WASF3: Difference between revisions

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'''Wiskott-Aldrich syndrome protein family member 3''' is a [[protein]] that in humans is encoded by the ''WASF3'' [[gene]].<ref name="pmid10381382">{{cite journal | vauthors = Suetsugu S, Miki H, Takenawa T | title = Identification of two human WAVE/SCAR homologues as general actin regulatory molecules which associate with the Arp2/3 complex | journal = Biochem Biophys Res Commun | volume = 260 | issue = 1 | pages = 296–302 |date=Jul 1999 | pmid = 10381382 | pmc =  | doi = 10.1006/bbrc.1999.0894 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: WASF3 WAS protein family, member 3| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10810| accessdate = }}</ref>
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| image = 
| image_source = 
| PDB =
| Name = WAS protein family, member 3
| HGNCid = 12734
| Symbol = WASF3
| AltSymbols =; KIAA0900; SCAR3; WAVE3
| OMIM = 605068
| ECnumber = 
| Homologene = 68527
| MGIid = 2658986
| GeneAtlas_image1 = PBB_GE_WASF3_204042_at_tn.png
| Function = {{GNF_GO|id=GO:0003779 |text = actin binding}}
| Component = {{GNF_GO|id=GO:0015629 |text = actin cytoskeleton}}
| Process = {{GNF_GO|id=GO:0006461 |text = protein complex assembly}} {{GNF_GO|id=GO:0030041 |text = actin filament polymerization}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 10810
    | Hs_Ensembl = ENSG00000132970
    | Hs_RefseqProtein = NP_006637
    | Hs_RefseqmRNA = NM_006646
    | Hs_GenLoc_db =   
    | Hs_GenLoc_chr = 13
    | Hs_GenLoc_start = 26029840
    | Hs_GenLoc_end = 26161085
    | Hs_Uniprot = Q9UPY6
    | Mm_EntrezGene = 245880
    | Mm_Ensembl = ENSMUSG00000029636
    | Mm_RefseqmRNA = NM_145155
    | Mm_RefseqProtein = NP_660137
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 5
    | Mm_GenLoc_start = 146689240
    | Mm_GenLoc_end = 146774650
    | Mm_Uniprot = Q3V386
  }}
}}
'''WAS protein family, member 3''', also known as '''WASF3''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: WASF3 WAS protein family, member 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10810| accessdate = }}</ref>


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{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = This gene encodes a member of the Wiskott-Aldrich syndrome protein family. The gene product is a protein that forms a multiprotein complex that links receptor kinases and actin. Binding to actin occurs through a C-terminal verprolin homology domain in all family members. The multiprotein complex serves to tranduce signals that involve changes in cell shape, motility or function.<ref name="entrez">{{cite web | title = Entrez Gene: WASF3 WAS protein family, member 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10810| accessdate = }}</ref>
| summary_text = This gene encodes a member of the Wiskott-Aldrich syndrome protein family. The gene product is a protein that forms a multiprotein complex that links receptor kinases and actin. Binding to actin occurs through a C-terminal verprolin homology domain in all family members. The multiprotein complex serves to tranduce signals that involve changes in cell shape, motility or function.<ref name="entrez" />
}}
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Jones GE |title=Cellular signaling in macrophage migration and chemotaxis. |journal=J. Leukoc. Biol. |volume=68 |issue= 5 |pages= 593-602 |year= 2000 |pmid= 11073096 |doi=  }}
*{{cite journal  | author=Jones GE |title=Cellular signaling in macrophage migration and chemotaxis |journal=J. Leukoc. Biol. |volume=68 |issue= 5 |pages= 593–602 |year= 2000 |pmid= 11073096 |doi=  }}
*{{cite journal | author=Nakajima D, Okazaki N, Yamakawa H, ''et al.'' |title=Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. |journal=DNA Res. |volume=9 |issue= 3 |pages= 99-106 |year= 2003 |pmid= 12168954 |doi=  }}
*{{cite journal   |vauthors=Nakajima D, Okazaki N, Yamakawa H, etal |title=Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones |journal=DNA Res. |volume=9 |issue= 3 |pages= 99–106 |year= 2003 |pmid= 12168954 |doi=10.1093/dnares/9.3.99 }}
*{{cite journal | author=Schott DR, Chang JN, Deng G, ''et al.'' |title=A candidate tumor suppressor gene in human breast cancers. |journal=Cancer Res. |volume=54 |issue= 6 |pages= 1393-6 |year= 1994 |pmid= 8137235 |doi=  }}
*{{cite journal   |vauthors=Schott DR, Chang JN, Deng G, etal |title=A candidate tumor suppressor gene in human breast cancers |journal=Cancer Res. |volume=54 |issue= 6 |pages= 1393–6 |year= 1994 |pmid= 8137235 |doi=  }}
*{{cite journal  | author=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791-806 |year= 1997 |pmid= 8889548 |doi=  }}
*{{cite journal  | vauthors=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery |journal=Genome Res. |volume=6 |issue= 9 |pages= 791–806 |year= 1997 |pmid= 8889548 |doi=10.1101/gr.6.9.791 }}
*{{cite journal  | author=Bear JE, Rawls JF, Saxe CL |title=SCAR, a WASP-related protein, isolated as a suppressor of receptor defects in late Dictyostelium development. |journal=J. Cell Biol. |volume=142 |issue= 5 |pages= 1325-35 |year= 1998 |pmid= 9732292 |doi=  }}
*{{cite journal  | vauthors=Bear JE, Rawls JF, Saxe CL |title=SCAR, a WASP-related protein, isolated as a suppressor of receptor defects in late Dictyostelium development |journal=J. Cell Biol. |volume=142 |issue= 5 |pages= 1325–35 |year= 1998 |pmid= 9732292 |doi=10.1083/jcb.142.5.1325  | pmc=2149354 }}
*{{cite journal | author=Nagase T, Ishikawa K, Suyama M, ''et al.'' |title=Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. |journal=DNA Res. |volume=5 |issue= 6 |pages= 355-64 |year= 1999 |pmid= 10048485 |doi=  }}
*{{cite journal   |vauthors=Nagase T, Ishikawa K, Suyama M, etal |title=Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro |journal=DNA Res. |volume=5 |issue= 6 |pages= 355–64 |year= 1999 |pmid= 10048485 |doi=10.1093/dnares/5.6.355  }}
*{{cite journal  | author=Suetsugu S, Miki H, Takenawa T |title=Identification of two human WAVE/SCAR homologues as general actin regulatory molecules which associate with the Arp2/3 complex. |journal=Biochem. Biophys. Res. Commun. |volume=260 |issue= 1 |pages= 296-302 |year= 1999 |pmid= 10381382 |doi= 10.1006/bbrc.1999.0894 }}
*{{cite journal  | vauthors=Marchand JB, Kaiser DA, Pollard TD, Higgs HN |title=Interaction of WASP/Scar proteins with actin and vertebrate Arp2/3 complex |journal=Nat. Cell Biol. |volume=3 |issue= 1 |pages= 76–82 |year= 2001 |pmid= 11146629 |doi= 10.1038/35050590 }}
*{{cite journal  | author=Marchand JB, Kaiser DA, Pollard TD, Higgs HN |title=Interaction of WASP/Scar proteins with actin and vertebrate Arp2/3 complex. |journal=Nat. Cell Biol. |volume=3 |issue= 1 |pages= 76-82 |year= 2001 |pmid= 11146629 |doi= 10.1038/35050590 }}
*{{cite journal  | vauthors=Millard TH, Machesky LM |title=The Wiskott-Aldrich syndrome protein (WASP) family |journal=Trends Biochem. Sci. |volume=26 |issue= 3 |pages= 198–9 |year= 2001 |pmid= 11246027 |doi=10.1016/S0968-0004(01)01788-1 }}
*{{cite journal  | author=Millard TH, Machesky LM |title=The Wiskott-Aldrich syndrome protein (WASP) family. |journal=Trends Biochem. Sci. |volume=26 |issue= 3 |pages= 198-9 |year= 2001 |pmid= 11246027 |doi=  }}
*{{cite journal   |vauthors=Sossey-Alaoui K, Su G, Malaj E, etal |title=WAVE3, an actin-polymerization gene, is truncated and inactivated as a result of a constitutional t(1;13)(q21;q12) chromosome translocation in a patient with ganglioneuroblastoma |journal=Oncogene |volume=21 |issue= 38 |pages= 5967–74 |year= 2002 |pmid= 12185600 |doi= 10.1038/sj.onc.1205734 }}
*{{cite journal | author=Sossey-Alaoui K, Su G, Malaj E, ''et al.'' |title=WAVE3, an actin-polymerization gene, is truncated and inactivated as a result of a constitutional t(1;13)(q21;q12) chromosome translocation in a patient with ganglioneuroblastoma. |journal=Oncogene |volume=21 |issue= 38 |pages= 5967-74 |year= 2002 |pmid= 12185600 |doi= 10.1038/sj.onc.1205734 }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | vauthors=Sossey-Alaoui K, Head K, Nowak N, Cowell JK |title=Genomic organization and expression profile of the human and mouse WAVE gene family |journal=Mamm. Genome |volume=14 |issue= 5 |pages= 314–22 |year= 2003 |pmid= 12856283 |doi= 10.1007/s00335-002-2247-7 }}
*{{cite journal  | author=Sossey-Alaoui K, Head K, Nowak N, Cowell JK |title=Genomic organization and expression profile of the human and mouse WAVE gene family. |journal=Mamm. Genome |volume=14 |issue= 5 |pages= 314-22 |year= 2003 |pmid= 12856283 |doi= 10.1007/s00335-002-2247-7 }}
*{{cite journal   |vauthors=Dunham A, Matthews LH, Burton J, etal |title=The DNA sequence and analysis of human chromosome 13 |journal=Nature |volume=428 |issue= 6982 |pages= 522–8 |year= 2004 |pmid= 15057823 |doi= 10.1038/nature02379 | pmc=2665288 }}
*{{cite journal | author=Dunham A, Matthews LH, Burton J, ''et al.'' |title=The DNA sequence and analysis of human chromosome 13. |journal=Nature |volume=428 |issue= 6982 |pages= 522-8 |year= 2004 |pmid= 15057823 |doi= 10.1038/nature02379 }}
*{{cite journal   |vauthors=Oda A, Miki H, Wada I, etal |title=WAVE/Scars in platelets |journal=Blood |volume=105 |issue= 8 |pages= 3141–8 |year= 2005 |pmid= 15280206 |doi= 10.1182/blood-2003-04-1319 }}
*{{cite journal | author=Oda A, Miki H, Wada I, ''et al.'' |title=WAVE/Scars in platelets. |journal=Blood |volume=105 |issue= 8 |pages= 3141-8 |year= 2005 |pmid= 15280206 |doi= 10.1182/blood-2003-04-1319 }}
*{{cite journal   |vauthors=Kashiwagi H, Shiraga M, Kato H, etal |title=Expression and subcellular localization of WAVE isoforms in the megakaryocyte/platelet lineage |journal=J. Thromb. Haemost. |volume=3 |issue= 2 |pages= 361–8 |year= 2005 |pmid= 15670045 |doi= 10.1111/j.1538-7836.2004.01082.x }}
*{{cite journal | author=Kashiwagi H, Shiraga M, Kato H, ''et al.'' |title=Expression and subcellular localization of WAVE isoforms in the megakaryocyte/platelet lineage. |journal=J. Thromb. Haemost. |volume=3 |issue= 2 |pages= 361-8 |year= 2005 |pmid= 15670045 |doi= 10.1111/j.1538-7836.2004.01082.x }}
*{{cite journal  | vauthors=Stovold CF, Millard TH, Machesky LM |title=Inclusion of Scar/WAVE3 in a similar complex to Scar/WAVE1 and 2 |journal=BMC Cell Biol. |volume=6 |pages= 11 |year= 2006 |pmid= 15752430 |doi= 10.1186/1471-2121-6-11 | pmc=555569 }}
*{{cite journal  | author=Stovold CF, Millard TH, Machesky LM |title=Inclusion of Scar/WAVE3 in a similar complex to Scar/WAVE1 and 2. |journal=BMC Cell Biol. |volume=6 |issue= 1 |pages= 11 |year= 2006 |pmid= 15752430 |doi= 10.1186/1471-2121-6-11 }}
*{{cite journal  | vauthors=Sossey-Alaoui K, Li X, Ranalli TA, Cowell JK |title=WAVE3-mediated cell migration and lamellipodia formation are regulated downstream of phosphatidylinositol 3-kinase |journal=J. Biol. Chem. |volume=280 |issue= 23 |pages= 21748–55 |year= 2005 |pmid= 15826941 |doi= 10.1074/jbc.M500503200 }}
*{{cite journal  | author=Sossey-Alaoui K, Li X, Ranalli TA, Cowell JK |title=WAVE3-mediated cell migration and lamellipodia formation are regulated downstream of phosphatidylinositol 3-kinase. |journal=J. Biol. Chem. |volume=280 |issue= 23 |pages= 21748-55 |year= 2005 |pmid= 15826941 |doi= 10.1074/jbc.M500503200 }}
*{{cite journal   |vauthors=Sossey-Alaoui K, Ranalli TA, Li X, etal |title=WAVE3 promotes cell motility and invasion through the regulation of MMP-1, MMP-3, and MMP-9 expression |journal=Exp. Cell Res. |volume=308 |issue= 1 |pages= 135–45 |year= 2005 |pmid= 15907837 |doi= 10.1016/j.yexcr.2005.04.011 }}
*{{cite journal | author=Sossey-Alaoui K, Ranalli TA, Li X, ''et al.'' |title=WAVE3 promotes cell motility and invasion through the regulation of MMP-1, MMP-3, and MMP-9 expression. |journal=Exp. Cell Res. |volume=308 |issue= 1 |pages= 135-45 |year= 2005 |pmid= 15907837 |doi= 10.1016/j.yexcr.2005.04.011 }}
}}
}}
{{refend}}
{{refend}}


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Revision as of 22:27, 17 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Wiskott-Aldrich syndrome protein family member 3 is a protein that in humans is encoded by the WASF3 gene.[1][2]

This gene encodes a member of the Wiskott-Aldrich syndrome protein family. The gene product is a protein that forms a multiprotein complex that links receptor kinases and actin. Binding to actin occurs through a C-terminal verprolin homology domain in all family members. The multiprotein complex serves to tranduce signals that involve changes in cell shape, motility or function.[2]

References

  1. ↑ Suetsugu S, Miki H, Takenawa T (Jul 1999). "Identification of two human WAVE/SCAR homologues as general actin regulatory molecules which associate with the Arp2/3 complex". Biochem Biophys Res Commun. 260 (1): 296–302. doi:10.1006/bbrc.1999.0894. PMID 10381382.
  2. ↑ 2.0 2.1 "Entrez Gene: WASF3 WAS protein family, member 3".

Further reading



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