CDC42EP1: Difference between revisions

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Latest revision as of 09:26, 30 August 2017

Cdc42 effector protein 1 is a protein that in humans is encoded by the CDC42EP1 gene.^[1]^[2]^[3]

CDC42 is a member of the Rho GTPase family that regulates multiple cellular activities, including actin polymerization. The protein encoded by this gene is a CDC42 binding protein that mediates actin cytoskeleton reorganization at the plasma membrane. The encoded protein, which is secreted, is primarily found in bone marrow. Two transcript variants encoding different isoforms have been found for this gene.^[3]

References

↑ Bahou WF, Campbell AD, Wicha MS (Aug 1992). "cDNA cloning and molecular characterization of MSE55, a novel human serum constituent protein that displays bone marrow stromal/endothelial cell-specific expression". J Biol Chem. 267 (20): 13986–92. PMID 1629197.
↑ Burbelo PD, Snow DM, Bahou W, Spiegel S (Sep 1999). "MSE55, a Cdc42 effector protein, induces long cellular extensions in fibroblasts". Proc Natl Acad Sci U S A. 96 (16): 9083–8. doi:10.1073/pnas.96.16.9083. PMC 17736. PMID 10430899.
↑ ^3.0 ^3.1 "Entrez Gene: CDC42EP1 CDC42 effector protein (Rho GTPase binding) 1".

External links

Human CDC42EP1 genome location and CDC42EP1 gene details page in the UCSC Genome Browser.

Joberty G, Perlungher RR, Macara IG (2000). "The Borgs, a New Family of Cdc42 and TC10 GTPase-Interacting Proteins". Mol. Cell. Biol. 19 (10): 6585–97. PMC 84628. PMID 10490598.
Dunham I, Shimizu N, Roe BA, et al. (1999). "The DNA sequence of human chromosome 22". Nature. 402 (6761): 489–95. doi:10.1038/990031. PMID 10591208.
Hirsch DS, Pirone DM, Burbelo PD (2001). "A new family of Cdc42 effector proteins, CEPs, function in fibroblast and epithelial cell shape changes". J. Biol. Chem. 276 (2): 875–83. doi:10.1074/jbc.M007039200. PMID 11035016.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Gevaert K, Goethals M, Martens L, et al. (2004). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides". Nat. Biotechnol. 21 (5): 566–9. doi:10.1038/nbt810. PMID 12665801.
Ballif BA, Villén J, Beausoleil SA, et al. (2005). "Phosphoproteomic analysis of the developing mouse brain". Mol. Cell. Proteomics. 3 (11): 1093–101. doi:10.1074/mcp.M400085-MCP200. PMID 15345747.
Collins JE, Wright CL, Edwards CA, et al. (2005). "A genome annotation-driven approach to cloning the human ORFeome". Genome Biol. 5 (10): R84. doi:10.1186/gb-2004-5-10-r84. PMC 545604. PMID 15461802.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Zhang J, Zhu J, Bu X, et al. (2005). "Cdc42 and RhoB Activation Are Required for Mannose Receptor-mediated Phagocytosis by Human Alveolar Macrophages". Mol. Biol. Cell. 16 (2): 824–34. doi:10.1091/mbc.E04-06-0463. PMC 545914. PMID 15574879.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.

This article on a gene on human chromosome 22 is a stub. You can help Wikipedia by expanding it.

[pmid1629197-1] Bahou WF, Campbell AD, Wicha MS (Aug 1992). "cDNA cloning and molecular characterization of MSE55, a novel human serum constituent protein that displays bone marrow stromal/endothelial cell-specific expression". J Biol Chem. 267 (20): 13986–92. PMID 1629197.

[pmid10430899-2] Burbelo PD, Snow DM, Bahou W, Spiegel S (Sep 1999). "MSE55, a Cdc42 effector protein, induces long cellular extensions in fibroblasts". Proc Natl Acad Sci U S A. 96 (16): 9083–8. doi:10.1073/pnas.96.16.9083. PMC 17736. PMID 10430899.

[entrez-3] 3.0 ^3.1 "Entrez Gene: CDC42EP1 CDC42 effector protein (Rho GTPase binding) 1".

[1]

[2]

[3]

@@ Line 1: / Line 1: @@
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+{{Infobox_gene}}
-{{GNF_Protein_box
+'''Cdc42 effector protein 1''' is a [[protein]] that in humans is encoded by the ''CDC42EP1'' [[gene]].<ref name="pmid1629197">{{cite journal | vauthors = Bahou WF, Campbell AD, Wicha MS | title = cDNA cloning and molecular characterization of MSE55, a novel human serum constituent protein that displays bone marrow stromal/endothelial cell-specific expression | journal = J Biol Chem | volume = 267 | issue = 20 | pages = 13986–92 |date=Aug 1992 | pmid = 1629197 | pmc =  | doi =  }}</ref><ref name="pmid10430899">{{cite journal | vauthors = Burbelo PD, Snow DM, Bahou W, Spiegel S | title = MSE55, a Cdc42 effector protein, induces long cellular extensions in fibroblasts | journal = Proc Natl Acad Sci U S A | volume = 96 | issue = 16 | pages = 9083–8 |date=Sep 1999 | pmid = 10430899 | pmc = 17736 | doi =10.1073/pnas.96.16.9083  }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: CDC42EP1 CDC42 effector protein (Rho GTPase binding) 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11135| accessdate = }}</ref>
- | image =
- | image_source =
- | PDB =
- | Name = CDC42 effector protein (Rho GTPase binding) 1
- | HGNCid = 17014
- | Symbol = CDC42EP1
- | AltSymbols =; CEP1; BORG5; MGC15316; MSE55
- | OMIM = 606084
- | ECnumber =
- | Homologene = 5128
- | MGIid = 1929763
- | GeneAtlas_image1 = PBB_GE_CDC42EP1_204693_at_tn.png
- | Function = {{GNF_GO|id=GO:0005515 |text = protein binding}}
- | Component = {{GNF_GO|id=GO:0005737 |text = cytoplasm}}
- | Process = {{GNF_GO|id=GO:0007266 |text = Rho protein signal transduction}} {{GNF_GO|id=GO:0008360 |text = regulation of cell shape}} {{GNF_GO|id=GO:0031274 |text = positive regulation of pseudopodium formation}}
- | Orthologs = {{GNF_Ortholog_box
-    | Hs_EntrezGene = 11135
-    | Hs_Ensembl = ENSG00000128283
-    | Hs_RefseqProtein = NP_008992
-    | Hs_RefseqmRNA = NM_007061
-    | Hs_GenLoc_db =
-    | Hs_GenLoc_chr = 22
-    | Hs_GenLoc_start = 36286446
-    | Hs_GenLoc_end = 36295358
-    | Hs_Uniprot = Q00587
-    | Mm_EntrezGene = 104445
-    | Mm_Ensembl = ENSMUSG00000049521
-    | Mm_RefseqmRNA = XM_001000925
-    | Mm_RefseqProtein = XP_001000925
-    | Mm_GenLoc_db =
-    | Mm_GenLoc_chr = 15
-    | Mm_GenLoc_start = 78669902
-    | Mm_GenLoc_end = 78678157
-    | Mm_Uniprot = Q91W92
-  }}
-}}
-'''CDC42 effector protein (Rho GTPase binding) 1''', also known as '''CDC42EP1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: CDC42EP1 CDC42 effector protein (Rho GTPase binding) 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11135| accessdate = }}</ref>
 <!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
 {{PBB_Summary
 | section_title =
-| summary_text = CDC42 is a member of the Rho GTPase family that regulates multiple cellular activities, including actin polymerization. The protein encoded by this gene is a CDC42 binding protein that mediates actin cytoskeleton reorganization at the plasma membrane. The encoded protein, which is secreted, is primarily found in bone marrow. Two transcript variants encoding different isoforms have been found for this gene.<ref name="entrez">{{cite web | title = Entrez Gene: CDC42EP1 CDC42 effector protein (Rho GTPase binding) 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11135| accessdate = }}</ref>
+| summary_text = CDC42 is a member of the Rho GTPase family that regulates multiple cellular activities, including actin polymerization. The protein encoded by this gene is a CDC42 binding protein that mediates actin cytoskeleton reorganization at the plasma membrane. The encoded protein, which is secreted, is primarily found in bone marrow. Two transcript variants encoding different isoforms have been found for this gene.<ref name="entrez" />
 }}
 ==References==
-{{reflist|2}}
+{{reflist}}
+==External links==
+* {{UCSC gene info|CDC42EP1}}
 ==Further reading==
 {{refbegin | 2}}
 {{PBB_Further_reading
 | citations =
-*{{cite journal  | author=Bahou WF, Campbell AD, Wicha MS |title=cDNA cloning and molecular characterization of MSE55, a novel human serum constituent protein that displays bone marrow stromal/endothelial cell-specific expression. |journal=J. Biol. Chem. |volume=267 |issue= 20 |pages= 13986-92 |year= 1992 |pmid= 1629197 |doi=  }}
+*{{cite journal  | vauthors=Joberty G, Perlungher RR, Macara IG |title=The Borgs, a New Family of Cdc42 and TC10 GTPase-Interacting Proteins |journal=Mol. Cell. Biol. |volume=19 |issue= 10 |pages= 6585–97 |year= 2000 |pmid= 10490598 |doi=  | pmc=84628  }}
-*{{cite journal  | author=Burbelo PD, Snow DM, Bahou W, Spiegel S |title=MSE55, a Cdc42 effector protein, induces long cellular extensions in fibroblasts. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=96 |issue= 16 |pages= 9083-8 |year= 1999 |pmid= 10430899 |doi=  }}
+*{{cite journal  | author=Dunham I |title=The DNA sequence of human chromosome 22 |journal=Nature |volume=402 |issue= 6761 |pages= 489–95 |year= 1999 |pmid= 10591208 |doi= 10.1038/990031  |name-list-format=vanc| author2=Shimizu N  | author3=Roe BA  | display-authors=3  | last4=Bruskiewich  | first4=R.  | last5=Beare  | first5=D. M.  | last6=Clamp  | first6=M.  | last7=Smink  | first7=L. J.  | last8=Ainscough  | first8=R.  | last9=Almeida  | first9=J. P. }}
-*{{cite journal  | author=Joberty G, Perlungher RR, Macara IG |title=The Borgs, a new family of Cdc42 and TC10 GTPase-interacting proteins. |journal=Mol. Cell. Biol. |volume=19 |issue= 10 |pages= 6585-97 |year= 2000 |pmid= 10490598 |doi=  }}
+*{{cite journal  | vauthors=Hirsch DS, Pirone DM, Burbelo PD |title=A new family of Cdc42 effector proteins, CEPs, function in fibroblast and epithelial cell shape changes |journal=J. Biol. Chem. |volume=276 |issue= 2 |pages= 875–83 |year= 2001 |pmid= 11035016 |doi= 10.1074/jbc.M007039200 }}
-*{{cite journal  | author=Dunham I, Shimizu N, Roe BA, ''et al.'' |title=The DNA sequence of human chromosome 22. |journal=Nature |volume=402 |issue= 6761 |pages= 489-95 |year= 1999 |pmid= 10591208 |doi= 10.1038/990031 }}
+*{{cite journal  | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241  |name-list-format=vanc| author2=Feingold EA  | author3=Grouse LH  | display-authors=3  | last4=Derge  | first4=JG  | last5=Klausner  | first5=RD  | last6=Collins  | first6=FS  | last7=Wagner  | first7=L  | last8=Shenmen  | first8=CM  | last9=Schuler  | first9=GD }}
-*{{cite journal  | author=Hirsch DS, Pirone DM, Burbelo PD |title=A new family of Cdc42 effector proteins, CEPs, function in fibroblast and epithelial cell shape changes. |journal=J. Biol. Chem. |volume=276 |issue= 2 |pages= 875-83 |year= 2001 |pmid= 11035016 |doi= 10.1074/jbc.M007039200 }}
+*{{cite journal  | author=Gevaert K |title=Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides |journal=Nat. Biotechnol. |volume=21 |issue= 5 |pages= 566–9 |year= 2004 |pmid= 12665801 |doi= 10.1038/nbt810  |name-list-format=vanc| author2=Goethals M  | author3=Martens L  | display-authors=3  | last4=Van Damme  | first4=Jozef  | last5=Staes  | first5=An  | last6=Thomas  | first6=Grégoire R.  | last7=Vandekerckhove  | first7=Joël }}
-*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
+*{{cite journal  | author=Ballif BA |title=Phosphoproteomic analysis of the developing mouse brain |journal=Mol. Cell. Proteomics |volume=3 |issue= 11 |pages= 1093–101 |year= 2005 |pmid= 15345747 |doi= 10.1074/mcp.M400085-MCP200  |name-list-format=vanc| author2=Villén J  | author3=Beausoleil SA  | display-authors=3  | last4=Schwartz  | first4=D  | last5=Gygi  | first5=SP }}
-*{{cite journal  | author=Gevaert K, Goethals M, Martens L, ''et al.'' |title=Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. |journal=Nat. Biotechnol. |volume=21 |issue= 5 |pages= 566-9 |year= 2004 |pmid= 12665801 |doi= 10.1038/nbt810 }}
+*{{cite journal  | author=Collins JE |title=A genome annotation-driven approach to cloning the human ORFeome |journal=Genome Biol. |volume=5 |issue= 10 |pages= R84 |year= 2005 |pmid= 15461802 |doi= 10.1186/gb-2004-5-10-r84  | pmc=545604  |name-list-format=vanc| author2=Wright CL  | author3=Edwards CA  | display-authors=3  | last4=Davis  | first4=Matthew P  | last5=Grinham  | first5=James A  | last6=Cole  | first6=Charlotte G  | last7=Goward  | first7=Melanie E  | last8=Aguado  | first8=Begoña  | last9=Mallya  | first9=Meera }}
-*{{cite journal  | author=Ballif BA, Villén J, Beausoleil SA, ''et al.'' |title=Phosphoproteomic analysis of the developing mouse brain. |journal=Mol. Cell Proteomics |volume=3 |issue= 11 |pages= 1093-101 |year= 2005 |pmid= 15345747 |doi= 10.1074/mcp.M400085-MCP200 }}
+*{{cite journal  | author=Gerhard DS |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504  | pmc=528928  |name-list-format=vanc| author2=Wagner L  | author3=Feingold EA  | display-authors=3  | last4=Shenmen  | first4=CM  | last5=Grouse  | first5=LH  | last6=Schuler  | first6=G  | last7=Klein  | first7=SL  | last8=Old  | first8=S  | last9=Rasooly  | first9=R }}
-*{{cite journal  | author=Collins JE, Wright CL, Edwards CA, ''et al.'' |title=A genome annotation-driven approach to cloning the human ORFeome. |journal=Genome Biol. |volume=5 |issue= 10 |pages= R84 |year= 2005 |pmid= 15461802 |doi= 10.1186/gb-2004-5-10-r84 }}
+*{{cite journal  | author=Zhang J |title=Cdc42 and RhoB Activation Are Required for Mannose Receptor-mediated Phagocytosis by Human Alveolar Macrophages |journal=Mol. Biol. Cell |volume=16 |issue= 2 |pages= 824–34 |year= 2005 |pmid= 15574879 |doi= 10.1091/mbc.E04-06-0463  | pmc=545914  |name-list-format=vanc| author2=Zhu J  | author3=Bu X  | display-authors=3  | last4=Cushion  | first4=M  | last5=Kinane  | first5=TB  | last6=Avraham  | first6=H  | last7=Koziel  | first7=H }}
-*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
+*{{cite journal  | author=Rual JF |title=Towards a proteome-scale map of the human protein-protein interaction network |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209  |name-list-format=vanc| author2=Venkatesan K  | author3=Hao T  | display-authors=3  | last4=Hirozane-Kishikawa  | first4=Tomoko  | last5=Dricot  | first5=Amélie  | last6=Li  | first6=Ning  | last7=Berriz  | first7=Gabriel F.  | last8=Gibbons  | first8=Francis D.  | last9=Dreze  | first9=Matija }}
-*{{cite journal  | author=Zhang J, Zhu J, Bu X, ''et al.'' |title=Cdc42 and RhoB activation are required for mannose receptor-mediated phagocytosis by human alveolar macrophages. |journal=Mol. Biol. Cell |volume=16 |issue= 2 |pages= 824-34 |year= 2005 |pmid= 15574879 |doi= 10.1091/mbc.E04-06-0463 }}
+*{{cite journal  | author=Kimura K |title=Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes |journal=Genome Res. |volume=16 |issue= 1 |pages= 55–65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406  | pmc=1356129  |name-list-format=vanc| author2=Wakamatsu A  | author3=Suzuki Y  | display-authors=3  | last4=Ota  | first4=T  | last5=Nishikawa  | first5=T  | last6=Yamashita  | first6=R  | last7=Yamamoto  | first7=J  | last8=Sekine  | first8=M  | last9=Tsuritani  | first9=K }}
-*{{cite journal  | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
+*{{cite journal  | author=Olsen JV |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks |journal=Cell |volume=127 |issue= 3 |pages= 635–48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026  |name-list-format=vanc| author2=Blagoev B  | author3=Gnad F  | display-authors=3  | last4=Macek  | first4=Boris  | last5=Kumar  | first5=Chanchal  | last6=Mortensen  | first6=Peter  | last7=Mann  | first7=Matthias }}
-*{{cite journal  | author=Kimura K, Wakamatsu A, Suzuki Y, ''et al.'' |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |journal=Genome Res. |volume=16 |issue= 1 |pages= 55-65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406 }}
-*{{cite journal  | author=Olsen JV, Blagoev B, Gnad F, ''et al.'' |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. |journal=Cell |volume=127 |issue= 3 |pages= 635-48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 }}
 }}
 {{refend}}
+<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
+{{PBB_Controls
+| update_page = yes
+| require_manual_inspection = no
+| update_protein_box = yes
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+| update_citations = yes
+}}
 {{gene-22-stub}}
-{{WikiDoc Sources}}

CDC42EP1: Difference between revisions

Latest revision as of 09:26, 30 August 2017

References

External links

Further reading

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