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{{Infobox_gene}}
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'''Dynein light chain Tctex-type 1''' is a [[protein]] that in humans is encoded by the ''DYNLT1'' [[gene]].<ref name="pmid8646886">{{cite journal | vauthors = Watanabe TK, Fujiwara T, Shimizu F, Okuno S, Suzuki M, Takahashi E, Nakamura Y, Hirai Y | title = Cloning, expression, and mapping of TCTEL1, a putative human homologue of murine Tcte1, to 6q | journal = Cytogenet Cell Genet | volume = 73 | issue = 1-2 | pages = 153–6 |date=Jul 1996 | pmid = 8646886 | pmc =  | doi =10.1159/000134329 }}</ref><ref name="pmid16260502">{{cite journal | vauthors = Pfister KK, Fisher EM, Gibbons IR, Hays TS, Holzbaur EL, McIntosh JR, Porter ME, Schroer TA, Vaughan KT, Witman GB, King SM, Vallee RB | title = Cytoplasmic dynein nomenclature | journal = J Cell Biol | volume = 171 | issue = 3 | pages = 411–3 |date=Nov 2005 | pmid = 16260502 | pmc = 2171247 | doi = 10.1083/jcb.200508078 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: DYNLT1 dynein, light chain, Tctex-type 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6993| accessdate = }}</ref>
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{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Dynein, light chain, Tctex-type 1
| HGNCid = 11697
| Symbol = DYNLT1
| AltSymbols =; CW-1; MGC111571; TCTEL1; tctex-1
| OMIM = 601554
| ECnumber =
| Homologene = 4754
| MGIid = 98643
  | GeneAtlas_image1 = PBB_GE_DYNLT1_201999_s_at_tn.png
  | Function = {{GNF_GO|id=GO:0003777 |text = microtubule motor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0005868 |text = cytoplasmic dynein complex}} {{GNF_GO|id=GO:0005874 |text = microtubule}}
| Process =
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 6993
    | Hs_Ensembl = ENSG00000146425
    | Hs_RefseqProtein = NP_006510
    | Hs_RefseqmRNA = NM_006519
    | Hs_GenLoc_db =
    | Hs_GenLoc_chr = 6
    | Hs_GenLoc_start = 158977494
    | Hs_GenLoc_end = 158985759
    | Hs_Uniprot = P63172
    | Mm_EntrezGene = 21648
    | Mm_Ensembl = 
    | Mm_RefseqmRNA = XM_001006801
    | Mm_RefseqProtein = XP_001006801
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 
    | Mm_GenLoc_start = 
    | Mm_GenLoc_end = 
    | Mm_Uniprot = 
  }}
}}
'''Dynein, light chain, Tctex-type 1''', also known as '''DYNLT1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: DYNLT1 dynein, light chain, Tctex-type 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6993| accessdate = }}</ref>


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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = Cytoplasmic dynein is the major motor protein complex responsible for minus-end, microtubule-based motile processes. Each dynein complex consists of 2 heavy chains that have ATPase and motor activities, plus a group of accessory polypeptides. TCTEX1 is a dynein light chain involved in cargo binding (Chuang et al., 2005).[supplied by OMIM]<ref name="entrez">{{cite web | title = Entrez Gene: DYNLT1 dynein, light chain, Tctex-type 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6993| accessdate = }}</ref>
| summary_text = Cytoplasmic dynein is the major motor protein complex responsible for minus-end, microtubule-based motile processes. Each dynein complex consists of 2 heavy chains that have ATPase and motor activities, plus a group of accessory polypeptides. TCTEX1 is a dynein light chain involved in cargo binding (Chuang et al., 2005).[supplied by OMIM]<ref name="entrez" />
}}
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Tete R, de Montgolfier R, Piante M |title=[Leiomyoma and leiomyosarcoma of the small intestine. Value of selective angiography] |journal=Journal de médecine de Lyon |volume=52 |issue= 192 |pages= 1523-6 passim |year= 1971 |pmid= 5503857 |doi=  }}
*{{cite journal  | vauthors=Tete R, de Montgolfier R, Piante M |title=[Leiomyoma and leiomyosarcoma of the small intestine. Value of selective angiography] |journal=Journal de médecine de Lyon |volume=52 |issue= 192 |pages= 1523–6 passim |year= 1971 |pmid= 5503857 |doi=  }}
*{{cite journal  | author=Watanabe TK, Fujiwara T, Shimizu F, ''et al.'' |title=Cloning, expression, and mapping of TCTEL1, a putative human homologue of murine Tcte1, to 6q. |journal=Cytogenet. Cell Genet. |volume=73 |issue= 1-2 |pages= 153-6 |year= 1996 |pmid= 8646886 |doi=  }}
*{{cite journal  | vauthors=King SM, Dillman JF, Benashski SE |title=The mouse t-complex-encoded protein Tctex-1 is a light chain of brain cytoplasmic dynein. |journal=J. Biol. Chem. |volume=271 |issue= 50 |pages= 32281–7 |year= 1997 |pmid= 8943288 |doi=10.1074/jbc.271.50.32281 |display-authors=etal}}
*{{cite journal  | author=King SM, Dillman JF, Benashski SE, ''et al.'' |title=The mouse t-complex-encoded protein Tctex-1 is a light chain of brain cytoplasmic dynein. |journal=J. Biol. Chem. |volume=271 |issue= 50 |pages= 32281-7 |year= 1997 |pmid= 8943288 |doi=  }}
*{{cite journal  | vauthors=Nagano F, Orita S, Sasaki T |title=Interaction of Doc2 with tctex-1, a light chain of cytoplasmic dynein. Implication in dynein-dependent vesicle transport. |journal=J. Biol. Chem. |volume=273 |issue= 46 |pages= 30065–8 |year= 1998 |pmid= 9804756 |doi=10.1074/jbc.273.46.30065 |display-authors=etal}}
*{{cite journal  | author=Nagano F, Orita S, Sasaki T, ''et al.'' |title=Interaction of Doc2 with tctex-1, a light chain of cytoplasmic dynein. Implication in dynein-dependent vesicle transport. |journal=J. Biol. Chem. |volume=273 |issue= 46 |pages= 30065-8 |year= 1998 |pmid= 9804756 |doi=  }}
*{{cite journal  | vauthors=Strovel ET, Wu D, Sussman DJ |title=Protein phosphatase 2Calpha dephosphorylates axin and activates LEF-1-dependent transcription. |journal=J. Biol. Chem. |volume=275 |issue= 4 |pages= 2399–403 |year= 2000 |pmid= 10644691 |doi=10.1074/jbc.275.4.2399 }}
*{{cite journal  | author=Strovel ET, Wu D, Sussman DJ |title=Protein phosphatase 2Calpha dephosphorylates axin and activates LEF-1-dependent transcription. |journal=J. Biol. Chem. |volume=275 |issue= 4 |pages= 2399-403 |year= 2000 |pmid= 10644691 |doi=  }}
*{{cite journal  | vauthors=Mueller S, Cao X, Welker R, Wimmer E |title=Interaction of the poliovirus receptor CD155 with the dynein light chain Tctex-1 and its implication for poliovirus pathogenesis. |journal=J. Biol. Chem. |volume=277 |issue= 10 |pages= 7897–904 |year= 2002 |pmid= 11751937 |doi= 10.1074/jbc.M111937200 }}
*{{cite journal  | author=Mueller S, Cao X, Welker R, Wimmer E |title=Interaction of the poliovirus receptor CD155 with the dynein light chain Tctex-1 and its implication for poliovirus pathogenesis. |journal=J. Biol. Chem. |volume=277 |issue= 10 |pages= 7897-904 |year= 2002 |pmid= 11751937 |doi= 10.1074/jbc.M111937200 }}
*{{cite journal  | vauthors=Schwarzer C, Barnikol-Watanabe S, Thinnes FP, Hilschmann N |title=Voltage-dependent anion-selective channel (VDAC) interacts with the dynein light chain Tctex1 and the heat-shock protein PBP74. |journal=Int. J. Biochem. Cell Biol. |volume=34 |issue= 9 |pages= 1059–70 |year= 2002 |pmid= 12009301 |doi=10.1016/S1357-2725(02)00026-2 }}
*{{cite journal  | author=Schwarzer C, Barnikol-Watanabe S, Thinnes FP, Hilschmann N |title=Voltage-dependent anion-selective channel (VDAC) interacts with the dynein light chain Tctex1 and the heat-shock protein PBP74. |journal=Int. J. Biochem. Cell Biol. |volume=34 |issue= 9 |pages= 1059-70 |year= 2002 |pmid= 12009301 |doi=  }}
*{{cite journal  | vauthors=Nadano D, Nakayama J, Matsuzawa S |title=Human tastin, a proline-rich cytoplasmic protein, associates with the microtubular cytoskeleton. |journal=Biochem. J. |volume=364 |issue= Pt 3 |pages= 669–77 |year= 2002 |pmid= 12049630 |doi= 10.1042/BJ20011836 | pmc=1222615 |display-authors=etal}}
*{{cite journal  | author=Nadano D, Nakayama J, Matsuzawa S, ''et al.'' |title=Human tastin, a proline-rich cytoplasmic protein, associates with the microtubular cytoskeleton. |journal=Biochem. J. |volume=364 |issue= Pt 3 |pages= 669-77 |year= 2002 |pmid= 12049630 |doi= 10.1042/BJ20011836 }}
*{{cite journal  | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |display-authors=etal}}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | vauthors=Machado RD, Rudarakanchana N, Atkinson C |title=Functional interaction between BMPR-II and Tctex-1, a light chain of Dynein, is isoform-specific and disrupted by mutations underlying primary pulmonary hypertension. |journal=Hum. Mol. Genet. |volume=12 |issue= 24 |pages= 3277–86 |year= 2004 |pmid= 14583445 |doi= 10.1093/hmg/ddg365 |display-authors=etal}}
*{{cite journal  | author=Machado RD, Rudarakanchana N, Atkinson C, ''et al.'' |title=Functional interaction between BMPR-II and Tctex-1, a light chain of Dynein, is isoform-specific and disrupted by mutations underlying primary pulmonary hypertension. |journal=Hum. Mol. Genet. |volume=12 |issue= 24 |pages= 3277-86 |year= 2004 |pmid= 14583445 |doi= 10.1093/hmg/ddg365 }}
*{{cite journal  | vauthors=Douglas MW, Diefenbach RJ, Homa FL |title=Herpes simplex virus type 1 capsid protein VP26 interacts with dynein light chains RP3 and Tctex1 and plays a role in retrograde cellular transport. |journal=J. Biol. Chem. |volume=279 |issue= 27 |pages= 28522–30 |year= 2004 |pmid= 15117959 |doi= 10.1074/jbc.M311671200 |display-authors=etal}}
*{{cite journal  | author=Douglas MW, Diefenbach RJ, Homa FL, ''et al.'' |title=Herpes simplex virus type 1 capsid protein VP26 interacts with dynein light chains RP3 and Tctex1 and plays a role in retrograde cellular transport. |journal=J. Biol. Chem. |volume=279 |issue= 27 |pages= 28522-30 |year= 2004 |pmid= 15117959 |doi= 10.1074/jbc.M311671200 }}
*{{cite journal  | vauthors=Ohka S, Matsuda N, Tohyama K |title=Receptor (CD155)-dependent endocytosis of poliovirus and retrograde axonal transport of the endosome. |journal=J. Virol. |volume=78 |issue= 13 |pages= 7186–98 |year= 2004 |pmid= 15194795 |doi= 10.1128/JVI.78.13.7186-7198.2004 | pmc=421661 |display-authors=etal}}
*{{cite journal  | author=Ohka S, Matsuda N, Tohyama K, ''et al.'' |title=Receptor (CD155)-dependent endocytosis of poliovirus and retrograde axonal transport of the endosome. |journal=J. Virol. |volume=78 |issue= 13 |pages= 7186-98 |year= 2004 |pmid= 15194795 |doi= 10.1128/JVI.78.13.7186-7198.2004 }}
*{{cite journal  | vauthors=Gerhard DS, Wagner L, Feingold EA |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |display-authors=etal}}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | vauthors=de Wit NJ, Verschuure P, Kappé G |title=Testis-specific human small heat shock protein HSPB9 is a cancer/testis antigen, and potentially interacts with the dynein subunit TCTEL1. |journal=Eur. J. Cell Biol. |volume=83 |issue= 7 |pages= 337–45 |year= 2005 |pmid= 15503857 |doi=10.1078/0171-9335-00396 |display-authors=etal}}
*{{cite journal  | author=de Wit NJ, Verschuure P, Kappé G, ''et al.'' |title=Testis-specific human small heat shock protein HSPB9 is a cancer/testis antigen, and potentially interacts with the dynein subunit TCTEL1. |journal=Eur. J. Cell Biol. |volume=83 |issue= 7 |pages= 337-45 |year= 2005 |pmid= 15503857 |doi=  }}
*{{cite journal  | vauthors=Chuang JZ, Yeh TY, Bollati F |title=The dynein light chain Tctex-1 has a dynein-independent role in actin remodeling during neurite outgrowth. |journal=Dev. Cell |volume=9 |issue= 1 |pages= 75–86 |year= 2005 |pmid= 15992542 |doi= 10.1016/j.devcel.2005.04.003 |display-authors=etal}}
*{{cite journal  | author=Chuang JZ, Yeh TY, Bollati F, ''et al.'' |title=The dynein light chain Tctex-1 has a dynein-independent role in actin remodeling during neurite outgrowth. |journal=Dev. Cell |volume=9 |issue= 1 |pages= 75-86 |year= 2005 |pmid= 15992542 |doi= 10.1016/j.devcel.2005.04.003 }}
*{{cite journal  | vauthors=Yeh TY, Peretti D, Chuang JZ |title=Regulatory dissociation of Tctex-1 light chain from dynein complex is essential for the apical delivery of rhodopsin. |journal=Traffic |volume=7 |issue= 11 |pages= 1495–502 |year= 2007 |pmid= 16956385 |doi= 10.1111/j.1600-0854.2006.00482.x |display-authors=etal}}
*{{cite journal  | author=Pfister KK, Fisher EM, Gibbons IR, ''et al.'' |title=Cytoplasmic dynein nomenclature. |journal=J. Cell Biol. |volume=171 |issue= 3 |pages= 411-3 |year= 2006 |pmid= 16260502 |doi= 10.1083/jcb.200508078 }}
*{{cite journal  | author=Yeh TY, Peretti D, Chuang JZ, ''et al.'' |title=Regulatory dissociation of Tctex-1 light chain from dynein complex is essential for the apical delivery of rhodopsin. |journal=Traffic |volume=7 |issue= 11 |pages= 1495-502 |year= 2007 |pmid= 16956385 |doi= 10.1111/j.1600-0854.2006.00482.x }}
}}
}}
{{refend}}
{{refend}}


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Revision as of 18:47, 30 August 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Dynein light chain Tctex-type 1 is a protein that in humans is encoded by the DYNLT1 gene.[1][2][3]

Cytoplasmic dynein is the major motor protein complex responsible for minus-end, microtubule-based motile processes. Each dynein complex consists of 2 heavy chains that have ATPase and motor activities, plus a group of accessory polypeptides. TCTEX1 is a dynein light chain involved in cargo binding (Chuang et al., 2005).[supplied by OMIM][3]

References

  1. ↑ Watanabe TK, Fujiwara T, Shimizu F, Okuno S, Suzuki M, Takahashi E, Nakamura Y, Hirai Y (Jul 1996). "Cloning, expression, and mapping of TCTEL1, a putative human homologue of murine Tcte1, to 6q". Cytogenet Cell Genet. 73 (1–2): 153–6. doi:10.1159/000134329. PMID 8646886.
  2. ↑ Pfister KK, Fisher EM, Gibbons IR, Hays TS, Holzbaur EL, McIntosh JR, Porter ME, Schroer TA, Vaughan KT, Witman GB, King SM, Vallee RB (Nov 2005). "Cytoplasmic dynein nomenclature". J Cell Biol. 171 (3): 411–3. doi:10.1083/jcb.200508078. PMC 2171247. PMID 16260502.
  3. ↑ 3.0 3.1 "Entrez Gene: DYNLT1 dynein, light chain, Tctex-type 1".

Further reading



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