Small nuclear ribonucleoprotein polypeptide C: Difference between revisions

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{{Infobox_gene}}
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'''U1 small nuclear ribonucleoprotein C''' is a [[protein]] that in humans is encoded by the ''SNRPC'' [[gene]].<ref name="pmid2971157">{{cite journal |vauthors=Sillekens PT, Beijer RP, Habets WJ, van Venrooij WJ | title = Human U1 snRNP-specific C protein: complete cDNA and protein sequence and identification of a multigene family in mammals | journal = Nucleic Acids Res | volume = 16 | issue = 17 | pages = 8307–8321 |date=October 1988 | pmid = 2971157 | pmc = 338560 | doi =10.1093/nar/16.17.8307 }}</ref><ref name="pmid8532530">{{cite journal |vauthors=Gunnewiek JM, van Aarssen Y, Wassenaar R, Legrain P, van Venrooij WJ, Nelissen RL | title = Homodimerization of the human U1 snRNP-specific protein C | journal = Nucleic Acids Res | volume = 23 | issue = 23 | pages = 4864–4871 |date=February 1996 | pmid = 8532530 | pmc = 307476 | doi =10.1093/nar/23.23.4864 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: SNRPC small nuclear ribonucleoprotein polypeptide C| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6631| accessdate = }}</ref>
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{{GNF_Protein_box
| image = PBB_Protein_SNRPC_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1uw2.
| PDB = {{PDB2|1uw2}}
| Name = Small nuclear ribonucleoprotein polypeptide C
| HGNCid = 11157
| Symbol = SNRPC
| AltSymbols =; FLJ20302
| OMIM = 603522
| ECnumber =
| Homologene = 31131
| MGIid = 109489
| GeneAtlas_image1 = PBB_GE_SNRPC_201342_at_tn.png
  | Function = {{GNF_GO|id=GO:0003676 |text = nucleic acid binding}} {{GNF_GO|id=GO:0003723 |text = RNA binding}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005685 |text = snRNP U1}} {{GNF_GO|id=GO:0030529 |text = ribonucleoprotein complex}}
| Process = {{GNF_GO|id=GO:0008380 |text = RNA splicing}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 6631
    | Hs_Ensembl = ENSG00000124562
    | Hs_RefseqProtein = NP_003084
    | Hs_RefseqmRNA = NM_003093
    | Hs_GenLoc_db =
    | Hs_GenLoc_chr = 6
    | Hs_GenLoc_start = 34833161
    | Hs_GenLoc_end = 34849549
    | Hs_Uniprot = P09234
    | Mm_EntrezGene = 20630
    | Mm_Ensembl = 
    | Mm_RefseqmRNA = NM_011432
    | Mm_RefseqProtein = NP_035562
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 
    | Mm_GenLoc_start = 
    | Mm_GenLoc_end = 
    | Mm_Uniprot =   
  }}
}}
'''Small nuclear ribonucleoprotein polypeptide C''', also known as '''SNRPC''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: SNRPC small nuclear ribonucleoprotein polypeptide C| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6631| accessdate = }}</ref>


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==Interactions==
Small nuclear ribonucleoprotein polypeptide C has been shown to [[Protein-protein interaction|interact]] with [[Ewing sarcoma breakpoint region 1]].<ref name=pmid10827180>{{cite journal |last=Knoop |first=L L |authorlink= |author2=Baker S J  |date=August 2000  |title=The splicing factor U1C represses EWS/FLI-mediated transactivation |journal=J. Biol. Chem. |volume=275 |issue=32 |pages=24865–24871 |publisher= |location = UNITED STATES| issn = 0021-9258| pmid = 10827180 |doi = 10.1074/jbc.M001661200 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref>


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Yamamoto K, Miura H, Moroi Y, ''et al.'' |title=Isolation and characterization of a complementary DNA expressing human U1 small nuclear ribonucleoprotein C polypeptide. |journal=J. Immunol. |volume=140 |issue= 1 |pages= 311-7 |year= 1988 |pmid= 2961811 |doi=  }}
*{{cite journal  | author=Yamamoto K |title=Isolation and characterization of a complementary DNA expressing human U1 small nuclear ribonucleoprotein C polypeptide |journal=J. Immunol. |volume=140 |issue= 1 |pages= 311–7 |year= 1988 |pmid= 2961811 |doi=  |name-list-format=vanc| author2=Miura H  | author3=Moroi Y | display-authors=3  | last4=Yoshinoya  | first4=S  | last5=Goto  | first5=M  | last6=Nishioka  | first6=K  | last7=Miyamoto  | first7=T }}
*{{cite journal | author=Sillekens PT, Beijer RP, Habets WJ, van Venrooij WJ |title=Human U1 snRNP-specific C protein: complete cDNA and protein sequence and identification of a multigene family in mammals. |journal=Nucleic Acids Res. |volume=16 |issue= 17 |pages= 8307-21 |year= 1988 |pmid= 2971157 |doi=  }}
*{{cite journal  |vauthors=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides |journal=Gene |volume=138 |issue= 1–2 |pages= 171–174 |year= 1994 |pmid= 8125298 |doi=10.1016/0378-1119(94)90802-8 }}
*{{cite journal  | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171-4 |year= 1994 |pmid= 8125298 |doi= }}
*{{cite journal  |vauthors=Nelissen RL, Gunnewiek JM, Lambermon MH, Van Venrooij WJ |title=Cloning and characterization of two processed pseudogenes and the cDNA for the murine U1 snRNP-specific protein C |journal=Gene |volume=184 |issue= 2 |pages= 273–278 |year= 1997 |pmid= 9031639 |doi=10.1016/S0378-1119(96)00612-9 }}
*{{cite journal  | author=Gunnewiek JM, van Aarssen Y, Wassenaar R, ''et al.'' |title=Homodimerization of the human U1 snRNP-specific protein C. |journal=Nucleic Acids Res. |volume=23 |issue= 23 |pages= 4864-71 |year= 1996 |pmid= 8532530 |doi= }}
*{{cite journal  | author=Suzuki Y |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library |journal=Gene |volume=200 |issue= 1–2 |pages= 149–156 |year= 1997 |pmid= 9373149 |doi=10.1016/S0378-1119(97)00411-3  |name-list-format=vanc| author2=Yoshitomo-Nakagawa K  | author3=Maruyama K  | display-authors=3  | last4=Suyama  | first4=A  | last5=Sugano  | first5=S }}
*{{cite journal  | author=Nelissen RL, Gunnewiek JM, Lambermon MH, Van Venrooij WJ |title=Cloning and characterization of two processed pseudogenes and the cDNA for the murine U1 snRNP-specific protein C. |journal=Gene |volume=184 |issue= 2 |pages= 273-8 |year= 1997 |pmid= 9031639 |doi=  }}
*{{cite journal  | author=Dumortier H |title=At least three linear regions but not the zinc-finger domain of U1C protein are exposed at the surface of the protein in solution and on the human spliceosomal U1 snRNP particle |journal=Nucleic Acids Res. |volume=26 |issue= 23 |pages= 5486–5491 |year= 1999 |pmid= 9826776 |doi=10.1093/nar/26.23.5486  | pmc=147990  |name-list-format=vanc| author2=Klein Gunnewiek J  | author3=Roussel JP  | display-authors=3  | last4=Van Aarssen  | first4=Y  | last5=Briand  | first5=JP  | last6=Van Venrooij  | first6=WJ  | last7=Muller  | first7=S }}
*{{cite journal  | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, ''et al.'' |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149-56 |year= 1997 |pmid= 9373149 |doi=  }}
*{{cite journal  | author=Charroux B |title=Gemin4. A novel component of the SMN complex that is found in both gems and nucleoli |journal=J. Cell Biol. |volume=148 |issue= 6 |pages= 1177–1186 |year= 2000 |pmid= 10725331 |doi=10.1083/jcb.148.6.1177  | pmc=2174312  |name-list-format=vanc| author2=Pellizzoni L  | author3=Perkinson RA  | display-authors=3  | last4=Yong  | first4=J  | last5=Shevchenko  | first5=A  | last6=Mann  | first6=M  | last7=Dreyfuss  | first7=G }}
*{{cite journal  | author=Dumortier H, Klein Gunnewiek J, Roussel JP, ''et al.'' |title=At least three linear regions but not the zinc-finger domain of U1C protein are exposed at the surface of the protein in solution and on the human spliceosomal U1 snRNP particle. |journal=Nucleic Acids Res. |volume=26 |issue= 23 |pages= 5486-91 |year= 1999 |pmid= 9826776 |doi=  }}
*{{cite journal  |vauthors=Knoop LL, Baker SJ |title=The splicing factor U1C represses EWS/FLI-mediated transactivation |journal=J. Biol. Chem. |volume=275 |issue= 32 |pages= 24865–24871 |year= 2000 |pmid= 10827180 |doi= 10.1074/jbc.M001661200 }}
*{{cite journal  | author=Charroux B, Pellizzoni L, Perkinson RA, ''et al.'' |title=Gemin4. A novel component of the SMN complex that is found in both gems and nucleoli. |journal=J. Cell Biol. |volume=148 |issue= 6 |pages= 1177-86 |year= 2000 |pmid= 10725331 |doi=  }}
*{{cite journal  | author=Pellizzoni L |title=Purification of native survival of motor neurons complexes and identification of Gemin6 as a novel component |journal=J. Biol. Chem. |volume=277 |issue= 9 |pages= 7540–7545 |year= 2002 |pmid= 11748230 |doi= 10.1074/jbc.M110141200 |name-list-format=vanc| author2=Baccon J  | author3=Rappsilber J  | display-authors=3  | last4=Mann  | first4=M  | last5=Dreyfuss  | first5=G }}
*{{cite journal  | author=Knoop LL, Baker SJ |title=The splicing factor U1C represses EWS/FLI-mediated transactivation. |journal=J. Biol. Chem. |volume=275 |issue= 32 |pages= 24865-71 |year= 2000 |pmid= 10827180 |doi= 10.1074/jbc.M001661200 }}
*{{cite journal  | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–16903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241  |name-list-format=vanc| author2=Feingold EA  | author3=Grouse LH  | display-authors=3  | last4=Derge  | first4=JG  | last5=Klausner  | first5=RD  | last6=Collins  | first6=FS  | last7=Wagner  | first7=L  | last8=Shenmen  | first8=CM  | last9=Schuler  | first9=GD }}
*{{cite journal  | author=Pellizzoni L, Baccon J, Rappsilber J, ''et al.'' |title=Purification of native survival of motor neurons complexes and identification of Gemin6 as a novel component. |journal=J. Biol. Chem. |volume=277 |issue= 9 |pages= 7540-5 |year= 2002 |pmid= 11748230 |doi= 10.1074/jbc.M110141200 }}
*{{cite journal  | author=Förch P |title=The splicing regulator TIA-1 interacts with U1-C to promote U1 snRNP recruitment to 5' splice sites |journal=EMBO J. |volume=21 |issue= 24 |pages= 6882–6892 |year= 2004 |pmid= 12486009 |doi=10.1093/emboj/cdf668  | pmc=139089  |name-list-format=vanc| author2=Puig O  | author3=Martínez C  | display-authors=3  | last4=Séraphin  | first4=B  | last5=Valcárcel  | first5=J }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | author=Rush J |title=Immunoaffinity profiling of tyrosine phosphorylation in cancer cells |journal=Nat. Biotechnol. |volume=23 |issue= 1 |pages= 94–101 |year= 2005 |pmid= 15592455 |doi= 10.1038/nbt1046 |name-list-format=vanc| author2=Moritz A  | author3=Lee KA  | display-authors=3  | last4=Guo  | first4=Ailan  | last5=Goss  | first5=Valerie L  | last6=Spek  | first6=Erik J  | last7=Zhang  | first7=Hui  | last8=Zha  | first8=Xiang-Ming  | last9=Polakiewicz  | first9=Roberto D }}
*{{cite journal  | author=Förch P, Puig O, Martínez C, ''et al.'' |title=The splicing regulator TIA-1 interacts with U1-C to promote U1 snRNP recruitment to 5' splice sites. |journal=EMBO J. |volume=21 |issue= 24 |pages= 6882-92 |year= 2004 |pmid= 12486009 |doi=  }}
*{{cite journal  | author=Andersen JS |title=Nucleolar proteome dynamics |journal=Nature |volume=433 |issue= 7021 |pages= 77–83 |year= 2005 |pmid= 15635413 |doi= 10.1038/nature03207 |name-list-format=vanc| author2=Lam YW  | author3=Leung AK  | display-authors=3  | last4=Ong  | first4=Shao-En  | last5=Lyon  | first5=Carol E.  | last6=Lamond  | first6=Angus I.  | last7=Mann  | first7=Matthias }}
*{{cite journal  | author=Rush J, Moritz A, Lee KA, ''et al.'' |title=Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. |journal=Nat. Biotechnol. |volume=23 |issue= 1 |pages= 94-101 |year= 2005 |pmid= 15592455 |doi= 10.1038/nbt1046 }}
*{{cite journal  | author=Andersen JS, Lam YW, Leung AK, ''et al.'' |title=Nucleolar proteome dynamics. |journal=Nature |volume=433 |issue= 7021 |pages= 77-83 |year= 2005 |pmid= 15635413 |doi= 10.1038/nature03207 }}
}}
}}
{{refend}}
{{refend}}
{{PDB Gallery|geneid=6631}}
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{{Ribonucleoproteins}}


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{{gene-6-stub}}
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Revision as of 00:03, 12 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

U1 small nuclear ribonucleoprotein C is a protein that in humans is encoded by the SNRPC gene.[1][2][3]


Interactions

Small nuclear ribonucleoprotein polypeptide C has been shown to interact with Ewing sarcoma breakpoint region 1.[4]

References

  1. ↑ Sillekens PT, Beijer RP, Habets WJ, van Venrooij WJ (October 1988). "Human U1 snRNP-specific C protein: complete cDNA and protein sequence and identification of a multigene family in mammals". Nucleic Acids Res. 16 (17): 8307–8321. doi:10.1093/nar/16.17.8307. PMC 338560. PMID 2971157.
  2. ↑ Gunnewiek JM, van Aarssen Y, Wassenaar R, Legrain P, van Venrooij WJ, Nelissen RL (February 1996). "Homodimerization of the human U1 snRNP-specific protein C". Nucleic Acids Res. 23 (23): 4864–4871. doi:10.1093/nar/23.23.4864. PMC 307476. PMID 8532530.
  3. ↑ "Entrez Gene: SNRPC small nuclear ribonucleoprotein polypeptide C".
  4. ↑ Knoop, L L; Baker S J (August 2000). "The splicing factor U1C represses EWS/FLI-mediated transactivation". J. Biol. Chem. UNITED STATES. 275 (32): 24865–24871. doi:10.1074/jbc.M001661200. ISSN 0021-9258. PMID 10827180.

Further reading



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