Aggressive NK-cell leukemia: Difference between revisions

Jump to navigation Jump to search
VisualWikitext
No edit summary
Line 7: Line 7:
==Overview==
==Overview==


'''Aggressive NK-cell leukemia''' is a disease with an aggressive, systemic proliferation of [[natural killer cells]] (NK cells) and a rapidly declining clinical course.<ref name="cha1">
[http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=9192774&query_hl=4&itool=pubmed_ExternalLink]
Chan JK, Sin VC, Wong KF, Ng CS, Tsang WY, Chan CH, Cheung MM, Lau WH. "Nonnasal lymphoma expressing the natural killer cell marker CD56: a clinicopathologic study of 49 cases of an uncommon aggressive neoplasm." '''Blood'''. 1997 Jun 15;89(12):4501-13. PMID 9192774</ref><ref name="ima1">
[http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=2375924&query_hl=6&itool=pubmed_ExternalLink]
Imamura N, Kusunoki Y, Kawa-Ha K, Yumura K, Hara J, Oda K, Abe K, Dohy H, Inada T, Kajihara H, ''et al''. "Aggressive natural killer cell leukaemia/lymphoma: report of four cases and review of the literature. Possible existence of a new clinical entity originating from the third lineage of lymphoid cells." '''Br J Haematol'''. 1990 May;75(1):49-59. PMID 2375924</ref><ref name="cha2">
[http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=10389582&query_hl=10&itool=pubmed_ExternalLink]
Chan JK. "Natural killer cell neoplasms." '''Anat Pathol'''. 1998;3:77-145. PMID 10389582</ref>


==Historical Perspective==
==Historical Perspective==
*Aggressive NK-cell leukemia was first discovered by [scientist name], a [nationality + occupation], in [year] during/following [event].
*Aggressive NK-cell leukemia was first discovered by [scientist name], a [nationality + occupation], in [year] during/following [event].
*In [year], [gene] mutations were first identified in the pathogenesis of aggressive NK-cell leukemia.
*In [year], the first [discovery] was developed by [scientist] to treat/diagnose aggressive NK-cell leukemia.
   
   
==Classification==
==Classification==
*Aggressive NK-cell leukemia may be classified according to [classification method] into [number] subtypes/groups:
*There is no classification system for aggressive NK-cell leukemia.  
:*[group1]
:*[group2]
:*[group3]
*Other variants of aggressive NK-cell leukemia include [disease subtype 1], [disease subtype 2], and [disease subtype 3].
==Pathophysiology==
==Pathophysiology==
*The pathogenesis of aggressive NK-cell leukemia is characterized by [feature1], [feature2], and [feature3].
*The pathogenesis of aggressive NK-cell leukemia is characterized by:
*The [gene name] gene/Mutation in [gene name] has been associated with the development of aggressive NK-cell leukemia, involving the [molecular pathway] pathway.
:*
*On gross pathology, [feature1], [feature2], and [feature3] are characteristic findings of aggressive NK-cell leukemia.
:*
*On microscopic histopathological analysis, [feature1], [feature2], and [feature3] are characteristic findings of aggressive NK-cell leukemia.
:*
*The XXXX has been associated with the development of aggressive NK-cell leukemia, involving the [molecular pathway] pathway.
*On gross pathology, characteristic findings of aggressive NK-cell leukemia, include:
:*
:*
:*
*On microscopic histopathological analysis, characteristic findings of aggressive NK-cell leukemia, include:
:*
:*
:*
   
   
==Causes==
==Causes==
* Aggressive NK-cell leukemia may be caused by either [cause1], [cause2], or [cause3].
* Aggressive NK-cell leukemia is caused by a mutation in the [gene1], [gene2], or [gene3] gene[s].
* There are no established causes for aggressive NK-cell leukemia.
* There are no established causes for aggressive NK-cell leukemia.
   
   
Line 60: Line 67:
   
   
==Risk Factors==
==Risk Factors==
*Common risk factors in the development of aggressive NK-cell leukemia are [risk factor 1], [risk factor 2], [risk factor 3], and [risk factor 4].
*Common risk factors in the development of aggressive NK-cell leukemia, include:
   
   
== Natural History, Complications and Prognosis==
== Natural History, Complications and Prognosis==
*The majority of patients with aggressive NK-cell leukemia remain asymptomatic for [duration/years].  
*The majority of patients with aggressive NK-cell leukemia are symptomatic at diagnosis.  
*Early clinical features include [manifestation 1], [manifestation 2], and [manifestation 3].
*Early clinical features include  
*If left untreated, [#%] of patients with aggressive NK-cell leukemia may progress to develop [manifestation 1], [manifestation 2], and [manifestation 3].
*If left untreated, patients with aggressive NK-cell leukemia may progress to develop  
*Common complications of aggressive NK-cell leukemia include [complication 1], [complication 2], and [complication 3].
*Common complications of aggressive NK-cell leukemia include [complication 1], [complication 2], and [complication 3].
*Prognosis is generally [excellent/good/poor], and the [1/5/10­year mortality/survival rate] of patients with aggressive NK-cell leukemia is approximately [#%].
*Prognosis is generally poor, and the median survival rate of patients with aggressive NK-cell leukemia is approximately 12 months.  
== Diagnosis ==
===Diagnostic Criteria===
*The diagnosis of aggressive NK-cell leukemia is made when at least [number] of the following [number] diagnostic criteria are met:
:*[criterion 1]
:*[criterion 2]
:*[criterion 3]
:*[criterion 4]
   
   
== Diagnosis ==
=== Symptoms ===
=== Symptoms ===
*Aggressive NK-cell leukemia is usually asymptomatic.
*Aggressive NK-cell leukemia is usually asymptomatic.
Line 98: Line 98:
   
   
=== Laboratory Findings ===
=== Laboratory Findings ===
*There are no specific laboratory findings associated with aggressive NK-cell leukemia.
*Laboratory findings consistent with the diagnosis of aggressive NK-cell leukemia, include:
 
*A  [positive/negative] [test name] is diagnostic of aggressive NK-cell leukemia.
*An [elevated/reduced] concentration of [serum/blood/urinary/CSF/other] [lab test] is diagnostic of aggressive NK-cell leukemia.
*Other laboratory findings consistent with the diagnosis of aggressive NK-cell leukemia include [abnormal test 1], [abnormal test 2], and [abnormal test 3].
   
   
===Imaging Findings===
===Imaging Findings===
*There are no [imaging study] findings associated with aggressive NK-cell leukemia.
*[Imaging study 1] is the imaging modality of choice for aggressive NK-cell leukemia.
*[Imaging study 1] is the imaging modality of choice for aggressive NK-cell leukemia.
*On [imaging study 1], aggressive NK-cell leukemia is characterized by [finding 1], [finding 2], and [finding 3].
*On [imaging study 1], aggressive NK-cell leukemia is characterized by [finding 1], [finding 2], and [finding 3].
Line 112: Line 106:
   
   
=== Other Diagnostic Studies ===
=== Other Diagnostic Studies ===
*Aggressive NK-cell leukemia may also be diagnosed using [diagnostic study name].
*Aggressive NK-cell leukemia may also be diagnosed using  
*Findings on [diagnostic study name] include [finding 1], [finding 2], and [finding 3].
*Findings on [diagnostic study name] include [finding 1], [finding 2], and [finding 3].
   
   
== Treatment ==
== Treatment ==
=== Medical Therapy ===
=== Medical Therapy ===
*There is no treatment for aggressive NK-cell leukemia; the mainstay of therapy is supportive care.
*The mainstay of therapy for aggressive NK-cell leukemia is [medical therapy 1] and [medical therapy 2].
*The mainstay of therapy for aggressive NK-cell leukemia is [medical therapy 1] and [medical therapy 2].
*[Medical therapy 1] acts by [mechanism of action1].
 
*Response to [medical therapy 1] can be monitored with [test/physical finding/imaging] every [frequency/duration].
=== Surgery ===
=== Surgery ===
*Surgery is the mainstay of therapy for aggressive NK-cell leukemia.
*Surgery is '''not''' recommended among patients with aggressive NK-cell leukemia.
*[Surgical procedure] in conjunction with [chemotherapy/radiation] is the most common approach to the treatment of aggressive NK-cell leukemia.
 
*[Surgical procedure] can only be performed for patients with [disease stage] aggressive NK-cell leukemia.
   
   
=== Prevention ===
=== Prevention ===
*There are no primary preventive measures available for aggressive NK-cell leukemia.
*There are no primary preventive measures available for aggressive NK-cell leukemia.
   
   
*Effective measures for the primary prevention of aggressive NK-cell leukemia include [measure1], [measure2], and [measure3].


*Once diagnosed and successfully treated, patients with aggressive NK-cell leukemia are followed-up every [duration]. Follow-up testing includes [test 1], [test 2], and [test 3].
==References==
==References==
{{Reflist|2}}
{{Reflist|2}}
   
   
[[Category: Oncology]]
[[Category: Oncology]]

Revision as of 16:11, 5 May 2016

WikiDoc Resources for Aggressive NK-cell leukemia

Articles

Most recent articles on Aggressive NK-cell leukemia

Most cited articles on Aggressive NK-cell leukemia

Review articles on Aggressive NK-cell leukemia

Articles on Aggressive NK-cell leukemia in N Eng J Med, Lancet, BMJ

Media

Powerpoint slides on Aggressive NK-cell leukemia

Images of Aggressive NK-cell leukemia

Photos of Aggressive NK-cell leukemia

Podcasts & MP3s on Aggressive NK-cell leukemia

Videos on Aggressive NK-cell leukemia

Evidence Based Medicine

Cochrane Collaboration on Aggressive NK-cell leukemia

Bandolier on Aggressive NK-cell leukemia

TRIP on Aggressive NK-cell leukemia

Clinical Trials

Ongoing Trials on Aggressive NK-cell leukemia at Clinical Trials.gov

Trial results on Aggressive NK-cell leukemia

Clinical Trials on Aggressive NK-cell leukemia at Google

Guidelines / Policies / Govt

US National Guidelines Clearinghouse on Aggressive NK-cell leukemia

NICE Guidance on Aggressive NK-cell leukemia

NHS PRODIGY Guidance

FDA on Aggressive NK-cell leukemia

CDC on Aggressive NK-cell leukemia

Books

Books on Aggressive NK-cell leukemia

News

Aggressive NK-cell leukemia in the news

Be alerted to news on Aggressive NK-cell leukemia

News trends on Aggressive NK-cell leukemia

Commentary

Blogs on Aggressive NK-cell leukemia

Definitions

Definitions of Aggressive NK-cell leukemia

Patient Resources / Community

Patient resources on Aggressive NK-cell leukemia

Discussion groups on Aggressive NK-cell leukemia

Patient Handouts on Aggressive NK-cell leukemia

Directions to Hospitals Treating Aggressive NK-cell leukemia

Risk calculators and risk factors for Aggressive NK-cell leukemia

Healthcare Provider Resources

Symptoms of Aggressive NK-cell leukemia

Causes & Risk Factors for Aggressive NK-cell leukemia

Diagnostic studies for Aggressive NK-cell leukemia

Treatment of Aggressive NK-cell leukemia

Continuing Medical Education (CME)

CME Programs on Aggressive NK-cell leukemia

International

Aggressive NK-cell leukemia en Espanol

Aggressive NK-cell leukemia en Francais

Business

Aggressive NK-cell leukemia in the Marketplace

Patents on Aggressive NK-cell leukemia

Experimental / Informatics

List of terms related to Aggressive NK-cell leukemia

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [4] Associate Editor(s)-in-Chief: Maria Fernanda Villarreal, M.D. [5]

Synonyms and keywords: Synonym 1; Synonym 2; Synonym 3

Overview

Aggressive NK-cell leukemia is a disease with an aggressive, systemic proliferation of natural killer cells (NK cells) and a rapidly declining clinical course.[1][2][3]

Historical Perspective

  • Aggressive NK-cell leukemia was first discovered by [scientist name], a [nationality + occupation], in [year] during/following [event].

Classification

  • There is no classification system for aggressive NK-cell leukemia.

Pathophysiology

  • The pathogenesis of aggressive NK-cell leukemia is characterized by:
  • The XXXX has been associated with the development of aggressive NK-cell leukemia, involving the [molecular pathway] pathway.
  • On gross pathology, characteristic findings of aggressive NK-cell leukemia, include:
  • On microscopic histopathological analysis, characteristic findings of aggressive NK-cell leukemia, include:

Causes

  • There are no established causes for aggressive NK-cell leukemia.

Differentiating Aggressive NK-cell Leukemia from Other Diseases

  • Aggressive NK-cell leukemia must be differentiated from other diseases that cause [clinical feature 1], [clinical feature 2], and [clinical feature 3], such as:
  • [Differential dx1]
  • [Differential dx2]
  • [Differential dx3]

Epidemiology and Demographics

  • The prevalence of aggressive NK-cell leukemia is approximately [number or range] per 100,000 individuals worldwide.
  • In [year], the incidence of aggressive NK-cell leukemia was estimated to be [number or range] cases per 100,000 individuals in [location].

Age

  • Patients of all age groups may develop aggressive NK-cell leukemia.
  • Aggressive NK-cell leukemia is more commonly observed among patients aged [age range] years old.
  • Aggressive NK-cell leukemia is more commonly observed among [elderly patients/young patients/children].

Gender

  • Aggressive NK-cell leukemia affects men and women equally.
  • [Gender 1] are more commonly affected with aggressive NK-cell leukemia than [gender 2].
  • The [gender 1] to [Gender 2] ratio is approximately [number > 1] to 1.

Race

  • There is no racial predilection for aggressive NK-cell leukemia.
  • Aggressive NK-cell leukemia usually affects individuals of the [race 1] race.
  • [Race 2] individuals are less likely to develop aggressive NK-cell leukemia.

Risk Factors

  • Common risk factors in the development of aggressive NK-cell leukemia, include:

Natural History, Complications and Prognosis

  • The majority of patients with aggressive NK-cell leukemia are symptomatic at diagnosis.
  • Early clinical features include
  • If left untreated, patients with aggressive NK-cell leukemia may progress to develop
  • Common complications of aggressive NK-cell leukemia include [complication 1], [complication 2], and [complication 3].
  • Prognosis is generally poor, and the median survival rate of patients with aggressive NK-cell leukemia is approximately 12 months.

Diagnosis

Symptoms

  • Aggressive NK-cell leukemia is usually asymptomatic.
  • Symptoms of aggressive NK-cell leukemia may include the following:
  • [symptom 1]
  • [symptom 2]
  • [symptom 3]
  • [symptom 4]
  • [symptom 5]
  • [symptom 6]

Physical Examination

  • Patients with aggressive NK-cell leukemia usually appear [general appearance].
  • Physical examination may be remarkable for:
  • [finding 1]
  • [finding 2]
  • [finding 3]
  • [finding 4]
  • [finding 5]
  • [finding 6]

Laboratory Findings

  • Laboratory findings consistent with the diagnosis of aggressive NK-cell leukemia, include:

Imaging Findings

  • [Imaging study 1] is the imaging modality of choice for aggressive NK-cell leukemia.
  • On [imaging study 1], aggressive NK-cell leukemia is characterized by [finding 1], [finding 2], and [finding 3].
  • [Imaging study 2] may demonstrate [finding 1], [finding 2], and [finding 3].

Other Diagnostic Studies

  • Aggressive NK-cell leukemia may also be diagnosed using
  • Findings on [diagnostic study name] include [finding 1], [finding 2], and [finding 3].

Treatment

Medical Therapy

  • The mainstay of therapy for aggressive NK-cell leukemia is [medical therapy 1] and [medical therapy 2].

Surgery

  • Surgery is not recommended among patients with aggressive NK-cell leukemia.


Prevention

  • There are no primary preventive measures available for aggressive NK-cell leukemia.


References

  1. ↑ [1] Chan JK, Sin VC, Wong KF, Ng CS, Tsang WY, Chan CH, Cheung MM, Lau WH. "Nonnasal lymphoma expressing the natural killer cell marker CD56: a clinicopathologic study of 49 cases of an uncommon aggressive neoplasm." Blood. 1997 Jun 15;89(12):4501-13. PMID 9192774
  2. ↑ [2] Imamura N, Kusunoki Y, Kawa-Ha K, Yumura K, Hara J, Oda K, Abe K, Dohy H, Inada T, Kajihara H, et al. "Aggressive natural killer cell leukaemia/lymphoma: report of four cases and review of the literature. Possible existence of a new clinical entity originating from the third lineage of lymphoid cells." Br J Haematol. 1990 May;75(1):49-59. PMID 2375924
  3. ↑ [3] Chan JK. "Natural killer cell neoplasms." Anat Pathol. 1998;3:77-145. PMID 10389582
Retrieved from "https://www.wikidoc.org/index.php?title=Aggressive_NK-cell_leukemia&oldid=1232353"