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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''Bifunctional polynucleotide phosphatase/kinase''' is an [[enzyme]] that in humans is encoded by the ''PNKP'' [[gene]].<ref name="pmid10446192">{{cite journal | vauthors = Jilani A, Ramotar D, Slack C, Ong C, Yang XM, Scherer SW, Lasko DD | title = Molecular cloning of the human gene, PNKP, encoding a polynucleotide kinase 3'-phosphatase and evidence for its role in repair of DNA strand breaks caused by oxidative damage | journal = J. Biol. Chem. | volume = 274 | issue = 34 | pages = 24176–86  | date = September 1999 | pmid = 10446192 | pmc =  | doi = 10.1074/jbc.274.34.24176 }}</ref><ref name="pmid10446193">{{cite journal | vauthors = Karimi-Busheri F, Daly G, Robins P, Canas B, Pappin DJ, Sgouros J, Miller GG, Fakhrai H, Davis EM, Le Beau MM, Weinfeld M | title = Molecular characterization of a human DNA kinase | journal = J. Biol. Chem. | volume = 274 | issue = 34 | pages = 24187–94  | date = September 1999 | pmid = 10446193 | pmc = | doi = 10.1074/jbc.274.34.24187 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: PNKP polynucleotide kinase 3'-phosphatase| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11284| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Interactions ==
{{GNF_Protein_box
| image = PBB_Protein_PNKP_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 2brf.
| PDB = {{PDB2|2brf}}
| Name = Polynucleotide kinase 3'-phosphatase
| HGNCid = 9154
| Symbol = PNKP
| AltSymbols =; PNK
| OMIM = 605610
| ECnumber = 
| Homologene = 5247
| MGIid = 1891698
| GeneAtlas_image1 = PBB_GE_PNKP_218961_s_at_tn.png
| Function = {{GNF_GO|id=GO:0003684 |text = damaged DNA binding}} {{GNF_GO|id=GO:0003690 |text = double-stranded DNA binding}} {{GNF_GO|id=GO:0004519 |text = endonuclease activity}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0016301 |text = kinase activity}} {{GNF_GO|id=GO:0016740 |text = transferase activity}} {{GNF_GO|id=GO:0016787 |text = hydrolase activity}} {{GNF_GO|id=GO:0017076 |text = purine nucleotide binding}} {{GNF_GO|id=GO:0019201 |text = nucleotide kinase activity}} {{GNF_GO|id=GO:0046403 |text = polynucleotide 3'-phosphatase activity}} {{GNF_GO|id=GO:0046404 |text = ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0000718 |text = nucleotide-excision repair, DNA damage removal}} {{GNF_GO|id=GO:0006261 |text = DNA-dependent DNA replication}} {{GNF_GO|id=GO:0006281 |text = DNA repair}} {{GNF_GO|id=GO:0006979 |text = response to oxidative stress}} {{GNF_GO|id=GO:0009314 |text = response to radiation}} {{GNF_GO|id=GO:0016311 |text = dephosphorylation}} {{GNF_GO|id=GO:0042769 |text = DNA damage response, detection of DNA damage}} {{GNF_GO|id=GO:0046939 |text = nucleotide phosphorylation}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 11284
    | Hs_Ensembl = ENSG00000039650
    | Hs_RefseqProtein = NP_009185
    | Hs_RefseqmRNA = NM_007254
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 19
    | Hs_GenLoc_start = 55056274
    | Hs_GenLoc_end = 55062630
    | Hs_Uniprot = Q96T60
    | Mm_EntrezGene = 59047
    | Mm_Ensembl = ENSMUSG00000002963
    | Mm_RefseqmRNA = NM_021549
    | Mm_RefseqProtein = NP_067524
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 7
    | Mm_GenLoc_start = 44725381
    | Mm_GenLoc_end = 44730967
    | Mm_Uniprot = Q9JLV6
  }}
}}
'''Polynucleotide kinase 3'-phosphatase''', also known as '''PNKP''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: PNKP polynucleotide kinase 3'-phosphatase| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11284| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
PNKP has been shown to [[Protein-protein interaction|interact]] with [[DNA polymerase beta]]<ref name=pmid11163244>{{cite journal | vauthors = Whitehouse CJ, Taylor RM, Thistlethwaite A, Zhang H, Karimi-Busheri F, Lasko DD, Weinfeld M, Caldecott KW | title = XRCC1 stimulates human polynucleotide kinase activity at damaged DNA termini and accelerates DNA single-strand break repair | journal = Cell | volume = 104 | issue = 1 | pages = 107–17 | date = January 2001 | pmid = 11163244 | doi = 10.1016/S0092-8674(01)00195-7 }}</ref> and [[XRCC1]].<ref name=pmid11163244/><ref name=pmid17353931>{{cite journal | vauthors = Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D | title = Large-scale mapping of human protein-protein interactions by mass spectrometry | journal = Mol. Syst. Biol. | volume = 3 | issue = 1 | pages = 89 | year = 2007 | pmid = 17353931 | pmc = 1847948 | doi = 10.1038/msb4100134 }}</ref>
{{PBB_Summary
| section_title =  
| summary_text =  
}}


==References==
== References ==
{{reflist|2}}
{{reflist}}
==Further reading==
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Whitehouse CJ, Taylor RM, Thistlethwaite A, Zhang H, Karimi-Busheri F, Lasko DD, Weinfeld M, Caldecott KW | title = XRCC1 stimulates human polynucleotide kinase activity at damaged DNA termini and accelerates DNA single-strand break repair | journal = Cell | volume = 104 | issue = 1 | pages = 107–17 | year = 2001 | pmid = 11163244 | doi = 10.1016/S0092-8674(01)00195-7 }}
| citations =
* {{cite journal | vauthors = Chappell C, Hanakahi LA, Karimi-Busheri F, Weinfeld M, West SC | title = Involvement of human polynucleotide kinase in double-strand break repair by non-homologous end joining | journal = EMBO J. | volume = 21 | issue = 11 | pages = 2827–32 | year = 2002 | pmid = 12032095 | pmc = 126026 | doi = 10.1093/emboj/21.11.2827 }}
*{{cite journal | author=Jilani A, Ramotar D, Slack C, ''et al.'' |title=Molecular cloning of the human gene, PNKP, encoding a polynucleotide kinase 3'-phosphatase and evidence for its role in repair of DNA strand breaks caused by oxidative damage. |journal=J. Biol. Chem. |volume=274 |issue= 34 |pages= 24176-86 |year= 1999 |pmid= 10446192 |doi= }}
* {{cite journal | vauthors = Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD, Altschul SF, Zeeberg B, Buetow KH, Schaefer CF, Bhat NK, Hopkins RF, Jordan H, Moore T, Max SI, Wang J, Hsieh F, Diatchenko L, Marusina K, Farmer AA, Rubin GM, Hong L, Stapleton M, Soares MB, Bonaldo MF, Casavant TL, Scheetz TE, Brownstein MJ, Usdin TB, Toshiyuki S, Carninci P, Prange C, Raha SS, Loquellano NA, Peters GJ, Abramson RD, Mullahy SJ, Bosak SA, McEwan PJ, McKernan KJ, Malek JA, Gunaratne PH, Richards S, Worley KC, Hale S, Garcia AM, Gay LJ, Hulyk SW, Villalon DK, Muzny DM, Sodergren EJ, Lu X, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madan A, Young AC, Shevchenko Y, Bouffard GG, Blakesley RW, Touchman JW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Krzywinski MI, Skalska U, Smailus DE, Schnerch A, Schein JE, Jones SJ, Marra MA | title = Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 99 | issue = 26 | pages = 16899–903 | year = 2002 | pmid = 12477932 | pmc = 139241 | doi = 10.1073/pnas.242603899 }}
*{{cite journal | author=Karimi-Busheri F, Daly G, Robins P, ''et al.'' |title=Molecular characterization of a human DNA kinase. |journal=J. Biol. Chem. |volume=274 |issue= 34 |pages= 24187-94 |year= 1999 |pmid= 10446193 |doi= }}
* {{cite journal | vauthors = Mani RS, Karimi-Busheri F, Fanta M, Cass CE, Weinfeld M | title = Spectroscopic studies of DNA and ATP binding to human polynucleotide kinase: evidence for a ternary complex | journal = Biochemistry | volume = 42 | issue = 41 | pages = 12077–84 | year = 2003 | pmid = 14556639 | doi = 10.1021/bi030127b }}
*{{cite journal | author=Whitehouse CJ, Taylor RM, Thistlethwaite A, ''et al.'' |title=XRCC1 stimulates human polynucleotide kinase activity at damaged DNA termini and accelerates DNA single-strand break repair. |journal=Cell |volume=104 |issue= 1 |pages= 107-17 |year= 2001 |pmid= 11163244 |doi=  }}
* {{cite journal | vauthors = Loizou JI, El-Khamisy SF, Zlatanou A, Moore DJ, Chan DW, Qin J, Sarno S, Meggio F, Pinna LA, Caldecott KW | title = The protein kinase CK2 facilitates repair of chromosomal DNA single-strand breaks | journal = Cell | volume = 117 | issue = 1 | pages = 17–28 | year = 2004 | pmid = 15066279 | doi = 10.1016/S0092-8674(04)00206-5 }}
*{{cite journal  | author=Chappell C, Hanakahi LA, Karimi-Busheri F, ''et al.'' |title=Involvement of human polynucleotide kinase in double-strand break repair by non-homologous end joining. |journal=EMBO J. |volume=21 |issue= 11 |pages= 2827-32 |year= 2002 |pmid= 12032095 |doi= 10.1093/emboj/21.11.2827 }}
* {{cite journal | vauthors = Colland F, Jacq X, Trouplin V, Mougin C, Groizeleau C, Hamburger A, Meil A, Wojcik J, Legrain P, Gauthier JM | title = Functional proteomics mapping of a human signaling pathway | journal = Genome Res. | volume = 14 | issue = 7 | pages = 1324–32 | year = 2004 | pmid = 15231748 | pmc = 442148 | doi = 10.1101/gr.2334104 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Wiederhold L, Leppard JB, Kedar P, Karimi-Busheri F, Rasouli-Nia A, Weinfeld M, Tomkinson AE, Izumi T, Prasad R, Wilson SH, Mitra S, Hazra TK | title = AP endonuclease-independent DNA base excision repair in human cells | journal = Mol. Cell | volume = 15 | issue = 2 | pages = 209–20 | year = 2004 | pmid = 15260972 | doi = 10.1016/j.molcel.2004.06.003 }}
*{{cite journal | author=Mani RS, Karimi-Busheri F, Fanta M, ''et al.'' |title=Spectroscopic studies of DNA and ATP binding to human polynucleotide kinase: evidence for a ternary complex. |journal=Biochemistry |volume=42 |issue= 41 |pages= 12077-84 |year= 2004 |pmid= 14556639 |doi= 10.1021/bi030127b }}
* {{cite journal | vauthors = Koch CA, Agyei R, Galicia S, Metalnikov P, O'Donnell P, Starostine A, Weinfeld M, Durocher D | title = Xrcc4 physically links DNA end processing by polynucleotide kinase to DNA ligation by DNA ligase IV | journal = EMBO J. | volume = 23 | issue = 19 | pages = 3874–85 | year = 2004 | pmid = 15385968 | pmc = 522785 | doi = 10.1038/sj.emboj.7600375 }}
*{{cite journal | author=Grimwood J, Gordon LA, Olsen A, ''et al.'' |title=The DNA sequence and biology of human chromosome 19. |journal=Nature |volume=428 |issue= 6982 |pages= 529-35 |year= 2004 |pmid= 15057824 |doi= 10.1038/nature02399 }}
* {{cite journal | vauthors = Andersen JS, Lam YW, Leung AK, Ong SE, Lyon CE, Lamond AI, Mann M | title = Nucleolar proteome dynamics | journal = Nature | volume = 433 | issue = 7021 | pages = 77–83 | year = 2005 | pmid = 15635413 | doi = 10.1038/nature03207 }}
*{{cite journal | author=Loizou JI, El-Khamisy SF, Zlatanou A, ''et al.'' |title=The protein kinase CK2 facilitates repair of chromosomal DNA single-strand breaks. |journal=Cell |volume=117 |issue= 1 |pages= 17-28 |year= 2004 |pmid= 15066279 |doi= }}
* {{cite journal | vauthors = Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M | title = Towards a proteome-scale map of the human protein-protein interaction network | journal = Nature | volume = 437 | issue = 7062 | pages = 1173–8 | year = 2005 | pmid = 16189514 | doi = 10.1038/nature04209 }}
*{{cite journal | author=Colland F, Jacq X, Trouplin V, ''et al.'' |title=Functional proteomics mapping of a human signaling pathway. |journal=Genome Res. |volume=14 |issue= 7 |pages= 1324-32 |year= 2004 |pmid= 15231748 |doi= 10.1101/gr.2334104 }}
* {{cite journal | vauthors = Audebert M, Salles B, Weinfeld M, Calsou P | title = Involvement of polynucleotide kinase in a poly(ADP-ribose) polymerase-1-dependent DNA double-strand breaks rejoining pathway | journal = J. Mol. Biol. | volume = 356 | issue = 2 | pages = 257–65 | year = 2006 | pmid = 16364363 | doi = 10.1016/j.jmb.2005.11.028 }}
*{{cite journal | author=Wiederhold L, Leppard JB, Kedar P, ''et al.'' |title=AP endonuclease-independent DNA base excision repair in human cells. |journal=Mol. Cell |volume=15 |issue= 2 |pages= 209-20 |year= 2004 |pmid= 15260972 |doi= 10.1016/j.molcel.2004.06.003 }}
* {{cite journal | vauthors = Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M | title = Global, in vivo, and site-specific phosphorylation dynamics in signaling networks | journal = Cell | volume = 127 | issue = 3 | pages = 635–48 | year = 2006 | pmid = 17081983 | doi = 10.1016/j.cell.2006.09.026 }}
*{{cite journal | author=Koch CA, Agyei R, Galicia S, ''et al.'' |title=Xrcc4 physically links DNA end processing by polynucleotide kinase to DNA ligation by DNA ligase IV. |journal=EMBO J. |volume=23 |issue= 19 |pages= 3874-85 |year= 2005 |pmid= 15385968 |doi= 10.1038/sj.emboj.7600375 }}
* {{cite journal | vauthors = Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D | title = Large-scale mapping of human protein-protein interactions by mass spectrometry | journal = Mol. Syst. Biol. | volume = 3 | issue = 1 | pages = 89 | year = 2007 | pmid = 17353931 | pmc = 1847948 | doi = 10.1038/msb4100134 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
* {{cite journal | vauthors = Karimi-Busheri F, Rasouli-Nia A, Allalunis-Turner J, Weinfeld M | title = Human polynucleotide kinase participates in repair of DNA double-strand breaks by nonhomologous end joining but not homologous recombination | journal = Cancer Res. | volume = 67 | issue = 14 | pages = 6619–25 | year = 2007 | pmid = 17638872 | doi = 10.1158/0008-5472.CAN-07-0480 }}
*{{cite journal | author=Andersen JS, Lam YW, Leung AK, ''et al.'' |title=Nucleolar proteome dynamics. |journal=Nature |volume=433 |issue= 7021 |pages= 77-83 |year= 2005 |pmid= 15635413 |doi= 10.1038/nature03207 }}
* {{cite journal | vauthors = Mani RS, Fanta M, Karimi-Busheri F, Silver E, Virgen CA, Caldecott KW, Cass CE, Weinfeld M | title = XRCC1 stimulates polynucleotide kinase by enhancing its damage discrimination and displacement from DNA repair intermediates | journal = J. Biol. Chem. | volume = 282 | issue = 38 | pages = 28004–13 | year = 2007 | pmid = 17650498 | doi = 10.1074/jbc.M704867200 }}
*{{cite journal | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal | author=Audebert M, Salles B, Weinfeld M, Calsou P |title=Involvement of polynucleotide kinase in a poly(ADP-ribose) polymerase-1-dependent DNA double-strand breaks rejoining pathway. |journal=J. Mol. Biol. |volume=356 |issue= 2 |pages= 257-65 |year= 2006 |pmid= 16364363 |doi= 10.1016/j.jmb.2005.11.028 }}
*{{cite journal | author=Olsen JV, Blagoev B, Gnad F, ''et al.'' |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. |journal=Cell |volume=127 |issue= 3 |pages= 635-48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 }}
*{{cite journal  | author=Ewing RM, Chu P, Elisma F, ''et al.'' |title=Large-scale mapping of human protein-protein interactions by mass spectrometry. |journal=Mol. Syst. Biol. |volume=3 |issue=  |pages= 89 |year= 2007 |pmid= 17353931 |doi= 10.1038/msb4100134 }}
*{{cite journal  | author=Karimi-Busheri F, Rasouli-Nia A, Allalunis-Turner J, Weinfeld M |title=Human polynucleotide kinase participates in repair of DNA double-strand breaks by nonhomologous end joining but not homologous recombination. |journal=Cancer Res. |volume=67 |issue= 14 |pages= 6619-25 |year= 2007 |pmid= 17638872 |doi= 10.1158/0008-5472.CAN-07-0480 }}
*{{cite journal  | author=Mani RS, Fanta M, Karimi-Busheri F, ''et al.'' |title=XRCC1 stimulates polynucleotide kinase by enhancing its damage discrimination and displacement from DNA repair intermediates. |journal=J. Biol. Chem. |volume=282 |issue= 38 |pages= 28004-13 |year= 2007 |pmid= 17650498 |doi= 10.1074/jbc.M704867200 }}
}}
{{refend}}
{{refend}}


{{protein-stub}}
{{PDB Gallery|geneid=11284}}
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{{gene-19-stub}}

Latest revision as of 18:22, 7 September 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

n/a

Ensembl

n/a

n/a

UniProt

n/a

n/a

RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Bifunctional polynucleotide phosphatase/kinase is an enzyme that in humans is encoded by the PNKP gene.[1][2][3]

Interactions

PNKP has been shown to interact with DNA polymerase beta[4] and XRCC1.[4][5]

References

  1. ↑ Jilani A, Ramotar D, Slack C, Ong C, Yang XM, Scherer SW, Lasko DD (September 1999). "Molecular cloning of the human gene, PNKP, encoding a polynucleotide kinase 3'-phosphatase and evidence for its role in repair of DNA strand breaks caused by oxidative damage". J. Biol. Chem. 274 (34): 24176–86. doi:10.1074/jbc.274.34.24176. PMID 10446192.
  2. ↑ Karimi-Busheri F, Daly G, Robins P, Canas B, Pappin DJ, Sgouros J, Miller GG, Fakhrai H, Davis EM, Le Beau MM, Weinfeld M (September 1999). "Molecular characterization of a human DNA kinase". J. Biol. Chem. 274 (34): 24187–94. doi:10.1074/jbc.274.34.24187. PMID 10446193.
  3. ↑ "Entrez Gene: PNKP polynucleotide kinase 3'-phosphatase".
  4. ↑ 4.0 4.1 Whitehouse CJ, Taylor RM, Thistlethwaite A, Zhang H, Karimi-Busheri F, Lasko DD, Weinfeld M, Caldecott KW (January 2001). "XRCC1 stimulates human polynucleotide kinase activity at damaged DNA termini and accelerates DNA single-strand break repair". Cell. 104 (1): 107–17. doi:10.1016/S0092-8674(01)00195-7. PMID 11163244.
  5. ↑ Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.

Further reading

  • Whitehouse CJ, Taylor RM, Thistlethwaite A, Zhang H, Karimi-Busheri F, Lasko DD, Weinfeld M, Caldecott KW (2001). "XRCC1 stimulates human polynucleotide kinase activity at damaged DNA termini and accelerates DNA single-strand break repair". Cell. 104 (1): 107–17. doi:10.1016/S0092-8674(01)00195-7. PMID 11163244.
  • Chappell C, Hanakahi LA, Karimi-Busheri F, Weinfeld M, West SC (2002). "Involvement of human polynucleotide kinase in double-strand break repair by non-homologous end joining". EMBO J. 21 (11): 2827–32. doi:10.1093/emboj/21.11.2827. PMC 126026. PMID 12032095.
  • Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD, Altschul SF, Zeeberg B, Buetow KH, Schaefer CF, Bhat NK, Hopkins RF, Jordan H, Moore T, Max SI, Wang J, Hsieh F, Diatchenko L, Marusina K, Farmer AA, Rubin GM, Hong L, Stapleton M, Soares MB, Bonaldo MF, Casavant TL, Scheetz TE, Brownstein MJ, Usdin TB, Toshiyuki S, Carninci P, Prange C, Raha SS, Loquellano NA, Peters GJ, Abramson RD, Mullahy SJ, Bosak SA, McEwan PJ, McKernan KJ, Malek JA, Gunaratne PH, Richards S, Worley KC, Hale S, Garcia AM, Gay LJ, Hulyk SW, Villalon DK, Muzny DM, Sodergren EJ, Lu X, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madan A, Young AC, Shevchenko Y, Bouffard GG, Blakesley RW, Touchman JW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Krzywinski MI, Skalska U, Smailus DE, Schnerch A, Schein JE, Jones SJ, Marra MA (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Mani RS, Karimi-Busheri F, Fanta M, Cass CE, Weinfeld M (2003). "Spectroscopic studies of DNA and ATP binding to human polynucleotide kinase: evidence for a ternary complex". Biochemistry. 42 (41): 12077–84. doi:10.1021/bi030127b. PMID 14556639.
  • Loizou JI, El-Khamisy SF, Zlatanou A, Moore DJ, Chan DW, Qin J, Sarno S, Meggio F, Pinna LA, Caldecott KW (2004). "The protein kinase CK2 facilitates repair of chromosomal DNA single-strand breaks". Cell. 117 (1): 17–28. doi:10.1016/S0092-8674(04)00206-5. PMID 15066279.
  • Colland F, Jacq X, Trouplin V, Mougin C, Groizeleau C, Hamburger A, Meil A, Wojcik J, Legrain P, Gauthier JM (2004). "Functional proteomics mapping of a human signaling pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
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