Cementoblastoma: Difference between revisions
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==Overview== | ==Overview== | ||
'''Cementoblastoma''' (also known as ''benign cementoblastoma''') is a relatively rare [[benign]] [[neoplasm]] of the [[cementum]] of the [[teeth]]. Cementoblastoma is derived from ectomesenchyme of odontogenic origin.<ref>Leena S Sankari and K Ramakrishnan, Benign cementoblastoma, ''Journal of Oral and Maxillofacial Pathology, ''2011 Sep-Dec; 15(3): 358–360 at http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3227271/</ref> Less than 0.69%–8% of all odontogenic tumors. | |||
==Historical Perspective== | ==Historical Perspective== | ||
*Cementoblastoma was first discovered by | *Cementoblastoma was first discovered by Norberg in 1930. | ||
==Classification== | ==Classification== | ||
* | |||
*According to the World Health Organization, cementoblastoma is classified as a true cemental neoplasm. | |||
==Pathophysiology== | ==Pathophysiology== | ||
*The pathogenesis of cementoblastoma is characterized by [feature1], [feature2], and [feature3]. | *The pathogenesis of cementoblastoma is characterized by [feature1], [feature2], and [feature3]. | ||
* | *Cementoblastoma is commonly located in the mandibular molar area. | ||
*On gross pathology, | *There are no genetic mutations associated with the development of cementoblastoma. | ||
*On microscopic histopathological analysis, | *On gross pathology, characteristic findings of cementoblastoma, include: | ||
:*Dense homogenous, irregular, and spherical mass. | |||
:*Tooth root | |||
*On microscopic histopathological analysis, characteristic findings of cementoblastoma, include: | |||
:*Large globules fused to form a mass | |||
:*Composed of proliferative fibrovascular stroma | |||
:*Trabeculae lined by plump osteoblasts | |||
==Causes== | ==Causes== | ||
* | * Common causes of cementoblastoma, include: | ||
==Differentiating | ==Differentiating Cementoblastoma from Other Diseases== | ||
*Cementoblastoma must be differentiated from other diseases that cause [clinical feature 1], [clinical feature 2], and [clinical feature 3], such as: | *Cementoblastoma must be differentiated from other diseases that cause [clinical feature 1], [clinical feature 2], and [clinical feature 3], such as: | ||
:*[Differential dx1] | :*[Differential dx1] | ||
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*Patients of all age groups may develop cementoblastoma. | *Patients of all age groups may develop cementoblastoma. | ||
*Cementoblastoma is more commonly observed among patients aged | *Cementoblastoma is more commonly observed among patients aged 25 to 30 years old. | ||
*Cementoblastoma is more commonly observed among | *Cementoblastoma is more commonly observed among young and middle aged adults. | ||
===Gender=== | ===Gender=== | ||
*Cementoblastoma affects men and women equally. | *Cementoblastoma affects men and women equally. | ||
===Race=== | ===Race=== | ||
*There is no racial predilection for cementoblastoma. | *There is no racial predilection for cementoblastoma. | ||
==Risk Factors== | ==Risk Factors== | ||
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== Natural History, Complications and Prognosis== | == Natural History, Complications and Prognosis== | ||
*The majority of patients with cementoblastoma remain asymptomatic for [duration/years]. | *The majority of patients with cementoblastoma remain asymptomatic for [duration/years]. | ||
*Early clinical features include | *Early clinical features include tooth pain, swelling, and | ||
*If left untreated, [#%] of patients with cementoblastoma may progress to develop [manifestation 1], [manifestation 2], and [manifestation 3]. | *If left untreated, [#%] of patients with cementoblastoma may progress to develop [manifestation 1], [manifestation 2], and [manifestation 3]. | ||
*Common complications of cementoblastoma include [complication 1], [complication 2], and [complication 3]. | *Common complications of cementoblastoma include [complication 1], [complication 2], and [complication 3]. | ||
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*There are no primary preventive measures available for cementoblastoma. | *There are no primary preventive measures available for cementoblastoma. | ||
==References== | ==References== | ||
{{Reflist|2}} | {{Reflist|2}} | ||
[[Category: Oncology]] | [[Category: Oncology]] |
Revision as of 19:13, 25 April 2016
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Maria Fernanda Villarreal, M.D. [2]
Synonyms and keywords: Synonym 1; Synonym 2; Synonym 3
Overview
'Cementoblastoma (also known as benign cementoblastoma) is a relatively rare benign neoplasm of the cementum of the teeth. Cementoblastoma is derived from ectomesenchyme of odontogenic origin.[1] Less than 0.69%–8% of all odontogenic tumors.
Historical Perspective
- Cementoblastoma was first discovered by Norberg in 1930.
Classification
- According to the World Health Organization, cementoblastoma is classified as a true cemental neoplasm.
Pathophysiology
- The pathogenesis of cementoblastoma is characterized by [feature1], [feature2], and [feature3].
- Cementoblastoma is commonly located in the mandibular molar area.
- There are no genetic mutations associated with the development of cementoblastoma.
- On gross pathology, characteristic findings of cementoblastoma, include:
- Dense homogenous, irregular, and spherical mass.
- Tooth root
- On microscopic histopathological analysis, characteristic findings of cementoblastoma, include:
- Large globules fused to form a mass
- Composed of proliferative fibrovascular stroma
- Trabeculae lined by plump osteoblasts
Causes
- Common causes of cementoblastoma, include:
Differentiating Cementoblastoma from Other Diseases
- Cementoblastoma must be differentiated from other diseases that cause [clinical feature 1], [clinical feature 2], and [clinical feature 3], such as:
- [Differential dx1]
- [Differential dx2]
- [Differential dx3]
Epidemiology and Demographics
- The prevalence of cementoblastoma is approximately [number or range] per 100,000 individuals worldwide.
- In [year], the incidence of cementoblastoma was estimated to be [number or range] cases per 100,000 individuals in [location].
Age
- Patients of all age groups may develop cementoblastoma.
- Cementoblastoma is more commonly observed among patients aged 25 to 30 years old.
- Cementoblastoma is more commonly observed among young and middle aged adults.
Gender
- Cementoblastoma affects men and women equally.
Race
- There is no racial predilection for cementoblastoma.
Risk Factors
- Common risk factors in the development of cementoblastoma are [risk factor 1], [risk factor 2], [risk factor 3], and [risk factor 4].
Natural History, Complications and Prognosis
- The majority of patients with cementoblastoma remain asymptomatic for [duration/years].
- Early clinical features include tooth pain, swelling, and
- If left untreated, [#%] of patients with cementoblastoma may progress to develop [manifestation 1], [manifestation 2], and [manifestation 3].
- Common complications of cementoblastoma include [complication 1], [complication 2], and [complication 3].
- Prognosis is generally [excellent/good/poor], and the [1/5/10year mortality/survival rate] of patients with cementoblastoma is approximately [#%].
Diagnosis
Diagnostic Criteria
- The diagnosis of cementoblastoma is made when at least [number] of the following [number] diagnostic criteria are met:
- [criterion 1]
- [criterion 2]
- [criterion 3]
- [criterion 4]
Symptoms
- Cementoblastoma is usually asymptomatic.
- Symptoms of cementoblastoma may include the following:
- [symptom 1]
- [symptom 2]
- [symptom 3]
- [symptom 4]
- [symptom 5]
- [symptom 6]
Physical Examination
- Patients with cementoblastoma usually appear [general appearance].
- Physical examination may be remarkable for:
- [finding 1]
- [finding 2]
- [finding 3]
- [finding 4]
- [finding 5]
- [finding 6]
Laboratory Findings
- There are no specific laboratory findings associated with cementoblastoma.
- A [positive/negative] [test name] is diagnostic of cementoblastoma.
- An [elevated/reduced] concentration of [serum/blood/urinary/CSF/other] [lab test] is diagnostic of cementoblastoma.
- Other laboratory findings consistent with the diagnosis of cementoblastoma include [abnormal test 1], [abnormal test 2], and [abnormal test 3].
Imaging Findings
- There are no [imaging study] findings associated with cementoblastoma.
- [Imaging study 1] is the imaging modality of choice for cementoblastoma.
- On [imaging study 1], cementoblastoma is characterized by [finding 1], [finding 2], and [finding 3].
- [Imaging study 2] may demonstrate [finding 1], [finding 2], and [finding 3].
Other Diagnostic Studies
- Cementoblastoma may also be diagnosed using [diagnostic study name].
- Findings on [diagnostic study name] include [finding 1], [finding 2], and [finding 3].
Treatment
Medical Therapy
- There is no treatment for cementoblastoma; the mainstay of therapy is supportive care.
- The mainstay of therapy for cementoblastoma is [medical therapy 1] and [medical therapy 2].
- [Medical therapy 1] acts by [mechanism of action1].
- Response to [medical therapy 1] can be monitored with [test/physical finding/imaging] every [frequency/duration].
Surgery
- Surgery is the mainstay of therapy for cementoblastoma.
- [Surgical procedure] in conjunction with [chemotherapy/radiation] is the most common approach to the treatment of cementoblastoma.
- [Surgical procedure] can only be performed for patients with [disease stage] cementoblastoma.
Prevention
- There are no primary preventive measures available for cementoblastoma.
References
- ↑ Leena S Sankari and K Ramakrishnan, Benign cementoblastoma, Journal of Oral and Maxillofacial Pathology, 2011 Sep-Dec; 15(3): 358–360 at http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3227271/