Sandbox:Filariasis pathogenesis: Difference between revisions
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* Infected mosquito bite introduces the third stage larva onto the skin and then enters to the blood through the wound. | * Infected mosquito bite introduces the third stage larva onto the skin and then enters to the blood through the wound. | ||
* The larvae reside in the lymphatic vessels | * The larvae develop to adult which reside in the '''lymphatic vessels'''. | ||
* Adult worm produce sheathed microfiliae that migrate to lymph and blood. They have nocturnal periodicity. | * Adult worm produce sheathed microfiliae that migrate to lymph and blood. They have '''nocturnal periodicity'''. | ||
* Another mosquito ingests the microfiliae. | * Another mosquito ingests the microfiliae. | ||
* The microfilariae lose their sheaths and work their way through the wall of the proventriculus and cardiac portion of the [[midgut]] to reach the thoracic muscles | * The microfilariae lose their sheaths and work their way through the wall of the proventriculus and cardiac portion of the [[midgut]] to reach the thoracic muscles | ||
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* C. silacea | * C. silacea | ||
* C. dimidiata | * C. dimidiata | ||
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|[[Image:L loa LifeCycle.gif|350 px|center]] | * Infected fly bite introduces the third stage larva onto the skin and then enters to the blood through the wound. | ||
| | * The larvae develop to adult which reside in the '''subcutaneous tissue'''. | ||
* Adult worm produce sheathed microfilariae that are found in the blood during day and in the lungs during the non circulating phase. They have '''diurnal periodicity'''. | |||
* Another fly ingests the microfiliae. | |||
* After ingestion, the microfilariae lose their sheaths and migrate from the fly's [[midgut]] through the [[hemocoel]] to the thoracic muscles of the [[arthropod]]. | |||
* Microfiliae grow up inside the fly till third stage larvae. | |||
* The third-stage infective larvae migrate to the fly's proboscis and in another bite the cycle restarts. | |||
| rowspan="3" |[[Image:L loa LifeCycle.gif|350 px|center]] | |||
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* Unlike Loa Loa filaria, Mansonella streptocerca and Onchocerca volvolus produce '''unsheathed non-periodic microfilariae'''. | |||
* Mansonela streptocerca adults residue in the dermis. | |||
* Onchocerca volvulus adults residue mainly in the subcutaneous nodules. Their microfilariae can be found in the peripheral [[blood]], [[urine]], and [[sputum]] but are typically found in the [[skin]] and in the [[Lymphatic|lymphatics]] of connective tissue. | |||
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|[[Mansonella streptocerca]] | |[[Mansonella streptocerca]] | ||
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* Midge (genus Culicoides) | |||
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|[[Onchocerca volvulus]] | |[[Onchocerca volvulus]] | ||
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* Blackfly (genus Simulium) | |||
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| rowspan="2" |Serous cavity filariasis | | rowspan="2" |Serous cavity filariasis |
Revision as of 15:06, 27 June 2017
Type of filariasis | Causative nematode | Vectors | Life cycle | Illustrative image | Comments |
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Lymphatic filariasis | Wuchereria bancrofti |
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Brugia timori and Brugia malayi |
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Subcutaneous filariasis | Loa loa filaria |
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Mansonella streptocerca |
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Onchocerca volvulus |
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Serous cavity filariasis | Mansonella ozzardi | ||||
Mansonella perstans |
Life cycles of the roundworms causing filariasis: