HNRNPL: Difference between revisions

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{{Infobox_gene}}
{{PBB_Controls
'''Heterogeneous nuclear ribonucleoprotein L''' is a [[protein]] that in humans is encoded by the ''HNRNPL'' [[gene]].<ref name="pmid2687284">{{cite journal |vauthors=Pinol-Roma S, Swanson MS, Gall JG, Dreyfuss G | title = A novel heterogeneous nuclear RNP protein with a unique distribution on nascent transcripts | journal = J Cell Biol | volume = 109 | issue = 6 Pt 1 | pages = 2575–87 |date=January 1990 | pmid = 2687284 | pmc = 2115934 | doi =10.1083/jcb.109.6.2575  }}</ref><ref name="entrez"/>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Heterogeneous nuclear ribonucleoprotein L
| HGNCid = 5045
| Symbol = HNRPL
| AltSymbols =; FLJ35509; P/OKcl.14; hnRNP-L
| OMIM = 603083
| ECnumber = 
| Homologene = 1174
| MGIid = 104816
| GeneAtlas_image1 = PBB_GE_HNRPL_35201_at_tn.png
| GeneAtlas_image2 = PBB_GE_HNRPL_202072_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0003723 |text = RNA binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005654 |text = nucleoplasm}} {{GNF_GO|id=GO:0030530 |text = heterogeneous nuclear ribonucleoprotein complex}}
| Process = {{GNF_GO|id=GO:0006397 |text = mRNA processing}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 3191
    | Hs_Ensembl = ENSG00000104824
    | Hs_RefseqProtein = NP_001005335
    | Hs_RefseqmRNA = NM_001005335
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 19
    | Hs_GenLoc_start = 44018869
    | Hs_GenLoc_end = 44032457
    | Hs_Uniprot = P14866
    | Mm_EntrezGene = 15388
    | Mm_Ensembl = ENSMUSG00000015165
    | Mm_RefseqmRNA = NM_177301
    | Mm_RefseqProtein = NP_796275
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 7
    | Mm_GenLoc_start = 28519655
    | Mm_GenLoc_end = 28531009
    | Mm_Uniprot = Q499X2
  }}
}}
'''Heterogeneous nuclear ribonucleoprotein L''', also known as '''HNRPL''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: HNRPL heterogeneous nuclear ribonucleoprotein L| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3191| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
[[Heterogeneous nuclear RNA]]s (hnRNAs) which include [[mRNA]] precursors and mature mRNAs are associated with specific proteins to form heterogeneous ribonucleoprotein (hnRNP) complexes. Heterogeneous nuclear ribonucleoprotein L is among the proteins that are stably associated with hnRNP complexes and along with other hnRNP proteins is likely to play a major role in the formation, packaging, processing, and function of mRNA. Heterogeneous nuclear ribonucleoprotein L is present in the nucleoplasm as part of the HNRP complex. HNRP proteins have also been identified outside of the nucleoplasm. Exchange of hnRNP for mRNA-binding proteins accompanies transport of mRNA from the nucleus to the cytoplasm. Since HNRP proteins have been shown to shuttle between the [[cell nucleus|nucleus]] and the [[cytoplasm]], it is possible that they also have cytoplasmic functions. Two transcript variants encoding different isoforms have been found for this gene.<ref name="entrez">{{cite web | title = Entrez Gene: HNRPL heterogeneous nuclear ribonucleoprotein L| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3191| accessdate = }}</ref>
{{PBB_Summary
 
| section_title =
==Interactions==
| summary_text = Heterogeneous nuclear RNAs (hnRNAs) which include mRNA precursors and mature mRNAs are associated with specific proteins to form heterogenous ribonucleoprotein (hnRNP) complexes. Heterogeneous nuclear ribonucleoprotein L is among the proteins that are stably associated with hnRNP complexes and along with other hnRNP proteins is likely to play a major role in the formation, packaging, processing, and function of mRNA. Heterogeneous nuclear ribonucleoprotein L is present in the nucleoplasm as part of the HNRP complex. HNRP proteins have also been identified outside of the nucleoplasm. Exchange of hnRNP for mRNA-binding proteins accompanies transport of mRNA from the nucleus to the cytoplasm. Since HNRP proteins have been shown to shuttle between the nucleus and the cytoplasm, it is possible that they also have cytoplasmic functions. Two transcript variants encoding different isoforms have been found for this gene.<ref name="entrez">{{cite web | title = Entrez Gene: HNRPL heterogeneous nuclear ribonucleoprotein L| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3191| accessdate = }}</ref>
HNRNPL has been shown to [[Protein-protein interaction|interact]] with:
}}
* [[HNRNPLL]],<ref name = pmid18669861>{{cite journal | date = Aug 2008 |vauthors=Oberdoerffer S, Moita LF, Neems D, Freitas RP, Hacohen N, Rao A | title = Regulation of CD45 alternative splicing by heterogeneous ribonucleoprotein, hnRNPLL | journal = Science | volume = 321 | issue = 5889 | pages = 686–91  | pmid = 18669861 | pmc = 2791692 | doi = 10.1126/science.1157610}}</ref>
* [[HNRPK]],<ref name = pmid10772858/>
* [[PCBP2]],<ref name = pmid10772858>{{cite journal | date = May 2000 |vauthors=Kim JH, Hahm B, Kim YK, Choi M, Jang SK | title = Protein-protein interaction among hnRNPs shuttling between nucleus and cytoplasm | journal = J. Mol. Biol. | volume = 298 | issue = 3 | pages = 395–405  | pmid = 10772858 | doi = 10.1006/jmbi.2000.3687}}</ref>  and
* [[PTBP1]].<ref name = pmid10772858/><ref name = pmid9563502>{{cite journal | date = April 1998 |vauthors=Hahm B, Cho OH, Kim JE, Kim YK, Kim JH, Oh YL, Jang SK | title = Polypyrimidine tract-binding protein interacts with HnRNP L | journal = FEBS Lett. | volume = 425 | issue = 3 | pages = 401–6  | pmid = 9563502 | doi = 10.1016/S0014-5793(98)00269-5}}</ref>


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
*{{cite journal  |vauthors=Dreyfuss G, Choi YD, Adam SA |title=The ribonucleoprotein structures along the pathway of mRNA formation |journal=Endocr. Res. |volume=15 |issue= 4 |pages= 441–74 |year= 1990 |pmid= 2576798 |doi=10.3109/07435808909036348 }}
| citations =
*{{cite journal   |vauthors=Rasmussen HH, van Damme J, Puype M, etal |title=Microsequences of 145 proteins recorded in the two-dimensional gel protein database of normal human epidermal keratinocytes |journal=Electrophoresis |volume=13 |issue= 12 |pages= 960–9 |year= 1993 |pmid= 1286667 |doi=10.1002/elps.11501301199 }}
*{{cite journal  | author=Dreyfuss G, Choi YD, Adam SA |title=The ribonucleoprotein structures along the pathway of mRNA formation. |journal=Endocr. Res. |volume=15 |issue= 4 |pages= 441-74 |year= 1990 |pmid= 2576798 |doi=  }}
*{{cite journal   |vauthors=Hahm B, Cho OH, Kim JE, etal |title=Polypyrimidine tract-binding protein interacts with HnRNP L |journal=FEBS Lett. |volume=425 |issue= 3 |pages= 401–6 |year= 1998 |pmid= 9563502 |doi=10.1016/S0014-5793(98)00269-5 }}
*{{cite journal | author=Rasmussen HH, van Damme J, Puype M, ''et al.'' |title=Microsequences of 145 proteins recorded in the two-dimensional gel protein database of normal human epidermal keratinocytes. |journal=Electrophoresis |volume=13 |issue= 12 |pages= 960-9 |year= 1993 |pmid= 1286667 |doi=  }}
*{{cite journal  |vauthors=Shih SC, Claffey KP |title=Regulation of human vascular endothelial growth factor mRNA stability in hypoxia by heterogeneous nuclear ribonucleoprotein L |journal=J. Biol. Chem. |volume=274 |issue= 3 |pages= 1359–65 |year= 1999 |pmid= 9880507 |doi=10.1074/jbc.274.3.1359  }}
*{{cite journal | author=Piñol-Roma S, Swanson MS, Gall JG, Dreyfuss G |title=A novel heterogeneous nuclear RNP protein with a unique distribution on nascent transcripts. |journal=J. Cell Biol. |volume=109 |issue= 6 Pt 1 |pages= 2575-87 |year= 1990 |pmid= 2687284 |doi=  }}
*{{cite journal   |vauthors=Hamilton BJ, Nichols RC, Tsukamoto H, etal |title=hnRNP A2 and hnRNP L bind the 3'UTR of glucose transporter 1 mRNA and exist as a complex in vivo |journal=Biochem. Biophys. Res. Commun. |volume=261 |issue= 3 |pages= 646–51 |year= 1999 |pmid= 10441480 |doi= 10.1006/bbrc.1999.1040 }}
*{{cite journal  | author=Hahm B, Cho OH, Kim JE, ''et al.'' |title=Polypyrimidine tract-binding protein interacts with HnRNP L. |journal=FEBS Lett. |volume=425 |issue= 3 |pages= 401-6 |year= 1998 |pmid= 9563502 |doi= }}
*{{cite journal   |vauthors=Dias Neto E, Correa RG, Verjovski-Almeida S, etal |title=Shotgun sequencing of the human transcriptome with ORF expressed sequence tags |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 7 |pages= 3491–6 |year= 2000 |pmid= 10737800 |doi=10.1073/pnas.97.7.3491  | pmc=16267  }}
*{{cite journal | author=Shih SC, Claffey KP |title=Regulation of human vascular endothelial growth factor mRNA stability in hypoxia by heterogeneous nuclear ribonucleoprotein L. |journal=J. Biol. Chem. |volume=274 |issue= 3 |pages= 1359-65 |year= 1999 |pmid= 9880507 |doi= }}
*{{cite journal   |vauthors=Kim JH, Hahm B, Kim YK, etal |title=Protein-protein interaction among hnRNPs shuttling between nucleus and cytoplasm |journal=J. Mol. Biol. |volume=298 |issue= 3 |pages= 395–405 |year= 2000 |pmid= 10772858 |doi= 10.1006/jmbi.2000.3687 }}
*{{cite journal | author=Hamilton BJ, Nichols RC, Tsukamoto H, ''et al.'' |title=hnRNP A2 and hnRNP L bind the 3'UTR of glucose transporter 1 mRNA and exist as a complex in vivo. |journal=Biochem. Biophys. Res. Commun. |volume=261 |issue= 3 |pages= 646-51 |year= 1999 |pmid= 10441480 |doi= 10.1006/bbrc.1999.1040 }}
*{{cite journal   |vauthors=Shnyreva M, Schullery DS, Suzuki H, etal |title=Interaction of two multifunctional proteins. Heterogeneous nuclear ribonucleoprotein K and Y-box-binding protein |journal=J. Biol. Chem. |volume=275 |issue= 20 |pages= 15498–503 |year= 2000 |pmid= 10809782 |doi=10.1074/jbc.275.20.15498  }}
*{{cite journal | author=Dias Neto E, Correa RG, Verjovski-Almeida S, ''et al.'' |title=Shotgun sequencing of the human transcriptome with ORF expressed sequence tags. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 7 |pages= 3491-6 |year= 2000 |pmid= 10737800 |doi= }}
*{{cite journal   |vauthors=Ito M, Shichijo S, Tsuda N, etal |title=Molecular basis of T cell-mediated recognition of pancreatic cancer cells |journal=Cancer Res. |volume=61 |issue= 5 |pages= 2038–46 |year= 2001 |pmid= 11280764 |doi=  }}
*{{cite journal | author=Kim JH, Hahm B, Kim YK, ''et al.'' |title=Protein-protein interaction among hnRNPs shuttling between nucleus and cytoplasm. |journal=J. Mol. Biol. |volume=298 |issue= 3 |pages= 395-405 |year= 2000 |pmid= 10772858 |doi= 10.1006/jmbi.2000.3687 }}
*{{cite journal  |vauthors=Kuninger DT, Izumi T, Papaconstantinou J, Mitra S |title=Human AP-endonuclease 1 and hnRNP-L interact with a nCaRE-like repressor element in the AP-endonuclease 1 promoter |journal=Nucleic Acids Res. |volume=30 |issue= 3 |pages= 823–9 |year= 2002 |pmid= 11809897 |doi=10.1093/nar/30.3.823  | pmc=100287 }}
*{{cite journal | author=Shnyreva M, Schullery DS, Suzuki H, ''et al.'' |title=Interaction of two multifunctional proteins. Heterogeneous nuclear ribonucleoprotein K and Y-box-binding protein. |journal=J. Biol. Chem. |volume=275 |issue= 20 |pages= 15498-503 |year= 2000 |pmid= 10809782 |doi=  }}
*{{cite journal  |vauthors=Söderberg M, Raffalli-Mathieu F, Lang MA |title=Inflammation modulates the interaction of heterogeneous nuclear ribonucleoprotein (hnRNP) I/polypyrimidine tract binding protein and hnRNP L with the 3'untranslated region of the murine inducible nitric-oxide synthase mRNA |journal=Mol. Pharmacol. |volume=62 |issue= 2 |pages= 423–31 |year= 2002 |pmid= 12130696 |doi=10.1124/mol.62.2.423 }}
*{{cite journal  | author=Ito M, Shichijo S, Tsuda N, ''et al.'' |title=Molecular basis of T cell-mediated recognition of pancreatic cancer cells. |journal=Cancer Res. |volume=61 |issue= 5 |pages= 2038-46 |year= 2001 |pmid= 11280764 |doi=  }}
*{{cite journal  |vauthors=Hui J, Stangl K, Lane WS, Bindereif A |title=HnRNP L stimulates splicing of the eNOS gene by binding to variable-length CA repeats |journal=Nat. Struct. Biol. |volume=10 |issue= 1 |pages= 33–7 |year= 2007 |pmid= 12447348 |doi= 10.1038/nsb875 }}
*{{cite journal  | author=Kuninger DT, Izumi T, Papaconstantinou J, Mitra S |title=Human AP-endonuclease 1 and hnRNP-L interact with a nCaRE-like repressor element in the AP-endonuclease 1 promoter. |journal=Nucleic Acids Res. |volume=30 |issue= 3 |pages= 823-9 |year= 2002 |pmid= 11809897 |doi=  }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 }}
*{{cite journal  | author=Söderberg M, Raffalli-Mathieu F, Lang MA |title=Inflammation modulates the interaction of heterogeneous nuclear ribonucleoprotein (hnRNP) I/polypyrimidine tract binding protein and hnRNP L with the 3'untranslated region of the murine inducible nitric-oxide synthase mRNA. |journal=Mol. Pharmacol. |volume=62 |issue= 2 |pages= 423-31 |year= 2002 |pmid= 12130696 |doi= }}
*{{cite journal  |vauthors=Costain WJ, Mishra RK |title=PLG regulates hnRNP-L expression in the rat striatum and pre-frontal cortex: identification by ddPCR |journal=Peptides |volume=24 |issue= 1 |pages= 137–46 |year= 2003 |pmid= 12576095 |doi=10.1016/S0196-9781(02)00286-3  }}
*{{cite journal | author=Hui J, Stangl K, Lane WS, Bindereif A |title=HnRNP L stimulates splicing of the eNOS gene by binding to variable-length CA repeats. |journal=Nat. Struct. Biol. |volume=10 |issue= 1 |pages= 33-7 |year= 2007 |pmid= 12447348 |doi= 10.1038/nsb875 }}
*{{cite journal  |vauthors=Hui J, Reither G, Bindereif A |title=Novel functional role of CA repeats and hnRNP L in RNA stability |journal=RNA |volume=9 |issue= 8 |pages= 931–6 |year= 2003 |pmid= 12869704 |doi=10.1261/rna.5660803 | pmc=1370459 }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  |vauthors=Gulesserian T, Engidawork E, Fountoulakis M, Lubec G |title=Decreased brain levels of Lupus La protein and increased U5 small ribonucleoprotein-specific 40 kDa protein in fetal Down syndrome |journal=Cell. Mol. Biol. (Noisy-le-grand) |volume=49 |issue= 5 |pages= 733–8 |year= 2004 |pmid= 14528909 |doi=  }}
*{{cite journal  | author=Costain WJ, Mishra RK |title=PLG regulates hnRNP-L expression in the rat striatum and pre-frontal cortex: identification by ddPCR. |journal=Peptides |volume=24 |issue= 1 |pages= 137-46 |year= 2003 |pmid= 12576095 |doi=  }}
*{{cite journal   |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal  | author=Hui J, Reither G, Bindereif A |title=Novel functional role of CA repeats and hnRNP L in RNA stability. |journal=RNA |volume=9 |issue= 8 |pages= 931-6 |year= 2003 |pmid= 12869704 |doi=  }}
*{{cite journal   |vauthors=Cheng J, Kapranov P, Drenkow J, etal |title=Transcriptional maps of 10 human chromosomes at 5-nucleotide resolution |journal=Science |volume=308 |issue= 5725 |pages= 1149–54 |year= 2005 |pmid= 15790807 |doi= 10.1126/science.1108625 }}
*{{cite journal  | author=Gulesserian T, Engidawork E, Fountoulakis M, Lubec G |title=Decreased brain levels of Lupus La protein and increased U5 small ribonucleoprotein-specific 40 kDa protein in fetal Down syndrome. |journal=Cell. Mol. Biol. (Noisy-le-grand) |volume=49 |issue= 5 |pages= 733-8 |year= 2004 |pmid= 14528909 |doi=  }}
*{{cite journal | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal | author=Cheng J, Kapranov P, Drenkow J, ''et al.'' |title=Transcriptional maps of 10 human chromosomes at 5-nucleotide resolution. |journal=Science |volume=308 |issue= 5725 |pages= 1149-54 |year= 2005 |pmid= 15790807 |doi= 10.1126/science.1108625 }}
}}
{{refend}}
{{refend}}


{{protein-stub}}
{{Ribonucleoproteins}}
{{WikiDoc Sources}}
 
 
{{gene-19-stub}}

Latest revision as of 13:57, 31 August 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Heterogeneous nuclear ribonucleoprotein L is a protein that in humans is encoded by the HNRNPL gene.[1][2]

Function

Heterogeneous nuclear RNAs (hnRNAs) which include mRNA precursors and mature mRNAs are associated with specific proteins to form heterogeneous ribonucleoprotein (hnRNP) complexes. Heterogeneous nuclear ribonucleoprotein L is among the proteins that are stably associated with hnRNP complexes and along with other hnRNP proteins is likely to play a major role in the formation, packaging, processing, and function of mRNA. Heterogeneous nuclear ribonucleoprotein L is present in the nucleoplasm as part of the HNRP complex. HNRP proteins have also been identified outside of the nucleoplasm. Exchange of hnRNP for mRNA-binding proteins accompanies transport of mRNA from the nucleus to the cytoplasm. Since HNRP proteins have been shown to shuttle between the nucleus and the cytoplasm, it is possible that they also have cytoplasmic functions. Two transcript variants encoding different isoforms have been found for this gene.[2]

Interactions

HNRNPL has been shown to interact with:

References

  1. ↑ Pinol-Roma S, Swanson MS, Gall JG, Dreyfuss G (January 1990). "A novel heterogeneous nuclear RNP protein with a unique distribution on nascent transcripts". J Cell Biol. 109 (6 Pt 1): 2575–87. doi:10.1083/jcb.109.6.2575. PMC 2115934. PMID 2687284.
  2. ↑ 2.0 2.1 "Entrez Gene: HNRPL heterogeneous nuclear ribonucleoprotein L".
  3. ↑ Oberdoerffer S, Moita LF, Neems D, Freitas RP, Hacohen N, Rao A (Aug 2008). "Regulation of CD45 alternative splicing by heterogeneous ribonucleoprotein, hnRNPLL". Science. 321 (5889): 686–91. doi:10.1126/science.1157610. PMC 2791692. PMID 18669861.
  4. ↑ 4.0 4.1 4.2 Kim JH, Hahm B, Kim YK, Choi M, Jang SK (May 2000). "Protein-protein interaction among hnRNPs shuttling between nucleus and cytoplasm". J. Mol. Biol. 298 (3): 395–405. doi:10.1006/jmbi.2000.3687. PMID 10772858.
  5. ↑ Hahm B, Cho OH, Kim JE, Kim YK, Kim JH, Oh YL, Jang SK (April 1998). "Polypyrimidine tract-binding protein interacts with HnRNP L". FEBS Lett. 425 (3): 401–6. doi:10.1016/S0014-5793(98)00269-5. PMID 9563502.

Further reading


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