Angiodysplasia pathophysiology: Difference between revisions
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Revision as of 13:57, 28 June 2016
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Angiodysplasia Microchapters |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
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Overview
Pathophysiology
Histologically, it resembles telangiectasia. Development is related to age and strain on the bowel wall, which is thought to influence the caliber change and proliferation of the vascular tissue.[1]
Although angiodysplasia is probably quite common, the risk of bleeding is increased in disorders of coagulation. A classic association is Heyde's syndrome (coincidence of aortic valve stenosis and bleeding from angiodysplasia). In this disorder, von Willebrand factor (vWF) is proteolysed due to high shear stress in the highly turbulent blood flow around the aortic valve. vWF is most active in vascular beds with high shear stress, including angiodysplasias, and deficiency of vWF increases the bleeding risk from such lesions.[1]
Warkentin et al argue that apart from aortic valve stenosis, some other conditions that feature high shear stress might also increase the risk of bleeding from angiodysplasia.[1]