NISCH: Difference between revisions

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Latest revision as of 13:01, 5 September 2017

Nischarin is a protein that in humans is encoded by the NISCH gene.^[1]^[2]^[3]

Function

This gene encodes a nonadrenergic imidazoline-1 receptor protein that localizes to the cytosol and anchors to the inner layer of the plasma membrane. The orthologous mouse protein has been shown to influence cytoskeletal organization and cell migration by binding to alpha-5-beta-1 integrin. In humans, this protein has been shown to bind to the adapter insulin receptor substrate 4 (IRS4) to mediate translocation of alpha-5 integrin from the cell membrane to endosomes. In human cardiac tissue, this gene was found to affect cell growth and death while in neural tissue it affected neuronal growth and differentiation.^[3]

Clinical significance

Expression of this protein was reduced in human breast cancers while its overexpression reduced tumor growth and metastasis; possibly by limiting the expression of alpha-5 integrin.^[3]

Interactions

NISCH has been shown to interact with IRS4.^[1]

References

↑ ^1.0 ^1.1 Sano H, Liu SC, Lane WS, Piletz JE, Lienhard GE (May 2002). "Insulin receptor substrate 4 associates with the protein IRAS". J Biol Chem. 277 (22): 19439–47. doi:10.1074/jbc.M111838200. PMID 11912194.
↑ Piletz JE, Ivanov TR, Sharp JD, Ernsberger P, Chang CH, Pickard RT, Gold G, Roth B, Zhu H, Jones JC, Baldwin J, Reis DJ (Jul 2000). "Imidazoline receptor antisera-selected (IRAS) cDNA: cloning and characterization". DNA Cell Biol. 19 (6): 319–29. doi:10.1089/10445490050043290. PMID 10882231.
↑ ^3.0 ^3.1 ^3.2 "Entrez Gene: NISCH nischarin".

Ivanov TR, Jones JC, Dontenwill M, et al. (1999). "Characterization of a partial cDNA clone detected by imidazoline receptor-selective antisera". J. Auton. Nerv. Syst. 72 (2–3): 98–110. doi:10.1016/S0165-1838(98)00094-0. PMID 9851558.
Nagase T, Ishikawa K, Suyama M, et al. (1999). "Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 6 (1): 63–70. doi:10.1093/dnares/6.1.63. PMID 10231032.
El-Ayoubi R, Gutkowska J, Regunathan S, Mukaddam-Daher S (2002). "Imidazoline receptors in the heart: characterization, distribution, and regulation". J. Cardiovasc. Pharmacol. 39 (6): 875–83. doi:10.1097/00005344-200206000-00013. PMID 12021582.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Edwards L, Ernsberger P (2003). "The I(1)-imidazoline receptor in PC12 pheochromocytoma cells reverses NGF-induced ERK activation and induces MKP-2 phosphatase". Brain Res. 980 (1): 71–9. doi:10.1016/S0006-8993(03)02893-2. PMID 12865160.
Dontenwill M, Pascal G, Piletz JE, et al. (2004). "IRAS, the human homologue of Nischarin, prolongs survival of transfected PC12 cells". Cell Death Differ. 10 (8): 933–5. doi:10.1038/sj.cdd.4401275. PMID 12868002.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Dontenwill M, Piletz JE, Chen M, et al. (2004). "IRAS is an anti-apoptotic protein". Ann. N. Y. Acad. Sci. 1009: 400–12. doi:10.1196/annals.1304.054. PMID 15028619.
Piletz JE, Deleersnijder W, Roth BL, et al. (2004). "IRAS splice variants". Ann. N. Y. Acad. Sci. 1009: 419–26. doi:10.1196/annals.1304.056. PMID 15028621.
Chen MJ, Zhu HE, Piletz JE (2004). "Intracellular effect of imidazoline receptor on alpha(2A)-noradrenergic receptor". Ann. N. Y. Acad. Sci. 1009: 427–38. doi:10.1196/annals.1304.057. PMID 15028622.
Zhu H, Hayes J, Chen M, et al. (2004). "Relationship between platelet imidazoline receptor-binding peptides and candidate imidazoline-1 receptor, IRAS". Ann. N. Y. Acad. Sci. 1009: 439–46. doi:10.1196/annals.1304.058. PMID 15028623.
Lim KP, Hong W (2005). "Human Nischarin/imidazoline receptor antisera-selected protein is targeted to the endosomes by a combined action of a PX domain and a coiled-coil region". J. Biol. Chem. 279 (52): 54770–82. doi:10.1074/jbc.M411315200. PMID 15475348.
Li F, Wu N, Su RB, et al. (2006). "Involvement of phosphatidylcholine-selective phospholipase C in activation of mitogen-activated protein kinase pathways in imidazoline receptor antisera-selected protein". J. Cell. Biochem. 98 (6): 1615–28. doi:10.1002/jcb.20806. PMID 16598778.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This article on a gene on human chromosome 3 is a stub. You can help Wikipedia by expanding it.

[pmid11912194-1] 1.0 ^1.1 Sano H, Liu SC, Lane WS, Piletz JE, Lienhard GE (May 2002). "Insulin receptor substrate 4 associates with the protein IRAS". J Biol Chem. 277 (22): 19439–47. doi:10.1074/jbc.M111838200. PMID 11912194.

[pmid10882231-2] Piletz JE, Ivanov TR, Sharp JD, Ernsberger P, Chang CH, Pickard RT, Gold G, Roth B, Zhu H, Jones JC, Baldwin J, Reis DJ (Jul 2000). "Imidazoline receptor antisera-selected (IRAS) cDNA: cloning and characterization". DNA Cell Biol. 19 (6): 319–29. doi:10.1089/10445490050043290. PMID 10882231.

[entrez-3] 3.0 ^3.1 ^3.2 "Entrez Gene: NISCH nischarin".

[1]

[2]

[3]

@@ Line 1: / Line 1: @@
-<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
+{{Infobox_gene}}
-{{PBB_Controls
+'''Nischarin''' is a [[protein]] that in humans is encoded by the ''NISCH'' [[gene]].<ref name="pmid11912194">{{cite journal | vauthors = Sano H, Liu SC, Lane WS, Piletz JE, Lienhard GE | title = Insulin receptor substrate 4 associates with the protein IRAS | journal = J Biol Chem | volume = 277 | issue = 22 | pages = 19439–47 |date=May 2002 | pmid = 11912194 | pmc =  | doi = 10.1074/jbc.M111838200 }}</ref><ref name="pmid10882231">{{cite journal | vauthors = Piletz JE, Ivanov TR, Sharp JD, Ernsberger P, Chang CH, Pickard RT, Gold G, Roth B, Zhu H, Jones JC, Baldwin J, Reis DJ | title = Imidazoline receptor antisera-selected (IRAS) cDNA: cloning and characterization | journal = DNA Cell Biol | volume = 19 | issue = 6 | pages = 319–29 |date=Jul 2000 | pmid = 10882231 | pmc =  | doi = 10.1089/10445490050043290 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: NISCH nischarin| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11188| accessdate = }}</ref>
-| update_page = yes
-| require_manual_inspection = no
-| update_protein_box = yes
-| update_summary = yes
-| update_citations = yes
-}}
-<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
+== Function ==
-{{GNF_Protein_box
- | image =
- | image_source =
- | PDB =
- | Name = Nischarin
- | HGNCid = 18006
- | Symbol = NISCH
- | AltSymbols =; FLJ14425; FLJ40413; FLJ90519; I-1; IRAS; KIAA0975
- | OMIM =
- | ECnumber =
- | Homologene = 5201
- | MGIid =
- | GeneAtlas_image1 = PBB_GE_NISCH_201591_s_at_tn.png
- | Function = {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0035091 |text = phosphoinositide binding}}
- | Component =
- | Process = {{GNF_GO|id=GO:0007154 |text = cell communication}}
- | Orthologs = {{GNF_Ortholog_box
-    | Hs_EntrezGene = 11188
-    | Hs_Ensembl = ENSG00000010322
-    | Hs_RefseqProtein = NP_009115
-    | Hs_RefseqmRNA = NM_007184
-    | Hs_GenLoc_db =
-    | Hs_GenLoc_chr = 3
-    | Hs_GenLoc_start = 52464174
-    | Hs_GenLoc_end = 52502124
-    | Hs_Uniprot =
-    | Mm_EntrezGene =
-    | Mm_Ensembl =
-    | Mm_RefseqmRNA =
-    | Mm_RefseqProtein =
-    | Mm_GenLoc_db =
-    | Mm_GenLoc_chr =
-    | Mm_GenLoc_start =
-    | Mm_GenLoc_end =
-    | Mm_Uniprot =
-  }}
-}}
-'''Nischarin''', also known as '''NISCH''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: NISCH nischarin| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11188| accessdate = }}</ref>
-<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
+This gene encodes a nonadrenergic [[imidazoline receptor|imidazoline-1 receptor]] protein that localizes to the [[cytosol]] and anchors to the inner layer of the plasma membrane. The [[orthologous]] mouse protein has been shown to influence [[cytoskeletal]] organization and [[cell migration]] by binding to [[alpha-5 beta-1|alpha-5-beta-1 integrin]]. In humans, this protein has been shown to bind to the adapter insulin receptor substrate 4 ([[IRS4]]) to mediate translocation of alpha-5 integrin from the cell membrane to [[endosome]]s. In human cardiac tissue, this gene was found to affect cell growth and death while in neural tissue it affected neuronal growth and differentiation.<ref name="entrez"/>
-{{PBB_Summary
-| section_title =
+== Clinical significance ==
-| summary_text =
-}}
+Expression of this protein was reduced in human breast cancers while its overexpression reduced tumor growth and metastasis; possibly by limiting the expression of alpha-5 integrin.<ref name="entrez"/>
+== Interactions ==
+NISCH has been shown to [[Protein-protein interaction|interact]] with [[IRS4]].<ref name="pmid11912194" />
+==See also==
+* [[Imidazoline receptor]]
 ==References==
-{{reflist|2}}
+{{reflist}}
 ==Further reading==
 {{refbegin | 2}}
-{{PBB_Further_reading
+*{{cite journal   |vauthors=Ivanov TR, Jones JC, Dontenwill M, etal |title=Characterization of a partial cDNA clone detected by imidazoline receptor-selective antisera. |journal=J. Auton. Nerv. Syst. |volume=72 |issue= 2–3 |pages= 98–110 |year= 1999 |pmid= 9851558 |doi=10.1016/S0165-1838(98)00094-0  }}
-| citations =
+*{{cite journal   |vauthors=Nagase T, Ishikawa K, Suyama M, etal |title=Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro |journal=DNA Res. |volume=6 |issue= 1 |pages= 63–70 |year= 1999 |pmid= 10231032 |doi=10.1093/dnares/6.1.63  }}
-*{{cite journal  | author=Ivanov TR, Jones JC, Dontenwill M, ''et al.'' |title=Characterization of a partial cDNA clone detected by imidazoline receptor-selective antisera. |journal=J. Auton. Nerv. Syst. |volume=72 |issue= 2-3 |pages= 98-110 |year= 1999 |pmid= 9851558 |doi=  }}
+*{{cite journal  | vauthors=El-Ayoubi R, Gutkowska J, Regunathan S, Mukaddam-Daher S |title=Imidazoline receptors in the heart: characterization, distribution, and regulation |journal=J. Cardiovasc. Pharmacol. |volume=39 |issue= 6 |pages= 875–83 |year= 2002 |pmid= 12021582 |doi=10.1097/00005344-200206000-00013  }}
-*{{cite journal  | author=Nagase T, Ishikawa K, Suyama M, ''et al.'' |title=Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. |journal=DNA Res. |volume=6 |issue= 1 |pages= 63-70 |year= 1999 |pmid= 10231032 |doi=  }}
+*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 }}
-*{{cite journal  | author=Piletz JE, Ivanov TR, Sharp JD, ''et al.'' |title=Imidazoline receptor antisera-selected (IRAS) cDNA: cloning and characterization. |journal=DNA Cell Biol. |volume=19 |issue= 6 |pages= 319-29 |year= 2000 |pmid= 10882231 |doi= 10.1089/10445490050043290 }}
+*{{cite journal  | vauthors=Edwards L, Ernsberger P |title=The I(1)-imidazoline receptor in PC12 pheochromocytoma cells reverses NGF-induced ERK activation and induces MKP-2 phosphatase |journal=Brain Res. |volume=980 |issue= 1 |pages= 71–9 |year= 2003 |pmid= 12865160 |doi=10.1016/S0006-8993(03)02893-2  }}
-*{{cite journal  | author=Sano H, Liu SC, Lane WS, ''et al.'' |title=Insulin receptor substrate 4 associates with the protein IRAS. |journal=J. Biol. Chem. |volume=277 |issue= 22 |pages= 19439-47 |year= 2002 |pmid= 11912194 |doi= 10.1074/jbc.M111838200 }}
+*{{cite journal   |vauthors=Dontenwill M, Pascal G, Piletz JE, etal |title=IRAS, the human homologue of Nischarin, prolongs survival of transfected PC12 cells |journal=Cell Death Differ. |volume=10 |issue= 8 |pages= 933–5 |year= 2004 |pmid= 12868002 |doi= 10.1038/sj.cdd.4401275 }}
-*{{cite journal  | author=El-Ayoubi R, Gutkowska J, Regunathan S, Mukaddam-Daher S |title=Imidazoline receptors in the heart: characterization, distribution, and regulation. |journal=J. Cardiovasc. Pharmacol. |volume=39 |issue= 6 |pages= 875-83 |year= 2002 |pmid= 12021582 |doi=  }}
+*{{cite journal   |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
-*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
+*{{cite journal   |vauthors=Dontenwill M, Piletz JE, Chen M, etal |title=IRAS is an anti-apoptotic protein |journal=Ann. N. Y. Acad. Sci. |volume=1009 |issue=  |pages= 400–12 |year= 2004 |pmid= 15028619 |doi=10.1196/annals.1304.054  }}
-*{{cite journal  | author=Edwards L, Ernsberger P |title=The I(1)-imidazoline receptor in PC12 pheochromocytoma cells reverses NGF-induced ERK activation and induces MKP-2 phosphatase. |journal=Brain Res. |volume=980 |issue= 1 |pages= 71-9 |year= 2003 |pmid= 12865160 |doi=  }}
+*{{cite journal   |vauthors=Piletz JE, Deleersnijder W, Roth BL, etal |title=IRAS splice variants |journal=Ann. N. Y. Acad. Sci. |volume=1009 |issue=  |pages= 419–26 |year= 2004 |pmid= 15028621 |doi=10.1196/annals.1304.056  }}
-*{{cite journal  | author=Dontenwill M, Pascal G, Piletz JE, ''et al.'' |title=IRAS, the human homologue of Nischarin, prolongs survival of transfected PC12 cells. |journal=Cell Death Differ. |volume=10 |issue= 8 |pages= 933-5 |year= 2004 |pmid= 12868002 |doi= 10.1038/sj.cdd.4401275 }}
+*{{cite journal  | vauthors=Chen MJ, Zhu HE, Piletz JE |title=Intracellular effect of imidazoline receptor on alpha(2A)-noradrenergic receptor |journal=Ann. N. Y. Acad. Sci. |volume=1009 |issue=  |pages= 427–38 |year= 2004 |pmid= 15028622 |doi=10.1196/annals.1304.057  }}
-*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
+*{{cite journal   |vauthors=Zhu H, Hayes J, Chen M, etal |title=Relationship between platelet imidazoline receptor-binding peptides and candidate imidazoline-1 receptor, IRAS |journal=Ann. N. Y. Acad. Sci. |volume=1009 |issue=  |pages= 439–46 |year= 2004 |pmid= 15028623 |doi=10.1196/annals.1304.058  }}
-*{{cite journal  | author=Dontenwill M, Piletz JE, Chen M, ''et al.'' |title=IRAS is an anti-apoptotic protein. |journal=Ann. N. Y. Acad. Sci. |volume=1009 |issue=  |pages= 400-12 |year= 2004 |pmid= 15028619 |doi=  }}
+*{{cite journal  | vauthors=Lim KP, Hong W |title=Human Nischarin/imidazoline receptor antisera-selected protein is targeted to the endosomes by a combined action of a PX domain and a coiled-coil region |journal=J. Biol. Chem. |volume=279 |issue= 52 |pages= 54770–82 |year= 2005 |pmid= 15475348 |doi= 10.1074/jbc.M411315200 }}
-*{{cite journal  | author=Piletz JE, Deleersnijder W, Roth BL, ''et al.'' |title=IRAS splice variants. |journal=Ann. N. Y. Acad. Sci. |volume=1009 |issue=  |pages= 419-26 |year= 2004 |pmid= 15028621 |doi=  }}
+*{{cite journal   |vauthors=Li F, Wu N, Su RB, etal |title=Involvement of phosphatidylcholine-selective phospholipase C in activation of mitogen-activated protein kinase pathways in imidazoline receptor antisera-selected protein |journal=J. Cell. Biochem. |volume=98 |issue= 6 |pages= 1615–28 |year= 2006 |pmid= 16598778 |doi= 10.1002/jcb.20806 }}
-*{{cite journal  | author=Chen MJ, Zhu HE, Piletz JE |title=Intracellular effect of imidazoline receptor on alpha(2A)-noradrenergic receptor. |journal=Ann. N. Y. Acad. Sci. |volume=1009 |issue=  |pages= 427-38 |year= 2004 |pmid= 15028622 |doi=  }}
-*{{cite journal  | author=Zhu H, Hayes J, Chen M, ''et al.'' |title=Relationship between platelet imidazoline receptor-binding peptides and candidate imidazoline-1 receptor, IRAS. |journal=Ann. N. Y. Acad. Sci. |volume=1009 |issue=  |pages= 439-46 |year= 2004 |pmid= 15028623 |doi=  }}
-*{{cite journal  | author=Lim KP, Hong W |title=Human Nischarin/imidazoline receptor antisera-selected protein is targeted to the endosomes by a combined action of a PX domain and a coiled-coil region. |journal=J. Biol. Chem. |volume=279 |issue= 52 |pages= 54770-82 |year= 2005 |pmid= 15475348 |doi= 10.1074/jbc.M411315200 }}
-*{{cite journal  | author=Li F, Wu N, Su RB, ''et al.'' |title=Involvement of phosphatidylcholine-selective phospholipase C in activation of mitogen-activated protein kinase pathways in imidazoline receptor antisera-selected protein. |journal=J. Cell. Biochem. |volume=98 |issue= 6 |pages= 1615-28 |year= 2006 |pmid= 16598778 |doi= 10.1002/jcb.20806 }}
-}}
 {{refend}}
-{{protein-stub}}
+{{Imidazolinergics}}
-{{WikiDoc Sources}}
+{{NLM content}}
+{{gene-3-stub}}

v t e Imidazoline receptor modulators
IR	Agonists: 2-BFI 7-Me-Marsanidine Agmatine Apraclonidine BU224 Clonidine Clorgyline Harmalas LNP-509 LNP-911 mCPP Moxonidine Rilmenidine S-23515 S-23757 Antagonists: BU99006 Efaroxan Idazoxan Unsorted/unknown: CR-4056 Pargyline
See also: Receptor/signaling modulators

NISCH: Difference between revisions

Latest revision as of 13:01, 5 September 2017

Contents

Function

Clinical significance

Interactions

See also

References

Further reading

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