Monoclonal gammopathy of undetermined significance causes: Difference between revisions
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The most common causes of [[Monoclonal gammopathy of undetermined significance classification]] are genetic mutations. However, there is no established cause of progression of [[Multiple myeloma]] to [[Monoclonal gammopathy of undetermined significance classification]]. | The most common causes of [[Monoclonal gammopathy of undetermined significance classification]] are genetic mutations. However, there is no established cause of progression of [[Multiple myeloma]] to [[Monoclonal gammopathy of undetermined significance classification]]. | ||
==== Genetic causes ==== | ==== Genetic causes<ref name="pmid20884827">{{cite journal |vauthors=Rajkumar SV, Kyle RA, Buadi FK |title=Advances in the diagnosis, classification, risk stratification, and management of monoclonal gammopathy of undetermined significance: implications for recategorizing disease entities in the presence of evolving scientific evidence |journal=Mayo Clin. Proc. |volume=85 |issue=10 |pages=945–8 |date=October 2010 |pmid=20884827 |pmc=2947967 |doi=10.4065/mcp.2010.0520 |url=}}</ref> ==== | ||
{| class="wikitable" | {| class="wikitable" | ||
|Abnormalities in cytogenes | |Abnormalities in cytogenes | ||
Revision as of 15:53, 7 August 2018
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Overview
The most common causes of Monoclonal gammopathy of undetermined significance classification are genetic mutations.
Causes[edit | edit source]
The most common causes of Monoclonal gammopathy of undetermined significance classification are genetic mutations. However, there is no established cause of progression of Multiple myeloma to Monoclonal gammopathy of undetermined significance classification.
Genetic causes[1]
| Abnormalities in cytogenes | Affected genes |
| IgH translocation: | |
| t(11;14), q(13;32) | cyclin D1 |
| t(4;14)(p16;q32) | FGFR-3, and MMSET |
| t(14;16)(q32;q23) | C-MAF |
| t(6;14)(q32;q11) | MAFB |
| IgH non-translocated : | |
| Hyper diploid | Numerous |
References
- ↑ Rajkumar SV, Kyle RA, Buadi FK (October 2010). "Advances in the diagnosis, classification, risk stratification, and management of monoclonal gammopathy of undetermined significance: implications for recategorizing disease entities in the presence of evolving scientific evidence". Mayo Clin. Proc. 85 (10): 945–8. doi:10.4065/mcp.2010.0520. PMC 2947967. PMID 20884827.