Hypoparathyroidism natural history, complications and prognosis: Difference between revisions
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===Natural History=== | ===Natural History=== | ||
*The symptoms of | *The symptoms of hypoparathyroidism usually develop due to hypocalcemia.<ref name="pmid23043192">{{cite journal |vauthors=Mitchell DM, Regan S, Cooley MR, Lauter KB, Vrla MC, Becker CB, Burnett-Bowie SA, Mannstadt M |title=Long-term follow-up of patients with hypoparathyroidism |journal=J. Clin. Endocrinol. Metab. |volume=97 |issue=12 |pages=4507–14 |year=2012 |pmid=23043192 |pmc=3513540 |doi=10.1210/jc.2012-1808 |url=}}</ref> | ||
* | *There is an increased risk of renal complications due to hypercalciuria in patients treated with calcium and vitamin D analogs. | ||
*If left untreated, [#]% of patients with [disease name] may progress to develop [manifestation 1], [manifestation 2], and [manifestation 3]. | *If left untreated, [#]% of patients with [disease name] may progress to develop [manifestation 1], [manifestation 2], and [manifestation 3]. | ||
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***Nephrolithiasis | ***Nephrolithiasis | ||
***Nephrocalcinosis | ***Nephrocalcinosis | ||
***renal | ***Impaired renal function | ||
**Symptomatic hypocalcemia and hypercalcemia | **Symptomatic hypocalcemia and hypercalcemia | ||
**Basal ganglia calcifications | **Basal ganglia calcifications<ref name="pmid22288727">{{cite journal |vauthors=Goswami R, Sharma R, Sreenivas V, Gupta N, Ganapathy A, Das S |title=Prevalence and progression of basal ganglia calcification and its pathogenic mechanism in patients with idiopathic hypoparathyroidism |journal=Clin. Endocrinol. (Oxf) |volume=77 |issue=2 |pages=200–6 |year=2012 |pmid=22288727 |doi=10.1111/j.1365-2265.2012.04353.x |url=}}</ref> | ||
**Complications of iv calcium extravasation | **Complications of iv calcium extravasation | ||
**Hypocalcemia seizure | **Hypocalcemia seizure | ||
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===Prognosis=== | ===Prognosis=== | ||
*Prognosis is generally excellent/good/poor, and the 1/5/10-year mortality/survival rate of patients with [disease name] is approximately [#]%. | *Prognosis is generally excellent/good/poor, and the 1/5/10-year mortality/survival rate of patients with [disease name] is approximately [#]%. | ||
*Hypocalcemia due to hypoparathyroidism leads to complications irrespective of treatment.<ref name="pmid23043192">{{cite journal |vauthors=Mitchell DM, Regan S, Cooley MR, Lauter KB, Vrla MC, Becker CB, Burnett-Bowie SA, Mannstadt M |title=Long-term follow-up of patients with hypoparathyroidism |journal=J. Clin. Endocrinol. Metab. |volume=97 |issue=12 |pages=4507–14 |year=2012 |pmid=23043192 |pmc=3513540 |doi=10.1210/jc.2012-1808 |url=}}</ref> | |||
*Depending on the extent of the [tumor/disease progression/etc.] at the time of diagnosis, the prognosis may vary. However, the prognosis is generally regarded as poor/good/excellent. | *Depending on the extent of the [tumor/disease progression/etc.] at the time of diagnosis, the prognosis may vary. However, the prognosis is generally regarded as poor/good/excellent. | ||
*The presence of [characteristic of disease] is associated with a particularly [good/poor] prognosis among patients with [disease/malignancy]. | *The presence of [characteristic of disease] is associated with a particularly [good/poor] prognosis among patients with [disease/malignancy]. |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Omodamola Aje B.Sc, M.D. [2]
Overview
If left untreated, [#]% of patients with [disease name] may progress to develop [manifestation 1], [manifestation 2], and [manifestation 3].
OR
Common complications of [disease name] include [complication 1], [complication 2], and [complication 3].
OR
Prognosis is generally excellent/good/poor, and the 1/5/10-year mortality/survival rate of patients with [disease name] is approximately [#]%.
Natural History, Complications, and Prognosis
Natural History
- The symptoms of hypoparathyroidism usually develop due to hypocalcemia.[1]
- There is an increased risk of renal complications due to hypercalciuria in patients treated with calcium and vitamin D analogs.
- If left untreated, [#]% of patients with [disease name] may progress to develop [manifestation 1], [manifestation 2], and [manifestation 3].
Complications
- Common complications of hypoparathyroidism include:[1]
- Renal complications
- Nephrolithiasis
- Nephrocalcinosis
- Impaired renal function
- Symptomatic hypocalcemia and hypercalcemia
- Basal ganglia calcifications[2]
- Complications of iv calcium extravasation
- Hypocalcemia seizure
- Dilated cardiomyopathy
- Pathologic fractures
- Renal complications
Prognosis
- Prognosis is generally excellent/good/poor, and the 1/5/10-year mortality/survival rate of patients with [disease name] is approximately [#]%.
- Hypocalcemia due to hypoparathyroidism leads to complications irrespective of treatment.[1]
- Depending on the extent of the [tumor/disease progression/etc.] at the time of diagnosis, the prognosis may vary. However, the prognosis is generally regarded as poor/good/excellent.
- The presence of [characteristic of disease] is associated with a particularly [good/poor] prognosis among patients with [disease/malignancy].
- [Subtype of disease/malignancy] is associated with the most favorable prognosis.
- The prognosis varies with the [characteristic] of tumor; [subtype of disease/malignancy] have the most favorable prognosis.
References
- ↑ 1.0 1.1 1.2 Mitchell DM, Regan S, Cooley MR, Lauter KB, Vrla MC, Becker CB, Burnett-Bowie SA, Mannstadt M (2012). "Long-term follow-up of patients with hypoparathyroidism". J. Clin. Endocrinol. Metab. 97 (12): 4507–14. doi:10.1210/jc.2012-1808. PMC 3513540. PMID 23043192.
- ↑ Goswami R, Sharma R, Sreenivas V, Gupta N, Ganapathy A, Das S (2012). "Prevalence and progression of basal ganglia calcification and its pathogenic mechanism in patients with idiopathic hypoparathyroidism". Clin. Endocrinol. (Oxf). 77 (2): 200–6. doi:10.1111/j.1365-2265.2012.04353.x. PMID 22288727.