Meningioma natural history: Difference between revisions

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==Prognosis==
==Prognosis==
 
*Depending on the extent of the meningioma at the time of diagnosis, the prognosis may vary. However, the prognosis is generally regarded as good.<ref name="Wiki">Meningioma. Wikipedia(2015) https://en.wikipedia.org/wiki/Meningioma#cite_ref-17 Accessed on September, 25th 2015</ref>


*The table below lists common prognostic factors for meningioma:
*The table below lists common prognostic factors for meningioma:


{| {{table}}
{| {{table}}
| align="center" style="background:#f0f0f0;"|'''Prognostic Factor'''
| align="center" style="background:#4479BA;"|'''Prognostic Factor'''
 
| align="center" style="background:#f0f0f0;"|'''Description'''
 
|-
 
| '''Stage'''||Advanced stages of multiple myeloma are associated with poor prognosis.<ref name="Canadian">Multiple myeloma. Canadian cancer society (2015)http://www.cancer.ca/en/cancer-information/cancer-type/multiple-myeloma/prognosis-and-survival/?region=mb Accessed on September, 20th 2015</ref>
 
|-
 
| '''Kidney function'''||An elevated level of creatinine is associated with poor prognosis.<ref name="Canadian">Multiple myeloma. Canadian cancer society (2015)http://www.cancer.ca/en/cancer-information/cancer-type/multiple-myeloma/prognosis-and-survival/?region=mb Accessed on September, 20th 2015</ref>
 
|-
 
| '''Labelling index'''||The labeling index indicates how fast the cancer cells are growing. A high plasma cell labeling index (PCLI) or proliferation (reproduction) rate is associated with poor prognosis.<ref name="Canadian">Multiple myeloma. Canadian cancer society (2015)http://www.cancer.ca/en/cancer-information/cancer-type/multiple-myeloma/prognosis-and-survival/?region=mb Accessed on September, 20th 2015</ref>
 
|-
 
| '''Age'''||Older patients have worse prognosis than younger patients.<ref name="Canadian">Multiple myeloma. Canadian cancer society (2015)http://www.cancer.ca/en/cancer-information/cancer-type/multiple-myeloma/prognosis-and-survival/?region=mb Accessed on September, 20th 2015</ref>
 
|-
 
| '''Chromosome changes'''||[[Cytogenetic]] analysis of multiple myeloma cells may be of [[prognosis|prognostic value]], with deletion of chromosome 13, non-hyperdiploidy and the balanced translocations t(4;14) and t(14;16) conferring a poorer prognosis.  The 11q13 and 6p21 cytogenetic abnormalities are associated with a better prognosis.<ref name="Canadian">Multiple myeloma. Canadian cancer society (2015)http://www.cancer.ca/en/cancer-information/cancer-type/multiple-myeloma/prognosis-and-survival/?region=mb Accessed on September, 20th 2015</ref><ref name="wiki">Multiple myeloma. Wikipedia (2015)https://en.wikipedia.org/wiki/Multiple_myeloma#Prognosis Accessed on September, 20th 2015</ref>
 
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| '''Assocciated plasma cell disorder'''||The presence of [[plasma cell leukemia]] or soft tissue plasmacytoma is associated with a particularly poor prognosis among patients with multiple myeloma.<ref>Plasma cell neoplasm. Cancer.gov (2015)http://www.cancer.gov/types/myeloma/hp/myeloma-treatment-pdq#link/_40_toc </ref>
| align="center" style="background:#4479BA;"|'''Description'''


|-
|-


| '''Performance status'''||Performance status is ranked on a 0–4 scale. The lower the number, the healthier and more active the person is, and the better the prognosis. Performance status is important in multiple myeloma because people who are healthier can withstand more intensive treatment.<ref name="Canadian">Multiple myeloma. Canadian cancer society (2015)http://www.cancer.ca/en/cancer-information/cancer-type/multiple-myeloma/prognosis-and-survival/?region=mb Accessed on September, 20th 2015</ref>
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" | '''Age'''|| style="padding: 5px 5px; background: #F5F5F5;" |Older patients have worse prognosis than younger patients.<ref name="Wiki">Meningioma. Wikipedia(2015) https://en.wikipedia.org/wiki/Meningioma#cite_ref-17 Accessed on September, 25th 2015</ref>


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|-


| '''Beta-2-microglobulin'''||A higher level of beta-2-microglobulin is associated with poor prognosis.<ref name="Canadian">Multiple myeloma. Canadian cancer society (2015)http://www.cancer.ca/en/cancer-information/cancer-type/multiple-myeloma/prognosis-and-survival/?region=mb Accessed on September, 20th 2015</ref>
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" | '''Anatomical location'''|| style="padding: 5px 5px; background: #F5F5F5;" |The tumor location is an important predictor for the success of the [[surgical resection]].<ref name="Wiki">Meningioma. Wikipedia(2015) https://en.wikipedia.org/wiki/Meningioma#cite_ref-17 Accessed on September, 25th 2015</ref>


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| '''Albumin level'''||A lower albumin level is associated with poor prognosis.<ref name="Canadian">Multiple myeloma. Canadian cancer society (2015)http://www.cancer.ca/en/cancer-information/cancer-type/multiple-myeloma/prognosis-and-survival/?region=mb Accessed on September, 20th 2015</ref>
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" | '''Labeling index using MIB-1 test'''|| style="padding: 5px 5px; background: #F5F5F5;" |A greater index is associated with a worse prognosis.<ref name="Wiki">Meningioma. Wikipedia(2015) https://en.wikipedia.org/wiki/Meningioma#cite_ref-17 Accessed on September, 25th 2015</ref>  


|-
|-


| '''Lactate dehydrogenase level'''||A higher level of lactate dehydrogenase (LDH) is associated with poor prognosis.<ref name="Canadian">Multiple myeloma. Canadian cancer society (2015)http://www.cancer.ca/en/cancer-information/cancer-type/multiple-myeloma/prognosis-and-survival/?region=mb Accessed on September, 20th 2015</ref>
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" | '''Histological grade'''|| style="padding: 5px 5px; background: #F5F5F5;" |A grade 3 [[anaplastic]] meningioma has the worst prognosis.<ref name="Wiki">Meningioma. Wikipedia(2015) https://en.wikipedia.org/wiki/Meningioma#cite_ref-17 Accessed on September, 25th 2015</ref>


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| '''Response to treatment'''||People whose cancer responds to treatment and goes into complete remission have a better prognosis than people whose cancer does not respond to the initial treatment.<ref name="Canadian">Multiple myeloma. Canadian cancer society (2015)http://www.cancer.ca/en/cancer-information/cancer-type/multiple-myeloma/prognosis-and-survival/?region=mb Accessed on September, 20th 2015</ref>
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" | '''Functional neurological status'''|| style="padding: 5px 5px; background: #F5F5F5;" |Low score on the [[Karnofsky Performance Scale]] predicts a worse prognosis.<ref name="Wiki">Meningioma. Wikipedia(2015) https://en.wikipedia.org/wiki/Meningioma#cite_ref-17 Accessed on September, 25th 2015</ref>
|}
|}


Revision as of 19:49, 25 September 2015

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Haytham Allaham, M.D. [2]

Overview

Natural History

Complications

Prognosis

  • Depending on the extent of the meningioma at the time of diagnosis, the prognosis may vary. However, the prognosis is generally regarded as good.[1]
  • The table below lists common prognostic factors for meningioma:
Prognostic Factor Description
Age Older patients have worse prognosis than younger patients.[1]
Anatomical location The tumor location is an important predictor for the success of the surgical resection.[1]
Labeling index using MIB-1 test A greater index is associated with a worse prognosis.[1]
Histological grade A grade 3 anaplastic meningioma has the worst prognosis.[1]
Functional neurological status Low score on the Karnofsky Performance Scale predicts a worse prognosis.[1]

References

  1. ↑ 1.0 1.1 1.2 1.3 1.4 1.5 Meningioma. Wikipedia(2015) https://en.wikipedia.org/wiki/Meningioma#cite_ref-17 Accessed on September, 25th 2015


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