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{{Infobox_gene}}
{{PBB_Controls
'''Mediator of RNA polymerase II transcription subunit 24''' is an [[enzyme]] that in humans is encoded by the ''MED24'' [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: THRAP4 thyroid hormone receptor associated protein 4| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9862| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Thyroid hormone receptor associated protein 4
| HGNCid = 22963
| Symbol = THRAP4
| AltSymbols =; MED24; ARC100; DRIP100; KIAA0130; MGC8748; TRAP100
| OMIM = 607000
| ECnumber = 
| Homologene = 40795
| MGIid = 1344385
| GeneAtlas_image1 = PBB_GE_THRAP4_213043_s_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0003712 |text = transcription cofactor activity}} {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0016455 |text = RNA polymerase II transcription mediator activity}} {{GNF_GO|id=GO:0016563 |text = transcription activator activity}} {{GNF_GO|id=GO:0030374 |text = ligand-dependent nuclear receptor transcription coactivator activity}} {{GNF_GO|id=GO:0042809 |text = vitamin D receptor binding}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}} {{GNF_GO|id=GO:0046966 |text = thyroid hormone receptor binding}}
| Component = {{GNF_GO|id=GO:0000119 |text = mediator complex}} {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0006367 |text = transcription initiation from RNA polymerase II promoter}} {{GNF_GO|id=GO:0030521 |text = androgen receptor signaling pathway}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 9862
    | Hs_Ensembl = ENSG00000008838
    | Hs_RefseqProtein = NP_001072986
    | Hs_RefseqmRNA = NM_001079518
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 17
    | Hs_GenLoc_start = 35428881
    | Hs_GenLoc_end = 35464175
    | Hs_Uniprot = O75448
    | Mm_EntrezGene = 23989
    | Mm_Ensembl = ENSMUSG00000017210
    | Mm_RefseqmRNA = NM_011869
    | Mm_RefseqProtein = NP_035999
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 11
    | Mm_GenLoc_start = 98352628
    | Mm_GenLoc_end = 98545508
    | Mm_Uniprot = 
  }}
}}
'''Thyroid hormone receptor associated protein 4''', also known as '''THRAP4''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: THRAP4 thyroid hormone receptor associated protein 4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9862| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
This gene encodes a component of the mediator complex (also known as TRAP, SMCC, DRIP, or ARC), a transcriptional coactivator complex thought to be required for the expression of almost all genes. The mediator complex is recruited by transcriptional activators or nuclear receptors to induce gene expression, possibly by interacting with RNA polymerase II and promoting the formation of a transcriptional pre-initiation complex. Multiple transcript variants encoding different isoforms have been found for this gene.<ref name="entrez" />
{{PBB_Summary
| section_title =
| summary_text = This gene encodes a component of the mediator complex (also known as TRAP, SMCC, DRIP, or ARC), a transcriptional coactivator complex thought to be required for the expression of almost all genes. The mediator complex is recruited by transcriptional activators or nuclear receptors to induce gene expression, possibly by interacting with RNA polymerase II and promoting the formation of a transcriptional pre-initiation complex. Multiple transcript variants encoding different isoforms have been found for this gene.<ref name="entrez">{{cite web | title = Entrez Gene: THRAP4 thyroid hormone receptor associated protein 4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9862| accessdate = }}</ref>
}}


==References==
== Interactions ==
{{reflist|2}}
 
==Further reading==
MED24 has been shown to [[Protein-protein interaction|interact]] with [[Estrogen receptor alpha]],<ref name=pmid12837248>{{cite journal | vauthors = Kitagawa H, Fujiki R, Yoshimura K, Mezaki Y, Uematsu Y, Matsui D, Ogawa S, Unno K, Okubo M, Tokita A, Nakagawa T, Ito T, Ishimi Y, Nagasawa H, Matsumoto T, Yanagisawa J, Kato S | title = The chromatin-remodeling complex WINAC targets a nuclear receptor to promoters and is impaired in Williams syndrome | journal = Cell | volume = 113 | issue = 7 | pages = 905–17 | date = Jun 2003 | pmid = 12837248 | doi = 10.1016/S0092-8674(03)00436-7 }}</ref><ref name=pmid11867769>{{cite journal | vauthors = Kang YK, Guermah M, Yuan CX, Roeder RG | title = The TRAP/Mediator coactivator complex interacts directly with estrogen receptors alpha and beta through the TRAP220 subunit and directly enhances estrogen receptor function in vitro | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 99 | issue = 5 | pages = 2642–7 | date = Mar 2002 | pmid = 11867769 | pmc = 122401 | doi = 10.1073/pnas.261715899 }}</ref> [[Cyclin-dependent kinase 8]],<ref name=pmid11867769/><ref name=pmid10198638>{{cite journal | vauthors = Ito M, Yuan CX, Malik S, Gu W, Fondell JD, Yamamura S, Fu ZY, Zhang X, Qin J, Roeder RG | title = Identity between TRAP and SMCC complexes indicates novel pathways for the function of nuclear receptors and diverse mammalian activators | journal = Molecular Cell | volume = 3 | issue = 3 | pages = 361–70 | date = Mar 1999 | pmid = 10198638 | doi = 10.1016/S1097-2765(00)80463-3 }}</ref> [[Calcitriol receptor]]<ref name=pmid12837248/><ref name=pmid10198638/> and [[BRCA1]].<ref name=pmid15208681>{{cite journal | vauthors = Wada O, Oishi H, Takada I, Yanagisawa J, Yano T, Kato S | title = BRCA1 function mediates a TRAP/DRIP complex through direct interaction with TRAP220 | journal = Oncogene | volume = 23 | issue = 35 | pages = 6000–5 | date = Aug 2004 | pmid = 15208681 | doi = 10.1038/sj.onc.1207786 }}</ref>
 
== References ==
{{reflist}}
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Gustafsson CM, Samuelsson T | title = Mediator--a universal complex in transcriptional regulation | journal = Molecular Microbiology | volume = 41 | issue = 1 | pages = 1–8 | date = Jul 2001 | pmid = 11454195 | doi = 10.1046/j.1365-2958.2001.02481.x }}
| citations =
* {{cite journal | vauthors = Malik S, Roeder RG | title = Dynamic regulation of pol II transcription by the mammalian Mediator complex | journal = Trends in Biochemical Sciences | volume = 30 | issue = 5 | pages = 256–63 | date = May 2005 | pmid = 15896744 | doi = 10.1016/j.tibs.2005.03.009 }}
*{{cite journal | author=Gustafsson CM, Samuelsson T |title=Mediator--a universal complex in transcriptional regulation. |journal=Mol. Microbiol. |volume=41 |issue= 1 |pages= 1-8 |year= 2001 |pmid= 11454195 |doi= }}
* {{cite journal | vauthors = Nagase T, Seki N, Tanaka A, Ishikawa K, Nomura N | title = Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1 | journal = DNA Research | volume = 2 | issue = 4 | pages = 167–74, 199-210 | date = Aug 1995 | pmid = 8590280 | doi = 10.1093/dnares/2.4.167 }}
*{{cite journal | author=Malik S, Roeder RG |title=Dynamic regulation of pol II transcription by the mammalian Mediator complex. |journal=Trends Biochem. Sci. |volume=30 |issue= 5 |pages= 256-63 |year= 2005 |pmid= 15896744 |doi= 10.1016/j.tibs.2005.03.009 }}
* {{cite journal | vauthors = Fondell JD, Ge H, Roeder RG | title = Ligand induction of a transcriptionally active thyroid hormone receptor coactivator complex | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 93 | issue = 16 | pages = 8329–33 | date = Aug 1996 | pmid = 8710870 | pmc = 38670 | doi = 10.1073/pnas.93.16.8329 }}
*{{cite journal | author=Nagase T, Seki N, Tanaka A, ''et al.'' |title=Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1. |journal=DNA Res. |volume=2 |issue= 4 |pages= 167-74, 199-210 |year= 1996 |pmid= 8590280 |doi= }}
* {{cite journal | vauthors = Rachez C, Suldan Z, Ward J, Chang CP, Burakov D, Erdjument-Bromage H, Tempst P, Freedman LP | title = A novel protein complex that interacts with the vitamin D3 receptor in a ligand-dependent manner and enhances VDR transactivation in a cell-free system | journal = Genes & Development | volume = 12 | issue = 12 | pages = 1787–800 | date = Jun 1998 | pmid = 9637681 | pmc = 316901 | doi = 10.1101/gad.12.12.1787 }}
*{{cite journal | author=Fondell JD, Ge H, Roeder RG |title=Ligand induction of a transcriptionally active thyroid hormone receptor coactivator complex. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=93 |issue= 16 |pages= 8329-33 |year= 1996 |pmid= 8710870 |doi= }}
* {{cite journal | vauthors = Yuan CX, Ito M, Fondell JD, Fu ZY, Roeder RG | title = The TRAP220 component of a thyroid hormone receptor- associated protein (TRAP) coactivator complex interacts directly with nuclear receptors in a ligand-dependent fashion | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 95 | issue = 14 | pages = 7939–44 | date = Jul 1998 | pmid = 9653119 | pmc = 20908 | doi = 10.1073/pnas.95.14.7939 }}
*{{cite journal | author=Rachez C, Suldan Z, Ward J, ''et al.'' |title=A novel protein complex that interacts with the vitamin D3 receptor in a ligand-dependent manner and enhances VDR transactivation in a cell-free system. |journal=Genes Dev. |volume=12 |issue= 12 |pages= 1787-800 |year= 1998 |pmid= 9637681 |doi= }}
* {{cite journal | vauthors = Gu W, Malik S, Ito M, Yuan CX, Fondell JD, Zhang X, Martinez E, Qin J, Roeder RG | title = A novel human SRB/MED-containing cofactor complex, SMCC, involved in transcription regulation | journal = Molecular Cell | volume = 3 | issue = 1 | pages = 97–108 | date = Jan 1999 | pmid = 10024883 | doi = 10.1016/S1097-2765(00)80178-1 }}
*{{cite journal | author=Yuan CX, Ito M, Fondell JD, ''et al.'' |title=The TRAP220 component of a thyroid hormone receptor- associated protein (TRAP) coactivator complex interacts directly with nuclear receptors in a ligand-dependent fashion. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=95 |issue= 14 |pages= 7939-44 |year= 1998 |pmid= 9653119 |doi= }}
* {{cite journal | vauthors = Ito M, Yuan CX, Malik S, Gu W, Fondell JD, Yamamura S, Fu ZY, Zhang X, Qin J, Roeder RG | title = Identity between TRAP and SMCC complexes indicates novel pathways for the function of nuclear receptors and diverse mammalian activators | journal = Molecular Cell | volume = 3 | issue = 3 | pages = 361–70 | date = Mar 1999 | pmid = 10198638 | doi = 10.1016/S1097-2765(00)80463-3 }}
*{{cite journal | author=Gu W, Malik S, Ito M, ''et al.'' |title=A novel human SRB/MED-containing cofactor complex, SMCC, involved in transcription regulation. |journal=Mol. Cell |volume=3 |issue= 1 |pages= 97-108 |year= 1999 |pmid= 10024883 |doi= }}
* {{cite journal | vauthors = Rachez C, Lemon BD, Suldan Z, Bromleigh V, Gamble M, Näär AM, Erdjument-Bromage H, Tempst P, Freedman LP | title = Ligand-dependent transcription activation by nuclear receptors requires the DRIP complex | journal = Nature | volume = 398 | issue = 6730 | pages = 824–8 | date = Apr 1999 | pmid = 10235266 | doi = 10.1038/19783 }}
*{{cite journal | author=Ito M, Yuan CX, Malik S, ''et al.'' |title=Identity between TRAP and SMCC complexes indicates novel pathways for the function of nuclear receptors and diverse mammalian activators. |journal=Mol. Cell |volume=3 |issue= 3 |pages= 361-70 |year= 1999 |pmid= 10198638 |doi= }}
* {{cite journal | vauthors = Näär AM, Beaurang PA, Zhou S, Abraham S, Solomon W, Tjian R | title = Composite co-activator ARC mediates chromatin-directed transcriptional activation | journal = Nature | volume = 398 | issue = 6730 | pages = 828–32 | date = Apr 1999 | pmid = 10235267 | doi = 10.1038/19789 }}
*{{cite journal | author=Rachez C, Lemon BD, Suldan Z, ''et al.'' |title=Ligand-dependent transcription activation by nuclear receptors requires the DRIP complex. |journal=Nature |volume=398 |issue= 6730 |pages= 824-8 |year= 1999 |pmid= 10235266 |doi= 10.1038/19783 }}
* {{cite journal | vauthors = Ryu S, Tjian R | title = Purification of transcription cofactor complex CRSP | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 96 | issue = 13 | pages = 7137–42 | date = Jun 1999 | pmid = 10377381 | pmc = 22029 | doi = 10.1073/pnas.96.13.7137 }}
*{{cite journal | author=Näär AM, Beaurang PA, Zhou S, ''et al.'' |title=Composite co-activator ARC mediates chromatin-directed transcriptional activation. |journal=Nature |volume=398 |issue= 6730 |pages= 828-32 |year= 1999 |pmid= 10235267 |doi= 10.1038/19789 }}
* {{cite journal | vauthors = Zhang J, Fondell JD | title = Identification of mouse TRAP100: a transcriptional coregulatory factor for thyroid hormone and vitamin D receptors | journal = Molecular Endocrinology | volume = 13 | issue = 7 | pages = 1130–40 | date = Jul 1999 | pmid = 10406464 | doi = 10.1210/me.13.7.1130 }}
*{{cite journal | author=Ryu S, Tjian R |title=Purification of transcription cofactor complex CRSP. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=96 |issue= 13 |pages= 7137-42 |year= 1999 |pmid= 10377381 |doi= }}
* {{cite journal | vauthors = Taatjes DJ, Näär AM, Andel F, Nogales E, Tjian R | title = Structure, function, and activator-induced conformations of the CRSP coactivator | journal = Science | volume = 295 | issue = 5557 | pages = 1058–62 | date = Feb 2002 | pmid = 11834832 | doi = 10.1126/science.1065249 }}
*{{cite journal | author=Zhang J, Fondell JD |title=Identification of mouse TRAP100: a transcriptional coregulatory factor for thyroid hormone and vitamin D receptors. |journal=Mol. Endocrinol. |volume=13 |issue= 7 |pages= 1130-40 |year= 1999 |pmid= 10406464 |doi= }}
* {{cite journal | vauthors = Surapureddi S, Yu S, Bu H, Hashimoto T, Yeldandi AV, Kashireddy P, Cherkaoui-Malki M, Qi C, Zhu YJ, Rao MS, Reddy JK | title = Identification of a transcriptionally active peroxisome proliferator-activated receptor alpha -interacting cofactor complex in rat liver and characterization of PRIC285 as a coactivator | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 99 | issue = 18 | pages = 11836–41 | date = Sep 2002 | pmid = 12189208 | pmc = 129355 | doi = 10.1073/pnas.182426699 }}
*{{cite journal | author=Taatjes DJ, Näär AM, Andel F, ''et al.'' |title=Structure, function, and activator-induced conformations of the CRSP coactivator. |journal=Science |volume=295 |issue= 5557 |pages= 1058-62 |year= 2002 |pmid= 11834832 |doi= 10.1126/science.1065249 }}
* {{cite journal | vauthors = Wang Q, Sharma D, Ren Y, Fondell JD | title = A coregulatory role for the TRAP-mediator complex in androgen receptor-mediated gene expression | journal = The Journal of Biological Chemistry | volume = 277 | issue = 45 | pages = 42852–8 | date = Nov 2002 | pmid = 12218053 | doi = 10.1074/jbc.M206061200 }}
*{{cite journal | author=Surapureddi S, Yu S, Bu H, ''et al.'' |title=Identification of a transcriptionally active peroxisome proliferator-activated receptor alpha -interacting cofactor complex in rat liver and characterization of PRIC285 as a coactivator. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 18 |pages= 11836-41 |year= 2002 |pmid= 12189208 |doi= 10.1073/pnas.182426699 }}
* {{cite journal | vauthors = Sato S, Tomomori-Sato C, Banks CA, Parmely TJ, Sorokina I, Brower CS, Conaway RC, Conaway JW | title = A mammalian homolog of Drosophila melanogaster transcriptional coactivator intersex is a subunit of the mammalian Mediator complex | journal = The Journal of Biological Chemistry | volume = 278 | issue = 50 | pages = 49671–4 | date = Dec 2003 | pmid = 14576168 | doi = 10.1074/jbc.C300444200 }}
*{{cite journal | author=Wang Q, Sharma D, Ren Y, Fondell JD |title=A coregulatory role for the TRAP-mediator complex in androgen receptor-mediated gene expression. |journal=J. Biol. Chem. |volume=277 |issue= 45 |pages= 42852-8 |year= 2003 |pmid= 12218053 |doi= 10.1074/jbc.M206061200 }}
* {{cite journal | vauthors = Tomomori-Sato C, Sato S, Parmely TJ, Banks CA, Sorokina I, Florens L, Zybailov B, Washburn MP, Brower CS, Conaway RC, Conaway JW | title = A mammalian mediator subunit that shares properties with Saccharomyces cerevisiae mediator subunit Cse2 | journal = The Journal of Biological Chemistry | volume = 279 | issue = 7 | pages = 5846–51 | date = Feb 2004 | pmid = 14638676 | doi = 10.1074/jbc.M312523200 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | author=Sato S, Tomomori-Sato C, Banks CA, ''et al.'' |title=A mammalian homolog of Drosophila melanogaster transcriptional coactivator intersex is a subunit of the mammalian Mediator complex. |journal=J. Biol. Chem. |volume=278 |issue= 50 |pages= 49671-4 |year= 2004 |pmid= 14576168 |doi= 10.1074/jbc.C300444200 }}
*{{cite journal | author=Tomomori-Sato C, Sato S, Parmely TJ, ''et al.'' |title=A mammalian mediator subunit that shares properties with Saccharomyces cerevisiae mediator subunit Cse2. |journal=J. Biol. Chem. |volume=279 |issue= 7 |pages= 5846-51 |year= 2004 |pmid= 14638676 |doi= 10.1074/jbc.M312523200 }}
*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
}}
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Latest revision as of 06:20, 4 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
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Wikidata
View/Edit Human

Mediator of RNA polymerase II transcription subunit 24 is an enzyme that in humans is encoded by the MED24 gene.[1]

Function

This gene encodes a component of the mediator complex (also known as TRAP, SMCC, DRIP, or ARC), a transcriptional coactivator complex thought to be required for the expression of almost all genes. The mediator complex is recruited by transcriptional activators or nuclear receptors to induce gene expression, possibly by interacting with RNA polymerase II and promoting the formation of a transcriptional pre-initiation complex. Multiple transcript variants encoding different isoforms have been found for this gene.[1]

Interactions

MED24 has been shown to interact with Estrogen receptor alpha,[2][3] Cyclin-dependent kinase 8,[3][4] Calcitriol receptor[2][4] and BRCA1.[5]

References

  1. ↑ 1.0 1.1 "Entrez Gene: THRAP4 thyroid hormone receptor associated protein 4".
  2. ↑ 2.0 2.1 Kitagawa H, Fujiki R, Yoshimura K, Mezaki Y, Uematsu Y, Matsui D, Ogawa S, Unno K, Okubo M, Tokita A, Nakagawa T, Ito T, Ishimi Y, Nagasawa H, Matsumoto T, Yanagisawa J, Kato S (Jun 2003). "The chromatin-remodeling complex WINAC targets a nuclear receptor to promoters and is impaired in Williams syndrome". Cell. 113 (7): 905–17. doi:10.1016/S0092-8674(03)00436-7. PMID 12837248.
  3. ↑ 3.0 3.1 Kang YK, Guermah M, Yuan CX, Roeder RG (Mar 2002). "The TRAP/Mediator coactivator complex interacts directly with estrogen receptors alpha and beta through the TRAP220 subunit and directly enhances estrogen receptor function in vitro". Proceedings of the National Academy of Sciences of the United States of America. 99 (5): 2642–7. doi:10.1073/pnas.261715899. PMC 122401. PMID 11867769.
  4. ↑ 4.0 4.1 Ito M, Yuan CX, Malik S, Gu W, Fondell JD, Yamamura S, Fu ZY, Zhang X, Qin J, Roeder RG (Mar 1999). "Identity between TRAP and SMCC complexes indicates novel pathways for the function of nuclear receptors and diverse mammalian activators". Molecular Cell. 3 (3): 361–70. doi:10.1016/S1097-2765(00)80463-3. PMID 10198638.
  5. ↑ Wada O, Oishi H, Takada I, Yanagisawa J, Yano T, Kato S (Aug 2004). "BRCA1 function mediates a TRAP/DRIP complex through direct interaction with TRAP220". Oncogene. 23 (35): 6000–5. doi:10.1038/sj.onc.1207786. PMID 15208681.

Further reading

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