PRPF4: Difference between revisions

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{{Infobox_gene}}
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'''U4/U6 small nuclear ribonucleoprotein Prp4''' is a [[protein]] that in humans is encoded by the ''PRPF4'' [[gene]].<ref name="pmid9257651">{{cite journal | vauthors = Lauber J, Plessel G, Prehn S, Will CL, Fabrizio P, Groning K, Lane WS, Luhrmann R | title = The human U4/U6 snRNP contains 60 and 90kD proteins that are structurally homologous to the yeast splicing factors Prp4p and Prp3p | journal = RNA | volume = 3 | issue = 8 | pages = 926–41 |date=Sep 1997 | pmid = 9257651 | pmc = 1369537 | doi =  }}</ref><ref name="pmid9404889">{{cite journal | vauthors = Horowitz DS, Kobayashi R, Krainer AR | title = A new cyclophilin and the human homologues of yeast Prp3 and Prp4 form a complex associated with U4/U6 snRNPs | journal = RNA | volume = 3 | issue = 12 | pages = 1374–87 |date=Dec 1997 | pmid = 9404889 | pmc = 1369579 | doi =  }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: PRPF4 PRP4 pre-mRNA processing factor 4 homolog (yeast)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9128| accessdate = }}</ref>
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{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = PRP4 pre-mRNA processing factor 4 homolog (yeast)
| HGNCid = 17349
| Symbol = PRPF4
| AltSymbols =; PRP4; HPRP4; HPRP4P; Prp4p
| OMIM = 607795
| ECnumber = 
| Homologene = 3446
| MGIid = 1917302
| GeneAtlas_image1 = PBB_GE_PRPF4_209162_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_PRPF4_209161_at_tn.png
| Function = {{GNF_GO|id=GO:0031202 |text = RNA splicing factor activity, transesterification mechanism}}
  | Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005681 |text = spliceosome}}
| Process = {{GNF_GO|id=GO:0006397 |text = mRNA processing}} {{GNF_GO|id=GO:0008380 |text = RNA splicing}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 9128
    | Hs_Ensembl = ENSG00000136875
    | Hs_RefseqProtein = NP_004688
    | Hs_RefseqmRNA = NM_004697
    | Hs_GenLoc_db =
    | Hs_GenLoc_chr = 9
    | Hs_GenLoc_start = 115077444
    | Hs_GenLoc_end = 115095287
    | Hs_Uniprot = O43172
    | Mm_EntrezGene = 70052
    | Mm_Ensembl = ENSMUSG00000066148
    | Mm_RefseqmRNA = NM_027297
    | Mm_RefseqProtein = NP_081573
    | Mm_GenLoc_db =   
    | Mm_GenLoc_chr = 4
    | Mm_GenLoc_start = 61895144
    | Mm_GenLoc_end = 61913351
    | Mm_Uniprot = Q059T9
  }}
}}
'''PRP4 pre-mRNA processing factor 4 homolog (yeast)''', also known as '''PRPF4''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: PRPF4 PRP4 pre-mRNA processing factor 4 homolog (yeast)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9128| accessdate = }}</ref>


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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = The removal of introns from nuclear pre-mRNAs occurs on complexes called spliceosomes, which are made up of 4 small nuclear ribonucleoprotein (snRNP) particles and an undefined number of transiently associated splicing factors. PRPF4 is 1 of several proteins that associate with U4 and U6 snRNPs.[supplied by OMIM]<ref name="entrez">{{cite web | title = Entrez Gene: PRPF4 PRP4 pre-mRNA processing factor 4 homolog (yeast)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9128| accessdate = }}</ref>
| summary_text = The removal of introns from nuclear pre-mRNAs occurs on complexes called spliceosomes, which are made up of 4 small nuclear ribonucleoprotein (snRNP) particles and an undefined number of transiently associated splicing factors. PRPF4 is 1 of several proteins that associate with U4 and U6 snRNPs.[supplied by OMIM]<ref name="entrez">{{cite web | title = Entrez Gene: PRPF4 PRP4 pre-mRNA processing factor 4 homolog (yeast)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9128| accessdate = }}</ref>
}}
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171-4 |year= 1994 |pmid= 8125298 |doi=  }}
*{{cite journal  | vauthors=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1–2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=10.1016/0378-1119(94)90802-8 }}
*{{cite journal  | author=Horowitz DS, Krainer AR |title=A human protein required for the second step of pre-mRNA splicing is functionally related to a yeast splicing factor. |journal=Genes Dev. |volume=11 |issue= 1 |pages= 139-51 |year= 1997 |pmid= 9000057 |doi= }}
*{{cite journal  | vauthors=Horowitz DS, Krainer AR |title=A human protein required for the second step of pre-mRNA splicing is functionally related to a yeast splicing factor. |journal=Genes Dev. |volume=11 |issue= 1 |pages= 139–51 |year= 1997 |pmid= 9000057 |doi=10.1101/gad.11.1.139 }}
*{{cite journal  | author=Lauber J, Plessel G, Prehn S, ''et al.'' |title=The human U4/U6 snRNP contains 60 and 90kD proteins that are structurally homologous to the yeast splicing factors Prp4p and Prp3p. |journal=RNA |volume=3 |issue= 8 |pages= 926-41 |year= 1997 |pmid= 9257651 |doi= }}
*{{cite journal   |vauthors=Wang A, Forman-Kay J, Luo Y, etal |title=Identification and characterization of human genes encoding Hprp3p and Hprp4p, interacting components of the spliceosome. |journal=Hum. Mol. Genet. |volume=6 |issue= 12 |pages= 2117–26 |year= 1997 |pmid= 9328476 |doi=10.1093/hmg/6.12.2117 }}
*{{cite journal | author=Wang A, Forman-Kay J, Luo Y, ''et al.'' |title=Identification and characterization of human genes encoding Hprp3p and Hprp4p, interacting components of the spliceosome. |journal=Hum. Mol. Genet. |volume=6 |issue= 12 |pages= 2117-26 |year= 1997 |pmid= 9328476 |doi=  }}
*{{cite journal   |vauthors=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, etal |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1–2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=10.1016/S0378-1119(97)00411-3  }}
*{{cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, ''et al.'' |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149-56 |year= 1997 |pmid= 9373149 |doi= }}
*{{cite journal  | vauthors=Heng HH, Wang A, Hu J |title=Mapping of the human HPRP3 and HPRP4 genes encoding U4/U6-associated splicing factors to chromosomes 1q21.1 and 9q31-q33. |journal=Genomics |volume=48 |issue= 2 |pages= 273–5 |year= 1998 |pmid= 9521884 |doi= 10.1006/geno.1997.5181 }}
*{{cite journal  | author=Horowitz DS, Kobayashi R, Krainer AR |title=A new cyclophilin and the human homologues of yeast Prp3 and Prp4 form a complex associated with U4/U6 snRNPs. |journal=RNA |volume=3 |issue= 12 |pages= 1374-87 |year= 1997 |pmid= 9404889 |doi= }}
*{{cite journal   |vauthors=Kojima T, Zama T, Wada K, etal |title=Cloning of human PRP4 reveals interaction with Clk1. |journal=J. Biol. Chem. |volume=276 |issue= 34 |pages= 32247–56 |year= 2001 |pmid= 11418604 |doi= 10.1074/jbc.M103790200 }}
*{{cite journal  | author=Heng HH, Wang A, Hu J |title=Mapping of the human HPRP3 and HPRP4 genes encoding U4/U6-associated splicing factors to chromosomes 1q21.1 and 9q31-q33. |journal=Genomics |volume=48 |issue= 2 |pages= 273-5 |year= 1998 |pmid= 9521884 |doi= 10.1006/geno.1997.5181 }}
*{{cite journal   |vauthors=Gonzalez-Santos JM, Wang A, Jones J, etal |title=Central region of the human splicing factor Hprp3p interacts with Hprp4p. |journal=J. Biol. Chem. |volume=277 |issue= 26 |pages= 23764–72 |year= 2002 |pmid= 11971898 |doi= 10.1074/jbc.M111461200 }}
*{{cite journal | author=Kojima T, Zama T, Wada K, ''et al.'' |title=Cloning of human PRP4 reveals interaction with Clk1. |journal=J. Biol. Chem. |volume=276 |issue= 34 |pages= 32247-56 |year= 2001 |pmid= 11418604 |doi= 10.1074/jbc.M103790200 }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal | author=Gonzalez-Santos JM, Wang A, Jones J, ''et al.'' |title=Central region of the human splicing factor Hprp3p interacts with Hprp4p. |journal=J. Biol. Chem. |volume=277 |issue= 26 |pages= 23764-72 |year= 2002 |pmid= 11971898 |doi= 10.1074/jbc.M111461200 }}
*{{cite journal   |vauthors=Reidt U, Wahl MC, Fasshauer D, etal |title=Crystal structure of a complex between human spliceosomal cyclophilin H and a U4/U6 snRNP-60K peptide. |journal=J. Mol. Biol. |volume=331 |issue= 1 |pages= 45–56 |year= 2003 |pmid= 12875835 |doi=10.1016/S0022-2836(03)00684-3 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Ingelfinger D, Göthel SF, Marahiel MA, etal |title=Two protein-protein interaction sites on the spliceosome-associated human cyclophilin CypH. |journal=Nucleic Acids Res. |volume=31 |issue= 16 |pages= 4791–6 |year= 2004 |pmid= 12907720 |doi=10.1093/nar/gkg660  | pmc=169899 }}
*{{cite journal | author=Reidt U, Wahl MC, Fasshauer D, ''et al.'' |title=Crystal structure of a complex between human spliceosomal cyclophilin H and a U4/U6 snRNP-60K peptide. |journal=J. Mol. Biol. |volume=331 |issue= 1 |pages= 45-56 |year= 2003 |pmid= 12875835 |doi=  }}
*{{cite journal  | vauthors=Stanĕk D, Neugebauer KM |title=Detection of snRNP assembly intermediates in Cajal bodies by fluorescence resonance energy transfer. |journal=J. Cell Biol. |volume=166 |issue= 7 |pages= 1015–25 |year= 2004 |pmid= 15452143 |doi= 10.1083/jcb.200405160 | pmc=2172029 }}
*{{cite journal | author=Ingelfinger D, Göthel SF, Marahiel MA, ''et al.'' |title=Two protein-protein interaction sites on the spliceosome-associated human cyclophilin CypH. |journal=Nucleic Acids Res. |volume=31 |issue= 16 |pages= 4791-6 |year= 2004 |pmid= 12907720 |doi=  }}
*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
*{{cite journal  | author=Stanĕk D, Neugebauer KM |title=Detection of snRNP assembly intermediates in Cajal bodies by fluorescence resonance energy transfer. |journal=J. Cell Biol. |volume=166 |issue= 7 |pages= 1015-25 |year= 2004 |pmid= 15452143 |doi= 10.1083/jcb.200405160 }}
*{{cite journal   |vauthors=Andersen JS, Lam YW, Leung AK, etal |title=Nucleolar proteome dynamics. |journal=Nature |volume=433 |issue= 7021 |pages= 77–83 |year= 2005 |pmid= 15635413 |doi= 10.1038/nature03207 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal   |vauthors=Barrios-Rodiles M, Brown KR, Ozdamar B, etal |title=High-throughput mapping of a dynamic signaling network in mammalian cells. |journal=Science |volume=307 |issue= 5715 |pages= 1621–5 |year= 2005 |pmid= 15761153 |doi= 10.1126/science.1105776 }}
*{{cite journal | author=Andersen JS, Lam YW, Leung AK, ''et al.'' |title=Nucleolar proteome dynamics. |journal=Nature |volume=433 |issue= 7021 |pages= 77-83 |year= 2005 |pmid= 15635413 |doi= 10.1038/nature03207 }}
*{{cite journal   |vauthors=Rual JF, Venkatesan K, Hao T, etal |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal | author=Barrios-Rodiles M, Brown KR, Ozdamar B, ''et al.'' |title=High-throughput mapping of a dynamic signaling network in mammalian cells. |journal=Science |volume=307 |issue= 5715 |pages= 1621-5 |year= 2005 |pmid= 15761153 |doi= 10.1126/science.1105776 }}
*{{cite journal  | vauthors=Liu S, Rauhut R, Vornlocher HP, Lührmann R |title=The network of protein-protein interactions within the human U4/U6.U5 tri-snRNP. |journal=RNA |volume=12 |issue= 7 |pages= 1418–30 |year= 2006 |pmid= 16723661 |doi= 10.1261/rna.55406 | pmc=1484429 }}
*{{cite journal | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal   |vauthors=Huang B, Ahn YT, McPherson L, etal |title=Interaction of PRP4 with Kruppel-like factor 13 regulates CCL5 transcription. |journal=J. Immunol. |volume=178 |issue= 11 |pages= 7081–7 |year= 2007 |pmid= 17513757 |doi= 10.4049/jimmunol.178.11.7081| pmc=2674583 }}
*{{cite journal  | author=Liu S, Rauhut R, Vornlocher HP, Lührmann R |title=The network of protein-protein interactions within the human U4/U6.U5 tri-snRNP. |journal=RNA |volume=12 |issue= 7 |pages= 1418-30 |year= 2006 |pmid= 16723661 |doi= 10.1261/rna.55406 }}
*{{cite journal | author=Huang B, Ahn YT, McPherson L, ''et al.'' |title=Interaction of PRP4 with Kruppel-like factor 13 regulates CCL5 transcription. |journal=J. Immunol. |volume=178 |issue= 11 |pages= 7081-7 |year= 2007 |pmid= 17513757 |doi=  }}
}}
}}
{{refend}}
{{refend}}


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{{Post transcriptional modification}}
 
[[Category:Spliceosome]]
 
 
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Revision as of 18:45, 7 September 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

U4/U6 small nuclear ribonucleoprotein Prp4 is a protein that in humans is encoded by the PRPF4 gene.[1][2][3]

The removal of introns from nuclear pre-mRNAs occurs on complexes called spliceosomes, which are made up of 4 small nuclear ribonucleoprotein (snRNP) particles and an undefined number of transiently associated splicing factors. PRPF4 is 1 of several proteins that associate with U4 and U6 snRNPs.[supplied by OMIM][3]

References

  1. ↑ Lauber J, Plessel G, Prehn S, Will CL, Fabrizio P, Groning K, Lane WS, Luhrmann R (Sep 1997). "The human U4/U6 snRNP contains 60 and 90kD proteins that are structurally homologous to the yeast splicing factors Prp4p and Prp3p". RNA. 3 (8): 926–41. PMC 1369537. PMID 9257651.
  2. ↑ Horowitz DS, Kobayashi R, Krainer AR (Dec 1997). "A new cyclophilin and the human homologues of yeast Prp3 and Prp4 form a complex associated with U4/U6 snRNPs". RNA. 3 (12): 1374–87. PMC 1369579. PMID 9404889.
  3. ↑ 3.0 3.1 "Entrez Gene: PRPF4 PRP4 pre-mRNA processing factor 4 homolog (yeast)".

Further reading



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