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{{technical|date=August 2017}}
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'''Hematopoietic lineage cell-specific protein''' is a [[protein]] that in humans is encoded by the ''HCLS1'' [[gene]].<ref name="pmid8978766">{{cite journal |vauthors=Egashira M, Kitamura D, Watanabe T, Niikawa N | title = The human HCLS1 gene maps to chromosome 3q13 by fluorescence in situ hybridization | journal = Cytogenet Cell Genet | volume = 72 | issue = 2-3 | pages = 175–6 |date=Jan 1997 | pmid = 8978766 | pmc =  | doi =10.1159/000134179 }}</ref><ref name="pmid15710041">{{cite journal |vauthors=van Rossum AG, Schuuring-Scholtes E, van Buuren-van Seggelen V, Kluin PM, Schuuring E | title = Comparative genome analysis of cortactin and HS1: the significance of the F-actin binding repeat domain | journal = BMC Genomics | volume = 6 | pages = 15 |date=Mar 2005 | pmid = 15710041 | pmc = 554100 | doi = 10.1186/1471-2164-6-15 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: HCLS1 hematopoietic cell-specific Lyn substrate 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3059| accessdate = }}</ref>
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{{GNF_Protein_box
| image =
| image_source =
| PDB =  
| Name = Hematopoietic cell-specific Lyn substrate 1
| HGNCid = 4844
| Symbol = HCLS1
| AltSymbols =; HS1; CTTNL
| OMIM = 601306
| ECnumber =
| Homologene = 38034
| MGIid = 104568
  | GeneAtlas_image1 = PBB_GE_HCLS1_202957_at_tn.png
  | GeneAtlas_image2 = PBB_GE_HCLS1_gnf1h09285_s_at_tn.png
| Function = {{GNF_GO|id=GO:0003700 |text = transcription factor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0017124 |text = SH3 domain binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005665 |text = DNA-directed RNA polymerase II, core complex}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}}
| Process = {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0007242 |text = intracellular signaling cascade}} {{GNF_GO|id=GO:0008284 |text = positive regulation of cell proliferation}} {{GNF_GO|id=GO:0009725 |text = response to hormone stimulus}} {{GNF_GO|id=GO:0030218 |text = erythrocyte differentiation}} {{GNF_GO|id=GO:0042531 |text = positive regulation of tyrosine phosphorylation of STAT protein}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 3059
    | Hs_Ensembl = ENSG00000180353
    | Hs_RefseqProtein = NP_005326
    | Hs_RefseqmRNA = NM_005335
    | Hs_GenLoc_db =
    | Hs_GenLoc_chr = 3
    | Hs_GenLoc_start = 122832937
    | Hs_GenLoc_end = 122862405
    | Hs_Uniprot = P14317
    | Mm_EntrezGene = 15163
    | Mm_Ensembl = ENSMUSG00000022831
    | Mm_RefseqmRNA = NM_008225
    | Mm_RefseqProtein = NP_032251
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 16
    | Mm_GenLoc_start = 36856526
    | Mm_GenLoc_end = 36881988
    | Mm_Uniprot = Q3V192
  }}
}}
'''Hematopoietic cell-specific Lyn substrate 1''', also known as '''HCLS1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: HCLS1 hematopoietic cell-specific Lyn substrate 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3059| accessdate = }}</ref>
 
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==Interactions==
HCLS1 has been shown to [[Protein-protein interaction|interact]] with [[Caspase 3]].<ref name=pmid11988074>{{cite journal |last=Ruzzene |first=Maria |authorlink= |author2=Penzo Daniele |author3=Pinna Lorenzo A  |date=May 2002 |title=Protein kinase CK2 inhibitor 4,5,6,7-tetrabromobenzotriazole (TBB) induces apoptosis and caspase-dependent degradation of haematopoietic lineage cell-specific protein 1 (HS1) in Jurkat cells |journal=Biochem. J. |volume=364 |issue=Pt 1 |pages=41–7 |publisher= |location = England| issn = 0264-6021| pmid = 11988074 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |pmc=1222543 | doi=10.1042/bj3640041}}</ref><ref name=pmid11689006>{{cite journal |last=Chen |first=Y R |authorlink= |author2=Kori R |author3=John B |author4=Tan T H  |date=Nov 2001 |title=Caspase-mediated cleavage of actin-binding and SH3-domain-containing proteins cortactin, HS1, and HIP-55 during apoptosis |journal=Biochem. Biophys. Res. Commun. |volume=288 |issue=4 |pages=981–9 |publisher= |location = United States| issn = 0006-291X| pmid = 11689006 |doi = 10.1006/bbrc.2001.5862 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref>


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal | author=Kitamura D, Kaneko H, Miyagoe Y, ''et al.'' |title=Isolation and characterization of a novel human gene expressed specifically in the cells of hematopoietic lineage. |journal=Nucleic Acids Res. |volume=17 |issue= 22 |pages= 9367-79 |year= 1990 |pmid= 2587259 |doi=  }}
*{{cite journal   |vauthors=Kitamura D, Kaneko H, Miyagoe Y, etal |title=Isolation and characterization of a novel human gene expressed specifically in the cells of hematopoietic lineage. |journal=Nucleic Acids Res. |volume=17 |issue= 22 |pages= 9367–79 |year= 1990 |pmid= 2587259 |doi= | pmc=335138 }}
*{{cite journal | author=Yamanashi Y, Okada M, Semba T, ''et al.'' |title=Identification of HS1 protein as a major substrate of protein-tyrosine kinase(s) upon B-cell antigen receptor-mediated signaling. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=90 |issue= 8 |pages= 3631-5 |year= 1993 |pmid= 7682714 |doi=  }}
*{{cite journal   |vauthors=Yamanashi Y, Okada M, Semba T, etal |title=Identification of HS1 protein as a major substrate of protein-tyrosine kinase(s) upon B-cell antigen receptor-mediated signaling. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=90 |issue= 8 |pages= 3631–5 |year= 1993 |pmid= 7682714 |doi=  10.1073/pnas.90.8.3631| pmc=46355  }}
*{{cite journal | author=Hata D, Nakamura T, Kawakami T, ''et al.'' |title=Tyrosine phosphorylation of MB-1, B29, and HS1 proteins in human B cells following receptor crosslinking. |journal=Immunol. Lett. |volume=40 |issue= 1 |pages= 65-71 |year= 1994 |pmid= 7927516 |doi= }}
*{{cite journal   |vauthors=Hata D, Nakamura T, Kawakami T, etal |title=Tyrosine phosphorylation of MB-1, B29, and HS1 proteins in human B cells following receptor crosslinking. |journal=Immunol. Lett. |volume=40 |issue= 1 |pages= 65–71 |year= 1994 |pmid= 7927516 |doi=10.1016/0165-2478(94)90208-9  }}
*{{cite journal  | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171-4 |year= 1994 |pmid= 8125298 |doi=  }}
*{{cite journal  |vauthors=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=10.1016/0378-1119(94)90802-8 }}
*{{cite journal | author=Egerton M, Moritz RL, Druker B, ''et al.'' |title=Identification of the 70kD heat shock cognate protein (Hsc70) and alpha-actinin-1 as novel phosphotyrosine-containing proteins in T lymphocytes. |journal=Biochem. Biophys. Res. Commun. |volume=224 |issue= 3 |pages= 666-74 |year= 1996 |pmid= 8713105 |doi= 10.1006/bbrc.1996.1082 }}
*{{cite journal   |vauthors=Egerton M, Moritz RL, Druker B, etal |title=Identification of the 70kD heat shock cognate protein (Hsc70) and alpha-actinin-1 as novel phosphotyrosine-containing proteins in T lymphocytes. |journal=Biochem. Biophys. Res. Commun. |volume=224 |issue= 3 |pages= 666–74 |year= 1996 |pmid= 8713105 |doi= 10.1006/bbrc.1996.1082 }}
*{{cite journal | author=Egashira M, Kitamura D, Watanabe T, Niikawa N |title=The human HCLS1 gene maps to chromosome 3q13 by fluorescence in situ hybridization. |journal=Cytogenet. Cell Genet. |volume=72 |issue= 2-3 |pages= 175-6 |year= 1997 |pmid= 8978766 |doi=  }}
*{{cite journal   |vauthors=Suzuki Y, Demoliere C, Kitamura D, etal |title=HAX-1, a novel intracellular protein, localized on mitochondria, directly associates with HS1, a substrate of Src family tyrosine kinases. |journal=J. Immunol. |volume=158 |issue= 6 |pages= 2736–44 |year= 1997 |pmid= 9058808 |doi=  }}
*{{cite journal | author=Suzuki Y, Demoliere C, Kitamura D, ''et al.'' |title=HAX-1, a novel intracellular protein, localized on mitochondria, directly associates with HS1, a substrate of Src family tyrosine kinases. |journal=J. Immunol. |volume=158 |issue= 6 |pages= 2736-44 |year= 1997 |pmid= 9058808 |doi=  }}
*{{cite journal   |vauthors=Yamanashi Y, Fukuda T, Nishizumi H, etal |title=Role of tyrosine phosphorylation of HS1 in B cell antigen receptor-mediated apoptosis. |journal=J. Exp. Med. |volume=185 |issue= 7 |pages= 1387–92 |year= 1997 |pmid= 9104825 |doi= 10.1084/jem.185.7.1387| pmc=2196252 }}
*{{cite journal | author=Yamanashi Y, Fukuda T, Nishizumi H, ''et al.'' |title=Role of tyrosine phosphorylation of HS1 in B cell antigen receptor-mediated apoptosis. |journal=J. Exp. Med. |volume=185 |issue= 7 |pages= 1387-92 |year= 1997 |pmid= 9104825 |doi=  }}
*{{cite journal   |vauthors=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, etal |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=10.1016/S0378-1119(97)00411-3 }}
*{{cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, ''et al.'' |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149-56 |year= 1997 |pmid= 9373149 |doi=  }}
*{{cite journal   |vauthors=Brunati AM, Donella-Deana A, James P, etal |title=Molecular features underlying the sequential phosphorylation of HS1 protein and its association with c-Fgr protein-tyrosine kinase. |journal=J. Biol. Chem. |volume=274 |issue= 11 |pages= 7557–64 |year= 1999 |pmid= 10066823 |doi=10.1074/jbc.274.11.7557 }}
*{{cite journal  | author=Brunati AM, Donella-Deana A, James P, ''et al.'' |title=Molecular features underlying the sequential phosphorylation of HS1 protein and its association with c-Fgr protein-tyrosine kinase. |journal=J. Biol. Chem. |volume=274 |issue= 11 |pages= 7557-64 |year= 1999 |pmid= 10066823 |doi=  }}
*{{cite journal  |vauthors=Nagata Y, Kiefer F, Watanabe T, Todokoro K |title=Activation of hematopoietic progenitor kinase-1 by erythropoietin. |journal=Blood |volume=93 |issue= 10 |pages= 3347–54 |year= 1999 |pmid= 10233887 |doi=  }}
*{{cite journal | author=Nagata Y, Kiefer F, Watanabe T, Todokoro K |title=Activation of hematopoietic progenitor kinase-1 by erythropoietin. |journal=Blood |volume=93 |issue= 10 |pages= 3347-54 |year= 1999 |pmid= 10233887 |doi=  }}
*{{cite journal   |vauthors=Takemoto Y, Furuta M, Sato M, etal |title=Isolation and characterization of a novel HS1 SH3 domain binding protein, HS1BP3. |journal=Int. Immunol. |volume=11 |issue= 12 |pages= 1957–64 |year= 2000 |pmid= 10590261 |doi=10.1093/intimm/11.12.1957 }}
*{{cite journal | author=Takemoto Y, Furuta M, Sato M, ''et al.'' |title=Isolation and characterization of a novel HS1 SH3 domain binding protein, HS1BP3. |journal=Int. Immunol. |volume=11 |issue= 12 |pages= 1957-64 |year= 2000 |pmid= 10590261 |doi= }}
*{{cite journal   |vauthors=Ruzzene M, Brunati AM, Sarno S, etal |title=Ser/Thr phosphorylation of hematopoietic specific protein 1 (HS1): implication of protein kinase CK2. |journal=Eur. J. Biochem. |volume=267 |issue= 10 |pages= 3065–72 |year= 2000 |pmid= 10806407 |doi=10.1046/j.1432-1033.2000.01333.x  }}
*{{cite journal  | author=Ruzzene M, Brunati AM, Sarno S, ''et al.'' |title=Ser/Thr phosphorylation of hematopoietic specific protein 1 (HS1): implication of protein kinase CK2. |journal=Eur. J. Biochem. |volume=267 |issue= 10 |pages= 3065-72 |year= 2000 |pmid= 10806407 |doi= }}
*{{cite journal  |vauthors=Chen YR, Kori R, John B, Tan TH |title=Caspase-mediated cleavage of actin-binding and SH3-domain-containing proteins cortactin, HS1, and HIP-55 during apoptosis. |journal=Biochem. Biophys. Res. Commun. |volume=288 |issue= 4 |pages= 981–9 |year= 2001 |pmid= 11689006 |doi= 10.1006/bbrc.2001.5862 }}
*{{cite journal  | author=Chen YR, Kori R, John B, Tan TH |title=Caspase-mediated cleavage of actin-binding and SH3-domain-containing proteins cortactin, HS1, and HIP-55 during apoptosis. |journal=Biochem. Biophys. Res. Commun. |volume=288 |issue= 4 |pages= 981-9 |year= 2001 |pmid= 11689006 |doi= 10.1006/bbrc.2001.5862 }}
*{{cite journal  |vauthors=Ruzzene M, Penzo D, Pinna LA |title=Protein kinase CK2 inhibitor 4,5,6,7-tetrabromobenzotriazole (TBB) induces apoptosis and caspase-dependent degradation of haematopoietic lineage cell-specific protein 1 (HS1) in Jurkat cells. |journal=Biochem. J. |volume=364 |issue= Pt 1 |pages= 41–7 |year= 2002 |pmid= 11988074 |doi= 10.1042/bj3640041| pmc=1222543  }}
*{{cite journal | author=Ruzzene M, Penzo D, Pinna LA |title=Protein kinase CK2 inhibitor 4,5,6,7-tetrabromobenzotriazole (TBB) induces apoptosis and caspase-dependent degradation of haematopoietic lineage cell-specific protein 1 (HS1) in Jurkat cells. |journal=Biochem. J. |volume=364 |issue= Pt 1 |pages= 41-7 |year= 2002 |pmid= 11988074 |doi=  }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Salomon AR, Ficarro SB, Brill LM, etal |title=Profiling of tyrosine phosphorylation pathways in human cells using mass spectrometry. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=100 |issue= 2 |pages= 443–8 |year= 2003 |pmid= 12522270 |doi= 10.1073/pnas.2436191100  | pmc=141014 }}
*{{cite journal | author=Salomon AR, Ficarro SB, Brill LM, ''et al.'' |title=Profiling of tyrosine phosphorylation pathways in human cells using mass spectrometry. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=100 |issue= 2 |pages= 443-8 |year= 2003 |pmid= 12522270 |doi= 10.1073/pnas.2436191100 }}
*{{cite journal   |vauthors=Uruno T, Zhang P, Liu J, etal |title=Haematopoietic lineage cell-specific protein 1 (HS1) promotes actin-related protein (Arp) 2/3 complex-mediated actin polymerization. |journal=Biochem. J. |volume=371 |issue= Pt 2 |pages= 485–93 |year= 2003 |pmid= 12534372 |doi= 10.1042/BJ20021791 | pmc=1223309 }}
*{{cite journal | author=Uruno T, Zhang P, Liu J, ''et al.'' |title=Haematopoietic lineage cell-specific protein 1 (HS1) promotes actin-related protein (Arp) 2/3 complex-mediated actin polymerization. |journal=Biochem. J. |volume=371 |issue= Pt 2 |pages= 485-93 |year= 2003 |pmid= 12534372 |doi= 10.1042/BJ20021791 }}
*{{cite journal   |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal   |vauthors=Brill LM, Salomon AR, Ficarro SB, etal |title=Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry. |journal=Anal. Chem. |volume=76 |issue= 10 |pages= 2763–72 |year= 2004 |pmid= 15144186 |doi= 10.1021/ac035352d }}
*{{cite journal | author=Brill LM, Salomon AR, Ficarro SB, ''et al.'' |title=Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry. |journal=Anal. Chem. |volume=76 |issue= 10 |pages= 2763-72 |year= 2004 |pmid= 15144186 |doi= 10.1021/ac035352d }}
}}
}}
{{refend}}
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Revision as of 13:29, 31 August 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Hematopoietic lineage cell-specific protein is a protein that in humans is encoded by the HCLS1 gene.[1][2][3]

Interactions

HCLS1 has been shown to interact with Caspase 3.[4][5]

References

  1. ↑ Egashira M, Kitamura D, Watanabe T, Niikawa N (Jan 1997). "The human HCLS1 gene maps to chromosome 3q13 by fluorescence in situ hybridization". Cytogenet Cell Genet. 72 (2–3): 175–6. doi:10.1159/000134179. PMID 8978766.
  2. ↑ van Rossum AG, Schuuring-Scholtes E, van Buuren-van Seggelen V, Kluin PM, Schuuring E (Mar 2005). "Comparative genome analysis of cortactin and HS1: the significance of the F-actin binding repeat domain". BMC Genomics. 6: 15. doi:10.1186/1471-2164-6-15. PMC 554100. PMID 15710041.
  3. ↑ "Entrez Gene: HCLS1 hematopoietic cell-specific Lyn substrate 1".
  4. ↑ Ruzzene, Maria; Penzo Daniele; Pinna Lorenzo A (May 2002). "Protein kinase CK2 inhibitor 4,5,6,7-tetrabromobenzotriazole (TBB) induces apoptosis and caspase-dependent degradation of haematopoietic lineage cell-specific protein 1 (HS1) in Jurkat cells". Biochem. J. England. 364 (Pt 1): 41–7. doi:10.1042/bj3640041. ISSN 0264-6021. PMC 1222543. PMID 11988074.
  5. ↑ Chen, Y R; Kori R; John B; Tan T H (Nov 2001). "Caspase-mediated cleavage of actin-binding and SH3-domain-containing proteins cortactin, HS1, and HIP-55 during apoptosis". Biochem. Biophys. Res. Commun. United States. 288 (4): 981–9. doi:10.1006/bbrc.2001.5862. ISSN 0006-291X. PMID 11689006.

Further reading



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