NRXN2: Difference between revisions
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| summary_text = | | summary_text = [[Neurexin]]s are a family of proteins that function in the vertebrate nervous system as cell adhesion molecules and receptors. They are encoded by several unlinked genes of which two, [[NRXN1]] and [[NRXN3]], are among the largest known human genes. Three of the genes (NRXN1-3) utilize two alternate promoters and include numerous [[alternative splicing|alternatively spliced]] exons to generate thousands of distinct mRNA transcripts and protein isoforms. The majority of transcripts are produced from the upstream promoter and encode alpha-neurexin isoforms; a much smaller number of transcripts are produced from the downstream promoter and encode beta-neurexin [[protein isoforms|isoforms]]. The alpha-neurexins contain epidermal growth factor-like ([[EGF-like]]) sequences and [[laminin G domain]]s, and have been shown to interact with neurexophilins. The beta-neurexins lack EGF-like sequences and contain fewer laminin G domains than alpha-neurexins.<ref name="entrez" /> | ||
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*{{cite journal |vauthors=Ichtchenko K, Nguyen T, Südhof TC |title=Structures, alternative splicing, and neurexin binding of multiple neuroligins |journal=J. Biol. Chem. |volume=271 |issue= 5 |pages= 2676–2682 |year= 1996 |pmid= 8576240 |doi=10.1074/jbc.271.5.2676 }} | *{{cite journal |vauthors=Ichtchenko K, Nguyen T, Südhof TC |title=Structures, alternative splicing, and neurexin binding of multiple neuroligins |journal=J. Biol. Chem. |volume=271 |issue= 5 |pages= 2676–2682 |year= 1996 |pmid= 8576240 |doi=10.1074/jbc.271.5.2676 }} | ||
*{{cite journal |vauthors=Hata Y, Butz S, Südhof TC |title=CASK: a novel dlg/PSD95 homolog with an N-terminal calmodulin-dependent protein kinase domain identified by interaction with neurexins |journal=J. Neurosci. |volume=16 |issue= 8 |pages= 2488–94 |year= 1996 |pmid= 8786425 |doi= }} | *{{cite journal |vauthors=Hata Y, Butz S, Südhof TC |title=CASK: a novel dlg/PSD95 homolog with an N-terminal calmodulin-dependent protein kinase domain identified by interaction with neurexins |journal=J. Neurosci. |volume=16 |issue= 8 |pages= 2488–94 |year= 1996 |pmid= 8786425 |doi= }} | ||
*{{cite journal | *{{cite journal |authorlink4=D. James Surmeier |vauthors=Kurschner C, Mermelstein PG, Holden WT, Surmeier DJ |title=CIPP, a novel multivalent PDZ domain protein, selectively interacts with Kir4.0 family members, NMDA receptor subunits, neurexins, and neuroligins |journal=Mol. Cell. Neurosci. |volume=11 |issue= 3 |pages= 161–172 |year= 1998 |pmid= 9647694 |doi= 10.1006/mcne.1998.0679 }} | ||
*{{cite journal | author=Hock B |title=PDZ-domain-mediated interaction of the Eph-related receptor tyrosine kinase EphB3 and the ras-binding protein AF6 depends on the kinase activity of the receptor |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=95 |issue= 17 |pages= 9779–9784 |year= 1998 |pmid= 9707552 |doi=10.1073/pnas.95.17.9779 | pmc=21413 |name-list-format=vanc| author2=Böhme B | author3=Karn T | display-authors=3 | last4=Yamamoto | first4=T | last5=Kaibuchi | first5=K | last6=Holtrich | first6=U | last7=Holland | first7=S | last8=Pawson | first8=T | last9=Rübsamen-Waigmann | first9=H }} | *{{cite journal | author=Hock B |title=PDZ-domain-mediated interaction of the Eph-related receptor tyrosine kinase EphB3 and the ras-binding protein AF6 depends on the kinase activity of the receptor |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=95 |issue= 17 |pages= 9779–9784 |year= 1998 |pmid= 9707552 |doi=10.1073/pnas.95.17.9779 | pmc=21413 |name-list-format=vanc| author2=Böhme B | author3=Karn T | display-authors=3 | last4=Yamamoto | first4=T | last5=Kaibuchi | first5=K | last6=Holtrich | first6=U | last7=Holland | first7=S | last8=Pawson | first8=T | last9=Rübsamen-Waigmann | first9=H }} | ||
*{{cite journal | author=Bergman L |title=A 500-kb sequence-ready cosmid contig and transcript map of the MEN1 region on 11q13 |journal=Genomics |volume=55 |issue= 1 |pages= 49–56 |year= 1999 |pmid= 9888998 |doi= 10.1006/geno.1998.5625 |name-list-format=vanc| author2=Silins G | author3=Grimmond S | display-authors=3 | last4=Hummerich | first4=H | last5=Stewart | first5=C | last6=Little | first6=P | last7=Hayward | first7=N }} | *{{cite journal | author=Bergman L |title=A 500-kb sequence-ready cosmid contig and transcript map of the MEN1 region on 11q13 |journal=Genomics |volume=55 |issue= 1 |pages= 49–56 |year= 1999 |pmid= 9888998 |doi= 10.1006/geno.1998.5625 |name-list-format=vanc| author2=Silins G | author3=Grimmond S | display-authors=3 | last4=Hummerich | first4=H | last5=Stewart | first5=C | last6=Little | first6=P | last7=Hayward | first7=N }} | ||
Latest revision as of 00:52, 18 May 2018
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Neurexin-2-alpha is a protein that in humans is encoded by the NRXN2 gene.[1][2]
Neurexins are a family of proteins that function in the vertebrate nervous system as cell adhesion molecules and receptors. They are encoded by several unlinked genes of which two, NRXN1 and NRXN3, are among the largest known human genes. Three of the genes (NRXN1-3) utilize two alternate promoters and include numerous alternatively spliced exons to generate thousands of distinct mRNA transcripts and protein isoforms. The majority of transcripts are produced from the upstream promoter and encode alpha-neurexin isoforms; a much smaller number of transcripts are produced from the downstream promoter and encode beta-neurexin isoforms. The alpha-neurexins contain epidermal growth factor-like (EGF-like) sequences and laminin G domains, and have been shown to interact with neurexophilins. The beta-neurexins lack EGF-like sequences and contain fewer laminin G domains than alpha-neurexins.[2]
References
- ↑ Ushkaryov YA, Petrenko AG, Geppert M, Sudhof TC (Aug 1992). "Neurexins: synaptic cell surface proteins related to the alpha-latrotoxin receptor and laminin". Science. 257 (5066): 50–56. doi:10.1126/science.1621094. PMID 1621094.
- ↑ 2.0 2.1 "Entrez Gene: NRXN2 neurexin 2".
Further reading
- Nakajima D, Okazaki N, Yamakawa H, et al. (2003). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones". DNA Res. 9 (3): 99–106. doi:10.1093/dnares/9.3.99. PMID 12168954.
- Ichtchenko K, Nguyen T, Südhof TC (1996). "Structures, alternative splicing, and neurexin binding of multiple neuroligins". J. Biol. Chem. 271 (5): 2676–2682. doi:10.1074/jbc.271.5.2676. PMID 8576240.
- Hata Y, Butz S, Südhof TC (1996). "CASK: a novel dlg/PSD95 homolog with an N-terminal calmodulin-dependent protein kinase domain identified by interaction with neurexins". J. Neurosci. 16 (8): 2488–94. PMID 8786425.
- Kurschner C, Mermelstein PG, Holden WT, Surmeier DJ (1998). "CIPP, a novel multivalent PDZ domain protein, selectively interacts with Kir4.0 family members, NMDA receptor subunits, neurexins, and neuroligins". Mol. Cell. Neurosci. 11 (3): 161–172. doi:10.1006/mcne.1998.0679. PMID 9647694.
- Hock B, Böhme B, Karn T, et al. (1998). "PDZ-domain-mediated interaction of the Eph-related receptor tyrosine kinase EphB3 and the ras-binding protein AF6 depends on the kinase activity of the receptor". Proc. Natl. Acad. Sci. U.S.A. 95 (17): 9779–9784. doi:10.1073/pnas.95.17.9779. PMC 21413. PMID 9707552.
- Bergman L, Silins G, Grimmond S, et al. (1999). "A 500-kb sequence-ready cosmid contig and transcript map of the MEN1 region on 11q13". Genomics. 55 (1): 49–56. doi:10.1006/geno.1998.5625. PMID 9888998.
- Nagase T, Ishikawa K, Suyama M, et al. (1999). "Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 6 (1): 63–70. doi:10.1093/dnares/6.1.63. PMID 10231032.
- Rowen L, Young J, Birditt B, et al. (2002). "Analysis of the human neurexin genes: alternative splicing and the generation of protein diversity". Genomics. 79 (4): 587–597. doi:10.1006/geno.2002.6734. PMID 11944992.
- Tabuchi K, Südhof TC (2002). "Structure and evolution of neurexin genes: insight into the mechanism of alternative splicing". Genomics. 79 (6): 849–859. doi:10.1006/geno.2002.6780. PMID 12036300.
- Nakayama M, Kikuno R, Ohara O (2003). "Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs". Genome Res. 12 (11): 1773–1784. doi:10.1101/gr.406902. PMC 187542. PMID 12421765.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–45. doi:10.1038/ng1285. PMID 14702039.
- Homma K, Kikuno RF, Nagase T, et al. (2004). "Alternative splice variants encoding unstable protein domains exist in the human brain". J. Mol. Biol. 343 (5): 1207–1220. doi:10.1016/j.jmb.2004.09.028. PMID 15491607.
- Taylor TD, Noguchi H, Totoki Y, et al. (2006). "Human chromosome 11 DNA sequence and analysis including novel gene identification". Nature. 440 (7083): 497–500. doi:10.1038/nature04632. PMID 16554811.
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