Paget's disease of the breast epidemiology and demographics: Difference between revisions
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*Lymph node involvement is correlated with median survival rates, reaching 75-95% when negative and 20 to 25% when positive. | *Lymph node involvement is correlated with median survival rates, reaching 75-95% when negative and 20 to 25% when positive. | ||
*In another study, the mean 10-year survival rate was estimated at 47% in cases with positive lymph nodes and 93% in those with negative lymph nodes. | *In another study, the mean 10-year survival rate was estimated at 47% in cases with positive lymph nodes and 93% in those with negative lymph nodes. | ||
*When the disease occurs in males, the prognosis is poor, with an average 5-year survival rate of 20-30%. | |||
==References== | ==References== |
Revision as of 21:26, 8 January 2016
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Epidemiology
Paget's disease of the breast is a rare disease that corresponds to 1-4.3% of all breast cancers and is frequently associated with intraductal, in situ or invasive neoplasms.[1] It is more prevalent in postmenopausal women, usually after the sixth decade of life, but it has also been reported in adolescent and elderly patients.2,3,4 It may affect male patients, albeit more rarely.
Prognosis
- Some factors indicate an unfavorable prognosis, among them:[1]
- The presence of a palpable breast tumor
- Enlarged lymph nodes
- Histological type of breast cancer
- Patients younger than 60 years
- Lymph node involvement is correlated with median survival rates, reaching 75-95% when negative and 20 to 25% when positive.
- In another study, the mean 10-year survival rate was estimated at 47% in cases with positive lymph nodes and 93% in those with negative lymph nodes.
- When the disease occurs in males, the prognosis is poor, with an average 5-year survival rate of 20-30%.
References
- ↑ 1.0 1.1 Lopes Filho, Lauro Lourival; Lopes, Ione Maria Ribeiro Soares; Lopes, Lauro Rodolpho Soares; Enokihara, Milvia M. S. S.; Michalany, Alexandre Osores; Matsunaga, Nobuo (2015). "Mammary and extramammary Paget's disease". Anais Brasileiros de Dermatologia. 90 (2): 225–231. doi:10.1590/abd1806-4841.20153189. ISSN 1806-4841.