Monoclonal gammopathy of undetermined significance causes: Difference between revisions
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== Causes[edit | edit source] == | == Causes[edit | edit source] == | ||
The most common causes of [[Monoclonal gammopathy of undetermined significance classification]] are genetic mutations. However, there is no established cause of progression of [[Multiple myeloma]] to [[Monoclonal gammopathy of undetermined significance classification]]. | The most common causes of [[Monoclonal gammopathy of undetermined significance classification]] are genetic mutations<ref name="pmid20884827">{{cite journal |vauthors=Rajkumar SV, Kyle RA, Buadi FK |title=Advances in the diagnosis, classification, risk stratification, and management of monoclonal gammopathy of undetermined significance: implications for recategorizing disease entities in the presence of evolving scientific evidence |journal=Mayo Clin. Proc. |volume=85 |issue=10 |pages=945–8 |date=October 2010 |pmid=20884827 |pmc=2947967 |doi=10.4065/mcp.2010.0520 |url=}}</ref>. However, there is no established cause of progression of [[Multiple myeloma]] to [[Monoclonal gammopathy of undetermined significance classification]]. | ||
==== Genetic causes ==== | ==== Genetic causes ==== | ||
Revision as of 15:51, 7 August 2018
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Overview
The most common causes of Monoclonal gammopathy of undetermined significance classification are genetic mutations.
Causes[edit | edit source]
The most common causes of Monoclonal gammopathy of undetermined significance classification are genetic mutations[1]. However, there is no established cause of progression of Multiple myeloma to Monoclonal gammopathy of undetermined significance classification.
Genetic causes
| Abnormalities in cytogenes | Affected genes |
| IgH translocation: | |
| t(11;14), q(13;32) | cyclin D1 |
| t(4;14)(p16;q32) | FGFR-3, and MMSET |
| t(14;16)(q32;q23) | C-MAF |
| t(6;14)(q32;q11) | MAFB |
| IgH non-translocated : | |
| Hyper diploid | Numerous |
- ↑ Rajkumar SV, Kyle RA, Buadi FK (October 2010). "Advances in the diagnosis, classification, risk stratification, and management of monoclonal gammopathy of undetermined significance: implications for recategorizing disease entities in the presence of evolving scientific evidence". Mayo Clin. Proc. 85 (10): 945–8. doi:10.4065/mcp.2010.0520. PMC 2947967. PMID 20884827.