Pseudotumor cerebri pathophysiology: Difference between revisions
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* Vitamin A intoxication(39 uptodate) | * Vitamin A intoxication(39 uptodate) | ||
* Sleep apnea(18uptodate) | * Sleep apnea(18uptodate) | ||
* Sex hormones(127 uptodate) | * Sex hormones: In one study regarding IIH etiology which was done on 8 men with this disease, Four of them had abnormal FSH and LH level, 2 of them had estradiol abnormalities and seven of them had reduced testosterone level.(127 uptodate) | ||
==Genetics== | ==Genetics== |
Revision as of 12:37, 27 July 2018
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief:
Overview
Pathophysiology
Pathogenesis
The exact pathogenesis of pseudotumor cerebri is not completely understood. Idiopathic intracranial hypertension or pseudotumor cerebri is defined by the symptoms of increased intracranial pressure without any evidence of tumor.(1uptodate)
Any theory regarding the pathophysiology of this disease should explain the following statements:
- High incidence rate in women with childbearing age
- Reduced conductance to CSF outflow(25 wall)
- Normal ventricle size and lack of hydrocephalus(26 wall)
- No evidence of cerebral edema(27 wall)
Some of the these theories are:
- Cerebral venous outflow abnormalities
- increased CSF outflow resistance
- obesity.(89 uptodate)
- Vitamin A intoxication(39 uptodate)
- Sleep apnea(18uptodate)
- Sex hormones: In one study regarding IIH etiology which was done on 8 men with this disease, Four of them had abnormal FSH and LH level, 2 of them had estradiol abnormalities and seven of them had reduced testosterone level.(127 uptodate)
Genetics
[Disease name] is transmitted in [mode of genetic transmission] pattern.
OR
Genes involved in the pathogenesis of [disease name] include:
- [Gene1]
- [Gene2]
- [Gene3]
OR
The development of [disease name] is the result of multiple genetic mutations such as:
- [Mutation 1]
- [Mutation 2]
- [Mutation 3]
Associated Conditions
Gross Pathology
On gross pathology, [feature1], [feature2], and [feature3] are characteristic findings of [disease name].
Microscopic Pathology
On microscopic histopathological analysis, [feature1], [feature2], and [feature3] are characteristic findings of [disease name].