Mesoblastic nephroma overview: Difference between revisions
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==Pathophysiology== | ==Pathophysiology== | ||
On gross pathology, a solid nonencapsulated [[mass]] that often occurs near the [[renal]] [[hilum]] is the characteristic finding of mesoblastic nephroma. On microscopic histopathological analysis, [[spindle cell]] is the characteristic finding of classic mesoblastic nephroma; whereas, plump [[cell]]s with vesicular [[nuclei]] is the characteristic finding of cellular mesoblastic nephroma.<ref>{{cite book | last = Humphrey | first = Peter | title = The Washington manual of surgical pathology | publisher = Lippincott Williams & Wilkins | location = Philadelphia | year = 2008 | isbn = 978-0781765275 }}</ref> | On gross pathology, a solid nonencapsulated [[mass]] that often occurs near the [[renal]] [[hilum]] is the characteristic finding of mesoblastic nephroma. On microscopic histopathological analysis, [[spindle cell]] is the characteristic finding of classic mesoblastic nephroma; whereas, plump [[cell]]s with vesicular [[nuclei]] is the characteristic finding of cellular mesoblastic nephroma.<ref>{{cite book | last = Humphrey | first = Peter | title = The Washington manual of surgical pathology | publisher = Lippincott Williams & Wilkins | location = Philadelphia | year = 2008 | isbn = 978-0781765275 }}</ref> | ||
==Causes== | |||
Mesoblastic nephroma may be caused by [[translocation]] t(12:15)(p13;q25) that generates the fusion of [[ETV6]]/NTRK3 gene.<ref name="pmid9462753">{{cite journal | vauthors = Knezevich SR, McFadden DE, Tao W, Lim JF, Sorensen PH | title = A novel ETV6-NTRK3 gene fusion in congenital fibrosarcoma | journal = [[Nature Genetics]] | volume = 18 | issue = 2 | pages = 184–7 | year = 1998 | pmid = 9462753 | doi = 10.1038/ng0298-184 | url = | issn = }}</ref> | |||
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Shanshan Cen, M.D. [2]
Overview
Mesoblastic nephroma is a type of kidney tumor.
Classification
Mesoblastic nephroma may be classified according to pathology into three subtypes: classic, cellular, and mixed mesoblastic nephroma.[1]
Pathophysiology
On gross pathology, a solid nonencapsulated mass that often occurs near the renal hilum is the characteristic finding of mesoblastic nephroma. On microscopic histopathological analysis, spindle cell is the characteristic finding of classic mesoblastic nephroma; whereas, plump cells with vesicular nuclei is the characteristic finding of cellular mesoblastic nephroma.[2]
Causes
Mesoblastic nephroma may be caused by translocation t(12:15)(p13;q25) that generates the fusion of ETV6/NTRK3 gene.[3]
References
- ↑ Malkan AD, Loh A, Bahrami A, et al. (2015). "An approach to renal masses in pediatrics". Pediatrics. 135 (1): 142–58. doi:10.1542/peds.2014-1011. PMID 25452658.
- ↑ Humphrey, Peter (2008). The Washington manual of surgical pathology. Philadelphia: Lippincott Williams & Wilkins. ISBN 978-0781765275.
- ↑ Knezevich SR, McFadden DE, Tao W, Lim JF, Sorensen PH (1998). "A novel ETV6-NTRK3 gene fusion in congenital fibrosarcoma". Nature Genetics. 18 (2): 184–7. doi:10.1038/ng0298-184. PMID 9462753.