SCGB3A1: Difference between revisions

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{{Underlinked|date=June 2016}}
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{{Infobox_gene}}
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'''Secretoglobin family 3A member 1''' is a [[protein]] that in humans is encoded by the ''SCGB3A1'' [[gene]].<ref name="pmid11682631">{{cite journal | vauthors = Niimi T, Keck-Waggoner CL, Popescu NC, Zhou Y, Levitt RC, Kimura S | title = UGRP1, a uteroglobin/Clara cell secretory protein-related protein, is a novel lung-enriched downstream target gene for the T/EBP/NKX2.1 homeodomain transcription factor | journal = Mol Endocrinol | volume = 15 | issue = 11 | pages = 2021–36 |date=Oct 2001 | pmid = 11682631 | pmc =  | doi =10.1210/me.15.11.2021 }}</ref><ref name="pmid11481438">{{cite journal | vauthors = Krop IE, Sgroi D, Porter DA, Lunetta KL, LeVangie R, Seth P, Kaelin CM, Rhei E, Bosenberg M, Schnitt S, Marks JR, Pagon Z, Belina D, Razumovic J, Polyak K | title = HIN-1, a putative cytokine highly expressed in normal but not cancerous mammary epithelial cells | journal = Proc Natl Acad Sci U S A | volume = 98 | issue = 17 | pages = 9796–801 |date=Aug 2001 | pmid = 11481438 | pmc = 55532 | doi = 10.1073/pnas.171138398 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: SCGB3A1 secretoglobin, family 3A, member 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=92304| accessdate = }}</ref>
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{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Secretoglobin, family 3A, member 1
| HGNCid = 18384
| Symbol = SCGB3A1
| AltSymbols =; HIN1; HIN-1; LU105; MGC87867; PnSP-2; UGRP2
| OMIM = 606500
| ECnumber =
| Homologene = 14160
| MGIid = 1915912
| Function = {{GNF_GO|id=GO:0005125 |text = cytokine activity}}
  | Component = {{GNF_GO|id=GO:0005576 |text = extracellular region}} {{GNF_GO|id=GO:0005615 |text = extracellular space}}
  | Process = {{GNF_GO|id=GO:0030308 |text = negative regulation of cell growth}} {{GNF_GO|id=GO:0042127 |text = regulation of cell proliferation}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 92304
    | Hs_Ensembl = ENSG00000161055
    | Hs_RefseqProtein = NP_443095
    | Hs_RefseqmRNA = NM_052863
    | Hs_GenLoc_db =
    | Hs_GenLoc_chr = 5
    | Hs_GenLoc_start = 179949712
    | Hs_GenLoc_end = 179951146
    | Hs_Uniprot = Q96QR1
    | Mm_EntrezGene = 68662
    | Mm_Ensembl = ENSMUSG00000064057
    | Mm_RefseqmRNA = NM_054037
    | Mm_RefseqProtein = NP_473378
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 11
    | Mm_GenLoc_start = 49507033
    | Mm_GenLoc_end = 49508541
    | Mm_Uniprot = Q5NCL1
  }}
}}
'''Secretoglobin, family 3A, member 1''', also known as '''SCGB3A1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: SCGB3A1 secretoglobin, family 3A, member 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=92304| accessdate = }}</ref>


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==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal | author=Krop IE, Sgroi D, Porter DA, ''et al.'' |title=HIN-1, a putative cytokine highly expressed in normal but not cancerous mammary epithelial cells. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=98 |issue= 17 |pages= 9796-801 |year= 2001 |pmid= 11481438 |doi= 10.1073/pnas.171138398 }}
*{{cite journal   |vauthors=Porter D, Lahti-Domenici J, Torres-Arzayus M, etal |title=Expression of high in normal-1 (HIN-1) and uteroglobin related protein-1 (UGRP-1) in adult and developing tissues. |journal=Mech. Dev. |volume=114 |issue= 1-2 |pages= 201–4 |year= 2003 |pmid= 12175512 |doi=10.1016/S0925-4773(02)00056-4  }}
*{{cite journal | author=Porter D, Lahti-Domenici J, Torres-Arzayus M, ''et al.'' |title=Expression of high in normal-1 (HIN-1) and uteroglobin related protein-1 (UGRP-1) in adult and developing tissues. |journal=Mech. Dev. |volume=114 |issue= 1-2 |pages= 201-4 |year= 2003 |pmid= 12175512 |doi= }}
*{{cite journal   |vauthors=Reynolds SD, Reynolds PR, Pryhuber GS, etal |title=Secretoglobins SCGB3A1 and SCGB3A2 define secretory cell subsets in mouse and human airways. |journal=Am. J. Respir. Crit. Care Med. |volume=166 |issue= 11 |pages= 1498–509 |year= 2003 |pmid= 12406855 |doi= 10.1164/rccm.200204-285OC }}
*{{cite journal | author=Reynolds SD, Reynolds PR, Pryhuber GS, ''et al.'' |title=Secretoglobins SCGB3A1 and SCGB3A2 define secretory cell subsets in mouse and human airways. |journal=Am. J. Respir. Crit. Care Med. |volume=166 |issue= 11 |pages= 1498-509 |year= 2003 |pmid= 12406855 |doi= 10.1164/rccm.200204-285OC }}
*{{cite journal   |vauthors=Niimi T, Copeland NG, Gilbert DJ, etal |title=Cloning, expression, and chromosomal localization of the mouse gene (Scgb3a1, alias Ugrp2) that encodes a member of the novel uteroglobin-related protein gene family. |journal=Cytogenet. Genome Res. |volume=97 |issue= 1-2 |pages= 120–7 |year= 2003 |pmid= 12438750 |doi=10.1159/000064067  }}
*{{cite journal | author=Niimi T, Copeland NG, Gilbert DJ, ''et al.'' |title=Cloning, expression, and chromosomal localization of the mouse gene (Scgb3a1, alias Ugrp2) that encodes a member of the novel uteroglobin-related protein gene family. |journal=Cytogenet. Genome Res. |volume=97 |issue= 1-2 |pages= 120-7 |year= 2003 |pmid= 12438750 |doi=  }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Krop I, Maguire P, Lahti-Domenici J, etal |title=Lack of HIN-1 methylation in BRCA1-linked and "BRCA1-like" breast tumors. |journal=Cancer Res. |volume=63 |issue= 9 |pages= 2024–7 |year= 2003 |pmid= 12727813 |doi= }}
*{{cite journal | author=Krop I, Maguire P, Lahti-Domenici J, ''et al.'' |title=Lack of HIN-1 methylation in BRCA1-linked and "BRCA1-like" breast tumors. |journal=Cancer Res. |volume=63 |issue= 9 |pages= 2024-7 |year= 2003 |pmid= 12727813 |doi=  }}
*{{cite journal   |vauthors=Bin LH, Nielson LD, Liu X, etal |title=Identification of uteroglobin-related protein 1 and macrophage scavenger receptor with collagenous structure as a lung-specific ligand-receptor pair. |journal=J. Immunol. |volume=171 |issue= 2 |pages= 924–30 |year= 2003 |pmid= 12847263 |doi=  10.4049/jimmunol.171.2.924}}
*{{cite journal | author=Bin LH, Nielson LD, Liu X, ''et al.'' |title=Identification of uteroglobin-related protein 1 and macrophage scavenger receptor with collagenous structure as a lung-specific ligand-receptor pair. |journal=J. Immunol. |volume=171 |issue= 2 |pages= 924-30 |year= 2003 |pmid= 12847263 |doi= }}
*{{cite journal   |vauthors=Clark HF, Gurney AL, Abaya E, etal |title=The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. |journal=Genome Res. |volume=13 |issue= 10 |pages= 2265–70 |year= 2003 |pmid= 12975309 |doi= 10.1101/gr.1293003  | pmc=403697 }}
*{{cite journal | author=Clark HF, Gurney AL, Abaya E, ''et al.'' |title=The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. |journal=Genome Res. |volume=13 |issue= 10 |pages= 2265-70 |year= 2003 |pmid= 12975309 |doi= 10.1101/gr.1293003 }}
*{{cite journal   |vauthors=Fackler MJ, McVeigh M, Evron E, etal |title=DNA methylation of RASSF1A, HIN-1, RAR-beta, Cyclin D2 and Twist in in situ and invasive lobular breast carcinoma. |journal=Int. J. Cancer |volume=107 |issue= 6 |pages= 970–5 |year= 2004 |pmid= 14601057 |doi= 10.1002/ijc.11508 }}
*{{cite journal | author=Fackler MJ, McVeigh M, Evron E, ''et al.'' |title=DNA methylation of RASSF1A, HIN-1, RAR-beta, Cyclin D2 and Twist in in situ and invasive lobular breast carcinoma. |journal=Int. J. Cancer |volume=107 |issue= 6 |pages= 970-5 |year= 2004 |pmid= 14601057 |doi= 10.1002/ijc.11508 }}
*{{cite journal   |vauthors=Tisserand P, Fouquet C, Barrois M, etal |title=Lack of HIN-1 methylation defines specific breast tumor subtypes including medullary carcinoma of the breast and BRCA1-linked tumors. |journal=Cancer Biol. Ther. |volume=2 |issue= 5 |pages= 559–63 |year= 2004 |pmid= 14614327 |doi= 10.4161/cbt.2.5.511}}
*{{cite journal | author=Tisserand P, Fouquet C, Barrois M, ''et al.'' |title=Lack of HIN-1 methylation defines specific breast tumor subtypes including medullary carcinoma of the breast and BRCA1-linked tumors. |journal=Cancer Biol. Ther. |volume=2 |issue= 5 |pages= 559-63 |year= 2004 |pmid= 14614327 |doi=  }}
*{{cite journal   |vauthors=Marchetti A, Barassi F, Martella C, etal |title=Down regulation of high in normal-1 (HIN-1) is a frequent event in stage I non-small cell lung cancer and correlates with poor clinical outcome. |journal=Clin. Cancer Res. |volume=10 |issue= 4 |pages= 1338–43 |year= 2004 |pmid= 14977834 |doi=10.1158/1078-0432.CCR-1174-03 }}
*{{cite journal  | author=Marchetti A, Barassi F, Martella C, ''et al.'' |title=Down regulation of high in normal-1 (HIN-1) is a frequent event in stage I non-small cell lung cancer and correlates with poor clinical outcome. |journal=Clin. Cancer Res. |volume=10 |issue= 4 |pages= 1338-43 |year= 2004 |pmid= 14977834 |doi=  }}
*{{cite journal  | vauthors=Zhang Z, Henzel WJ |title=Signal peptide prediction based on analysis of experimentally verified cleavage sites. |journal=Protein Sci. |volume=13 |issue= 10 |pages= 2819–24 |year= 2005 |pmid= 15340161 |doi= 10.1110/ps.04682504  | pmc=2286551 }}
*{{cite journal | author=Zhang Z, Henzel WJ |title=Signal peptide prediction based on analysis of experimentally verified cleavage sites. |journal=Protein Sci. |volume=13 |issue= 10 |pages= 2819-24 |year= 2005 |pmid= 15340161 |doi= 10.1110/ps.04682504 }}
*{{cite journal   |vauthors=Krop I, Player A, Tablante A, etal |title=Frequent HIN-1 promoter methylation and lack of expression in multiple human tumor types. |journal=Mol. Cancer Res. |volume=2 |issue= 9 |pages= 489–94 |year= 2005 |pmid= 15383627 |doi= }}
*{{cite journal | author=Krop I, Player A, Tablante A, ''et al.'' |title=Frequent HIN-1 promoter methylation and lack of expression in multiple human tumor types. |journal=Mol. Cancer Res. |volume=2 |issue= 9 |pages= 489-94 |year= 2005 |pmid= 15383627 |doi= }}
*{{cite journal   |vauthors=Shigematsu H, Suzuki M, Takahashi T, etal |title=Aberrant methylation of HIN-1 (high in normal-1) is a frequent event in many human malignancies. |journal=Int. J. Cancer |volume=113 |issue= 4 |pages= 600–4 |year= 2005 |pmid= 15472908 |doi= 10.1002/ijc.20622 }}
*{{cite journal | author=Shigematsu H, Suzuki M, Takahashi T, ''et al.'' |title=Aberrant methylation of HIN-1 (high in normal-1) is a frequent event in many human malignancies. |journal=Int. J. Cancer |volume=113 |issue= 4 |pages= 600-4 |year= 2005 |pmid= 15472908 |doi= 10.1002/ijc.20622 }}
*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504  | pmc=528928 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal   |vauthors=Krop I, Parker MT, Bloushtain-Qimron N, etal |title=HIN-1, an inhibitor of cell growth, invasion, and AKT activation. |journal=Cancer Res. |volume=65 |issue= 21 |pages= 9659–69 |year= 2005 |pmid= 16266985 |doi= 10.1158/0008-5472.CAN-05-1663 }}
*{{cite journal | author=Krop I, Parker MT, Bloushtain-Qimron N, ''et al.'' |title=HIN-1, an inhibitor of cell growth, invasion, and AKT activation. |journal=Cancer Res. |volume=65 |issue= 21 |pages= 9659-69 |year= 2005 |pmid= 16266985 |doi= 10.1158/0008-5472.CAN-05-1663 }}
*{{cite journal   |vauthors=Yang Q, Kiernan CM, Tian Y, etal |title=Methylation of CASP8, DCR2, and HIN-1 in neuroblastoma is associated with poor outcome. |journal=Clin. Cancer Res. |volume=13 |issue= 11 |pages= 3191–7 |year= 2007 |pmid= 17545522 |doi= 10.1158/1078-0432.CCR-06-2846 }}
*{{cite journal | author=Yang Q, Kiernan CM, Tian Y, ''et al.'' |title=Methylation of CASP8, DCR2, and HIN-1 in neuroblastoma is associated with poor outcome. |journal=Clin. Cancer Res. |volume=13 |issue= 11 |pages= 3191-7 |year= 2007 |pmid= 17545522 |doi= 10.1158/1078-0432.CCR-06-2846 }}
*{{cite journal   |vauthors=Wu Q, Lothe RA, Ahlquist T, etal |title=DNA methylation profiling of ovarian carcinomas and their in vitro models identifies HOXA9, HOXB5, SCGB3A1, and CRABP1 as novel targets. |journal=Mol. Cancer |volume=6 |issue= |pages= 45 |year= 2007 |pmid= 17623056 |doi= 10.1186/1476-4598-6-45 | pmc=1964763 }}
*{{cite journal  | author=Wu Q, Lothe RA, Ahlquist T, ''et al.'' |title=DNA methylation profiling of ovarian carcinomas and their in vitro models identifies HOXA9, HOXB5, SCGB3A1, and CRABP1 as novel targets. |journal=Mol. Cancer |volume=6 |issue= |pages= 45 |year= 2007 |pmid= 17623056 |doi= 10.1186/1476-4598-6-45 }}
}}
}}
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Revision as of 05:58, 11 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Secretoglobin family 3A member 1 is a protein that in humans is encoded by the SCGB3A1 gene.[1][2][3]


References

  1. ↑ Niimi T, Keck-Waggoner CL, Popescu NC, Zhou Y, Levitt RC, Kimura S (Oct 2001). "UGRP1, a uteroglobin/Clara cell secretory protein-related protein, is a novel lung-enriched downstream target gene for the T/EBP/NKX2.1 homeodomain transcription factor". Mol Endocrinol. 15 (11): 2021–36. doi:10.1210/me.15.11.2021. PMID 11682631.
  2. ↑ Krop IE, Sgroi D, Porter DA, Lunetta KL, LeVangie R, Seth P, Kaelin CM, Rhei E, Bosenberg M, Schnitt S, Marks JR, Pagon Z, Belina D, Razumovic J, Polyak K (Aug 2001). "HIN-1, a putative cytokine highly expressed in normal but not cancerous mammary epithelial cells". Proc Natl Acad Sci U S A. 98 (17): 9796–801. doi:10.1073/pnas.171138398. PMC 55532. PMID 11481438.
  3. ↑ "Entrez Gene: SCGB3A1 secretoglobin, family 3A, member 1".

Further reading



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