Pseudomyxoma peritonei pathophysiology: Difference between revisions
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Pseudomyxoma peritonei is commonly discovered during surgery for other conditions, i.e., hernia repair, following which an experienced pathologist can confirm the diagnosis. Due to the rarity of this disease, it is important to obtain an accurate diagnosis so that appropriate treatment may be obtained. | Pseudomyxoma peritonei is commonly discovered during surgery for other conditions, i.e., hernia repair, following which an experienced pathologist can confirm the diagnosis. Due to the rarity of this disease, it is important to obtain an accurate diagnosis so that appropriate treatment may be obtained. | ||
==Pathology== | |||
The remarkable feature of pseudomyxoma peritonei is that this neoplastic, progressive process often arises from a seemingly benign or well differentiated primary tumour. | |||
Pseudomyxoma peritonei may be divided into two pathological subtypes which have aetiological and prognostic significance 4. | |||
peritoneal adenomucinosis | |||
a peritoneal neoplasm composed largely of mucin associated with fibrosis with minimal cytologic atypia and mitoses | |||
primary tumour is generally an adenoma | |||
peritoneal mucinous carcinoma | |||
characterised by proliferative epithelium, glands, nests, or individual cells with marked cytologic atypia | |||
the primary is a mucinous adenocarcinoma | |||
Not all cases fit neatly into these categories, and many patients have intermediate or discordant features. | |||
== References == | == References == | ||
Revision as of 15:48, 18 November 2015
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Parminder Dhingra, M.D. [2]
Overview
Pathophysiology
Pseudomyxoma peritonei refers to intraperitoneal accumulation of a gelatinous ascites secondary to rupture of a mucinous tumour. The most common cause is a ruptured mucinous tumour of the appendix / appendiceal mucocoele.
Pseudomyxoma peritonei is commonly discovered during surgery for other conditions, i.e., hernia repair, following which an experienced pathologist can confirm the diagnosis. Due to the rarity of this disease, it is important to obtain an accurate diagnosis so that appropriate treatment may be obtained.
Pathology
The remarkable feature of pseudomyxoma peritonei is that this neoplastic, progressive process often arises from a seemingly benign or well differentiated primary tumour.
Pseudomyxoma peritonei may be divided into two pathological subtypes which have aetiological and prognostic significance 4.
peritoneal adenomucinosis a peritoneal neoplasm composed largely of mucin associated with fibrosis with minimal cytologic atypia and mitoses primary tumour is generally an adenoma
peritoneal mucinous carcinoma characterised by proliferative epithelium, glands, nests, or individual cells with marked cytologic atypia the primary is a mucinous adenocarcinoma
Not all cases fit neatly into these categories, and many patients have intermediate or discordant features.