Peutz-Jeghers syndrome pathophysiology: Difference between revisions
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==Pathophysiology== | ==Pathophysiology== | ||
===Genetics=== | ===Genetics=== | ||
Peutz- Jeghers syndrome is caused by a mutation in ''[[STK11]]'' (''LKB1'') tumor suppressor gene On [[Chromosome 19 (human)|chromosome 19]].<ref>Jenne DE, et al. 'Peutz-Jeghers Syndrome Is Caused By Mutations In A Novel Serine Threonine Kinase. - Pubmed - NCBI'. Ncbi.nlm.nih.gov. N.p., 2015. Web. 9 Sept. 2015.</ref> It is inherited in an ''Autosomal Dominant'' pattern (see [[Mendelian inheritance]]) which means that anyone who has Peutz-Jeghers syndrome (PJS) has a 50% chance of passing it onto his/her offspring. | |||
== References == | == References == | ||
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[[Category:Syndromes]] | [[Category:Syndromes]] | ||
[[Category:Needs content]] | [[Category:Needs content]] | ||
[[Category:Disease | [[Category:Disease]] | ||
{{WH}} | {{WH}} | ||
{{WS}} | {{WS}} | ||
Revision as of 14:15, 9 September 2015
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Peutz-Jeghers syndrome is transmitted in autosomal dominant pattern.
Pathophysiology
Genetics
Peutz- Jeghers syndrome is caused by a mutation in STK11 (LKB1) tumor suppressor gene On chromosome 19.[1] It is inherited in an Autosomal Dominant pattern (see Mendelian inheritance) which means that anyone who has Peutz-Jeghers syndrome (PJS) has a 50% chance of passing it onto his/her offspring.
References
- ↑ Jenne DE, et al. 'Peutz-Jeghers Syndrome Is Caused By Mutations In A Novel Serine Threonine Kinase. - Pubmed - NCBI'. Ncbi.nlm.nih.gov. N.p., 2015. Web. 9 Sept. 2015.