Adult T-cell leukemia laboratory findings: Difference between revisions
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==Overview== | ==Overview== | ||
Laboratory findings consistent with the diagnosis of adult T-cell leukemia include abnormal [[anemia]], [[thrombocytopenia]], and elevated [[lymphocyte]] count. [[Hypercalcemia]] is a key feature among patients with adult T-cell leukemia.<ref name="pmid18042693">Matutes E (2007) [http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&retmode=ref&cmd=prlinks&id=18042693 Adult T-cell leukaemia/lymphoma.] ''J Clin Pathol'' 60 (12):1373-7. [http://dx.doi.org/10.1136/jcp.2007.052456 DOI:10.1136/jcp.2007.052456] PMID: [http://pubmed.gov/18042693 18042693]</ref> | Laboratory findings consistent with the diagnosis of adult T-cell leukemia include abnormal [[anemia]], [[thrombocytopenia]], and elevated [[lymphocyte]] count. [[Hypercalcemia]] is a key feature among patients with adult T-cell leukemia.<ref name="pmid18042693">Matutes E (2007) [http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&retmode=ref&cmd=prlinks&id=18042693 Adult T-cell leukaemia/lymphoma.] ''J Clin Pathol'' 60 (12):1373-7. [http://dx.doi.org/10.1136/jcp.2007.052456 DOI:10.1136/jcp.2007.052456] PMID: [http://pubmed.gov/18042693 18042693]</ref><ref name="pmid1751370">{{cite journal| author=Shimoyama M| title=Diagnostic criteria and classification of clinical subtypes of adult T-cell leukaemia-lymphoma. A report from the Lymphoma Study Group (1984-87). | journal=Br J Haematol | year= 1991 | volume= 79 | issue= 3 | pages= 428-37 | pmid=1751370 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=1751370 }} </ref> | ||
==Laboratory Findings== | ==Laboratory Findings== | ||
===Complete Blood Count=== | ===Complete Blood Count=== | ||
Revision as of 14:45, 25 January 2016
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Haytham Allaham, M.D. [2]
Overview
Laboratory findings consistent with the diagnosis of adult T-cell leukemia include abnormal anemia, thrombocytopenia, and elevated lymphocyte count. Hypercalcemia is a key feature among patients with adult T-cell leukemia.[1][2]
Laboratory Findings
Complete Blood Count
- Anemia
- Thrombocytopenia
- Elevated lymphocyte count
Basic Metabolic Panel
Peripheral Smear
- Charecterstic leukemia cells with sharp nuclear indentations and a prominent nucleoli
- "Cloverleaf" or "flower" cells
Antibody Titres
- Detects antibodies present against HTLV antigens
Immunohistochemistry
References
- ↑ Matutes E (2007) Adult T-cell leukaemia/lymphoma. J Clin Pathol 60 (12):1373-7. DOI:10.1136/jcp.2007.052456 PMID: 18042693
- ↑ Shimoyama M (1991). "Diagnostic criteria and classification of clinical subtypes of adult T-cell leukaemia-lymphoma. A report from the Lymphoma Study Group (1984-87)". Br J Haematol. 79 (3): 428–37. PMID 1751370.