SYT2: Difference between revisions

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{{Infobox_gene}}
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'''Synaptotagmin-2''' is a [[protein]] that in humans is encoded by the ''SYT2'' [[gene]].<ref name="pmid7749232">{{cite journal | vauthors = Jones JM, Popma SJ, Mizuta M, Seino S, Meisler MH | title = Synaptotagmin genes on mouse chromosomes 1, 7, and 10 and human chromosome 19 | journal = Mammalian Genome | volume = 6 | issue = 3 | pages = 212–3 | date = March 1995 | pmid = 7749232 | pmc = | doi = 10.1007/BF00293017 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: SYT2 synaptotagmin II| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=127833| accessdate = }}</ref>
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== References ==
{{GNF_Protein_box
{{reflist}}
| image = 
| image_source = 
| PDB =
| Name = Synaptotagmin II
| HGNCid = 11510
| Symbol = SYT2
| AltSymbols =; SytII
| OMIM = 600104
| ECnumber = 
| Homologene = 22516
| MGIid = 99666
| GeneAtlas_image1 = PBB_GE_SYT2_214903_at_tn.png
| Function = {{GNF_GO|id=GO:0005215 |text = transporter activity}} {{GNF_GO|id=GO:0005509 |text = calcium ion binding}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0005544 |text = calcium-dependent phospholipid binding}}
| Component = {{GNF_GO|id=GO:0005886 |text = plasma membrane}} {{GNF_GO|id=GO:0008021 |text = synaptic vesicle}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}} {{GNF_GO|id=GO:0042598 |text = vesicular fraction}} {{GNF_GO|id=GO:0045202 |text = synapse}}
| Process = {{GNF_GO|id=GO:0006810 |text = transport}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 127833
    | Hs_Ensembl = ENSG00000143858
    | Hs_RefseqProtein = NP_796376
    | Hs_RefseqmRNA = NM_177402
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 1
    | Hs_GenLoc_start = 200826347
    | Hs_GenLoc_end = 200946168
    | Hs_Uniprot = Q8N9I0
    | Mm_EntrezGene = 20980
    | Mm_Ensembl = ENSMUSG00000026452
    | Mm_RefseqmRNA = NM_009307
    | Mm_RefseqProtein = NP_033333
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 1
    | Mm_GenLoc_start = 136525717
    | Mm_GenLoc_end = 136565477
    | Mm_Uniprot = Q5DTI3
  }}
}}
'''Synaptotagmin II''', also known as '''SYT2''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: SYT2 synaptotagmin II| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=127833| accessdate = }}</ref>


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== Further reading ==
{{PBB_Summary
| section_title =
| summary_text =
}}
 
==References==
{{reflist|2}}
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Fukuda M, Aruga J, Niinobe M, Aimoto S, Mikoshiba K | title = Inositol-1,3,4,5-tetrakisphosphate binding to C2B domain of IP4BP/synaptotagmin II | journal = The Journal of Biological Chemistry | volume = 269 | issue = 46 | pages = 29206–11 | date = November 1994 | pmid = 7961887 | doi =  }}
| citations =
* {{cite journal | vauthors = Perin MS | title = Mirror image motifs mediate the interaction of the COOH terminus of multiple synaptotagmins with the neurexins and calmodulin | journal = Biochemistry | volume = 35 | issue = 43 | pages = 13808–16 | date = October 1996 | pmid = 8901523 | doi = 10.1021/bi960853x }}
*{{cite journal  | author=Jones JM, Popma SJ, Mizuta M, ''et al.'' |title=Synaptotagmin genes on mouse chromosomes 1, 7, and 10 and human chromosome 19. |journal=Mamm. Genome |volume=6 |issue= 3 |pages= 212-3 |year= 1995 |pmid= 7749232 |doi=  }}
* {{cite journal | vauthors = Baram D, Adachi R, Medalia O, Tuvim M, Dickey BF, Mekori YA, Sagi-Eisenberg R | title = Synaptotagmin II negatively regulates Ca2+-triggered exocytosis of lysosomes in mast cells | journal = The Journal of Experimental Medicine | volume = 189 | issue = 10 | pages = 1649–58 | date = May 1999 | pmid = 10330444 | pmc = 2193646 | doi = 10.1084/jem.189.10.1649 }}
*{{cite journal | author=Fukuda M, Aruga J, Niinobe M, ''et al.'' |title=Inositol-1,3,4,5-tetrakisphosphate binding to C2B domain of IP4BP/synaptotagmin II. |journal=J. Biol. Chem. |volume=269 |issue= 46 |pages= 29206-11 |year= 1994 |pmid= 7961887 |doi=  }}
* {{cite journal | vauthors = Mizutani A, Fukuda M, Ibata K, Shiraishi Y, Mikoshiba K | title = SYNCRIP, a cytoplasmic counterpart of heterogeneous nuclear ribonucleoprotein R, interacts with ubiquitous synaptotagmin isoforms | journal = The Journal of Biological Chemistry | volume = 275 | issue = 13 | pages = 9823–31 | date = March 2000 | pmid = 10734137 | doi = 10.1074/jbc.275.13.9823 }}
*{{cite journal | author=Perin MS |title=Mirror image motifs mediate the interaction of the COOH terminus of multiple synaptotagmins with the neurexins and calmodulin. |journal=Biochemistry |volume=35 |issue= 43 |pages= 13808-16 |year= 1996 |pmid= 8901523 |doi= 10.1021/bi960853x }}
* {{cite journal | vauthors = Kida Y, Sakaguchi M, Fukuda M, Mikoshiba K, Mihara K | title = Membrane topogenesis of a type I signal-anchor protein, mouse synaptotagmin II, on the endoplasmic reticulum | journal = The Journal of Cell Biology | volume = 150 | issue = 4 | pages = 719–30 | date = August 2000 | pmid = 10952998 | pmc = 2175286 | doi = 10.1083/jcb.150.4.719 }}
*{{cite journal | author=Baram D, Adachi R, Medalia O, ''et al.'' |title=Synaptotagmin II negatively regulates Ca2+-triggered exocytosis of lysosomes in mast cells. |journal=J. Exp. Med. |volume=189 |issue= 10 |pages= 1649-58 |year= 1999 |pmid= 10330444 |doi= }}
* {{cite journal | vauthors = Martina JA, Bonangelino CJ, Aguilar RC, Bonifacino JS | title = Stonin 2: an adaptor-like protein that interacts with components of the endocytic machinery | journal = The Journal of Cell Biology | volume = 153 | issue = 5 | pages = 1111–20 | date = May 2001 | pmid = 11381094 | pmc = 2174325 | doi = 10.1083/jcb.153.5.1111 }}
*{{cite journal | author=Mizutani A, Fukuda M, Ibata K, ''et al.'' |title=SYNCRIP, a cytoplasmic counterpart of heterogeneous nuclear ribonucleoprotein R, interacts with ubiquitous synaptotagmin isoforms. |journal=J. Biol. Chem. |volume=275 |issue= 13 |pages= 9823-31 |year= 2000 |pmid= 10734137 |doi= }}
* {{cite journal | vauthors = Kida Y, Sakaguchi M, Fukuda M, Mikoshiba K, Mihara K | title = Amino acid residues before the hydrophobic region which are critical for membrane translocation of the N-terminal domain of synaptotagmin II | journal = FEBS Letters | volume = 507 | issue = 3 | pages = 341–5 | date = November 2001 | pmid = 11696368 | doi = 10.1016/S0014-5793(01)03000-9 }}
*{{cite journal | author=Kida Y, Sakaguchi M, Fukuda M, ''et al.'' |title=Membrane topogenesis of a type I signal-anchor protein, mouse synaptotagmin II, on the endoplasmic reticulum. |journal=J. Cell Biol. |volume=150 |issue= 4 |pages= 719-30 |year= 2000 |pmid= 10952998 |doi= }}
* {{cite journal | vauthors = Lindmark IM, Karlsson A, Serrander L, Francois P, Lew D, Rasmusson B, Stendahl O, Nüsse O | title = Synaptotagmin II could confer Ca(2+) sensitivity to phagocytosis in human neutrophils | journal = Biochimica et Biophysica Acta | volume = 1590 | issue = 1-3 | pages = 159–66 | date = June 2002 | pmid = 12063179 | doi = 10.1016/S0167-4889(02)00209-4 }}
*{{cite journal | author=Martina JA, Bonangelino CJ, Aguilar RC, Bonifacino JS |title=Stonin 2: an adaptor-like protein that interacts with components of the endocytic machinery. |journal=J. Cell Biol. |volume=153 |issue= 5 |pages= 1111-20 |year= 2001 |pmid= 11381094 |doi= }}
* {{cite journal | vauthors = Rickman C, Archer DA, Meunier FA, Craxton M, Fukuda M, Burgoyne RD, Davletov B | title = Synaptotagmin interaction with the syntaxin/SNAP-25 dimer is mediated by an evolutionarily conserved motif and is sensitive to inositol hexakisphosphate | journal = The Journal of Biological Chemistry | volume = 279 | issue = 13 | pages = 12574–9 | date = March 2004 | pmid = 14709554 | doi = 10.1074/jbc.M310710200 }}
*{{cite journal | author=Kida Y, Sakaguchi M, Fukuda M, ''et al.'' |title=Amino acid residues before the hydrophobic region which are critical for membrane translocation of the N-terminal domain of synaptotagmin II. |journal=FEBS Lett. |volume=507 |issue= 3 |pages= 341-5 |year= 2001 |pmid= 11696368 |doi= }}
* {{cite journal | vauthors = Lee BH, Min X, Heise CJ, Xu BE, Chen S, Shu H, Luby-Phelps K, Goldsmith EJ, Cobb MH | title = WNK1 phosphorylates synaptotagmin 2 and modulates its membrane binding | journal = Molecular Cell | volume = 15 | issue = 5 | pages = 741–51 | date = September 2004 | pmid = 15350218 | doi = 10.1016/j.molcel.2004.07.018 }}
*{{cite journal | author=Lindmark IM, Karlsson A, Serrander L, ''et al.'' |title=Synaptotagmin II could confer Ca(2+) sensitivity to phagocytosis in human neutrophils. |journal=Biochim. Biophys. Acta |volume=1590 |issue= 1-3 |pages= 159-66 |year= 2002 |pmid= 12063179 |doi=  }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal | author=Rickman C, Archer DA, Meunier FA, ''et al.'' |title=Synaptotagmin interaction with the syntaxin/SNAP-25 dimer is mediated by an evolutionarily conserved motif and is sensitive to inositol hexakisphosphate. |journal=J. Biol. Chem. |volume=279 |issue= 13 |pages= 12574-9 |year= 2004 |pmid= 14709554 |doi= 10.1074/jbc.M310710200 }}
*{{cite journal | author=Lee BH, Min X, Heise CJ, ''et al.'' |title=WNK1 phosphorylates synaptotagmin 2 and modulates its membrane binding. |journal=Mol. Cell |volume=15 |issue= 5 |pages= 741-51 |year= 2004 |pmid= 15350218 |doi= 10.1016/j.molcel.2004.07.018 }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
}}
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{{refend}}


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{{Vesicular transport proteins}}
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Revision as of 02:28, 27 October 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Synaptotagmin-2 is a protein that in humans is encoded by the SYT2 gene.[1][2]

References

  1. ↑ Jones JM, Popma SJ, Mizuta M, Seino S, Meisler MH (March 1995). "Synaptotagmin genes on mouse chromosomes 1, 7, and 10 and human chromosome 19". Mammalian Genome. 6 (3): 212–3. doi:10.1007/BF00293017. PMID 7749232.
  2. ↑ "Entrez Gene: SYT2 synaptotagmin II".

Further reading

Retrieved from "https://www.wikidoc.org/index.php?title=SYT2&oldid=1411277"