Paroxysmal nocturnal hemoglobinuria history and symptoms: Difference between revisions

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{{CMG}}; {{AE}}  
{{CMG}}; {{AE}}  
==Overview==
==Overview==
The majority of patients with [disease name] are asymptomatic.
OR
The hallmark of [disease name] is [finding]. A positive history of [finding 1] and [finding 2] is suggestive of [disease name]. The most common symptoms of [disease name] include [symptom 1], [symptom 2], and [symptom 3]. Common symptoms of [disease] include [symptom 1], [symptom 2], and [symptom 3]. Less common symptoms of [disease name] include [symptom 1], [symptom 2], and [symptom 3].
==History and Symptoms==
==History and Symptoms==
*There is no single hallmark symptom of [PNH]. [PNH] is associated with a wide range of symptoms.
===History===
===History===
Patients with [PNH]] may have a positive history of:
Patients with PNH may have a positive history of:
* feeling tired/ weak
* Feeling tired/ weak
* shortness of breath
* Shortness of breath
* dark (red/pink/black) colored urine  
* Dark colored urine  
* jaundice
* Jaundice
* blood clots
* Blood clots
* difficulty swallowing
* Difficulty swallowing
* chest pain
* Chest pain
* abdominal pain
* Abdominal pain
* headaches
* Headaches
* confusion
* Confusion
* dysphagia
* Dysphagia
* erectile dysfunction
* Erectile dysfunction
* low blood cell counts
* Low blood cell counts
* iron deficiency
* Iron deficiency
* kidney problems: acute or chronic insufficiency


===Common Symptoms===
===Common Symptoms===

Revision as of 18:42, 23 October 2018

Paroxysmal nocturnal hemoglobinuria Microchapters

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Differentiating Paroxysmal nocturnal hemoglobinuria from other Diseases

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History and Symptoms

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief:

Overview

History and Symptoms

History

Patients with PNH may have a positive history of:

  • Feeling tired/ weak
  • Shortness of breath
  • Dark colored urine
  • Jaundice
  • Blood clots
  • Difficulty swallowing
  • Chest pain
  • Abdominal pain
  • Headaches
  • Confusion
  • Dysphagia
  • Erectile dysfunction
  • Low blood cell counts
  • Iron deficiency

Common Symptoms

Common symptoms of [PNH] include:

  • Due to hemolysis
    1. fatigue
    2. dyspnea
    3. dark (red/pink/black) colored urine
    4. jaundice
  • Due to thrombosis
    1. headaches
    2. confusion
    3. abdominal pain
    4. chest pain
  • Due to nitric oxide depletion
    1. dysphagia
    2. chest pain from esophageal spasm
    3. abdominal pain
    4. erectile dysfunction

Less Common Symptoms

Less common symptoms of [PNH] include

  • necrotic skin lesions
  • abdominal fullness/ distension

References

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