NPTX2: Difference between revisions

Jump to navigation Jump to search
m (Bot: HTTP→HTTPS)
 
imported>FrescoBot
m (Bot: link syntax)
 
Line 4: Line 4:
== Function ==
== Function ==


This gene encodes a member of the family of neuronal [[pentraxins|petraxins]], synaptic proteins that are related to [[C-reactive protein]]. This protein is involved in excitatory synapse formation. It also plays a role in clustering of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid ([[AMPA]])-type glutamate receptors at established synapses, resulting in non-apoptotic cell death of dopaminergic nerve cells.<ref name="entrez"/>
This gene encodes a member of the family of neuronal [[pentraxins]], synaptic proteins that are related to [[C-reactive protein]]. This protein is involved in excitatory synapse formation. It also plays a role in clustering of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid ([[AMPA]])-type glutamate receptors at established synapses, resulting in non-apoptotic cell death of dopaminergic nerve cells.<ref name="entrez"/>


== Clinical significance ==
== Clinical significance ==

Latest revision as of 21:50, 3 July 2018

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Neuronal pentraxin-2 is a protein that in humans is encoded by the NPTX2 gene.[1][2]

Function

This gene encodes a member of the family of neuronal pentraxins, synaptic proteins that are related to C-reactive protein. This protein is involved in excitatory synapse formation. It also plays a role in clustering of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-type glutamate receptors at established synapses, resulting in non-apoptotic cell death of dopaminergic nerve cells.[2]

Clinical significance

Up-regulation of this gene in Parkinson disease (PD) tissues suggests that the protein may be involved in the pathology of PD.[2]

References

  1. Hsu YC, Perin MS (Feb 1996). "Human neuronal pentraxin II (NPTX2): conservation, genomic structure, and chromosomal localization". Genomics. 28 (2): 220–7. doi:10.1006/geno.1995.1134. PMID 8530029.
  2. 2.0 2.1 2.2 "Entrez Gene: NPTX2 neuronal pentraxin II".

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.