Sandbox MKK: Difference between revisions

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Common causes <ref name="pmid19683340">{{cite journal| author=Malfertheiner P, Chan FK, McColl KE| title=Peptic ulcer disease. | journal=Lancet | year= 2009 | volume= 374 | issue= 9699 | pages= 1449-61 | pmid=19683340 | doi=10.1016/S0140-6736(09)60938-7 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=19683340  }} </ref>
Common causes <ref name="pmid19683340">{{cite journal| author=Malfertheiner P, Chan FK, McColl KE| title=Peptic ulcer disease. | journal=Lancet | year= 2009 | volume= 374 | issue= 9699 | pages= 1449-61 | pmid=19683340 | doi=10.1016/S0140-6736(09)60938-7 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=19683340  }} </ref>
*Helicobacter pylori(60% gastric and 50-75% duodenal ulcers )
*[[Helicobacter pylori|Helicobacter pylori (]]60% gastric and 50-75% duodenal ulcers )
*Drugs-NSAIDs including aspirin<ref name="pmid11960062">{{cite journal |vauthors=Hirschowitz BI, Lanas A |title=Atypical and aggressive upper gastrointestinal ulceration associated with aspirin abuse |journal=J. Clin. Gastroenterol. |volume=34 |issue=5 |pages=523–8 |year=2002 |pmid=11960062 |doi= |url=}}</ref>
*Drugs-[[Non-steroidal anti-inflammatory drug|NSAIDs]] including [[aspirin]]<ref name="pmid11960062">{{cite journal |vauthors=Hirschowitz BI, Lanas A |title=Atypical and aggressive upper gastrointestinal ulceration associated with aspirin abuse |journal=J. Clin. Gastroenterol. |volume=34 |issue=5 |pages=523–8 |year=2002 |pmid=11960062 |doi= |url=}}</ref>
Less common causes of peptic ulcer disease
Less common causes of peptic ulcer disease
*Hormonal or mediator-induced including secondary acid hypersecretory states  
*Hormonal or mediator-induced including secondary acid hypersecretory states  
**Gastrinomas
**[[Gastrinomas]]
** Systemic mastocytosis
** [[Mastocytosis|Systemic mastocytosis]]
** Carcinoid syndrome
** [[Carcinoid syndrome]]
** Myeloproliferative disorder   
** [[Myeloproliferative disease|Myeloproliferative disorder]]  
*Antral g - cell hyperfunction  
*Antral g - cell hyperfunction  
*Post-surgical -Antral exclusion and post gastric bypass surgery
*Post-surgical -Antral exclusion and post gastric bypass surgery
*Tumors-cancers and lymphoma  
*Tumors-cancers and [[lymphoma]]
*Cameron ulcer (gastric ulcer where a hiatus hernia passes through the diaphragmatic hiatus)
*Cameron [[ulcer]] (gastric ulcer where a [[hiatus hernia]] passes through the [[diaphragmatic hiatus]])
*True idiopathic ulcer.
*True idiopathic ulcer.
'''Rare causes of peptic ulcer disease''' <ref name="pmid19683340">{{cite journal| author=Malfertheiner P, Chan FK, McColl KE| title=Peptic ulcer disease. | journal=Lancet | year= 2009 | volume= 374 | issue= 9699 | pages= 1449-61 | pmid=19683340 | doi=10.1016/S0140-6736(09)60938-7 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=19683340  }} </ref>
'''Rare causes of peptic ulcer disease''' <ref name="pmid19683340">{{cite journal| author=Malfertheiner P, Chan FK, McColl KE| title=Peptic ulcer disease. | journal=Lancet | year= 2009 | volume= 374 | issue= 9699 | pages= 1449-61 | pmid=19683340 | doi=10.1016/S0140-6736(09)60938-7 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=19683340  }} </ref>
* Crohn’s disease of the stomach or duodenum
* [[Crohn's disease|Crohn’s disease]] of the stomach or duodenum
* Eosinophilic gastroduodenitis
* [[Eosinophilic gastroduodenitis]]
* Systemic mastocytosis
* Systemic mastocytosis
* Radiation damage
* Radiation damage
* Viral infections (eg cytomegalovirus or herpes simplex infection, in particular in immunocompromised patients)
* Viral infections (eg [[cytomegalovirus]] or [[Herpes simplex|herpes simplex infection]], in particular in immunocompromised patients)
*Colonisation of stomach with H heilmanii
*Colonisation of stomach with H heilmanii
* Severe systemic disease
* Severe systemic disease
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'''Genetic causes''' -<ref name="pmid17312377">{{cite journal| author=Jensen RT, Niederle B, Mitry E, Ramage JK, Steinmuller T, Lewington V et al.| title=Gastrinoma (duodenal and pancreatic). | journal=Neuroendocrinology | year= 2006 | volume= 84 | issue= 3 | pages= 173-82 | pmid=17312377 | doi=10.1159/000098009 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=17312377  }} </ref>
'''Genetic causes''' -<ref name="pmid17312377">{{cite journal| author=Jensen RT, Niederle B, Mitry E, Ramage JK, Steinmuller T, Lewington V et al.| title=Gastrinoma (duodenal and pancreatic). | journal=Neuroendocrinology | year= 2006 | volume= 84 | issue= 3 | pages= 173-82 | pmid=17312377 | doi=10.1159/000098009 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=17312377  }} </ref>
*Peptic ulcer disease is caused by gastrinomas (Zollinger-Ellison syndrome)caused by a mutation in MEN gene present on chromosome 11q13.
*Peptic ulcer disease is caused by gastrinomas [[Zollinger-Ellison syndrome|(Zollinger-Ellison syndrome]])caused by a mutation in MEN gene present on chromosome 11q13.


===Causes by organ system===
===Causes by organ system===

Revision as of 17:13, 13 October 2017

Common causes [1]

Less common causes of peptic ulcer disease

Rare causes of peptic ulcer disease [1]


Genetic causes -[3]

  • Peptic ulcer disease is caused by gastrinomas (Zollinger-Ellison syndrome)caused by a mutation in MEN gene present on chromosome 11q13.

Causes by organ system

  • To obtain the coding for the table seen below, click here. You need to copy the table content from the edit box, and paste it into the edit box.
  • You can then list the causes by organ system. List the causes, separated by a comma under the appropriate category where it says "No underlying causes". Erase "No underlying causes" if you are listing causes in that category.
  • For an example of the causes by organ system table in a causes microchapter, click here.
Cardiovascular No underlying causes
Chemical/Poisoning No underlying causes
Dental No underlying causes
Dermatologic Rosacea,Chronic idiopathic urticaria ,Psoriasis vulgaris ,Behcet's disease ,Alopecia areata,Sweet's syndrome [4]
Drug Side Effect serotonin reuptake -NSAIDs,Clopidogrel,spironolactone,sirolimus,bisphosphonates (when combined with NSAIDs),mycophenolate mofetil,spironolactone ,chemotherapy (hepatic infusion of 5 - fluorouracil ,selective serotonin reuptake inhibitor
Ear Nose Throat No underlying causes
Endocrine Diabetes mellitus
Environmental smoking, excess alcohol consumption, caffeine ,more common in patients with Diabetes Mellitus ,hypertension ,metabolic syndrome[5]
Gastroenterologic Crohn’s disease of the stomach or duodenum, Eosinophilic gastroduodenitis
Genetic No underlying causes
Hematologic No underlying causes
Iatrogenic No underlying causes
Infectious Disease No underlying causes
Musculoskeletal/Orthopedic No underlying causes
Neurologic No underlying causes
Nutritional/Metabolic No underlying causes
Obstetric/Gynecologic No underlying causes
Oncologic Non-beta cell tumor , carcinoid syndrome , gastrinomas
Ophthalmologic No underlying causes
Overdose/Toxicity No underlying causes
Psychiatric severe stress, depressed mood, suicidal ideation and psychological counseling [5]
Pulmonary COPD,Sarcoidosis
Renal/Electrolyte Hypercalcemia
Rheumatology/Immunology/Allergy Fibromyalgia[6]
Sexual No underlying causes
Trauma Cushing ulcers
Urologic No underlying causes
Miscellaneous No underlying causes

Causes in alphabetical order[edit | edit source] List the causes of the disease in alphabetical order.

Cause 1 Alopecia areata Cause 2 Behcet's disease Cause 3 caffeine Cause 4 Cause 5 Cause 6 Cause 7 Cause 8 Cause 9 Cause 10

  1. ↑ 1.0 1.1 Malfertheiner P, Chan FK, McColl KE (2009). "Peptic ulcer disease". Lancet. 374 (9699): 1449–61. doi:10.1016/S0140-6736(09)60938-7. PMID 19683340.
  2. ↑ Hirschowitz BI, Lanas A (2002). "Atypical and aggressive upper gastrointestinal ulceration associated with aspirin abuse". J. Clin. Gastroenterol. 34 (5): 523–8. PMID 11960062.
  3. ↑ Jensen RT, Niederle B, Mitry E, Ramage JK, Steinmuller T, Lewington V; et al. (2006). "Gastrinoma (duodenal and pancreatic)". Neuroendocrinology. 84 (3): 173–82. doi:10.1159/000098009. PMID 17312377.
  4. ↑ Kutlubay Z, Zara T, Engin B, Serdaroğlu S, Tüzün Y, Yilmaz E; et al. (2014). "Helicobacter pylori infection and skin disorders". Hong Kong Med J. 20 (4): 317–24. doi:10.12809/hkmj134174. PMID 25045884.
  5. ↑ 5.0 5.1 Lee YB, Yu J, Choi HH, Jeon BS, Kim HK, Kim SW; et al. (2017). "The association between peptic ulcer diseases and mental health problems: A population-based study: a STROBE compliant article". Medicine (Baltimore). 96 (34): e7828. doi:10.1097/MD.0000000000007828. PMC 5572011. PMID 28834889.
  6. ↑ Wang KA, Wang JC, Lin CL, Tseng CH (2017) Association between fibromyalgia syndrome and peptic ulcer disease development. PLoS One 12 (4):e0175370. DOI:10.1371/journal.pone.0175370 PMID: 28384332
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