RIPK3: Difference between revisions

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
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View/Edit Human

Receptor-interacting serine/threonine-protein kinase 3 is an enzyme that in humans is encoded by the RIPK3 gene.[1][2][3][4]

The product of this gene is a member of the receptor-interacting protein (RIP) family of serine/threonine protein kinases, and contains a C-terminal domain unique from other RIP family members. The encoded protein is predominantly localized to the cytoplasm, and can undergo nucleocytoplasmic shuttling dependent on novel nuclear localization and export signals. It is a component of the tumor necrosis factor (TNF) receptor-I signaling complex, and can induce apoptosis and weakly activate the NF-kappaB transcription factor.[3]

Interactions

RIPK3 has been shown to interact with RIPK1 to form an amyloid spine [1][4]

References

  1. 1.0 1.1 Yu PW, Huang BC, Shen M, Quast J, Chan E, Xu X, Nolan GP, Payan DG, Luo Y (Jun 1999). "Identification of RIP3, a RIP-like kinase that activates apoptosis and NFkappaB". Curr Biol. 9 (10): 539–42. doi:10.1016/S0960-9822(99)80239-5. PMID 10339433.
  2. Sun X, Lee J, Navas T, Baldwin DT, Stewart TA, Dixit VM (Jul 1999). "RIP3, a novel apoptosis-inducing kinase". J Biol Chem. 274 (24): 16871–5. doi:10.1074/jbc.274.24.16871. PMID 10358032.
  3. 3.0 3.1 "Entrez Gene: RIPK3 receptor-interacting serine-threonine kinase 3".
  4. 4.0 4.1 Li J, McQuade T, Siemer AB, Napetschnig J, Moriwaki K, Hsiao YS, Damko E, Moquin D, Walz T, McDermott A, Chan FK, Wu H. (July 2012) The RIP1/RIP3 necrosome forms a functional amyloid signaling complex required for programmed necrosis. Cell 150 (2):339-50. doi:10.1016/j.cell.2012.06.019. PMID 22817896

Further reading