RECQL: Difference between revisions

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*{{cite journal  |vauthors=Zhang AH, Xi X |title=Molecular cloning of a splicing variant of human RECQL helicase |journal=Biochem. Biophys. Res. Commun. |volume=298 |issue= 5 |pages= 789–92 |year= 2003 |pmid= 12419324 |doi=10.1016/S0006-291X(02)02542-1  }}
*{{cite journal  |vauthors=Zhang AH, Xi X |title=Molecular cloning of a splicing variant of human RECQL helicase |journal=Biochem. Biophys. Res. Commun. |volume=298 |issue= 5 |pages= 789–92 |year= 2003 |pmid= 12419324 |doi=10.1016/S0006-291X(02)02542-1  }}
*{{cite journal  |vauthors=Cui S, Klima R, Ochem A, etal |title=Characterization of the DNA-unwinding activity of human RECQ1, a helicase specifically stimulated by human replication protein A |journal=J. Biol. Chem. |volume=278 |issue= 3 |pages= 1424–32 |year= 2003 |pmid= 12419808 |doi= 10.1074/jbc.M209407200 }}
*{{cite journal  |vauthors=Cui S, Klima R, Ochem A, etal |title=Characterization of the DNA-unwinding activity of human RECQ1, a helicase specifically stimulated by human replication protein A |journal=J. Biol. Chem. |volume=278 |issue= 3 |pages= 1424–32 |year= 2003 |pmid= 12419808 |doi= 10.1074/jbc.M209407200 }}
*{{cite journal  |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 }}
*{{cite journal  |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 |bibcode=2002PNAS...9916899M }}
*{{cite journal  |vauthors=Cui S, Arosio D, Doherty KM, etal |title=Analysis of the unwinding activity of the dimeric RECQ1 helicase in the presence of human replication protein A |journal=Nucleic Acids Res. |volume=32 |issue= 7 |pages= 2158–70 |year= 2004 |pmid= 15096578 |doi= 10.1093/nar/gkh540  | pmc=407823 }}
*{{cite journal  |vauthors=Cui S, Arosio D, Doherty KM, etal |title=Analysis of the unwinding activity of the dimeric RECQ1 helicase in the presence of human replication protein A |journal=Nucleic Acids Res. |volume=32 |issue= 7 |pages= 2158–70 |year= 2004 |pmid= 15096578 |doi= 10.1093/nar/gkh540  | pmc=407823 }}
*{{cite journal  |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504  | pmc=528928 }}
*{{cite journal  |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504  | pmc=528928 }}

Latest revision as of 01:38, 26 June 2018

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Wikidata
View/Edit Human

ATP-dependent DNA helicase Q1 is an enzyme that in humans is encoded by the RECQL gene.[1][2][3]

The protein encoded by this gene is a member of the RecQ DNA helicase family. DNA helicases are enzymes involved in various types of DNA repair, including mismatch repair, nucleotide excision repair and direct repair. Some members of this family are associated with genetic disorders with predisposition to malignancy and chromosomal instability. The biological function of this helicase has not yet been determined. Two alternatively spliced transcripts, which encode the same isoform but differ in their 5' and 3' UTRs, have been described.[3]

Interactions

RECQL has been shown to interact with KPNA4[4] and Karyopherin alpha 2.[4]

References

  1. ↑ Seki M, Miyazawa H, Tada S, Yanagisawa J, Yamaoka T, Hoshino S, Ozawa K, Eki T, Nogami M, Okumura K, et al. (January 1995). "Molecular cloning of cDNA encoding human DNA helicase Q1 which has homology to Escherichia coli Rec Q helicase and localization of the gene at chromosome 12p12". Nucleic Acids Res. 22 (22): 4566–73. doi:10.1093/nar/22.22.4566. PMC 308502. PMID 7527136.
  2. ↑ Puranam KL, Blackshear PJ (December 1994). "Cloning and characterization of RECQL, a potential human homologue of the Escherichia coli DNA helicase RecQ". J Biol Chem. 269 (47): 29838–45. PMID 7961977.
  3. ↑ 3.0 3.1 "Entrez Gene: RECQL RecQ protein-like (DNA helicase Q1-like)".
  4. ↑ 4.0 4.1 Seki, T; Tada S; Katada T; Enomoto T (May 1997). "Cloning of a cDNA encoding a novel importin-alpha homologue, Qip1: discrimination of Qip1 and Rch1 from hSrp1 by their ability to interact with DNA helicase Q1/RecQL". Biochem. Biophys. Res. Commun. UNITED STATES. 234 (1): 48–53. doi:10.1006/bbrc.1997.6535. ISSN 0006-291X. PMID 9168958.

Further reading



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