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==Historical Perspective==
==Historical Perspective==
Hemophilia is sometimes referred to as “The Royal Disease”, as it affected many members of the English, German, Russian and Spanish monarchies in the 19th and 20th centuries.


==Classification==
==Classification==

Revision as of 07:05, 27 March 2017

Hemophilia A Microchapters

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Fahd Yunus, M.D. [2]

Overview

Hemophilia A is a blood clotting disorder caused by a mutation of the factor VIII gene, leading to a deficiency in Factor VIII. It is the most common hemophilia. Inheritance is X-linked recessive; hence, males are affected while females are carriers or very rarely display a mild phenotype. 1 in 5,000 males are affected.

Historical Perspective

Hemophilia is sometimes referred to as “The Royal Disease”, as it affected many members of the English, German, Russian and Spanish monarchies in the 19th and 20th centuries.

Classification

Pathophysiology

Causes

Differentiating [Disease] from Other Diseases

Epidemiology and Demographics

Risk Factors

Screening

Natural History, Complications, and Prognosis

Natural History

Complications

Prognosis

Diagnosis

Diagnostic Criteria

History and Symptoms

Physical Examination

Laboratory Findings

Imaging Findings

Other Diagnostic Studies

Treatment

Medical Therapy

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Prevention

References

  1. History of Bleeding Disorders | National Hemophilia Foundation. Available at . Accessed on July 30, 2016
  2. How is Hemophilia Diagnosed? – NHLBI, NIH. Available at . Accessed on July 30, 2016
  3. Severity of Hemophilia – World Federation of Hemophilia. Available at . Accessed on July 30,2016
  4. Facts | Hemophilia | NCBDDD | CDC. Available at . Accessed on July 30,2016
  5. Data & Statistics | Hemophilia | NCBDDD | CDC. Available at Accessed on July 30,2016
  6. Handbook of Genetic Counseling/Hemophilia and Von Willebrand Disease – Wikibooks, open books for an open world. Available at Accessed on July 30,2016
  7. Konkle BA, Josephson NC, Nakaya Fletcher S. Hemophilia A. 2000 Sep 21 [Updated 2014 Jun 5]. In: Pagon RA, Adam MP, Ardinger HH, et al., editors. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993-2016. Available from:http://www-ncbi-nlm-nih-gov.laneproxy.stanford.edu/books/NBK1404/


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