RAB2A: Difference between revisions

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{{Infobox_gene}}
{{PBB_Controls
'''Ras-related protein Rab-2A''' is a [[protein]] that in humans is encoded by the ''RAB2A'' [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: RAB2A RAB2A, member RAS oncogene family| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5862| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image = PBB_Protein_RAB2A_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1z0a.
| PDB = {{PDB2|1z0a}}, {{PDB2|2a5j}}
| Name = RAB2A, member RAS oncogene family
| HGNCid = 9763
| Symbol = RAB2A
| AltSymbols =; RAB2
| OMIM = 179509
| ECnumber = 
| Homologene = 20628
| MGIid = 1928750
| GeneAtlas_image1 = PBB_GE_RAB2A_208732_at_tn.png
| GeneAtlas_image2 = PBB_GE_RAB2A_208731_at_tn.png
| GeneAtlas_image3 = PBB_GE_RAB2A_208733_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0003924 |text = GTPase activity}} {{GNF_GO|id=GO:0005525 |text = GTP binding}}
| Component = {{GNF_GO|id=GO:0005783 |text = endoplasmic reticulum}} {{GNF_GO|id=GO:0005794 |text = Golgi apparatus}}
| Process = {{GNF_GO|id=GO:0006888 |text = ER to Golgi vesicle-mediated transport}} {{GNF_GO|id=GO:0007264 |text = small GTPase mediated signal transduction}} {{GNF_GO|id=GO:0015031 |text = protein transport}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 5862
    | Hs_Ensembl = ENSG00000104388
    | Hs_RefseqProtein = NP_002856
    | Hs_RefseqmRNA = NM_002865
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 8
    | Hs_GenLoc_start = 61592316
    | Hs_GenLoc_end = 61696850
    | Hs_Uniprot = P61019
    | Mm_EntrezGene = 59021
    | Mm_Ensembl = ENSMUSG00000047187
    | Mm_RefseqmRNA = NM_021518
    | Mm_RefseqProtein = NP_067493
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 4
    | Mm_GenLoc_start = 8462824
    | Mm_GenLoc_end = 8534925
    | Mm_Uniprot = Q0PD65
  }}
}}
'''RAB2A, member RAS oncogene family''', also known as '''RAB2A''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: RAB2A RAB2A, member RAS oncogene family| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5862| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
Members of the Rab protein family are nontransforming monomeric GTP-binding proteins of the Ras superfamily that contain 4 highly conserved regions involved in GTP binding and hydrolysis. Rabs are prenylated, membrane-bound proteins involved in vesicular fusion and trafficking. The mammalian RAB proteins show striking similarities to the S. cerevisiae YPT1 and SEC4 proteins, Ras-related GTP-binding proteins involved in the regulation of secretion.[supplied by OMIM]<ref name="entrez" />
{{PBB_Summary
| section_title =
| summary_text = Members of the Rab protein family are nontransforming monomeric GTP-binding proteins of the Ras superfamily that contain 4 highly conserved regions involved in GTP binding and hydrolysis. Rabs are prenylated, membrane-bound proteins involved in vesicular fusion and trafficking. The mammalian RAB proteins show striking similarities to the S. cerevisiae YPT1 and SEC4 proteins, Ras-related GTP-binding proteins involved in the regulation of secretion.[supplied by OMIM]<ref name="entrez">{{cite web | title = Entrez Gene: RAB2A RAB2A, member RAS oncogene family| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5862| accessdate = }}</ref>
}}


==References==
== Interactions ==
{{reflist|2}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal  | author=Khosravi-Far R, Lutz RJ, Cox AD, ''et al.'' |title=Isoprenoid modification of rab proteins terminating in CC or CXC motifs. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=88 |issue= 14 |pages= 6264-8 |year= 1991 |pmid= 1648736 |doi=  }}
*{{cite journal  | author=Zahraoui A, Touchot N, Chardin P, Tavitian A |title=The human Rab genes encode a family of GTP-binding proteins related to yeast YPT1 and SEC4 products involved in secretion. |journal=J. Biol. Chem. |volume=264 |issue= 21 |pages= 12394-401 |year= 1989 |pmid= 2501306 |doi=  }}
*{{cite journal  | author=Tachibana K, Umezawa A, Kato S, Takano T |title=Nucleotide sequence of a new YPT1-related human cDNA which belongs to the ras gene superfamily. |journal=Nucleic Acids Res. |volume=16 |issue= 21 |pages= 10368 |year= 1989 |pmid= 3057444 |doi=  }}
*{{cite journal  | author=Andersson B, Wentland MA, Ricafrente JY, ''et al.'' |title=A "double adaptor" method for improved shotgun library construction. |journal=Anal. Biochem. |volume=236 |issue= 1 |pages= 107-13 |year= 1996 |pmid= 8619474 |doi= 10.1006/abio.1996.0138 }}
*{{cite journal  | author=Tisdale EJ, Balch WE |title=Rab2 is essential for the maturation of pre-Golgi intermediates. |journal=J. Biol. Chem. |volume=271 |issue= 46 |pages= 29372-9 |year= 1997 |pmid= 8910601 |doi=  }}
*{{cite journal  | author=Yu W, Andersson B, Worley KC, ''et al.'' |title=Large-scale concatenation cDNA sequencing. |journal=Genome Res. |volume=7 |issue= 4 |pages= 353-8 |year= 1997 |pmid= 9110174 |doi=  }}
*{{cite journal  | author=de Leeuw HP, Koster PM, Calafat J, ''et al.'' |title=Small GTP-binding proteins in human endothelial cells. |journal=Br. J. Haematol. |volume=103 |issue= 1 |pages= 15-9 |year= 1998 |pmid= 9792283 |doi=  }}
*{{cite journal  | author=Shisheva A, Chinni SR, DeMarco C |title=General role of GDP dissociation inhibitor 2 in membrane release of Rab proteins: modulations of its functional interactions by in vitro and in vivo structural modifications. |journal=Biochemistry |volume=38 |issue= 36 |pages= 11711-21 |year= 1999 |pmid= 10512627 |doi=  }}
*{{cite journal  | author=Caillol N, Pasqualini E, Lloubes R, Lombardo D |title=Impairment of bile salt-dependent lipase secretion in human pancreatic tumoral SOJ-6 cells. |journal=J. Cell. Biochem. |volume=79 |issue= 4 |pages= 628-47 |year= 2000 |pmid= 10996854 |doi=  }}
*{{cite journal  | author=Short B, Preisinger C, Körner R, ''et al.'' |title=A GRASP55-rab2 effector complex linking Golgi structure to membrane traffic. |journal=J. Cell Biol. |volume=155 |issue= 6 |pages= 877-83 |year= 2002 |pmid= 11739401 |doi= 10.1083/jcb.200108079 }}
*{{cite journal  | author=Ni X, Ma Y, Cheng H, ''et al.'' |title=Molecular cloning and characterization of a novel human Rab ( Rab2B) gene. |journal=J. Hum. Genet. |volume=47 |issue= 10 |pages= 548-51 |year= 2002 |pmid= 12376746 |doi= 10.1007/s100380200083 }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | author=Tisdale EJ |title=Rab2 interacts directly with atypical protein kinase C (aPKC) iota/lambda and inhibits aPKCiota/lambda-dependent glyceraldehyde-3-phosphate dehydrogenase phosphorylation. |journal=J. Biol. Chem. |volume=278 |issue= 52 |pages= 52524-30 |year= 2004 |pmid= 14570876 |doi= 10.1074/jbc.M309343200 }}
*{{cite journal  | author=Tisdale EJ, Kelly C, Artalejo CR |title=Glyceraldehyde-3-phosphate dehydrogenase interacts with Rab2 and plays an essential role in endoplasmic reticulum to Golgi transport exclusive of its glycolytic activity. |journal=J. Biol. Chem. |volume=279 |issue= 52 |pages= 54046-52 |year= 2005 |pmid= 15485821 |doi= 10.1074/jbc.M409472200 }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal  | author=Chi A, Valencia JC, Hu ZZ, ''et al.'' |title=Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes. |journal=J. Proteome Res. |volume=5 |issue= 11 |pages= 3135-44 |year= 2007 |pmid= 17081065 |doi= 10.1021/pr060363j }}
*{{cite journal  | author=Dong C, Wu G |title=Regulation of anterograde transport of adrenergic and angiotensin II receptors by Rab2 and Rab6 GTPases. |journal=Cell. Signal. |volume=19 |issue= 11 |pages= 2388-99 |year= 2007 |pmid= 17716866 |doi= 10.1016/j.cellsig.2007.07.017 }}
}}
{{refend}}


{{protein-stub}}
RAB2A has been shown to [[Protein-protein interaction|interact]] with [[GOLGA2]].<ref name=pmid16189514>{{cite journal | vauthors = Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M | title = Towards a proteome-scale map of the human protein-protein interaction network | journal = Nature | volume = 437 | issue = 7062 | pages = 1173–8 | date = Oct 2005 | pmid = 16189514 | doi = 10.1038/nature04209 }}</ref><ref name=pmid11739401>{{cite journal | vauthors = Short B, Preisinger C, Körner R, Kopajtich R, Byron O, Barr FA | title = A GRASP55-rab2 effector complex linking Golgi structure to membrane traffic | journal = The Journal of Cell Biology | volume = 155 | issue = 6 | pages = 877–83 | date = Dec 2001 | pmid = 11739401 | pmc = 2150909 | doi = 10.1083/jcb.200108079 }}</ref>
{{WikiDoc Sources}}
 
== References ==
{{Reflist}}
 
== Further reading ==
{{Refbegin | 2}}
* {{cite journal | vauthors = Khosravi-Far R, Lutz RJ, Cox AD, Conroy L, Bourne JR, Sinensky M, Balch WE, Buss JE, Der CJ | title = Isoprenoid modification of rab proteins terminating in CC or CXC motifs | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 88 | issue = 14 | pages = 6264–8 | date = Jul 1991 | pmid = 1648736 | pmc = 52063 | doi = 10.1073/pnas.88.14.6264 }}
* {{cite journal | vauthors = Zahraoui A, Touchot N, Chardin P, Tavitian A | title = The human Rab genes encode a family of GTP-binding proteins related to yeast YPT1 and SEC4 products involved in secretion | journal = The Journal of Biological Chemistry | volume = 264 | issue = 21 | pages = 12394–401 | date = Jul 1989 | pmid = 2501306 | doi =  }}
* {{cite journal | vauthors = Tachibana K, Umezawa A, Kato S, Takano T | title = Nucleotide sequence of a new YPT1-related human cDNA which belongs to the ras gene superfamily | journal = Nucleic Acids Research | volume = 16 | issue = 21 | pages = 10368 | date = Nov 1988 | pmid = 3057444 | pmc = 338870 | doi = 10.1093/nar/16.21.10368 }}
* {{cite journal | vauthors = Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA | title = A "double adaptor" method for improved shotgun library construction | journal = Analytical Biochemistry | volume = 236 | issue = 1 | pages = 107–13 | date = Apr 1996 | pmid = 8619474 | doi = 10.1006/abio.1996.0138 }}
* {{cite journal | vauthors = Tisdale EJ, Balch WE | title = Rab2 is essential for the maturation of pre-Golgi intermediates | journal = The Journal of Biological Chemistry | volume = 271 | issue = 46 | pages = 29372–9 | date = Nov 1996 | pmid = 8910601 | doi = 10.1074/jbc.271.46.29372 }}
* {{cite journal | vauthors = Yu W, Andersson B, Worley KC, Muzny DM, Ding Y, Liu W, Ricafrente JY, Wentland MA, Lennon G, Gibbs RA | title = Large-scale concatenation cDNA sequencing | journal = Genome Research | volume = 7 | issue = 4 | pages = 353–8 | date = Apr 1997 | pmid = 9110174 | pmc = 139146 | doi = 10.1101/gr.7.4.353 }}
* {{cite journal | vauthors = de Leeuw HP, Koster PM, Calafat J, Janssen H, van Zonneveld AJ, van Mourik JA, Voorberg J | title = Small GTP-binding proteins in human endothelial cells | journal = British Journal of Haematology | volume = 103 | issue = 1 | pages = 15–9 | date = Oct 1998 | pmid = 9792283 | doi = 10.1046/j.1365-2141.1998.00965.x }}
* {{cite journal | vauthors = Shisheva A, Chinni SR, DeMarco C | title = General role of GDP dissociation inhibitor 2 in membrane release of Rab proteins: modulations of its functional interactions by in vitro and in vivo structural modifications | journal = Biochemistry | volume = 38 | issue = 36 | pages = 11711–21 | date = Sep 1999 | pmid = 10512627 | doi = 10.1021/bi990200r }}
* {{cite journal | vauthors = Caillol N, Pasqualini E, Lloubes R, Lombardo D | title = Impairment of bile salt-dependent lipase secretion in human pancreatic tumoral SOJ-6 cells | journal = Journal of Cellular Biochemistry | volume = 79 | issue = 4 | pages = 628–47 | date = Sep 2000 | pmid = 10996854 | doi = 10.1002/1097-4644(20001215)79:4<628::AID-JCB120>3.0.CO;2-T }}
* {{cite journal | vauthors = Short B, Preisinger C, Körner R, Kopajtich R, Byron O, Barr FA | title = A GRASP55-rab2 effector complex linking Golgi structure to membrane traffic | journal = The Journal of Cell Biology | volume = 155 | issue = 6 | pages = 877–83 | date = Dec 2001 | pmid = 11739401 | pmc = 2150909 | doi = 10.1083/jcb.200108079 }}
* {{cite journal | vauthors = Ni X, Ma Y, Cheng H, Jiang M, Guo L, Ji C, Gu S, Cao Y, Xie Y, Mao Y | title = Molecular cloning and characterization of a novel human Rab ( Rab2B) gene | journal = Journal of Human Genetics | volume = 47 | issue = 10 | pages = 548–51 | year = 2002 | pmid = 12376746 | doi = 10.1007/s100380200083 }}
* {{cite journal | vauthors = Tisdale EJ | title = Rab2 interacts directly with atypical protein kinase C (aPKC) iota/lambda and inhibits aPKCiota/lambda-dependent glyceraldehyde-3-phosphate dehydrogenase phosphorylation | journal = The Journal of Biological Chemistry | volume = 278 | issue = 52 | pages = 52524–30 | date = Dec 2003 | pmid = 14570876 | doi = 10.1074/jbc.M309343200 }}
* {{cite journal | vauthors = Tisdale EJ, Kelly C, Artalejo CR | title = Glyceraldehyde-3-phosphate dehydrogenase interacts with Rab2 and plays an essential role in endoplasmic reticulum to Golgi transport exclusive of its glycolytic activity | journal = The Journal of Biological Chemistry | volume = 279 | issue = 52 | pages = 54046–52 | date = Dec 2004 | pmid = 15485821 | doi = 10.1074/jbc.M409472200 }}
* {{cite journal | vauthors = Chi A, Valencia JC, Hu ZZ, Watabe H, Yamaguchi H, Mangini NJ, Huang H, Canfield VA, Cheng KC, Yang F, Abe R, Yamagishi S, Shabanowitz J, Hearing VJ, Wu C, Appella E, Hunt DF | title = Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes | journal = Journal of Proteome Research | volume = 5 | issue = 11 | pages = 3135–44 | date = Nov 2006 | pmid = 17081065 | doi = 10.1021/pr060363j }}
* {{cite journal | vauthors = Dong C, Wu G | title = Regulation of anterograde transport of adrenergic and angiotensin II receptors by Rab2 and Rab6 GTPases | journal = Cellular Signalling | volume = 19 | issue = 11 | pages = 2388–99 | date = Nov 2007 | pmid = 17716866 | pmc = 2072516 | doi = 10.1016/j.cellsig.2007.07.017 }}
{{Refend}}
 
{{PDB Gallery|geneid=5862}}
 
{{Gene-8-stub}}

Latest revision as of 08:46, 10 September 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

n/a

Ensembl

n/a

n/a

UniProt

n/a

n/a

RefSeq (mRNA)

n/a

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Ras-related protein Rab-2A is a protein that in humans is encoded by the RAB2A gene.[1]

Function

Members of the Rab protein family are nontransforming monomeric GTP-binding proteins of the Ras superfamily that contain 4 highly conserved regions involved in GTP binding and hydrolysis. Rabs are prenylated, membrane-bound proteins involved in vesicular fusion and trafficking. The mammalian RAB proteins show striking similarities to the S. cerevisiae YPT1 and SEC4 proteins, Ras-related GTP-binding proteins involved in the regulation of secretion.[supplied by OMIM][1]

Interactions

RAB2A has been shown to interact with GOLGA2.[2][3]

References

  1. ↑ 1.0 1.1 "Entrez Gene: RAB2A RAB2A, member RAS oncogene family".
  2. ↑ Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
  3. ↑ Short B, Preisinger C, Körner R, Kopajtich R, Byron O, Barr FA (Dec 2001). "A GRASP55-rab2 effector complex linking Golgi structure to membrane traffic". The Journal of Cell Biology. 155 (6): 877–83. doi:10.1083/jcb.200108079. PMC 2150909. PMID 11739401.

Further reading

Retrieved from "https://www.wikidoc.org/index.php?title=RAB2A&oldid=1422228"