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{{ | '''U2 small nuclear ribonucleoprotein A'''' is a [[protein]] that in humans is encoded by the ''SNRPA1'' [[gene]].<ref name="pmid2928112">{{cite journal |author1=Sillekens PT |author2=Beijer RP |author3=Habets WJ |author4=van Verooij WJ | title = Molecular cloning of the cDNA for the human U2 snRNA-specific A' protein | journal = Nucleic Acids Res | volume = 17 | issue = 5 | pages = 1893–906 |date=May 1989 | pmid = 2928112 | pmc = 317531 | doi =10.1093/nar/17.5.1893 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: SNRPA1 small nuclear ribonucleoprotein polypeptide A'| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6627| accessdate = }}</ref> | ||
}} | |||
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==Interactions== | |||
SNRPA1 has been shown to [[Protein-protein interaction|interact]] with [[CDC5L]].<ref name=pmid11101529>{{cite journal |last=Ajuh |first=P |authorlink= |author2=Kuster B |author3=Panov K |author4=Zomerdijk J C |author5=Mann M |author6=Lamond A I |date=December 2000 |title=Functional analysis of the human CDC5L complex and identification of its components by mass spectrometry |journal=EMBO J. |volume=19 |issue=23 |pages=6569–81 |publisher= |location = ENGLAND| issn = 0261-4189| pmid = 11101529 |doi = 10.1093/emboj/19.23.6569 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |pmc=305846 }}</ref> | |||
==References== | ==References== | ||
{{reflist | {{reflist}} | ||
==Further reading== | ==Further reading== | ||
{{refbegin | 2}} | {{refbegin | 2}} | ||
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| citations = | | citations = | ||
*{{cite journal | | *{{cite journal |author1=Ohno M |author2=Kataoka N |author3=Shimura Y |title=A nuclear cap binding protein from HeLa cells. |journal=Nucleic Acids Res. |volume=18 |issue= 23 |pages= 6989–95 |year= 1991 |pmid= 2148205 |doi=10.1093/nar/18.23.6989 | pmc=332760 }} | ||
*{{cite journal |author1=Maruyama K |author2=Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1–2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=10.1016/0378-1119(94)90802-8 }} | |||
*{{cite journal | | *{{cite journal |author1=Kjems J |author2=Sharp PA |title=The basic domain of Rev from human immunodeficiency virus type 1 specifically blocks the entry of U4/U6.U5 small nuclear ribonucleoprotein in spliceosome assembly |journal=J. Virol. |volume=67 |issue= 8 |pages= 4769–76 |year= 1993 |pmid= 8331728 |doi= | pmc=237863 }} | ||
*{{cite journal | | *{{cite journal |vauthors=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, etal |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library |journal=Gene |volume=200 |issue= 1–2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=10.1016/S0378-1119(97)00411-3 }} | ||
*{{cite journal | *{{cite journal |author1=Blencowe BJ |author2=Issner R |author3=Nickerson JA |author4=Sharp PA |title=A coactivator of pre-mRNA splicing |journal=Genes Dev. |volume=12 |issue= 7 |pages= 996–1009 |year= 1998 |pmid= 9531537 |doi=10.1101/gad.12.7.996 | pmc=316672 }} | ||
*{{cite journal | | *{{cite journal |author1=Price SR |author2=Evans PR |author3=Nagai K |title=Crystal structure of the spliceosomal U2B"-U2A' protein complex bound to a fragment of U2 small nuclear RNA |journal=Nature |volume=394 |issue= 6694 |pages= 645–50 |year= 1998 |pmid= 9716128 |doi= 10.1038/29234 }} | ||
*{{cite journal | | *{{cite journal |vauthors=Neubauer G, King A, Rappsilber J, etal |title=Mass spectrometry and EST-database searching allows characterization of the multi-protein spliceosome complex |journal=Nat. Genet. |volume=20 |issue= 1 |pages= 46–50 |year= 1998 |pmid= 9731529 |doi= 10.1038/1700 }} | ||
*{{cite journal | *{{cite journal |author1=Eldridge AG |author2=Li Y |author3=Sharp PA |author4=Blencowe BJ |title=The SRm160/300 splicing coactivator is required for exon-enhancer function |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=96 |issue= 11 |pages= 6125–30 |year= 1999 |pmid= 10339552 |doi=10.1073/pnas.96.11.6125 | pmc=26846 }} | ||
*{{cite journal | | *{{cite journal |author1=Lundin M |author2=Mikkelsen B |author3=Gudim M |author4=Syed M |title=Gene Structure of the U2 snRNP-Specific A' Protein Gene from Salmo salar: Alternative Transcripts Observed |journal= Marine biotechnology|volume=2 |issue= 2 |pages= 204–211 |year= 2000|pmid= 10811961 |doi=10.1007/s101269900015 }} | ||
*{{cite journal | | *{{cite journal |author1=Fong YW |author2=Zhou Q |title=Stimulatory effect of splicing factors on transcriptional elongation |journal=Nature |volume=414 |issue= 6866 |pages= 929–33 |year= 2002 |pmid= 11780068 |doi= 10.1038/414929a }} | ||
*{{cite journal | | *{{cite journal |vauthors=Andersen JS, Lyon CE, Fox AH, etal |title=Directed proteomic analysis of the human nucleolus |journal=Curr. Biol. |volume=12 |issue= 1 |pages= 1–11 |year= 2002 |pmid= 11790298 |doi=10.1016/S0960-9822(01)00650-9 }} | ||
*{{cite journal | *{{cite journal |vauthors=Jurica MS, Licklider LJ, Gygi SR, etal |title=Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis |journal=RNA |volume=8 |issue= 4 |pages= 426–39 |year= 2002 |pmid= 11991638 |doi=10.1017/S1355838202021088 | pmc=1370266 }} | ||
*{{cite journal | *{{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }} | ||
*{{cite journal | *{{cite journal |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }} | ||
*{{cite journal | *{{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }} | ||
*{{cite journal | *{{cite journal |vauthors=Andersen JS, Lam YW, Leung AK, etal |title=Nucleolar proteome dynamics |journal=Nature |volume=433 |issue= 7021 |pages= 77–83 |year= 2005 |pmid= 15635413 |doi= 10.1038/nature03207 }} | ||
*{{cite journal | *{{cite journal |vauthors=Beausoleil SA, Villén J, Gerber SA, etal |title=A probability-based approach for high-throughput protein phosphorylation analysis and site localization |journal=Nat. Biotechnol. |volume=24 |issue= 10 |pages= 1285–92 |year= 2006 |pmid= 16964243 |doi= 10.1038/nbt1240 }} | ||
*{{cite journal | *{{cite journal |vauthors=Ewing RM, Chu P, Elisma F, etal |title=Large-scale mapping of human protein-protein interactions by mass spectrometry |journal=Mol. Syst. Biol. |volume=3 |issue= 1|pages= 89 |year= 2007 |pmid= 17353931 |doi= 10.1038/msb4100134 | pmc=1847948 }} | ||
*{{cite journal | |||
}} | }} | ||
{{refend}} | {{refend}} | ||
{{PDB Gallery|geneid=6627}} | |||
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{{Ribonucleoproteins}} | |||
{{ | {{gene-15-stub}} | ||
Revision as of 06:46, 11 September 2017
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| Location (UCSC) | n/a | n/a | |||||
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U2 small nuclear ribonucleoprotein A' is a protein that in humans is encoded by the SNRPA1 gene.[1][2]
Interactions
SNRPA1 has been shown to interact with CDC5L.[3]
References
- ↑ Sillekens PT; Beijer RP; Habets WJ; van Verooij WJ (May 1989). "Molecular cloning of the cDNA for the human U2 snRNA-specific A' protein". Nucleic Acids Res. 17 (5): 1893–906. doi:10.1093/nar/17.5.1893. PMC 317531. PMID 2928112.
- ↑ "Entrez Gene: SNRPA1 small nuclear ribonucleoprotein polypeptide A'".
- ↑ Ajuh, P; Kuster B; Panov K; Zomerdijk J C; Mann M; Lamond A I (December 2000). "Functional analysis of the human CDC5L complex and identification of its components by mass spectrometry". EMBO J. ENGLAND. 19 (23): 6569–81. doi:10.1093/emboj/19.23.6569. ISSN 0261-4189. PMC 305846. PMID 11101529.
Further reading
- Ohno M; Kataoka N; Shimura Y (1991). "A nuclear cap binding protein from HeLa cells". Nucleic Acids Res. 18 (23): 6989–95. doi:10.1093/nar/18.23.6989. PMC 332760. PMID 2148205.
- Maruyama K; Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
- Kjems J; Sharp PA (1993). "The basic domain of Rev from human immunodeficiency virus type 1 specifically blocks the entry of U4/U6.U5 small nuclear ribonucleoprotein in spliceosome assembly". J. Virol. 67 (8): 4769–76. PMC 237863. PMID 8331728.
- Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
- Blencowe BJ; Issner R; Nickerson JA; Sharp PA (1998). "A coactivator of pre-mRNA splicing". Genes Dev. 12 (7): 996–1009. doi:10.1101/gad.12.7.996. PMC 316672. PMID 9531537.
- Price SR; Evans PR; Nagai K (1998). "Crystal structure of the spliceosomal U2B"-U2A' protein complex bound to a fragment of U2 small nuclear RNA". Nature. 394 (6694): 645–50. doi:10.1038/29234. PMID 9716128.
- Neubauer G, King A, Rappsilber J, et al. (1998). "Mass spectrometry and EST-database searching allows characterization of the multi-protein spliceosome complex". Nat. Genet. 20 (1): 46–50. doi:10.1038/1700. PMID 9731529.
- Eldridge AG; Li Y; Sharp PA; Blencowe BJ (1999). "The SRm160/300 splicing coactivator is required for exon-enhancer function". Proc. Natl. Acad. Sci. U.S.A. 96 (11): 6125–30. doi:10.1073/pnas.96.11.6125. PMC 26846. PMID 10339552.
- Lundin M; Mikkelsen B; Gudim M; Syed M (2000). "Gene Structure of the U2 snRNP-Specific A' Protein Gene from Salmo salar: Alternative Transcripts Observed". Marine biotechnology. 2 (2): 204–211. doi:10.1007/s101269900015. PMID 10811961.
- Fong YW; Zhou Q (2002). "Stimulatory effect of splicing factors on transcriptional elongation". Nature. 414 (6866): 929–33. doi:10.1038/414929a. PMID 11780068.
- Andersen JS, Lyon CE, Fox AH, et al. (2002). "Directed proteomic analysis of the human nucleolus". Curr. Biol. 12 (1): 1–11. doi:10.1016/S0960-9822(01)00650-9. PMID 11790298.
- Jurica MS, Licklider LJ, Gygi SR, et al. (2002). "Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis". RNA. 8 (4): 426–39. doi:10.1017/S1355838202021088. PMC 1370266. PMID 11991638.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Andersen JS, Lam YW, Leung AK, et al. (2005). "Nucleolar proteome dynamics". Nature. 433 (7021): 77–83. doi:10.1038/nature03207. PMID 15635413.
- Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243.
- Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
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