Mycosis fungoides pathophysiology: Difference between revisions
Jump to navigation
Jump to search
No edit summary |
No edit summary |
||
Line 11: | Line 11: | ||
* "Sézary's cells" are [[T-cells]] that have pathological quantities of [[mucopolysaccharide]]s | * "Sézary's cells" are [[T-cells]] that have pathological quantities of [[mucopolysaccharide]]s | ||
* Sézary's disease is sometimes considered a late stage of [[mycosis fungoides]] | * Sézary's disease is sometimes considered a late stage of [[mycosis fungoides]] | ||
==Microscopic Pathology== | ==Microscopic Pathology== | ||
* Mycosis fungoides has been divided into three stages: | |||
:* Premycotic stage | |||
:* Mycotic stage | |||
:* Tumorous stage | |||
* The premycotic stage | |||
:* Non-diagnostic and represented by chronic nonspecific dermatisis associated with psoriasiform changes in epidermis | |||
* The mycotic stage | |||
:* Shows a polymorphous inflammatory infiltrate in the dermis that contains small numbers of frankly atypical lymphoid cells | |||
:* These cells may line up individually along the epidermal basal layer | |||
:* The latter finding if unaccompanied by spongiosis is highly suggestive of mycosis fungoides | |||
* Tumorous stage | |||
:* Dense infiltrate of medium sized lymphocytes with cerebroid nuclei, expands the dermis | |||
<gallery widths=200px> | <gallery widths=200px> | ||
Image:Sezary syndrome 0001.jpg| Sézary's disease | Image:Sezary syndrome 0001.jpg| Sézary's disease |
Revision as of 16:17, 21 January 2016
Cutaneous T cell lymphoma Microchapters |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sowminya Arikapudi, M.B,B.S. [2]
Overview
Pathophysiology
- Cutaneous T cell lymphoma is an unusual expression of T-cells, a part of the immune system
- These T-cells are skin-associated, meaning that they biochemically and biologically are most related to the skin, in a dynamic manner
- Sezary syndrome and Mycosis Fungoides are T-cell lymphomas whose primary manifestation is in the skin
- Mycosis Fungoides is the most common type of 'Cutaneous T cell lymphoma' (CTCL)
- Mycosis fungoides is initially an indolent lymphoma but in its later stages can cause peripheral lymphadenopathy and can finally progress to widespread extracutaneous visceral / internal organ involvement
- "Sézary's cells" are T-cells that have pathological quantities of mucopolysaccharides
- Sézary's disease is sometimes considered a late stage of mycosis fungoides
Microscopic Pathology
- Mycosis fungoides has been divided into three stages:
- Premycotic stage
- Mycotic stage
- Tumorous stage
- The premycotic stage
- Non-diagnostic and represented by chronic nonspecific dermatisis associated with psoriasiform changes in epidermis
- The mycotic stage
- Shows a polymorphous inflammatory infiltrate in the dermis that contains small numbers of frankly atypical lymphoid cells
- These cells may line up individually along the epidermal basal layer
- The latter finding if unaccompanied by spongiosis is highly suggestive of mycosis fungoides
- Tumorous stage
- Dense infiltrate of medium sized lymphocytes with cerebroid nuclei, expands the dermis
-
Sézary's disease
-
Features: Nests of lymphocytes in the epidermis; "Pautrier microabscesses". Single lymphocytes in epidermis; "lymphocyte exocytosis". Short linear arrays of lymphocytes along the basal layer of the epidermis; "epidermotropism".