EIF1AX: Difference between revisions

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{{Infobox_gene}}
{{PBB_Controls
'''Eukaryotic translation initiation factor 1A, X-chromosomal''' ('''eIF1A''') is a [[protein]] that in humans is encoded by the ''EIF1AX'' [[gene]].<ref name="pmid8106356">{{cite journal | vauthors = Dever TE, Wei CL, Benkowski LA, Browning K, Merrick WC, Hershey JW | title = Determination of the amino acid sequence of rabbit, human, and wheat germ protein synthesis factor eIF-4C by cloning and chemical sequencing | journal = The Journal of Biological Chemistry | volume = 269 | issue = 5 | pages = 3212–8 | date = Feb 1994 | pmid = 8106356 | pmc =  | doi =  }}</ref><ref name="pmid9381176">{{cite journal | vauthors = Lahn BT, Page DC | title = Functional coherence of the human Y chromosome | journal = Science | volume = 278 | issue = 5338 | pages = 675–80 | date = Oct 1997 | pmid = 9381176 | pmc =  | doi = 10.1126/science.278.5338.675 | bibcode = 1997Sci...278..675L }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: EIF1AX eukaryotic translation initiation factor 1A, X-linked| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1964| accessdate = }}</ref> This gene encodes an essential eukaryotic translation initiation factor. The protein is a component of the 43S pre-initiation complex (PIC), which mediates the recruitment of the small [[40S]] ribosomal subunit to the [[Five-prime cap|5' cap]] of messenger RNAs.<ref name="entrez"/>
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| update_protein_box = yes
| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
eIF1A is a small proteins (17 kDa in budding yeast) and a component of the 43S preinitiation complexes (PIC). eIF1A binds near the ribosomal [[A-site]], in a manner similar to the functionally related bacterial counterpart [[Prokaryotic initiation factor-3|IF1]].<ref name="Fraser">{{cite journal|last1=Fraser|first1=Christopher S.|title=Quantitative studies of mRNA recruitment to the eukaryotic ribosome|journal=Biochimie|date=2015|volume=114|pages=58–71|doi=10.1016/j.biochi.2015.02.017|pmid=25742741|url=http://www.sciencedirect.com/science/article/pii/S0300908415000528|accessdate=6 March 2016|pmc=4458453}}</ref>
| image = PBB_Protein_EIF1AX_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1d7q.
| PDB = {{PDB2|1d7q}}
| Name = Eukaryotic translation initiation factor 1A, X-linked
| HGNCid = 3250
| Symbol = EIF1AX
| AltSymbols =; EIF1A; EIF4C; eIF-1A; eIF-4C
| OMIM = 300186
| ECnumber =
| Homologene = 20364
| MGIid = 1913485
| GeneAtlas_image1 = PBB_GE_EIF1AX_201016_at_tn.png
| GeneAtlas_image2 = PBB_GE_EIF1AX_201017_at_tn.png
| GeneAtlas_image3 = PBB_GE_EIF1AX_201019_s_at_tn.png
| Function = {{GNF_GO|id=GO:0003723 |text = RNA binding}} {{GNF_GO|id=GO:0003743 |text = translation initiation factor activity}}
| Component = {{GNF_GO|id=GO:0016281 |text = eukaryotic translation initiation factor 4F complex}}
| Process = {{GNF_GO|id=GO:0006413 |text = translational initiation}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 1964
    | Hs_Ensembl = ENSG00000173674
    | Hs_RefseqProtein = XP_001134077
    | Hs_RefseqmRNA = XM_001134077
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = X
    | Hs_GenLoc_start = 20052557
    | Hs_GenLoc_end = 20069887
    | Hs_Uniprot = O75642
    | Mm_EntrezGene = 66235
    | Mm_Ensembl = 
    | Mm_RefseqmRNA = NM_025437
    | Mm_RefseqProtein = NP_079713
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 
    | Mm_GenLoc_start = 
    | Mm_GenLoc_end = 
    | Mm_Uniprot = 
  }}
}}
'''Eukaryotic translation initiation factor 1A, X-linked''', also known as '''EIF1AX''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: EIF1AX eukaryotic translation initiation factor 1A, X-linked| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1964| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Clinical significance ==
{{PBB_Summary
| section_title =  
| summary_text = This gene encodes an essential eukaryotic translation initiation factor. The protein is required for the binding of the 43S complex (a 40S subunit, eIF2/GTP/Met-tRNAi and eIF3) to the 5' end of capped RNA.<ref name="entrez">{{cite web | title = Entrez Gene: EIF1AX eukaryotic translation initiation factor 1A, X-linked| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1964| accessdate = }}</ref>
}}


==References==
Mutations in this gene have been recurrently seen associated to cases of uveal melanoma with disomy 3.<ref>{{cite journal | vauthors = Martin M, Maßhöfer L, Temming P, Rahmann S, Metz C, Bornfeld N, van de Nes J, Klein-Hitpass L, Hinnebusch AG, Horsthemke B, Lohmann DR, Zeschnigk M | title = Exome sequencing identifies recurrent somatic mutations in EIF1AX and SF3B1 in uveal melanoma with disomy 3 | journal = Nature Genetics | volume = 45 | issue = 8 | pages = 933–6 | date = Aug 2013 | pmid = 23793026 | doi = 10.1038/ng.2674 | pmc=4307600}}</ref>
{{reflist|2}}
 
==Further reading==
== Interactions ==
 
EIF1AX has been shown to [[Protein-protein interaction|interact]] with [[IPO13]].<ref name=pmid11447110>{{cite journal | vauthors = Mingot JM, Kostka S, Kraft R, Hartmann E, Görlich D | title = Importin 13: a novel mediator of nuclear import and export | journal = The EMBO Journal | volume = 20 | issue = 14 | pages = 3685–94 | date = Jul 2001 | pmid = 11447110 | pmc = 125545 | doi = 10.1093/emboj/20.14.3685 }}</ref>
 
==See also==
* [[Eukaryotic initiation factors]]
 
== References ==
{{reflist}}
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Battiste JL, Pestova TV, Hellen CU, Wagner G | title = The eIF1A solution structure reveals a large RNA-binding surface important for scanning function | journal = Molecular Cell | volume = 5 | issue = 1 | pages = 109–19 | date = Jan 2000 | pmid = 10678173 | doi = 10.1016/S1097-2765(00)80407-4 }}
| citations =
* {{cite journal | vauthors = Choi SK, Olsen DS, Roll-Mecak A, Martung A, Remo KL, Burley SK, Hinnebusch AG, Dever TE | title = Physical and functional interaction between the eukaryotic orthologs of prokaryotic translation initiation factors IF1 and IF2 | journal = Molecular and Cellular Biology | volume = 20 | issue = 19 | pages = 7183–91 | date = Oct 2000 | pmid = 10982835 | pmc = 86272 | doi = 10.1128/MCB.20.19.7183-7191.2000 }}
*{{cite journal | author=Dever TE, Wei CL, Benkowski LA, ''et al.'' |title=Determination of the amino acid sequence of rabbit, human, and wheat germ protein synthesis factor eIF-4C by cloning and chemical sequencing. |journal=J. Biol. Chem. |volume=269 |issue= 5 |pages= 3212-8 |year= 1994 |pmid= 8106356 |doi=  }}
* {{cite journal | vauthors = Mingot JM, Kostka S, Kraft R, Hartmann E, Görlich D | title = Importin 13: a novel mediator of nuclear import and export | journal = The EMBO Journal | volume = 20 | issue = 14 | pages = 3685–94 | date = Jul 2001 | pmid = 11447110 | pmc = 125545 | doi = 10.1093/emboj/20.14.3685 }}
*{{cite journal  | author=Lahn BT, Page DC |title=Functional coherence of the human Y chromosome. |journal=Science |volume=278 |issue= 5338 |pages= 675-80 |year= 1997 |pmid= 9381176 |doi=  }}
* {{cite journal | vauthors = Sørensen HP, Hedegaard J, Sperling-Petersen HU, Mortensen KK | title = Remarkable conservation of translation initiation factors: IF1/eIF1A and IF2/eIF5B are universally distributed phylogenetic markers | journal = IUBMB Life | volume = 51 | issue = 5 | pages = 321–7 | date = May 2001 | pmid = 11699879 | doi = 10.1080/152165401317190842 }}
*{{cite journal  | author=Battiste JL, Pestova TV, Hellen CU, Wagner G |title=The eIF1A solution structure reveals a large RNA-binding surface important for scanning function. |journal=Mol. Cell |volume=5 |issue= 1 |pages= 109-19 |year= 2000 |pmid= 10678173 |doi= }}
* {{cite journal | vauthors = Bohnsack MT, Regener K, Schwappach B, Saffrich R, Paraskeva E, Hartmann E, Görlich D | title = Exp5 exports eEF1A via tRNA from nuclei and synergizes with other transport pathways to confine translation to the cytoplasm | journal = The EMBO Journal | volume = 21 | issue = 22 | pages = 6205–15 | date = Nov 2002 | pmid = 12426392 | pmc = 137205 | doi = 10.1093/emboj/cdf613 }}
*{{cite journal | author=Choi SK, Olsen DS, Roll-Mecak A, ''et al.'' |title=Physical and functional interaction between the eukaryotic orthologs of prokaryotic translation initiation factors IF1 and IF2. |journal=Mol. Cell. Biol. |volume=20 |issue= 19 |pages= 7183-91 |year= 2000 |pmid= 10982835 |doi= }}
* {{cite journal | vauthors = Olsen DS, Savner EM, Mathew A, Zhang F, Krishnamoorthy T, Phan L, Hinnebusch AG | title = Domains of eIF1A that mediate binding to eIF2, eIF3 and eIF5B and promote ternary complex recruitment in vivo | journal = The EMBO Journal | volume = 22 | issue = 2 | pages = 193–204 | date = Jan 2003 | pmid = 12514125 | pmc = 140105 | doi = 10.1093/emboj/cdg030 }}
*{{cite journal | author=Mingot JM, Kostka S, Kraft R, ''et al.'' |title=Importin 13: a novel mediator of nuclear import and export. |journal=EMBO J. |volume=20 |issue= 14 |pages= 3685-94 |year= 2001 |pmid= 11447110 |doi= 10.1093/emboj/20.14.3685 }}
* {{cite journal | vauthors = Marintchev A, Kolupaeva VG, Pestova TV, Wagner G | title = Mapping the binding interface between human eukaryotic initiation factors 1A and 5B: a new interaction between old partners | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 100 | issue = 4 | pages = 1535–40 | date = Feb 2003 | pmid = 12569173 | pmc = 149867 | doi = 10.1073/pnas.0437845100 }}
*{{cite journal | author=Sørensen HP, Hedegaard J, Sperling-Petersen HU, Mortensen KK |title=Remarkable conservation of translation initiation factors: IF1/eIF1A and IF2/eIF5B are universally distributed phylogenetic markers. |journal=IUBMB Life |volume=51 |issue= 5 |pages= 321-7 |year= 2002 |pmid= 11699879 |doi= }}
* {{cite journal | vauthors = Agate RJ, Choe M, Arnold AP | title = Sex differences in structure and expression of the sex chromosome genes CHD1Z and CHD1W in zebra finches | journal = Molecular Biology and Evolution | volume = 21 | issue = 2 | pages = 384–96 | date = Feb 2004 | pmid = 14660691 | doi = 10.1093/molbev/msh027 }}
*{{cite journal | author=Bohnsack MT, Regener K, Schwappach B, ''et al.'' |title=Exp5 exports eEF1A via tRNA from nuclei and synergizes with other transport pathways to confine translation to the cytoplasm. |journal=EMBO J. |volume=21 |issue= 22 |pages= 6205-15 |year= 2003 |pmid= 12426392 |doi= }}
* {{cite journal|authorlink30=Huda Zoghbi | vauthors = Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M | title = Towards a proteome-scale map of the human protein-protein interaction network | journal = Nature | volume = 437 | issue = 7062 | pages = 1173–8 | date = Oct 2005 | pmid = 16189514 | doi = 10.1038/nature04209 }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Kim S, Kim GJ, Miyoshi H, Moon SH, Ahn SE, Lee JH, Lee HJ, Cha KY, Chung HM | title = Efficiency of the elongation factor-1alpha promoter in mammalian embryonic stem cells using lentiviral gene delivery systems | journal = Stem Cells and Development | volume = 16 | issue = 4 | pages = 537–45 | date = Aug 2007 | pmid = 17784828 | doi = 10.1089/scd.2006.0088 }}
*{{cite journal | author=Olsen DS, Savner EM, Mathew A, ''et al.'' |title=Domains of eIF1A that mediate binding to eIF2, eIF3 and eIF5B and promote ternary complex recruitment in vivo. |journal=EMBO J. |volume=22 |issue= 2 |pages= 193-204 |year= 2003 |pmid= 12514125 |doi= 10.1093/emboj/cdg030 }}
*{{cite journal | author=Marintchev A, Kolupaeva VG, Pestova TV, Wagner G |title=Mapping the binding interface between human eukaryotic initiation factors 1A and 5B: a new interaction between old partners. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=100 |issue= 4 |pages= 1535-40 |year= 2003 |pmid= 12569173 |doi= 10.1073/pnas.0437845100 }}
*{{cite journal | author=Agate RJ, Choe M, Arnold AP |title=Sex differences in structure and expression of the sex chromosome genes CHD1Z and CHD1W in zebra finches. |journal=Mol. Biol. Evol. |volume=21 |issue= 2 |pages= 384-96 |year= 2004 |pmid= 14660691 |doi= 10.1093/molbev/msh027 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | author=Ross MT, Grafham DV, Coffey AJ, ''et al.'' |title=The DNA sequence of the human X chromosome. |journal=Nature |volume=434 |issue= 7031 |pages= 325-37 |year= 2005 |pmid= 15772651 |doi= 10.1038/nature03440 }}
*{{cite journal  | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal | author=Gregory SG, Barlow KF, McLay KE, ''et al.'' |title=The DNA sequence and biological annotation of human chromosome 1. |journal=Nature |volume=441 |issue= 7091 |pages= 315-21 |year= 2006 |pmid= 16710414 |doi= 10.1038/nature04727 }}
*{{cite journal  | author=Kim S, Kim GJ, Miyoshi H, ''et al.'' |title=Efficiency of the elongation factor-1alpha promoter in mammalian embryonic stem cells using lentiviral gene delivery systems. |journal=Stem Cells Dev. |volume=16 |issue= 4 |pages= 537-45 |year= 2007 |pmid= 17784828 |doi= 10.1089/scd.2006.0088 }}
}}
{{refend}}
{{refend}}
{{PDB Gallery|geneid=1964}}
{{Initiation factors}}


{{protein-stub}}
{{gene-X-stub}}
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Revision as of 00:03, 20 November 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
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Eukaryotic translation initiation factor 1A, X-chromosomal (eIF1A) is a protein that in humans is encoded by the EIF1AX gene.[1][2][3] This gene encodes an essential eukaryotic translation initiation factor. The protein is a component of the 43S pre-initiation complex (PIC), which mediates the recruitment of the small 40S ribosomal subunit to the 5' cap of messenger RNAs.[3]

Function

eIF1A is a small proteins (17 kDa in budding yeast) and a component of the 43S preinitiation complexes (PIC). eIF1A binds near the ribosomal A-site, in a manner similar to the functionally related bacterial counterpart IF1.[4]

Clinical significance

Mutations in this gene have been recurrently seen associated to cases of uveal melanoma with disomy 3.[5]

Interactions

EIF1AX has been shown to interact with IPO13.[6]

See also

References

  1. ↑ Dever TE, Wei CL, Benkowski LA, Browning K, Merrick WC, Hershey JW (Feb 1994). "Determination of the amino acid sequence of rabbit, human, and wheat germ protein synthesis factor eIF-4C by cloning and chemical sequencing". The Journal of Biological Chemistry. 269 (5): 3212–8. PMID 8106356.
  2. ↑ Lahn BT, Page DC (Oct 1997). "Functional coherence of the human Y chromosome". Science. 278 (5338): 675–80. Bibcode:1997Sci...278..675L. doi:10.1126/science.278.5338.675. PMID 9381176.
  3. ↑ 3.0 3.1 "Entrez Gene: EIF1AX eukaryotic translation initiation factor 1A, X-linked".
  4. ↑ Fraser, Christopher S. (2015). "Quantitative studies of mRNA recruitment to the eukaryotic ribosome". Biochimie. 114: 58–71. doi:10.1016/j.biochi.2015.02.017. PMC 4458453. PMID 25742741. Retrieved 6 March 2016.
  5. ↑ Martin M, Maßhöfer L, Temming P, Rahmann S, Metz C, Bornfeld N, van de Nes J, Klein-Hitpass L, Hinnebusch AG, Horsthemke B, Lohmann DR, Zeschnigk M (Aug 2013). "Exome sequencing identifies recurrent somatic mutations in EIF1AX and SF3B1 in uveal melanoma with disomy 3". Nature Genetics. 45 (8): 933–6. doi:10.1038/ng.2674. PMC 4307600. PMID 23793026.
  6. ↑ Mingot JM, Kostka S, Kraft R, Hartmann E, Görlich D (Jul 2001). "Importin 13: a novel mediator of nuclear import and export". The EMBO Journal. 20 (14): 3685–94. doi:10.1093/emboj/20.14.3685. PMC 125545. PMID 11447110.

Further reading


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