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{{Infobox_gene}}
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'''6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2''' is an [[enzyme]] that in humans is encoded by the ''PFKFB2'' [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: PFKFB2 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5208| accessdate = }}</ref>
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{{GNF_Protein_box
| image = 
| image_source = 
| PDB =
| Name = 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2
| HGNCid = 8873
| Symbol = PFKFB2
| AltSymbols =; DKFZp781D2217; MGC138308; MGC138310; PFK-2/FBPase-2
| OMIM = 171835
| ECnumber = 
| Homologene = 88554
| MGIid = 107815
| GeneAtlas_image1 = PBB_GE_PFKFB2_209992_at_tn.png
| GeneAtlas_image2 = PBB_GE_PFKFB2_207931_s_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0003873 |text = 6-phosphofructo-2-kinase activity}} {{GNF_GO|id=GO:0004331 |text = fructose-2,6-bisphosphate 2-phosphatase activity}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0016301 |text = kinase activity}} {{GNF_GO|id=GO:0016740 |text = transferase activity}} {{GNF_GO|id=GO:0016787 |text = hydrolase activity}}
| Component =
| Process = {{GNF_GO|id=GO:0006003 |text = fructose 2,6-bisphosphate metabolic process}} {{GNF_GO|id=GO:0008152 |text = metabolic process}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 5208
    | Hs_Ensembl = ENSG00000123836
    | Hs_RefseqProtein = NP_001018063
    | Hs_RefseqmRNA = NM_001018053
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 1
    | Hs_GenLoc_start = 205293228
    | Hs_GenLoc_end = 205320991
    | Hs_Uniprot = O60825
    | Mm_EntrezGene = 18640
    | Mm_Ensembl = ENSMUSG00000026409
    | Mm_RefseqmRNA = NM_008825
    | Mm_RefseqProtein = NP_032851
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 1
    | Mm_GenLoc_start = 132516728
    | Mm_GenLoc_end = 132543360
    | Mm_Uniprot = Q6GTL7
  }}
}}
'''6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2''', also known as '''PFKFB2''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: PFKFB2 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5208| accessdate = }}</ref>


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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = The protein encoded by this gene is involved in both the synthesis and degradation of fructose-2,6-bisphosphate, a regulatory molecule that controls glycolysis in eukaryotes. The encoded protein has a 6-phosphofructo-2-kinase activity that catalyzes the synthesis of fructose-2,6-bisphosphate, and a fructose-2,6-biphosphatase activity that catalyzes the degradation of fructose-2,6-bisphosphate. This protein regulates fructose-2,6-bisphosphate levels in the heart, while a related enzyme encoded by a different gene regulates fructose-2,6-bisphosphate levels in the liver and muscle. This enzyme functions as a homodimer. Two transcript variants encoding two different isoforms have been found for this gene.<ref name="entrez">{{cite web | title = Entrez Gene: PFKFB2 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5208| accessdate = }}</ref>
| summary_text = The protein encoded by this gene is involved in both the synthesis and degradation of fructose-2,6-bisphosphate, a regulatory molecule that controls glycolysis in eukaryotes. The encoded protein has a 6-phosphofructo-2-kinase activity that catalyzes the synthesis of fructose-2,6-bisphosphate, and a fructose-2,6-biphosphatase activity that catalyzes the degradation of fructose-2,6-bisphosphate. This protein regulates fructose-2,6-bisphosphate levels in the heart, while a related enzyme encoded by a different gene regulates fructose-2,6-bisphosphate levels in the liver and muscle. This enzyme functions as a homodimer. Two transcript variants encoding two different isoforms have been found for this gene.<ref name="entrez">{{cite web | title = Entrez Gene: PFKFB2 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5208| accessdate = }}</ref>
}}
}}
==Interactions==
PFKFB2 has been shown to [[Protein-protein interaction|interact]] with [[YWHAQ]].<ref name=pmid12853467>{{cite journal |last=Pozuelo Rubio |first=Mercedes |authorlink= |author2=Peggie Mark |author3=Wong Barry H C |author4=Morrice Nick |author5=MacKintosh Carol  |date=Jul 2003 |title=14-3-3s regulate fructose-2,6-bisphosphate levels by binding to PKB-phosphorylated cardiac fructose-2,6-bisphosphate kinase/phosphatase |journal=EMBO J. |volume=22 |issue=14 |pages=3514–23 |publisher= |location = England| issn = 0261-4189| pmid = 12853467 |doi = 10.1093/emboj/cdg363 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |pmc=165633 }}</ref>


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal | author=Rider MH, Vandamme J, Lebeau E, ''et al.'' |title=The two forms of bovine heart 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase result from alternative splicing. |journal=Biochem. J. |volume=285 ( Pt 2) |issue=  |pages= 405-11 |year= 1992 |pmid= 1322130 |doi=  }}
*{{cite journal   |vauthors=Rider MH, Vandamme J, Lebeau E, etal |title=The two forms of bovine heart 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase result from alternative splicing. |journal=Biochem. J. |volume=285 |issue=  2|pages= 405–11 |year= 1992 |pmid= 1322130 |doi= | pmc=1132803 }}
*{{cite journal | author=Hilliker CE, Darville MI, Aly MS, ''et al.'' |title=Human and rat chromosomal localization of two genes for 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase by analysis of somatic cell hybrids and in situ hybridization. |journal=Genomics |volume=10 |issue= 4 |pages= 867-73 |year= 1991 |pmid= 1655632 |doi=  }}
*{{cite journal   |vauthors=Hilliker CE, Darville MI, Aly MS, etal |title=Human and rat chromosomal localization of two genes for 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase by analysis of somatic cell hybrids and in situ hybridization. |journal=Genomics |volume=10 |issue= 4 |pages= 867–73 |year= 1991 |pmid= 1655632 |doi=10.1016/0888-7543(91)90174-D }}
*{{cite journal | author=Goldmuntz EA, Remmers EF, Zha H, ''et al.'' |title=Genetic map of seven polymorphic markers comprising a single linkage group on rat chromosome 5. |journal=Mamm. Genome |volume=4 |issue= 11 |pages= 670-5 |year= 1994 |pmid= 7904197 |doi=  }}
*{{cite journal   |vauthors=Goldmuntz EA, Remmers EF, Zha H, etal |title=Genetic map of seven polymorphic markers comprising a single linkage group on rat chromosome 5. |journal=Mamm. Genome |volume=4 |issue= 11 |pages= 670–5 |year= 1994 |pmid= 7904197 |doi=10.1007/BF00360905 }}
*{{cite journal | author=Hirata T, Kato M, Okamura N, ''et al.'' |title=Expression of human placental-type 6-phosphofructo-2-kinase/fructose 2,6-bisphosphatase in various cells and cell lines. |journal=Biochem. Biophys. Res. Commun. |volume=242 |issue= 3 |pages= 680-4 |year= 1998 |pmid= 9464277 |doi= 10.1006/bbrc.1997.8024 }}
*{{cite journal   |vauthors=Hirata T, Kato M, Okamura N, etal |title=Expression of human placental-type 6-phosphofructo-2-kinase/fructose 2,6-bisphosphatase in various cells and cell lines. |journal=Biochem. Biophys. Res. Commun. |volume=242 |issue= 3 |pages= 680–4 |year= 1998 |pmid= 9464277 |doi= 10.1006/bbrc.1997.8024 }}
*{{cite journal  | author=Heine-Suñer D, Díaz-Guillén MA, Lange AJ, Rodríguez de Córdoba S |title=Sequence and structure of the human 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase heart isoform gene (PFKFB2). |journal=Eur. J. Biochem. |volume=254 |issue= 1 |pages= 103-10 |year= 1998 |pmid= 9652401 |doi=  }}
*{{cite journal  |vauthors=Heine-Suñer D, Díaz-Guillén MA, Lange AJ, Rodríguez de Córdoba S |title=Sequence and structure of the human 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase heart isoform gene (PFKFB2). |journal=Eur. J. Biochem. |volume=254 |issue= 1 |pages= 103–10 |year= 1998 |pmid= 9652401 |doi=10.1046/j.1432-1327.1998.2540103.x }}
*{{cite journal | author=Hirata T, Watanabe M, Miura S, ''et al.'' |title=Inhibition of tumor cell growth by a specific 6-phosphofructo-2-kinase inhibitor, N-bromoacetylethanolamine phosphate, and its analogues. |journal=Biosci. Biotechnol. Biochem. |volume=64 |issue= 10 |pages= 2047-52 |year= 2001 |pmid= 11129574 |doi=  }}
*{{cite journal   |vauthors=Hirata T, Watanabe M, Miura S, etal |title=Inhibition of tumor cell growth by a specific 6-phosphofructo-2-kinase inhibitor, N-bromoacetylethanolamine phosphate, and its analogues. |journal=Biosci. Biotechnol. Biochem. |volume=64 |issue= 10 |pages= 2047–52 |year= 2001 |pmid= 11129574 |doi=10.1271/bbb.64.2047 }}
*{{cite journal  | author=Kessler R, Eschrich K |title=Splice isoforms of ubiquitous 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase in human brain. |journal=Brain Res. Mol. Brain Res. |volume=87 |issue= 2 |pages= 190-5 |year= 2001 |pmid= 11245921 |doi=  }}
*{{cite journal  |vauthors=Kessler R, Eschrich K |title=Splice isoforms of ubiquitous 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase in human brain. |journal=Brain Res. Mol. Brain Res. |volume=87 |issue= 2 |pages= 190–5 |year= 2001 |pmid= 11245921 |doi=10.1016/S0169-328X(01)00014-6 }}
*{{cite journal | author=Soejima H, Kawamoto S, Akai J, ''et al.'' |title=Isolation of novel heart-specific genes using the BodyMap database. |journal=Genomics |volume=74 |issue= 1 |pages= 115-20 |year= 2001 |pmid= 11374908 |doi= 10.1006/geno.2001.6527 }}
*{{cite journal   |vauthors=Soejima H, Kawamoto S, Akai J, etal |title=Isolation of novel heart-specific genes using the BodyMap database. |journal=Genomics |volume=74 |issue= 1 |pages= 115–20 |year= 2001 |pmid= 11374908 |doi= 10.1006/geno.2001.6527 }}
*{{cite journal | author=Baltrusch S, Lenzen S, Okar DA, ''et al.'' |title=Characterization of glucokinase-binding protein epitopes by a phage-displayed peptide library. Identification of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase as a novel interaction partner. |journal=J. Biol. Chem. |volume=276 |issue= 47 |pages= 43915-23 |year= 2001 |pmid= 11522786 |doi= 10.1074/jbc.M105470200 }}
*{{cite journal   |vauthors=Baltrusch S, Lenzen S, Okar DA, etal |title=Characterization of glucokinase-binding protein epitopes by a phage-displayed peptide library. Identification of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase as a novel interaction partner. |journal=J. Biol. Chem. |volume=276 |issue= 47 |pages= 43915–23 |year= 2001 |pmid= 11522786 |doi= 10.1074/jbc.M105470200 }}
*{{cite journal  | author=Marsin AS, Bouzin C, Bertrand L, Hue L |title=The stimulation of glycolysis by hypoxia in activated monocytes is mediated by AMP-activated protein kinase and inducible 6-phosphofructo-2-kinase. |journal=J. Biol. Chem. |volume=277 |issue= 34 |pages= 30778-83 |year= 2002 |pmid= 12065600 |doi= 10.1074/jbc.M205213200 }}
*{{cite journal  |vauthors=Marsin AS, Bouzin C, Bertrand L, Hue L |title=The stimulation of glycolysis by hypoxia in activated monocytes is mediated by AMP-activated protein kinase and inducible 6-phosphofructo-2-kinase. |journal=J. Biol. Chem. |volume=277 |issue= 34 |pages= 30778–83 |year= 2002 |pmid= 12065600 |doi= 10.1074/jbc.M205213200 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal | author=Pozuelo Rubio M, Peggie M, Wong BH, ''et al.'' |title=14-3-3s regulate fructose-2,6-bisphosphate levels by binding to PKB-phosphorylated cardiac fructose-2,6-bisphosphate kinase/phosphatase. |journal=EMBO J. |volume=22 |issue= 14 |pages= 3514-23 |year= 2003 |pmid= 12853467 |doi= 10.1093/emboj/cdg363 }}
*{{cite journal   |vauthors=Pozuelo Rubio M, Peggie M, Wong BH, etal |title=14-3-3s regulate fructose-2,6-bisphosphate levels by binding to PKB-phosphorylated cardiac fructose-2,6-bisphosphate kinase/phosphatase. |journal=EMBO J. |volume=22 |issue= 14 |pages= 3514–23 |year= 2003 |pmid= 12853467 |doi= 10.1093/emboj/cdg363 | pmc=165633 }}
*{{cite journal | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal   |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal | author=Jin J, Smith FD, Stark C, ''et al.'' |title=Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization. |journal=Curr. Biol. |volume=14 |issue= 16 |pages= 1436-50 |year= 2004 |pmid= 15324660 |doi= 10.1016/j.cub.2004.07.051 }}
*{{cite journal   |vauthors=Jin J, Smith FD, Stark C, etal |title=Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization. |journal=Curr. Biol. |volume=14 |issue= 16 |pages= 1436–50 |year= 2004 |pmid= 15324660 |doi= 10.1016/j.cub.2004.07.051 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
*{{cite journal | author=Gregory SG, Barlow KF, McLay KE, ''et al.'' |title=The DNA sequence and biological annotation of human chromosome 1. |journal=Nature |volume=441 |issue= 7091 |pages= 315-21 |year= 2006 |pmid= 16710414 |doi= 10.1038/nature04727 }}
*{{cite journal   |vauthors=Gregory SG, Barlow KF, McLay KE, etal |title=The DNA sequence and biological annotation of human chromosome 1. |journal=Nature |volume=441 |issue= 7091 |pages= 315–21 |year= 2006 |pmid= 16710414 |doi= 10.1038/nature04727 }}
}}
}}
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{{Glycolysis enzymes}}
 
 
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Revision as of 17:59, 7 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
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Wikidata
View/Edit Human

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 is an enzyme that in humans is encoded by the PFKFB2 gene.[1]

The protein encoded by this gene is involved in both the synthesis and degradation of fructose-2,6-bisphosphate, a regulatory molecule that controls glycolysis in eukaryotes. The encoded protein has a 6-phosphofructo-2-kinase activity that catalyzes the synthesis of fructose-2,6-bisphosphate, and a fructose-2,6-biphosphatase activity that catalyzes the degradation of fructose-2,6-bisphosphate. This protein regulates fructose-2,6-bisphosphate levels in the heart, while a related enzyme encoded by a different gene regulates fructose-2,6-bisphosphate levels in the liver and muscle. This enzyme functions as a homodimer. Two transcript variants encoding two different isoforms have been found for this gene.[1]

Interactions

PFKFB2 has been shown to interact with YWHAQ.[2]

References

  1. ↑ 1.0 1.1 "Entrez Gene: PFKFB2 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2".
  2. ↑ Pozuelo Rubio, Mercedes; Peggie Mark; Wong Barry H C; Morrice Nick; MacKintosh Carol (Jul 2003). "14-3-3s regulate fructose-2,6-bisphosphate levels by binding to PKB-phosphorylated cardiac fructose-2,6-bisphosphate kinase/phosphatase". EMBO J. England. 22 (14): 3514–23. doi:10.1093/emboj/cdg363. ISSN 0261-4189. PMC 165633. PMID 12853467.

Further reading



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