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{{Infobox_gene}}
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'''Centromere/kinetochore protein zw10 homolog''' is a [[protein]] that in humans is encoded by the ''ZW10'' [[gene]].<ref name="pmid9298984">{{cite journal | vauthors = Starr DA, Williams BC, Li Z, Etemad-Moghadam B, Dawe RK, Goldberg ML | title = Conservation of the centromere/kinetochore protein ZW10 | journal = J Cell Biol | volume = 138 | issue = 6 | pages = 1289–301 |date=Oct 1997 | pmid = 9298984 | pmc = 2132553 | doi =10.1083/jcb.138.6.1289  }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: ZW10 ZW10, kinetochore associated, homolog (Drosophila)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9183| accessdate = }}</ref> This gene encodes a protein that is one of many involved in mechanisms to ensure proper [[chromosome segregation]] during [[cell division]]. The encoded protein binds to [[centromere]]s during the [[prophase]], [[metaphase]], and early [[anaphase]] cell division stages and to [[kinetochore]] [[microtubule]]s during metaphase.<ref name="entrez"/>
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| require_manual_inspection = no
==Function==
| update_protein_box = yes
{{stack|
| update_summary = yes
{{Infobox protein family
| update_citations = yes
| Symbol      = Zw10
| Name        = Zw10
| image      =
| width      =
| caption    =
| Pfam        = PF06248
| Pfam_clan  = CL0295
| InterPro    = IPR009361
| SMART      =
| PROSITE    =
| MEROPS      =
| SCOP        =
| TCDB        =
| OPM family  =
| OPM protein =
| CAZy        =
| CDD        =
}}
}}
}}
Zeste white 10 (ZW10) was initially identified as a mitotic [[Cell cycle checkpoint|checkpoint]] [[protein]] involved in [[chromosome]] segregation, and then implicated in targeting [[cytoplasm]]ic [[dynein]] and dynactin to mitotic kinetochores, but it is also important in non-dividing [[Cell (biology)|cell]]s. These include [[cytoplasmic]] dynein targeting to Golgi and other membranes, and SNARE-mediated ER-Golgi trafficking.<ref name="pmid17102640">{{cite journal | vauthors = Vallee RB, Varma D, Dujardin DL | title = ZW10 function in mitotic checkpoint control, dynein targeting and membrane trafficking: is dynein the unifying theme? | journal = Cell Cycle | volume = 5 | issue = 21 | pages = 2447–51 |date=November 2006 | pmid = 17102640 | pmc = 2794429 | doi = 10.4161/cc.5.21.3395| url = }}</ref><ref name="pmid16505164">{{cite journal | vauthors = Varma D, Dujardin DL, Stehman SA, Vallee RB | title = Role of the kinetochore/cell cycle checkpoint protein ZW10 in interphase cytoplasmic dynein function | journal = J. Cell Biol. | volume = 172 | issue = 5 | pages = 655–62 |date=February 2006 | pmid = 16505164 | pmc = 2063698 | doi = 10.1083/jcb.200510120 | url = }}</ref> Dominant-negative ZW10, anti-ZW10 antibody, and ZW10 RNA interference (RNAi) cause Golgi dispersal. ZW10 RNAi also disperse [[endosome]]s and [[lysosome]]s.<ref name="pmid16505164"/>


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
[[Drosophila]] kinetochore components Rough deal (Rod) and Zw10 are required for the proper functioning of the metaphase checkpoint in flies.<ref name="pmid11146659">{{cite journal | vauthors = Basto R, Gomes R, Karess RE | title = Rough deal and Zw10 are required for the metaphase checkpoint in Drosophila | journal = Nat. Cell Biol. | volume = 2 | issue = 12 | pages = 939–43 |date=December 2000 | pmid = 11146659 | doi = 10.1038/35046592 | url = }}</ref> The [[eukaryotic]] [[mitotic spindle|spindle]] assembly checkpoint (SAC) monitors [[microtubule]] [[Virus|attachment]] to kinetochores and prevents anaphase onset until all kinetochores are aligned on the metaphase plate. It is an essential surveillance [[Nuclear receptor#Mechanism of action|mechanism]] that ensures high fidelity [[chromosome segregation]] during [[mitosis]]. In higher eukaryotes, cytoplasmic dynein is involved in silencing the SAC by removing the checkpoint [[protein]]s Mad2 and the Rod-Zw10-Zwilch [[Protein complex|complex]] (RZZ) from aligned kinetochores.<ref name="pmid17576797">{{cite journal | vauthors = Griffis ER, Stuurman N, Vale RD | title = Spindly, a novel protein essential for silencing the spindle assembly checkpoint, recruits dynein to the kinetochore | journal = J. Cell Biol. | volume = 177 | issue = 6 | pages = 1005–15 |date=June 2007 | pmid = 17576797 | pmc = 2064361 | doi = 10.1083/jcb.200702062 | url = }}</ref><ref name="pmid18268100">{{cite journal | vauthors = Famulski JK, Vos L, Sun X, Chan G | title = Stable hZW10 kinetochore residency, mediated by hZwint-1 interaction, is essential for the mitotic checkpoint | journal = J. Cell Biol. | volume = 180 | issue = 3 | pages = 507–20 |date=February 2008 | pmid = 18268100 | pmc = 2234252 | doi = 10.1083/jcb.200708021 | url = }}</ref><ref name="pmid17509882">{{cite journal | vauthors = Yang Z, Tulu US, Wadsworth P, Rieder CL | title = Kinetochore dynein is required for chromosome motion and congression independent of the spindle checkpoint | journal = Curr. Biol. | volume = 17 | issue = 11 | pages = 973–80 |date=June 2007 | pmid = 17509882 | pmc = 2570756 | doi = 10.1016/j.cub.2007.04.056 | url = }}</ref>
{{GNF_Protein_box
| image =
| image_source = 
| PDB =
| Name = ZW10, kinetochore associated, homolog (Drosophila)
| HGNCid = 13194
| Symbol = ZW10
| AltSymbols =; HZW10; KNTC1AP; MGC149821
| OMIM = 603954
| ECnumber =
| Homologene = 37959
| MGIid = 1349478
| GeneAtlas_image1 = PBB_GE_ZW10_204812_at_tn.png
| Function = {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0019237 |text = centromeric DNA binding}}
| Component = {{GNF_GO|id=GO:0000776 |text = kinetochore}} {{GNF_GO|id=GO:0000922 |text = spindle pole}} {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005783 |text = endoplasmic reticulum}} {{GNF_GO|id=GO:0005828 |text = kinetochore microtubule}}
| Process = {{GNF_GO|id=GO:0000070 |text = mitotic sister chromatid segregation}} {{GNF_GO|id=GO:0006461 |text = protein complex assembly}} {{GNF_GO|id=GO:0006888 |text = ER to Golgi vesicle-mediated transport}} {{GNF_GO|id=GO:0007049 |text = cell cycle}} {{GNF_GO|id=GO:0007093 |text = mitotic cell cycle checkpoint}} {{GNF_GO|id=GO:0007096 |text = regulation of exit from mitosis}} {{GNF_GO|id=GO:0007126 |text = meiosis}} {{GNF_GO|id=GO:0015031 |text = protein transport}} {{GNF_GO|id=GO:0051301 |text = cell division}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 9183
    | Hs_Ensembl = ENSG00000086827
    | Hs_RefseqProtein = NP_004715
    | Hs_RefseqmRNA = NM_004724
    | Hs_GenLoc_db =
    | Hs_GenLoc_chr = 11
    | Hs_GenLoc_start = 113109123
    | Hs_GenLoc_end = 113149635
    | Hs_Uniprot = O43264
    | Mm_EntrezGene = 26951
    | Mm_Ensembl = ENSMUSG00000032264
    | Mm_RefseqmRNA = NM_012039
    | Mm_RefseqProtein = NP_036169
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 9
    | Mm_GenLoc_start = 48807564
    | Mm_GenLoc_end = 48830707
    | Mm_Uniprot = O54692
  }}
}}
'''ZW10, kinetochore associated, homolog (Drosophila)''', also known as '''ZW10''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: ZW10 ZW10, kinetochore associated, homolog (Drosophila)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9183| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
==Interactions==
{{PBB_Summary
ZW10 has been shown to [[Protein-protein interaction|interact]] with [[RINT1]]<ref name="pmid15029241">{{cite journal | vauthors = Hirose H, Arasaki K, Dohmae N, Takio K, Hatsuzawa K, Nagahama M, Tani K, Yamamoto A, Tohyama M, Tagaya M | title = Implication of ZW10 in membrane trafficking between the endoplasmic reticulum and Golgi | journal = EMBO J. | volume = 23 | issue = 6 | pages = 1267–78 |date=March 2004 | pmid = 15029241 | pmc = 381410 | doi = 10.1038/sj.emboj.7600135 }}</ref>
| section_title =  
{{Clear}}
| summary_text = This gene encodes a protein that is one of many involved in mechanisms to ensure proper chromosome segregation during cell division. The encoded protein binds to centromeres during the prophase, metaphase, and early anaphase cell division stages and to kinetochore microtubules during metaphase.<ref name="entrez">{{cite web | title = Entrez Gene: ZW10 ZW10, kinetochore associated, homolog (Drosophila)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9183| accessdate = }}</ref>
}}


==References==
==References==
{{reflist|2}}
{{reflist|35em}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 35em}}
{{PBB_Further_reading
*{{cite journal  | vauthors=Starr DA, Williams BC, Hays TS, Goldberg ML |title=ZW10 helps recruit dynactin and dynein to the kinetochore. |journal=J. Cell Biol. |volume=142 |issue= 3 |pages= 763–74 |year= 1998 |pmid= 9700164 |doi=10.1083/jcb.142.3.763  | pmc=2148168 }}
| citations =
*{{cite journal   |vauthors=Starr DA, Saffery R, Li Z, etal |title=HZwint-1, a novel human kinetochore component that interacts with HZW10. |journal=J. Cell Sci. |volume=113 |issue=  11|pages= 1939–50 |year= 2000 |pmid= 10806105 |doi=  }}
*{{cite journal  | author=Starr DA, Williams BC, Li Z, ''et al.'' |title=Conservation of the centromere/kinetochore protein ZW10. |journal=J. Cell Biol. |volume=138 |issue= 6 |pages= 1289-301 |year= 1997 |pmid= 9298984 |doi=  }}
*{{cite journal   |vauthors=Chan GK, Jablonski SA, Starr DA, etal |title=Human Zw10 and ROD are mitotic checkpoint proteins that bind to kinetochores. |journal=Nat. Cell Biol. |volume=2 |issue= 12 |pages= 944–7 |year= 2001 |pmid= 11146660 |doi= 10.1038/35046598 }}
*{{cite journal  | author=Starr DA, Williams BC, Hays TS, Goldberg ML |title=ZW10 helps recruit dynactin and dynein to the kinetochore. |journal=J. Cell Biol. |volume=142 |issue= 3 |pages= 763-74 |year= 1998 |pmid= 9700164 |doi=  }}
*{{cite journal   |vauthors=Scaërou F, Starr DA, Piano F, etal |title=The ZW10 and Rough Deal checkpoint proteins function together in a large, evolutionarily conserved complex targeted to the kinetochore. |journal=J. Cell Sci. |volume=114 |issue= Pt 17 |pages= 3103–14 |year= 2001 |pmid= 11590237 |doi=  }}
*{{cite journal | author=Starr DA, Saffery R, Li Z, ''et al.'' |title=HZwint-1, a novel human kinetochore component that interacts with HZW10. |journal=J. Cell. Sci. |volume=113 ( Pt 11) |issue=  |pages= 1939-50 |year= 2000 |pmid= 10806105 |doi=  }}
*{{cite journal   |vauthors=Gevaert K, Goethals M, Martens L, etal |title=Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. |journal=Nat. Biotechnol. |volume=21 |issue= 5 |pages= 566–9 |year= 2004 |pmid= 12665801 |doi= 10.1038/nbt810 }}
*{{cite journal | author=Chan GK, Jablonski SA, Starr DA, ''et al.'' |title=Human Zw10 and ROD are mitotic checkpoint proteins that bind to kinetochores. |journal=Nat. Cell Biol. |volume=2 |issue= 12 |pages= 944-7 |year= 2001 |pmid= 11146660 |doi= 10.1038/35046598 }}
*{{cite journal   |vauthors=Hirose H, Arasaki K, Dohmae N, etal |title=Implication of ZW10 in membrane trafficking between the endoplasmic reticulum and Golgi. |journal=EMBO J. |volume=23 |issue= 6 |pages= 1267–78 |year= 2005 |pmid= 15029241 |doi= 10.1038/sj.emboj.7600135 | pmc=381410 }}
*{{cite journal | author=Scaërou F, Starr DA, Piano F, ''et al.'' |title=The ZW10 and Rough Deal checkpoint proteins function together in a large, evolutionarily conserved complex targeted to the kinetochore. |journal=J. Cell. Sci. |volume=114 |issue= Pt 17 |pages= 3103-14 |year= 2001 |pmid= 11590237 |doi=  }}
*{{cite journal   |vauthors=Musio A, Mariani T, Montagna C, etal |title=Recapitulation of the Roberts syndrome cellular phenotype by inhibition of INCENP, ZWINT-1 and ZW10 genes. |journal=Gene |volume=331 |issue=  |pages= 33–40 |year= 2004 |pmid= 15094189 |doi= 10.1016/j.gene.2004.01.028 }}
*{{cite journal | author=Gevaert K, Goethals M, Martens L, ''et al.'' |title=Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. |journal=Nat. Biotechnol. |volume=21 |issue= 5 |pages= 566-9 |year= 2004 |pmid= 12665801 |doi= 10.1038/nbt810 }}
*{{cite journal   |vauthors=Nakajima K, Hirose H, Taniguchi M, etal |title=Involvement of BNIP1 in apoptosis and endoplasmic reticulum membrane fusion. |journal=EMBO J. |volume=23 |issue= 16 |pages= 3216–26 |year= 2005 |pmid= 15272311 |doi= 10.1038/sj.emboj.7600333 | pmc=514507 }}
*{{cite journal | author=Hirose H, Arasaki K, Dohmae N, ''et al.'' |title=Implication of ZW10 in membrane trafficking between the endoplasmic reticulum and Golgi. |journal=EMBO J. |volume=23 |issue= 6 |pages= 1267-78 |year= 2005 |pmid= 15029241 |doi= 10.1038/sj.emboj.7600135 }}
*{{cite journal   |vauthors=Wang H, Hu X, Ding X, etal |title=Human Zwint-1 specifies localization of Zeste White 10 to kinetochores and is essential for mitotic checkpoint signaling. |journal=J. Biol. Chem. |volume=279 |issue= 52 |pages= 54590–8 |year= 2005 |pmid= 15485811 |doi= 10.1074/jbc.M407588200 }}
*{{cite journal | author=Musio A, Mariani T, Montagna C, ''et al.'' |title=Recapitulation of the Roberts syndrome cellular phenotype by inhibition of INCENP, ZWINT-1 and ZW10 genes. |journal=Gene |volume=331 |issue=  |pages= 33-40 |year= 2004 |pmid= 15094189 |doi= 10.1016/j.gene.2004.01.028 }}
*{{cite journal   |vauthors=Kops GJ, Kim Y, Weaver BA, etal |title=ZW10 links mitotic checkpoint signaling to the structural kinetochore. |journal=J. Cell Biol. |volume=169 |issue= 1 |pages= 49–60 |year= 2005 |pmid= 15824131 |doi= 10.1083/jcb.200411118 | pmc=1351127 }}
*{{cite journal | author=Nakajima K, Hirose H, Taniguchi M, ''et al.'' |title=Involvement of BNIP1 in apoptosis and endoplasmic reticulum membrane fusion. |journal=EMBO J. |volume=23 |issue= 16 |pages= 3216-26 |year= 2005 |pmid= 15272311 |doi= 10.1038/sj.emboj.7600333 }}
*{{cite journal  | vauthors=Varma D, Dujardin DL, Stehman SA, Vallee RB |title=Role of the kinetochore/cell cycle checkpoint protein ZW10 in interphase cytoplasmic dynein function. |journal=J. Cell Biol. |volume=172 |issue= 5 |pages= 655–62 |year= 2006 |pmid= 16505164 |doi= 10.1083/jcb.200510120 | pmc=2063698 }}
*{{cite journal | author=Wang H, Hu X, Ding X, ''et al.'' |title=Human Zwint-1 specifies localization of Zeste White 10 to kinetochores and is essential for mitotic checkpoint signaling. |journal=J. Biol. Chem. |volume=279 |issue= 52 |pages= 54590-8 |year= 2005 |pmid= 15485811 |doi= 10.1074/jbc.M407588200 }}
*{{cite journal   |vauthors=Nousiainen M, Silljé HH, Sauer G, etal |title=Phosphoproteome analysis of the human mitotic spindle. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=103 |issue= 14 |pages= 5391–6 |year= 2006 |pmid= 16565220 |doi= 10.1073/pnas.0507066103 | pmc=1459365 }}
*{{cite journal | author=Kops GJ, Kim Y, Weaver BA, ''et al.'' |title=ZW10 links mitotic checkpoint signaling to the structural kinetochore. |journal=J. Cell Biol. |volume=169 |issue= 1 |pages= 49-60 |year= 2005 |pmid= 15824131 |doi= 10.1083/jcb.200411118 }}
*{{cite journal  | vauthors=Arasaki K, Taniguchi M, Tani K, Tagaya M |title=RINT-1 regulates the localization and entry of ZW10 to the syntaxin 18 complex. |journal=Mol. Biol. Cell |volume=17 |issue= 6 |pages= 2780–8 |year= 2006 |pmid= 16571679 |doi= 10.1091/mbc.E05-10-0973 | pmc=1474792 }}
*{{cite journal  | author=Varma D, Dujardin DL, Stehman SA, Vallee RB |title=Role of the kinetochore/cell cycle checkpoint protein ZW10 in interphase cytoplasmic dynein function. |journal=J. Cell Biol. |volume=172 |issue= 5 |pages= 655-62 |year= 2006 |pmid= 16505164 |doi= 10.1083/jcb.200510120 }}
*{{cite journal  | vauthors=Lin YT, Chen Y, Wu G, Lee WH |title=Hec1 sequentially recruits Zwint-1 and ZW10 to kinetochores for faithful chromosome segregation and spindle checkpoint control. |journal=Oncogene |volume=25 |issue= 52 |pages= 6901–14 |year= 2006 |pmid= 16732327 |doi= 10.1038/sj.onc.1209687 }}
*{{cite journal | author=Nousiainen M, Silljé HH, Sauer G, ''et al.'' |title=Phosphoproteome analysis of the human mitotic spindle. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=103 |issue= 14 |pages= 5391-6 |year= 2006 |pmid= 16565220 |doi= 10.1073/pnas.0507066103 }}
*{{cite journal   |vauthors=Ewing RM, Chu P, Elisma F, etal |title=Large-scale mapping of human protein-protein interactions by mass spectrometry. |journal=Mol. Syst. Biol. |volume=3 |issue=  1|pages= 89 |year= 2007 |pmid= 17353931 |doi= 10.1038/msb4100134 | pmc=1847948 }}
*{{cite journal  | author=Arasaki K, Taniguchi M, Tani K, Tagaya M |title=RINT-1 regulates the localization and entry of ZW10 to the syntaxin 18 complex. |journal=Mol. Biol. Cell |volume=17 |issue= 6 |pages= 2780-8 |year= 2006 |pmid= 16571679 |doi= 10.1091/mbc.E05-10-0973 }}
*{{cite journal  | vauthors=Arasaki K, Uemura T, Tani K, Tagaya M |title=Correlation of Golgi localization of ZW10 and centrosomal accumulation of dynactin. |journal=Biochem. Biophys. Res. Commun. |volume=359 |issue= 3 |pages= 811–6 |year= 2007 |pmid= 17560939 |doi= 10.1016/j.bbrc.2007.05.188 }}
*{{cite journal  | author=Lin YT, Chen Y, Wu G, Lee WH |title=Hec1 sequentially recruits Zwint-1 and ZW10 to kinetochores for faithful chromosome segregation and spindle checkpoint control. |journal=Oncogene |volume=25 |issue= 52 |pages= 6901-14 |year= 2006 |pmid= 16732327 |doi= 10.1038/sj.onc.1209687 }}
*{{cite journal   |vauthors=Sun Y, Shestakova A, Hunt L, etal |title=Rab6 regulates both ZW10/RINT-1 and conserved oligomeric Golgi complex-dependent Golgi trafficking and homeostasis. |journal=Mol. Biol. Cell |volume=18 |issue= 10 |pages= 4129–42 |year= 2007 |pmid= 17699596 |doi= 10.1091/mbc.E07-01-0080 | pmc=1995728 }}
*{{cite journal | author=Ewing RM, Chu P, Elisma F, ''et al.'' |title=Large-scale mapping of human protein-protein interactions by mass spectrometry. |journal=Mol. Syst. Biol. |volume=3 |issue=  |pages= 89 |year= 2007 |pmid= 17353931 |doi= 10.1038/msb4100134 }}
*{{cite journal  | author=Arasaki K, Uemura T, Tani K, Tagaya M |title=Correlation of Golgi localization of ZW10 and centrosomal accumulation of dynactin. |journal=Biochem. Biophys. Res. Commun. |volume=359 |issue= 3 |pages= 811-6 |year= 2007 |pmid= 17560939 |doi= 10.1016/j.bbrc.2007.05.188 }}
*{{cite journal | author=Sun Y, Shestakova A, Hunt L, ''et al.'' |title=Rab6 regulates both ZW10/RINT-1 and conserved oligomeric Golgi complex-dependent Golgi trafficking and homeostasis. |journal=Mol. Biol. Cell |volume=18 |issue= 10 |pages= 4129-42 |year= 2007 |pmid= 17699596 |doi= 10.1091/mbc.E07-01-0080 }}
}}
{{refend}}
{{refend}}


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Latest revision as of 22:40, 8 November 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Centromere/kinetochore protein zw10 homolog is a protein that in humans is encoded by the ZW10 gene.[1][2] This gene encodes a protein that is one of many involved in mechanisms to ensure proper chromosome segregation during cell division. The encoded protein binds to centromeres during the prophase, metaphase, and early anaphase cell division stages and to kinetochore microtubules during metaphase.[2]

Function

Zw10
Identifiers
SymbolZw10
PfamPF06248
Pfam clanCL0295
InterProIPR009361

Zeste white 10 (ZW10) was initially identified as a mitotic checkpoint protein involved in chromosome segregation, and then implicated in targeting cytoplasmic dynein and dynactin to mitotic kinetochores, but it is also important in non-dividing cells. These include cytoplasmic dynein targeting to Golgi and other membranes, and SNARE-mediated ER-Golgi trafficking.[3][4] Dominant-negative ZW10, anti-ZW10 antibody, and ZW10 RNA interference (RNAi) cause Golgi dispersal. ZW10 RNAi also disperse endosomes and lysosomes.[4]

Drosophila kinetochore components Rough deal (Rod) and Zw10 are required for the proper functioning of the metaphase checkpoint in flies.[5] The eukaryotic spindle assembly checkpoint (SAC) monitors microtubule attachment to kinetochores and prevents anaphase onset until all kinetochores are aligned on the metaphase plate. It is an essential surveillance mechanism that ensures high fidelity chromosome segregation during mitosis. In higher eukaryotes, cytoplasmic dynein is involved in silencing the SAC by removing the checkpoint proteins Mad2 and the Rod-Zw10-Zwilch complex (RZZ) from aligned kinetochores.[6][7][8]

Interactions

ZW10 has been shown to interact with RINT1[9]

References

  1. ↑ Starr DA, Williams BC, Li Z, Etemad-Moghadam B, Dawe RK, Goldberg ML (Oct 1997). "Conservation of the centromere/kinetochore protein ZW10". J Cell Biol. 138 (6): 1289–301. doi:10.1083/jcb.138.6.1289. PMC 2132553. PMID 9298984.
  2. ↑ 2.0 2.1 "Entrez Gene: ZW10 ZW10, kinetochore associated, homolog (Drosophila)".
  3. ↑ Vallee RB, Varma D, Dujardin DL (November 2006). "ZW10 function in mitotic checkpoint control, dynein targeting and membrane trafficking: is dynein the unifying theme?". Cell Cycle. 5 (21): 2447–51. doi:10.4161/cc.5.21.3395. PMC 2794429. PMID 17102640.
  4. ↑ 4.0 4.1 Varma D, Dujardin DL, Stehman SA, Vallee RB (February 2006). "Role of the kinetochore/cell cycle checkpoint protein ZW10 in interphase cytoplasmic dynein function". J. Cell Biol. 172 (5): 655–62. doi:10.1083/jcb.200510120. PMC 2063698. PMID 16505164.
  5. ↑ Basto R, Gomes R, Karess RE (December 2000). "Rough deal and Zw10 are required for the metaphase checkpoint in Drosophila". Nat. Cell Biol. 2 (12): 939–43. doi:10.1038/35046592. PMID 11146659.
  6. ↑ Griffis ER, Stuurman N, Vale RD (June 2007). "Spindly, a novel protein essential for silencing the spindle assembly checkpoint, recruits dynein to the kinetochore". J. Cell Biol. 177 (6): 1005–15. doi:10.1083/jcb.200702062. PMC 2064361. PMID 17576797.
  7. ↑ Famulski JK, Vos L, Sun X, Chan G (February 2008). "Stable hZW10 kinetochore residency, mediated by hZwint-1 interaction, is essential for the mitotic checkpoint". J. Cell Biol. 180 (3): 507–20. doi:10.1083/jcb.200708021. PMC 2234252. PMID 18268100.
  8. ↑ Yang Z, Tulu US, Wadsworth P, Rieder CL (June 2007). "Kinetochore dynein is required for chromosome motion and congression independent of the spindle checkpoint". Curr. Biol. 17 (11): 973–80. doi:10.1016/j.cub.2007.04.056. PMC 2570756. PMID 17509882.
  9. ↑ Hirose H, Arasaki K, Dohmae N, Takio K, Hatsuzawa K, Nagahama M, Tani K, Yamamoto A, Tohyama M, Tagaya M (March 2004). "Implication of ZW10 in membrane trafficking between the endoplasmic reticulum and Golgi". EMBO J. 23 (6): 1267–78. doi:10.1038/sj.emboj.7600135. PMC 381410. PMID 15029241.

Further reading


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