Tropical sprue pathophysiology: Difference between revisions
Jump to navigation
Jump to search
Dima Nimri (talk | contribs) No edit summary |
|||
Line 6: | Line 6: | ||
==Pathophysiology== | ==Pathophysiology== | ||
Pathogenesis of tropical sprue is unclear and multiple theories are proposed.The factors involved in the pathogenesis of tropical sprue include: | |||
*Small intestinal bacterial overgrowth affects the enterocyte brush border activity. Bacteria also affect the duodenal morphology causing villous atrophy and increased number of lymphocytes in the intestinal cells. | |||
*Impaired host immune response resulting in prolonged inflammation of the small bowel | |||
*Reduced gut defense mechanisms | |||
*Intestinal villous atrophy | |||
*Bile acid deconjugation affects the enterohepatic circulation and cause steatorrhea. | |||
*Vitamin B12 deficiency causing megaloblastic change in the intestinal mucuosal epithelium | |||
*Slow mouth to ceacum transit promotes small intestinal bacterial over growth | |||
*Mucosal disaccharidase deficiency | |||
*Post infectious diarrhea: This theory is supported by the occurrence of the disease following an episode of acute gastroenteritis, occurrence of the disease in epidemics in rural areas with poor sanitation, susceptibility of visitors from developed countries to endemic regions and the frequency of small bowel bacterial overgrowth in patients with tropical sprue. | |||
==References== | ==References== |
Revision as of 14:51, 11 April 2017
Tropical sprue Microchapters |
Diagnosis |
---|
Treatment |
Case Studies |
Tropical sprue pathophysiology On the Web |
American Roentgen Ray Society Images of Tropical sprue pathophysiology |
Risk calculators and risk factors for Tropical sprue pathophysiology |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief:
Overview
Pathophysiology
Pathogenesis of tropical sprue is unclear and multiple theories are proposed.The factors involved in the pathogenesis of tropical sprue include:
- Small intestinal bacterial overgrowth affects the enterocyte brush border activity. Bacteria also affect the duodenal morphology causing villous atrophy and increased number of lymphocytes in the intestinal cells.
- Impaired host immune response resulting in prolonged inflammation of the small bowel
- Reduced gut defense mechanisms
- Intestinal villous atrophy
- Bile acid deconjugation affects the enterohepatic circulation and cause steatorrhea.
- Vitamin B12 deficiency causing megaloblastic change in the intestinal mucuosal epithelium
- Slow mouth to ceacum transit promotes small intestinal bacterial over growth
- Mucosal disaccharidase deficiency
- Post infectious diarrhea: This theory is supported by the occurrence of the disease following an episode of acute gastroenteritis, occurrence of the disease in epidemics in rural areas with poor sanitation, susceptibility of visitors from developed countries to endemic regions and the frequency of small bowel bacterial overgrowth in patients with tropical sprue.