Mesoblastic nephroma overview: Difference between revisions
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<ref name=radio> Mesoblastic nephroma.Dr Ayush Goel and Dr Yuranga Weerakkody et al. Radiopaedia.org 2015. http://radiopaedia.org/articles/mesoblastic-nephroma </ref><ref>{{cite book | last = Tavassoli | first = Fattaneh | title = Pathology and genetics of tumours of the breast and female genital organs | publisher = IAPS Press | location = Lyon | year = 2003 | isbn = 9283224124 }}</ref> The male to female ratio is approximately 2 to 1.<ref name="pmid16596620">{{cite journal| author=Furtwaengler R, Reinhard H, Leuschner I, Schenk JP, Goebel U, Claviez A et al.| title=Mesoblastic nephroma--a report from the Gesellschaft fur Pädiatrische Onkologie und Hämatologie (GPOH). | journal=Cancer | year= 2006 | volume= 106 | issue= 10 | pages= 2275-83 | pmid=16596620 | doi=10.1002/cncr.21836 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=16596620 }} </ref> | <ref name=radio> Mesoblastic nephroma.Dr Ayush Goel and Dr Yuranga Weerakkody et al. Radiopaedia.org 2015. http://radiopaedia.org/articles/mesoblastic-nephroma </ref><ref>{{cite book | last = Tavassoli | first = Fattaneh | title = Pathology and genetics of tumours of the breast and female genital organs | publisher = IAPS Press | location = Lyon | year = 2003 | isbn = 9283224124 }}</ref> The male to female ratio is approximately 2 to 1.<ref name="pmid16596620">{{cite journal| author=Furtwaengler R, Reinhard H, Leuschner I, Schenk JP, Goebel U, Claviez A et al.| title=Mesoblastic nephroma--a report from the Gesellschaft fur Pädiatrische Onkologie und Hämatologie (GPOH). | journal=Cancer | year= 2006 | volume= 106 | issue= 10 | pages= 2275-83 | pmid=16596620 | doi=10.1002/cncr.21836 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=16596620 }} </ref> | ||
==Risk Factors== | |||
There are no established risk factors for mesoblastic nephroma. | |||
Revision as of 19:09, 5 November 2015
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Shanshan Cen, M.D. [2]
Overview
Mesoblastic nephroma is a type of kidney tumor.
Classification
Mesoblastic nephroma may be classified according to pathology into three subtypes: classic, cellular, and mixed mesoblastic nephroma.[1]
Pathophysiology
On gross pathology, a solid nonencapsulated mass that often occurs near the renal hilum is the characteristic finding of mesoblastic nephroma. On microscopic histopathological analysis, spindle cell is the characteristic finding of classic mesoblastic nephroma; whereas, plump cells with vesicular nuclei is the characteristic finding of cellular mesoblastic nephroma.[2]
Causes
Mesoblastic nephroma may be caused by translocation t(12:15)(p13;q25) that generates the fusion of ETV6/NTRK3 gene.[3]
Differential diagnosis
Mesoblastic nephroma must be differentiated from rhabdoid tumor, clear cell sarcoma of the kidney, and Wilm's tumor.
Epidemiology and Demographics
Mesoblastic nephroma is a rare disease that tends to affect children under 3 years of age, especially neonates. [4][5] The male to female ratio is approximately 2 to 1.[6]
Risk Factors
There are no established risk factors for mesoblastic nephroma.
References
- ↑ Malkan AD, Loh A, Bahrami A, et al. (2015). "An approach to renal masses in pediatrics". Pediatrics. 135 (1): 142–58. doi:10.1542/peds.2014-1011. PMID 25452658.
- ↑ Humphrey, Peter (2008). The Washington manual of surgical pathology. Philadelphia: Lippincott Williams & Wilkins. ISBN 978-0781765275.
- ↑ Knezevich SR, McFadden DE, Tao W, Lim JF, Sorensen PH (1998). "A novel ETV6-NTRK3 gene fusion in congenital fibrosarcoma". Nature Genetics. 18 (2): 184–7. doi:10.1038/ng0298-184. PMID 9462753.
- ↑ Mesoblastic nephroma.Dr Ayush Goel and Dr Yuranga Weerakkody et al. Radiopaedia.org 2015. http://radiopaedia.org/articles/mesoblastic-nephroma
- ↑ Tavassoli, Fattaneh (2003). Pathology and genetics of tumours of the breast and female genital organs. Lyon: IAPS Press. ISBN 9283224124.
- ↑ Furtwaengler R, Reinhard H, Leuschner I, Schenk JP, Goebel U, Claviez A; et al. (2006). "Mesoblastic nephroma--a report from the Gesellschaft fur Pädiatrische Onkologie und Hämatologie (GPOH)". Cancer. 106 (10): 2275–83. doi:10.1002/cncr.21836. PMID 16596620.