Myelofibrosis risk factors

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Sujit Routray, M.D. [2]

Overview

Common risk factors in the development of myelofibrosis may be age, other myeloproliferative disorders, radiation, or industrial chemical exposure.

Risk Factors

Common risk factors in the development of myelofibrosis may include:

• Age: Myelofibrosis most commonly individuals in their 50s and 60s.
• Other myeloproliferative disorder: Myelofibrosis may also develop secondary to essential thrombocythemia or polycythemia vera.
• Radiation exposure:Individuals exposed to high levels of radiation (e.g. Thorotrast) have an increased risk of myelofibrosis.
• Chemicals: Industrial chemicals, such as toluene and benzene, may have an increased risk of developing myelofibrosis.