Glomerulonephritis differential diagnosis: Difference between revisions

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==Differential Diagnosis==
==Differential Diagnosis==
Glomerulonephritis should further be distinguished from [[syphilis]], as it may presents as [[blood]] in the [[urine]] (dark, rust-colored, or brown urine), foamy urine (due to excess [[protein]] in the urine), [[swelling]] ([[edema]]) of the face, eyes, ankles, feet, legs, or [[abdomen]].<ref>{{cite book | last = Mandell | first = Gerald | title = Mandell, Douglas, and Bennett's principles and practice of infectious diseases | publisher = Churchill Livingstone/Elsevier | location = Philadelphia, PA | year = 2010 | isbn = 978-0-443-06839-3 }}</ref>
{| class="wikitable"
!Glomerulonephritis
!Sub-entity
!Causes and associations
!History and symtoms
!Nephrotic features
!Nephritic features
!ANCA
!Anti-glomerular basement membrane antibody (Anti-GBM antibody)
!Immune complex formation
!Light microscope
!Electron microscope
!Immunoflourescence pattern
|-
! rowspan="3" |Non-proliferative
!Minimal change disease
!
* Idiopathic
* Protein tyrosine phosphatase receptor type O (glomerular epithelial protein 1- GLEPP1)
!
* Young children
* Recent infection and immunization
* Atopy
* Hodgkin lymphoma
* Thrombosis (due to urinary loss of antithrombin-III)
* Pitting edema
* Hyperlipidemia and hyper colesterolemia
!+
!-
!-
!
!
!Normal
!Fusion of podocytes
!-
|-
!Focal segmental glomerulosclerosis
|
* Idiopathic
* HIV
* Heroine use
* Sickle cell disease
* Interferon
* Severe obesity
* Mixed cryoglobunemia (Hepatitis C)
|
* Adults
* Pitting edema
* Hyperlipidemia and hyper colesterolemia
| +
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!Membranous glomerulonephritis
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* Idiopathic
* Hepatitis B and C
* Solid tumors
* Systemic lupus erythmatosus
* Drugs (NSAIDS, penclliamine, gold, captopril)
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| +
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| rowspan="7" |Proliferative
|IgA nephropathy
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* Idiopathic
* Viral infections
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* Young children
* History of mucosal infections (e.g. gastroenteritis) and upper respiratory tract infection
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| +
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| rowspan="5" |Rapidly progressive glomerulonephritis
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* Goodpasture syndrome
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* Post infectious glomerulonephritis
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* Granulomatosis with polyangitis (Wegner's granulomatosis)
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* Churg Strauss syndrome
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* Microscopic polyngitis
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|Membranoproliferative glomerulonephritis
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* Idiopathic
* Hepatitis B and C (Type 1)
* C3 nepritic factor (Type2)
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|}


==References==
==References==

Revision as of 05:00, 11 April 2018


Glomerulonephritis Main page

Glomerulonephritis patient information

Overview

Classification

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Pathophysiology

Differential Diagnosis

Screening

Diagnosis

Prevention

Overview

Differential Diagnosis

Glomerulonephritis Sub-entity Causes and associations History and symtoms Nephrotic features Nephritic features ANCA Anti-glomerular basement membrane antibody (Anti-GBM antibody) Immune complex formation Light microscope Electron microscope Immunoflourescence pattern
Non-proliferative Minimal change disease
  • Idiopathic
  • Protein tyrosine phosphatase receptor type O (glomerular epithelial protein 1- GLEPP1)
  • Young children
  • Recent infection and immunization
  • Atopy
  • Hodgkin lymphoma
  • Thrombosis (due to urinary loss of antithrombin-III)
  • Pitting edema
  • Hyperlipidemia and hyper colesterolemia
+ - - Normal Fusion of podocytes -
Focal segmental glomerulosclerosis
  • Idiopathic
  • HIV
  • Heroine use
  • Sickle cell disease
  • Interferon
  • Severe obesity
  • Mixed cryoglobunemia (Hepatitis C)
  • Adults
  • Pitting edema
  • Hyperlipidemia and hyper colesterolemia
+
Membranous glomerulonephritis
  • Idiopathic
  • Hepatitis B and C
  • Solid tumors
  • Systemic lupus erythmatosus
  • Drugs (NSAIDS, penclliamine, gold, captopril)
+
Proliferative IgA nephropathy
  • Idiopathic
  • Viral infections
  • Young children
  • History of mucosal infections (e.g. gastroenteritis) and upper respiratory tract infection
+
Rapidly progressive glomerulonephritis
  • Goodpasture syndrome
  • Post infectious glomerulonephritis
  • Granulomatosis with polyangitis (Wegner's granulomatosis)
  • Churg Strauss syndrome
  • Microscopic polyngitis
Membranoproliferative glomerulonephritis
  • Idiopathic
  • Hepatitis B and C (Type 1)
  • C3 nepritic factor (Type2)

References

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