DOK2: Difference between revisions

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*{{cite journal  | vauthors=Dunant NM, Wisniewski D, Strife A |title=The phosphatidylinositol polyphosphate 5-phosphatase SHIP1 associates with the dok1 phosphoprotein in bcr-Abl transformed cells. |journal=Cell. Signal. |volume=12 |issue= 5 |pages= 317–26 |year= 2000 |pmid= 10822173 |doi=10.1016/S0898-6568(00)00073-5  |display-authors=etal}}
*{{cite journal  | vauthors=Dunant NM, Wisniewski D, Strife A |title=The phosphatidylinositol polyphosphate 5-phosphatase SHIP1 associates with the dok1 phosphoprotein in bcr-Abl transformed cells. |journal=Cell. Signal. |volume=12 |issue= 5 |pages= 317–26 |year= 2000 |pmid= 10822173 |doi=10.1016/S0898-6568(00)00073-5  |display-authors=etal}}
*{{cite journal  | vauthors=Némorin JG, Laporte P, Bérubé G, Duplay P |title=p62dok negatively regulates CD2 signaling in Jurkat cells. |journal=J. Immunol. |volume=166 |issue= 7 |pages= 4408–15 |year= 2001 |pmid= 11254695 |doi=  10.4049/jimmunol.166.7.4408}}
*{{cite journal  | vauthors=Némorin JG, Laporte P, Bérubé G, Duplay P |title=p62dok negatively regulates CD2 signaling in Jurkat cells. |journal=J. Immunol. |volume=166 |issue= 7 |pages= 4408–15 |year= 2001 |pmid= 11254695 |doi=  10.4049/jimmunol.166.7.4408}}
*{{cite journal  | vauthors=Grimm J, Sachs M, Britsch S |title=Novel p62dok family members, dok-4 and dok-5, are substrates of the c-Ret receptor tyrosine kinase and mediate neuronal differentiation. |journal=J. Cell Biol. |volume=154 |issue= 2 |pages= 345–54 |year= 2001 |pmid= 11470823 |doi=10.1083/jcb.200102032  | pmc=2150770  |display-authors=etal}}
*{{cite journal  | vauthors=Grimm J, Sachs M, Britsch S |title=Novel p62dok family members, dok-4 and dok-5, are substrates of the c-Ret receptor tyrosine kinase and mediate neuronal differentiation. |journal=J. Cell Biol. |volume=154 |issue= 2 |pages= 345–54 |year= 2001 |pmid= 11470823 |doi=10.1083/jcb.200102032  | pmc=2150770  |display-authors=etal|url=http://edoc.mdc-berlin.de/4926/1/4926oa.pdf}}
*{{cite journal  | vauthors=Master Z, Jones N, Tran J |title=Dok-R plays a pivotal role in angiopoietin-1-dependent cell migration through recruitment and activation of Pak. |journal=EMBO J. |volume=20 |issue= 21 |pages= 5919–28 |year= 2001 |pmid= 11689432 |doi= 10.1093/emboj/20.21.5919  | pmc=125712 |display-authors=etal}}
*{{cite journal  | vauthors=Master Z, Jones N, Tran J |title=Dok-R plays a pivotal role in angiopoietin-1-dependent cell migration through recruitment and activation of Pak. |journal=EMBO J. |volume=20 |issue= 21 |pages= 5919–28 |year= 2001 |pmid= 11689432 |doi= 10.1093/emboj/20.21.5919  | pmc=125712 |display-authors=etal}}
*{{cite journal  | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 |display-authors=etal}}
*{{cite journal  | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 |display-authors=etal}}

Revision as of 15:58, 4 November 2018

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Docking protein 2 is a protein that in humans is encoded by the DOK2 gene.[1][2][3]

Function

The protein encoded by this gene is constitutively tyrosine phosphorylated in hematopoietic progenitors isolated from chronic myelogenous leukemia (CML) patients in the chronic phase. It may be a critical substrate for p210(bcr/abl), a chimeric protein whose presence is associated with CML. This encoded protein binds p120 (RasGAP) from CML cells.[3]

Interactions

DOK2 has been shown to interact with INPP5D[4] and TEK tyrosine kinase.[5][6]

References

  1. Di Cristofano A, Carpino N, Dunant N, Friedland G, Kobayashi R, Strife A, Wisniewski D, Clarkson B, Pandolfi PP, Resh MD (March 1998). "Molecular cloning and characterization of p56dok-2 defines a new family of RasGAP-binding proteins". J Biol Chem. 273 (9): 4827–30. doi:10.1074/jbc.273.9.4827. PMID 9478921.
  2. Garcia A, Prabhakar S, Hughan S, Anderson TW, Brock CJ, Pearce AC, Dwek RA, Watson SP, Hebestreit HF, Zitzmann N (March 2004). "Differential proteome analysis of TRAP-activated platelets: involvement of DOK-2 and phosphorylation of RGS proteins". Blood. 103 (6): 2088–95. doi:10.1182/blood-2003-07-2392. PMID 14645010.
  3. 3.0 3.1 "Entrez Gene: DOK2 docking protein 2, 56kDa".
  4. Dunant NM, Wisniewski D, Strife A, Clarkson B, Resh MD (2000). "The phosphatidylinositol polyphosphate 5-phosphatase SHIP1 associates with the dok1 phosphoprotein in bcr-Abl transformed cells". Cell. Signal. 12 (5): 317–26. doi:10.1016/S0898-6568(00)00073-5. PMID 10822173.
  5. Jones N, Dumont DJ (1998). "The Tek/Tie2 receptor signals through a novel Dok-related docking protein, Dok-R". Oncogene. 17 (9): 1097–108. doi:10.1038/sj.onc.1202115. PMID 9764820.
  6. Master Z, Jones N, Tran J, Jones J, Kerbel RS, Dumont DJ (2001). "Dok-R plays a pivotal role in angiopoietin-1-dependent cell migration through recruitment and activation of Pak". EMBO J. 20 (21): 5919–28. doi:10.1093/emboj/20.21.5919. PMC 125712. PMID 11689432.

Further reading