Sandbox MKK: Difference between revisions

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Dental No underlying causes
Dental No underlying causes
Dermatologic No underlying causes
Dermatologic No underlying causes
Drug Side Effect No underlying causes
Drug Side Effect -<ref name="pmid17312377">{{cite journal| author=Jensen RT, Niederle B, Mitry E, Ramage JK, Steinmuller T, Lewington V et al.| title=Gastrinoma (duodenal and pancreatic). | journal=Neuroendocrinology | year= 2006 | volume= 84 | issue= 3 | pages= 173-82 | pmid=17312377 | doi=10.1159/000098009 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=17312377  }} </ref>
*Peptic ulcer disease is caused by gastrinomas (Zollinger-Ellison syndrome)caused by a mutation in MEN gene present on chromosome 11q13.
Ear Nose Throat No underlying causes
Ear Nose Throat No underlying causes
Endocrine No underlying causes
Endocrine No underlying causes
Environmental No underlying causes
Environmental <ref name="pmid28834889">{{cite journal| author=Lee YB, Yu J, Choi HH, Jeon BS, Kim HK, Kim SW et al.| title=The association between peptic ulcer diseases and mental health problems: A population-based study: a STROBE compliant article. | journal=Medicine (Baltimore) | year= 2017 | volume= 96 | issue= 34 | pages= e7828 | pmid=28834889 | doi=10.1097/MD.0000000000007828 | pmc=5572011 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=28834889  }} </ref>-smoking, excess alcohol consumption, caffeine intake ,more common in patients with Diabetes Mellitus ,hypertension ,metabolic syndrome
Gastroenterologic No underlying causes
Gastroenterologic-Crohn's disease, Eosinophilic gastroduodenitis.
Genetic No underlying causes
Genetic --<ref name="pmid17312377">{{cite journal| author=Jensen RT, Niederle B, Mitry E, Ramage JK, Steinmuller T, Lewington V et al.| title=Gastrinoma (duodenal and pancreatic). | journal=Neuroendocrinology | year= 2006 | volume= 84 | issue= 3 | pages= 173-82 | pmid=17312377 | doi=10.1159/000098009 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=17312377  }} </ref>
*Peptic ulcer disease is caused by gastrinomas (Zollinger-Ellison syndrome)caused by a mutation in MEN gene present on chromosome 11q13.
Hematologic No underlying causes
Hematologic No underlying causes
Iatrogenic No underlying causes
Iatrogenic No underlying causes
Infectious Disease No underlying causes
Infectious Disease Bacteria: Helicobacter pylori (60% gastric and 50-75% duodenal ulcers ), Viruses:cytomegalovirus,herpes simplex type 1.
Musculoskeletal/Orthopedic No underlying causes
Musculoskeletal/Orthopedic No underlying cause
Neurologic No underlying causes
Neurologic No underlying causes
Nutritional/Metabolic No underlying causes
Nutritional/Metabolic No underlying causes
Obstetric/Gynecologic No underlying causes
Obstetric/Gynecologic No underlying causes
Oncologic No underlying causes
Oncologic non-beta cell tumor, carcinoid syndrome, gastrinomas
Ophthalmologic No underlying causes
Ophthalmologic No underlying causes
Overdose/Toxicity No underlying causes
Overdose/Toxicity No underlying causes
Psychiatric No underlying causes
Psychiatric severe stress, depressed mood, suicidal ideation and psychological counseling
Pulmonary No underlying causes
Pulmonary No underlying causes
Renal/Electrolyte No underlying causes
Renal/Electrolyte No underlying causes

Revision as of 15:23, 13 October 2017

Common causes[edit | edit source][1]

  • Helicobacter pylori(60% gastric and 50-75% duodenal ulcers ).
  • Drugs-NSAIDs including aspirin{[2]

Less common causes of peptic ulcer disease

  • Hormonal or mediator-induced including secondary acid hypersecretory states
    • Gastrinomas
    • systemic mastocytosis
    • carcinoid syndrome
    • myeloproliferative disorder
    • antral g - cell hyperfunction.
  • Post-surgical -Antral exclusion and post gastric bypass surgery.
  • Tumors-cancers and lymphoma
  • Cameron ulcer (gastric ulcer where a hiatus hernia passes

through the diaphragmatic hiatus)

  • True idiopathic ulcer.

Rare causes of peptic ulcer disease [1]

  • Crohn’s disease of the stomach or duodenum
  • Eosinophilic gastroduodenitis
  • Systemic mastocytosis
  • Radiation damage
  • Viral infections (eg, cytomegalovirus or herpes simplex

infection, in particular in immunocompromised patients)

  • Colonisation of stomach with H heilmanii
  • Severe systemic disease


Genetic causes -[3]

  • Peptic ulcer disease is caused by gastrinomas (Zollinger-Ellison syndrome)caused by a mutation in MEN gene present on chromosome 11q13.

Causes by organ system[edit | edit source] To obtain the coding for the table seen below, click here. You need to copy the table content from the edit box, and paste it into the edit box. You can then list the causes by organ system. List the causes, separated by a comma under the appropriate category where it says "No underlying causes". Erase "No underlying causes" if you are listing causes in that category. For an example of the causes by organ system table in a causes microchapter, click here. Cardiovascular No underlying causes Chemical/Poisoning No underlying causes Dental No underlying causes Dermatologic No underlying causes Drug Side Effect -[3]

  • Peptic ulcer disease is caused by gastrinomas (Zollinger-Ellison syndrome)caused by a mutation in MEN gene present on chromosome 11q13.

Ear Nose Throat No underlying causes Endocrine No underlying causes Environmental [4]-smoking, excess alcohol consumption, caffeine intake ,more common in patients with Diabetes Mellitus ,hypertension ,metabolic syndrome Gastroenterologic-Crohn's disease, Eosinophilic gastroduodenitis. Genetic --[3]

  • Peptic ulcer disease is caused by gastrinomas (Zollinger-Ellison syndrome)caused by a mutation in MEN gene present on chromosome 11q13.

Hematologic No underlying causes Iatrogenic No underlying causes Infectious Disease Bacteria: Helicobacter pylori (60% gastric and 50-75% duodenal ulcers ), Viruses:cytomegalovirus,herpes simplex type 1. Musculoskeletal/Orthopedic No underlying cause Neurologic No underlying causes Nutritional/Metabolic No underlying causes Obstetric/Gynecologic No underlying causes Oncologic non-beta cell tumor, carcinoid syndrome, gastrinomas Ophthalmologic No underlying causes Overdose/Toxicity No underlying causes Psychiatric severe stress, depressed mood, suicidal ideation and psychological counseling Pulmonary No underlying causes Renal/Electrolyte No underlying causes Rheumatology/Immunology/Allergy No underlying causes Sexual No underlying causes Trauma No underlying causes Urologic No underlying causes Miscellaneous No underlying causes Causes in alphabetical order[edit | edit source] List the causes of the disease in alphabetical order.

Cause 1 Cause 2 Cause 3 Cause 4 Cause 5 Cause 6 Cause 7 Cause 8 Cause 9 Cause 10

  1. 1.0 1.1 Malfertheiner P, Chan FK, McColl KE (2009). "Peptic ulcer disease". Lancet. 374 (9699): 1449–61. doi:10.1016/S0140-6736(09)60938-7. PMID 19683340.
  2. Hirschowitz BI, Lanas A (2002). "Atypical and aggressive upper gastrointestinal ulceration associated with aspirin abuse". J. Clin. Gastroenterol. 34 (5): 523–8. PMID 11960062.
  3. 3.0 3.1 3.2 Jensen RT, Niederle B, Mitry E, Ramage JK, Steinmuller T, Lewington V; et al. (2006). "Gastrinoma (duodenal and pancreatic)". Neuroendocrinology. 84 (3): 173–82. doi:10.1159/000098009. PMID 17312377.
  4. Lee YB, Yu J, Choi HH, Jeon BS, Kim HK, Kim SW; et al. (2017). "The association between peptic ulcer diseases and mental health problems: A population-based study: a STROBE compliant article". Medicine (Baltimore). 96 (34): e7828. doi:10.1097/MD.0000000000007828. PMC 5572011. PMID 28834889.