PPP4C: Difference between revisions

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{{Infobox_gene}}
{{PBB_Controls
'''Serine/threonine-protein phosphatase 4 catalytic subunit''' is an [[enzyme]] that in humans is encoded by the ''PPP4C'' [[gene]].<ref name="pmid9177794">{{cite journal | vauthors = Bastians H, Krebber H, Hoheisel J, Ohl S, Lichter P, Ponstingl H, Joos S | title = Assignment of the human serine/threonine protein phosphatase 4 gene (PPP4C) to chromosome 16p11-p12 by fluorescence in situ hybridization | journal = Genomics | volume = 42 | issue = 1 | pages = 181–2 | date = May 1997 | pmid = 9177794 | pmc = | doi = 10.1006/geno.1997.4693 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: PPP4C protein phosphatase 4 (formerly X), catalytic subunit| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5531| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Interactions ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =  
| Name = Protein phosphatase 4 (formerly X), catalytic subunit
| HGNCid = 9319
| Symbol = PPP4C
| AltSymbols =; PP4; PPH3; PPX
| OMIM = 602035
| ECnumber = 
| Homologene = 2038
| MGIid = 1891763
| GeneAtlas_image1 = PBB_GE_PPP4C_208932_at_tn.png
| Function = {{GNF_GO|id=GO:0004704 |text = NF-kappaB-inducing kinase activity}} {{GNF_GO|id=GO:0004722 |text = protein serine/threonine phosphatase activity}} {{GNF_GO|id=GO:0005506 |text = iron ion binding}} {{GNF_GO|id=GO:0016787 |text = hydrolase activity}} {{GNF_GO|id=GO:0030145 |text = manganese ion binding}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005813 |text = centrosome}}
| Process = {{GNF_GO|id=GO:0000226 |text = microtubule cytoskeleton organization and biogenesis}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 5531
    | Hs_Ensembl = ENSG00000149923
    | Hs_RefseqProtein = NP_002711
    | Hs_RefseqmRNA = NM_002720
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 16
    | Hs_GenLoc_start = 29994839
    | Hs_GenLoc_end = 30004193
    | Hs_Uniprot = P60510
    | Mm_EntrezGene = 56420
    | Mm_Ensembl = ENSMUSG00000030697
    | Mm_RefseqmRNA = NM_019674
    | Mm_RefseqProtein = NP_062648
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 7
    | Mm_GenLoc_start = 126577014
    | Mm_GenLoc_end = 126583619
    | Mm_Uniprot = Q3UNF2
  }}
}}
'''Protein phosphatase 4 (formerly X), catalytic subunit''', also known as '''PPP4C''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: PPP4C protein phosphatase 4 (formerly X), catalytic subunit| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5531| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
PPP4C has been shown to [[Protein-protein interaction|interact]] with:
{{PBB_Summary
{{div col|colwidth=20em}}
| section_title =  
* [[CCDC6]],<ref name = pmid18715871/><ref name = pmid17353931/>
| summary_text =  
* [[CCT2 (gene)|CCT2]],<ref name = pmid18715871>{{cite journal | vauthors = Chen GI, Tisayakorn S, Jorgensen C, D'Ambrosio LM, Goudreault M, Gingras AC | title = PP4R4/KIAA1622 forms a novel stable cytosolic complex with phosphoprotein phosphatase 4 | journal = The Journal of Biological Chemistry | volume = 283 | issue = 43 | pages = 29273–84 | date = Oct 2008 | pmid = 18715871 | pmc = 2662017 | doi = 10.1074/jbc.M803443200 }}</ref><ref name = pmid16085932>{{cite journal | vauthors = Gingras AC, Caballero M, Zarske M, Sanchez A, Hazbun TR, Fields S, Sonenberg N, Hafen E, Raught B, Aebersold R | title = A novel, evolutionarily conserved protein phosphatase complex involved in cisplatin sensitivity | journal = Molecular & Cellular Proteomics | volume = 4 | issue = 11 | pages = 1725–40 | date = Nov 2005 | pmid = 16085932 | doi = 10.1074/mcp.M500231-MCP200 }}</ref>
}}
* [[CCT3]],<ref name = pmid18715871/><ref name = pmid16085932/>
* [[CCT4]],<ref name = pmid18715871/><ref name = pmid16085932/>
* [[CCT5 (gene)|CCT5]],<ref name = pmid18715871/><ref name = pmid16085932/>
* [[CCT6A]],<ref name = pmid18715871/><ref name = pmid16085932/>
* [[CCT7]],<ref name = pmid18715871/><ref name = pmid16085932/>
* [[IGBP1]],<ref name = pmid18715871/><ref name = pmid16085932/><ref name = pmid9647778>{{cite journal | vauthors = Chen J, Peterson RT, Schreiber SL | title = Alpha 4 associates with protein phosphatases 2A, 4, and 6 | journal = Biochemical and Biophysical Research Communications | volume = 247 | issue = 3 | pages = 827–32 | date = Jun 1998 | pmid = 9647778 | doi = 10.1006/bbrc.1998.8792 }}</ref>
* [[PPP2R1A]],<ref name = pmid18715871/><ref name = pmid17353931/>
* [[PPP4R1]],<ref name = pmid18715871/><ref name = pmid17353931/><ref name = pmid16085932/>
* [[REL]],<ref name = pmid9837938>{{cite journal | vauthors = Hu MC, Tang-Oxley Q, Qiu WR, Wang YP, Mihindukulasuriya KA, Afshar R, Tan TH | title = Protein phosphatase X interacts with c-Rel and stimulates c-Rel/nuclear factor kappaB activity | journal = The Journal of Biological Chemistry | volume = 273 | issue = 50 | pages = 33561–5 | date = Dec 1998 | pmid = 9837938 | doi =  10.1074/jbc.273.50.33561}}</ref>
* [[SMEK2]],<ref name = pmid18715871/><ref name = pmid17353931>{{cite journal | vauthors = Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D | title = Large-scale mapping of human protein-protein interactions by mass spectrometry | journal = Molecular Systems Biology | volume = 3 | issue = | pages = 89 | pmid = 17353931 | pmc = 1847948 | doi = 10.1038/msb4100134 }}</ref><ref name = pmid16085932/>
* [[T-complex 1]],<ref name = pmid18715871/><ref name = pmid16085932/> and
* [[TRAF6]].<ref name = pmid18634786>{{cite journal | vauthors = Chen L, Dong W, Zou T, Ouyang L, He G, Liu Y, Qi Y | title = Protein phosphatase 4 negatively regulates LPS cascade by inhibiting ubiquitination of TRAF6 | journal = FEBS Letters | volume = 582 | issue = 19 | pages = 2843–9 | date = Aug 2008 | pmid = 18634786 | doi = 10.1016/j.febslet.2008.07.014 }}</ref>
{{Div col end}}


==References==
== References ==
{{reflist|2}}
{{Reflist}}
==Further reading==
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Brewis ND, Cohen PT | title = Protein phosphatase X has been highly conserved during mammalian evolution | journal = Biochimica et Biophysica Acta | volume = 1171 | issue = 2 | pages = 231–3 | date = Dec 1992 | pmid = 1336397 | doi = 10.1016/0167-4781(92)90129-n }}
| citations =
* {{cite journal | vauthors = Brewis ND, Street AJ, Prescott AR, Cohen PT | title = PPX, a novel protein serine/threonine phosphatase localized to centrosomes | journal = The EMBO Journal | volume = 12 | issue = 3 | pages = 987–96 | date = Mar 1993 | pmid = 8384557 | pmc = 413299 | doi = }}
*{{cite journal | author=Brewis ND, Cohen PT |title=Protein phosphatase X has been highly conserved during mammalian evolution. |journal=Biochim. Biophys. Acta |volume=1171 |issue= 2 |pages= 231-3 |year= 1993 |pmid= 1336397 |doi= }}
* {{cite journal | vauthors = Kloeker S, Bryant JC, Strack S, Colbran RJ, Wadzinski BE | title = Carboxymethylation of nuclear protein serine/threonine phosphatase X | journal = The Biochemical Journal | volume = 327 ( Pt 2) | issue = Pt 2 | pages = 481–6 | date = Oct 1997 | pmid = 9359419 | pmc = 1218819 | doi =  }}
*{{cite journal | author=Brewis ND, Street AJ, Prescott AR, Cohen PT |title=PPX, a novel protein serine/threonine phosphatase localized to centrosomes. |journal=EMBO J. |volume=12 |issue= 3 |pages= 987-96 |year= 1993 |pmid= 8384557 |doi= }}
* {{cite journal | vauthors = Chen J, Peterson RT, Schreiber SL | title = Alpha 4 associates with protein phosphatases 2A, 4, and 6 | journal = Biochemical and Biophysical Research Communications | volume = 247 | issue = 3 | pages = 827–32 | date = Jun 1998 | pmid = 9647778 | doi = 10.1006/bbrc.1998.8792 }}
*{{cite journal  | author=Bastians H, Krebber H, Hoheisel J, ''et al.'' |title=Assignment of the human serine/threonine protein phosphatase 4 gene (PPP4C) to chromosome 16p11-p12 by fluorescence in situ hybridization. |journal=Genomics |volume=42 |issue= 1 |pages= 181-2 |year= 1997 |pmid= 9177794 |doi= 10.1006/geno.1997.4693 }}
* {{cite journal | vauthors = Hu MC, Tang-Oxley Q, Qiu WR, Wang YP, Mihindukulasuriya KA, Afshar R, Tan TH | title = Protein phosphatase X interacts with c-Rel and stimulates c-Rel/nuclear factor kappaB activity | journal = The Journal of Biological Chemistry | volume = 273 | issue = 50 | pages = 33561–5 | date = Dec 1998 | pmid = 9837938 | doi = 10.1074/jbc.273.50.33561 }}
*{{cite journal | author=Kloeker S, Bryant JC, Strack S, ''et al.'' |title=Carboxymethylation of nuclear protein serine/threonine phosphatase X. |journal=Biochem. J. |volume=327 ( Pt 2) |issue= |pages= 481-6 |year= 1997 |pmid= 9359419 |doi=  }}
* {{cite journal | vauthors = Kloeker S, Wadzinski BE | title = Purification and identification of a novel subunit of protein serine/threonine phosphatase 4 | journal = The Journal of Biological Chemistry | volume = 274 | issue = 9 | pages = 5339–47 | date = Feb 1999 | pmid = 10026142 | doi = 10.1074/jbc.274.9.5339 }}
*{{cite journal | author=Chen J, Peterson RT, Schreiber SL |title=Alpha 4 associates with protein phosphatases 2A, 4, and 6. |journal=Biochem. Biophys. Res. Commun. |volume=247 |issue= 3 |pages= 827-32 |year= 1998 |pmid= 9647778 |doi= 10.1006/bbrc.1998.8792 }}
* {{cite journal | vauthors = Hastie CJ, Carnegie GK, Morrice N, Cohen PT | title = A novel 50 kDa protein forms complexes with protein phosphatase 4 and is located at centrosomal microtubule organizing centres | journal = The Biochemical Journal | volume = 347 Pt 3 | issue = Pt 3 | pages = 845–55 | date = May 2000 | pmid = 10769191 | pmc = 1221024 | doi = 10.1042/0264-6021:3470845 }}
*{{cite journal | author=Hu MC, Tang-Oxley Q, Qiu WR, ''et al.'' |title=Protein phosphatase X interacts with c-Rel and stimulates c-Rel/nuclear factor kappaB activity. |journal=J. Biol. Chem. |volume=273 |issue= 50 |pages= 33561-5 |year= 1999 |pmid= 9837938 |doi= }}
* {{cite journal | vauthors = Carnegie GK, Sleeman JE, Morrice N, Hastie CJ, Peggie MW, Philp A, Lamond AI, Cohen PT | title = Protein phosphatase 4 interacts with the Survival of Motor Neurons complex and enhances the temporal localisation of snRNPs | journal = Journal of Cell Science | volume = 116 | issue = Pt 10 | pages = 1905–13 | date = May 2003 | pmid = 12668731 | doi = 10.1242/jcs.00409 }}
*{{cite journal | author=Kloeker S, Wadzinski BE |title=Purification and identification of a novel subunit of protein serine/threonine phosphatase 4. |journal=J. Biol. Chem. |volume=274 |issue= 9 |pages= 5339-47 |year= 1999 |pmid= 10026142 |doi= }}
* {{cite journal | vauthors = Yeh PY, Yeh KH, Chuang SE, Song YC, Cheng AL | title = Suppression of MEK/ERK signaling pathway enhances cisplatin-induced NF-kappaB activation by protein phosphatase 4-mediated NF-kappaB p65 Thr dephosphorylation | journal = The Journal of Biological Chemistry | volume = 279 | issue = 25 | pages = 26143–8 | date = Jun 2004 | pmid = 15073167 | doi = 10.1074/jbc.M402362200 }}
*{{cite journal | author=Hastie CJ, Carnegie GK, Morrice N, Cohen PT |title=A novel 50 kDa protein forms complexes with protein phosphatase 4 and is located at centrosomal microtubule organizing centres. |journal=Biochem. J. |volume=347 Pt 3 |issue= |pages= 845-55 |year= 2000 |pmid= 10769191 |doi=  }}
* {{cite journal | vauthors = Mihindukulasuriya KA, Zhou G, Qin J, Tan TH | title = Protein phosphatase 4 interacts with and down-regulates insulin receptor substrate 4 following tumor necrosis factor-alpha stimulation | journal = The Journal of Biological Chemistry | volume = 279 | issue = 45 | pages = 46588–94 | date = Nov 2004 | pmid = 15331607 | doi = 10.1074/jbc.M408067200 }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Zhou G, Boomer JS, Tan TH | title = Protein phosphatase 4 is a positive regulator of hematopoietic progenitor kinase 1 | journal = The Journal of Biological Chemistry | volume = 279 | issue = 47 | pages = 49551–61 | date = Nov 2004 | pmid = 15364934 | doi = 10.1074/jbc.M410317200 }}
*{{cite journal | author=Carnegie GK, Sleeman JE, Morrice N, ''et al.'' |title=Protein phosphatase 4 interacts with the Survival of Motor Neurons complex and enhances the temporal localisation of snRNPs. |journal=J. Cell. Sci. |volume=116 |issue= Pt 10 |pages= 1905-13 |year= 2004 |pmid= 12668731 |doi= 10.1242/jcs.00409 }}
* {{cite journal | vauthors = Zhang X, Ozawa Y, Lee H, Wen YD, Tan TH, Wadzinski BE, Seto E | title = Histone deacetylase 3 (HDAC3) activity is regulated by interaction with protein serine/threonine phosphatase 4 | journal = Genes & Development | volume = 19 | issue = 7 | pages = 827–39 | date = Apr 2005 | pmid = 15805470 | pmc = 1074320 | doi = 10.1101/gad.1286005 }}
*{{cite journal | author=Yeh PY, Yeh KH, Chuang SE, ''et al.'' |title=Suppression of MEK/ERK signaling pathway enhances cisplatin-induced NF-kappaB activation by protein phosphatase 4-mediated NF-kappaB p65 Thr dephosphorylation. |journal=J. Biol. Chem. |volume=279 |issue= 25 |pages= 26143-8 |year= 2004 |pmid= 15073167 |doi= 10.1074/jbc.M402362200 }}
* {{cite journal | vauthors = Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M | title = Towards a proteome-scale map of the human protein-protein interaction network | journal = Nature | volume = 437 | issue = 7062 | pages = 1173–8 | date = Oct 2005 | pmid = 16189514 | doi = 10.1038/nature04209 }}
*{{cite journal | author=Mihindukulasuriya KA, Zhou G, Qin J, Tan TH |title=Protein phosphatase 4 interacts with and down-regulates insulin receptor substrate 4 following tumor necrosis factor-alpha stimulation. |journal=J. Biol. Chem. |volume=279 |issue= 45 |pages= 46588-94 |year= 2004 |pmid= 15331607 |doi= 10.1074/jbc.M408067200 }}
*{{cite journal | author=Zhou G, Boomer JS, Tan TH |title=Protein phosphatase 4 is a positive regulator of hematopoietic progenitor kinase 1. |journal=J. Biol. Chem. |volume=279 |issue= 47 |pages= 49551-61 |year= 2005 |pmid= 15364934 |doi= 10.1074/jbc.M410317200 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | author=Zhang X, Ozawa Y, Lee H, ''et al.'' |title=Histone deacetylase 3 (HDAC3) activity is regulated by interaction with protein serine/threonine phosphatase 4. |journal=Genes Dev. |volume=19 |issue= 7 |pages= 827-39 |year= 2005 |pmid= 15805470 |doi= 10.1101/gad.1286005 }}
*{{cite journal | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal  | author=Ewing RM, Chu P, Elisma F, ''et al.'' |title=Large-scale mapping of human protein-protein interactions by mass spectrometry. |journal=Mol. Syst. Biol. |volume=3 |issue=  |pages= 89 |year= 2007 |pmid= 17353931 |doi= 10.1038/msb4100134 }}
}}
{{refend}}
{{refend}}


{{protein-stub}}
 
{{WikiDoc Sources}}
{{Gene-16-stub}}

Latest revision as of 18:36, 7 September 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Serine/threonine-protein phosphatase 4 catalytic subunit is an enzyme that in humans is encoded by the PPP4C gene.[1][2]

Interactions

PPP4C has been shown to interact with:

References

  1. Bastians H, Krebber H, Hoheisel J, Ohl S, Lichter P, Ponstingl H, Joos S (May 1997). "Assignment of the human serine/threonine protein phosphatase 4 gene (PPP4C) to chromosome 16p11-p12 by fluorescence in situ hybridization". Genomics. 42 (1): 181–2. doi:10.1006/geno.1997.4693. PMID 9177794.
  2. "Entrez Gene: PPP4C protein phosphatase 4 (formerly X), catalytic subunit".
  3. 3.00 3.01 3.02 3.03 3.04 3.05 3.06 3.07 3.08 3.09 3.10 3.11 Chen GI, Tisayakorn S, Jorgensen C, D'Ambrosio LM, Goudreault M, Gingras AC (Oct 2008). "PP4R4/KIAA1622 forms a novel stable cytosolic complex with phosphoprotein phosphatase 4". The Journal of Biological Chemistry. 283 (43): 29273–84. doi:10.1074/jbc.M803443200. PMC 2662017. PMID 18715871.
  4. 4.0 4.1 4.2 4.3 Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D. "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology. 3: 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
  5. 5.0 5.1 5.2 5.3 5.4 5.5 5.6 5.7 5.8 5.9 Gingras AC, Caballero M, Zarske M, Sanchez A, Hazbun TR, Fields S, Sonenberg N, Hafen E, Raught B, Aebersold R (Nov 2005). "A novel, evolutionarily conserved protein phosphatase complex involved in cisplatin sensitivity". Molecular & Cellular Proteomics. 4 (11): 1725–40. doi:10.1074/mcp.M500231-MCP200. PMID 16085932.
  6. Chen J, Peterson RT, Schreiber SL (Jun 1998). "Alpha 4 associates with protein phosphatases 2A, 4, and 6". Biochemical and Biophysical Research Communications. 247 (3): 827–32. doi:10.1006/bbrc.1998.8792. PMID 9647778.
  7. Hu MC, Tang-Oxley Q, Qiu WR, Wang YP, Mihindukulasuriya KA, Afshar R, Tan TH (Dec 1998). "Protein phosphatase X interacts with c-Rel and stimulates c-Rel/nuclear factor kappaB activity". The Journal of Biological Chemistry. 273 (50): 33561–5. doi:10.1074/jbc.273.50.33561. PMID 9837938.
  8. Chen L, Dong W, Zou T, Ouyang L, He G, Liu Y, Qi Y (Aug 2008). "Protein phosphatase 4 negatively regulates LPS cascade by inhibiting ubiquitination of TRAF6". FEBS Letters. 582 (19): 2843–9. doi:10.1016/j.febslet.2008.07.014. PMID 18634786.

Further reading