
*APC mutation 3' to codon 1399 | *APC mutation 3' to codon 1399 | ||
==Reference== | ==Reference== |
Revision as of 17:08, 27 February 2019
Desmoid tumor Microchapters |
Diagnosis |
---|
Treatment |
Case Studies |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Sara Mohsin, M.D.[2]Faizan Sheraz, M.D. [3]
Overview
Common risk factors for the development of desmoid tumor include an APC mutation 3' to codon 1399, previous abdominal surgery, and the female sex.[1]
Risk Factors
Common risk factors for the development of desmoid tumor include:[1]
Risk factors | |
---|---|
Familial adenomatous polyposis (FAP) (10-20%) |
|
Gardner syndrome | |
Specific location of APC (adenomatous polyposis coli) gene mutation i.e. 3' of codon 1444 | |
Family history of desmoid tumor | |
Pregnancy | |
History of antecedent trauma at the tumor site (30%) |
|
Female gender |
- APC mutation 3' to codon 1399
Reference
- ↑ 1.0 1.1 Jenayah, Amel Achour; Bettaieb, Hajer; Saoudi, Sarra; Gharsa, Anissa; Sfar, Ezzeddine; Boudaya, Fethia; Chelli, Dalenda (2015). "Desmoid tumors: clinical features and treatment options: a case report and a review of literature". Pan African Medical Journal. 21. doi:10.11604/pamj.2015.21.93.7037. ISSN 1937-8688.