Carbinoxamine: Difference between revisions

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|drugClass=H1 blocking agent
|drugClass=H1 blocking agent
|indicationType=treatment
|indicationType=treatment
|indication=seasonal and perennial [[allergic rhinitis]], vasomotor [[rhinitis]], [[allergic conjunctivitis] due to inhalant [[allergen]]s and foods, mild uncomplicated allergic skin manifestations of [[urticaria]] and [[angioedema], and [[dermatographism]]
|indication=seasonal and perennial [[allergic rhinitis]], vasomotor [[rhinitis]], [[allergic conjunctivitis] due to inhalant [[allergen]]s and foods, mild uncomplicated allergic skin manifestations of [[urticaria]] and [[angioedema]], and [[dermatographism]]
|blackBoxWarningTitle=<b><span style="color:#FF0000;">TITLE</span></b>
|blackBoxWarningTitle=<b><span style="color:#FF0000;">TITLE</span></b>
|blackBoxWarningBody=<i><span style="color:#FF0000;">Condition Name:</span></i> (Content)
|blackBoxWarningBody=<i><span style="color:#FF0000;">Condition Name:</span></i> (Content)
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|alcohol=Alcohol-Carbinoxamine interaction has not been established. Talk to your doctor about the effects of taking alcohol with this medication.
|alcohol=Alcohol-Carbinoxamine interaction has not been established. Talk to your doctor about the effects of taking alcohol with this medication.
}}
}}
{{drugbox
| IUPAC_name = 2-[(4-chlorophenyl)-pyridin-2-yl-methoxy]-''N'',''N''-<br>dimethyl-ethanamine
| image = Carbinoxamine.svg
| CAS_number = 486-16-8
| ATC_prefix = R06
| ATC_suffix = AA08
| ATC_supplemental =
| PubChem = 2564
| DrugBank = APRD00765
| C=16 | H=19 | Cl=1 | N=2 | O=1
| molecular_weight = 290.788 g/mol
| bioavailability =
| protein_bound =
| metabolism =
| elimination_half-life = 10 to 20 hours
| pregnancy_category = C
| legal_status = 4 mg is FDA approved
| routes_of_administration = Oral: 4 mg tablet or 4 mg/5 mL liquid
}}
'''Carbinoxamine''' is an H1 class [[antihistamine]].  It was first launched in the United States by the [[McNeil Laboratories|McNeil Corporation]] under the brand name Clistin.  It is now available under the brand name Palgic as 4 mg tablets or 4 mg/5 mL liquid.  It is [[FDA]] approved (specifically at the 4 mg dose/strength) for [[hay fever]] (a.k.a. allergic rhinitis, SAR and PAR); vasomotor rhinitis; mild [[urticaria]]; angioedema, dermatographism and allergic conjunctivitis.
Carbinoxamine liquid is popular with children because the taste is very mild and easily swallowed.  Palgic liquid is clear and has a bubble gum flavor.
In June, 2006 the FDA announced that more than 120 branded pharmacy products containing carbinoxamine were being illegally marketed, and demanded they be removed from the marketplace.  This action was precipitated by twenty-one reported deaths in children under the age of two who had been administered carbinoxamine-containing products.  Despite the fact that the drug had not been studied in this age group, a multitude of OTC preparations containing carbinoxamine were being marketed for infants and toddlers.  At present, all carbinoxamine-containing formulations are approved only for adults or children ages 3 or older. [http://www.fda.gov/cder/drug/unapproved_drugs/qa.pdf]
==External links==
*[http://www.carbinoxamine.com Carbinoxamine]
{{Antihistamines}}
[[Category:H1 receptor antagonists]]
[[th:คาร์บินอกซามีน]]
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Revision as of 14:16, 17 February 2015

{{DrugProjectFormSinglePage |authorTag=Sree Teja Yelamanchili, MBBS [1] |genericName=Carbinoxamine |aOrAn=a |drugClass=H1 blocking agent |indicationType=treatment |indication=seasonal and perennial allergic rhinitis, vasomotor rhinitis, [[allergic conjunctivitis] due to inhalant allergens and foods, mild uncomplicated allergic skin manifestations of urticaria and angioedema, and dermatographism |blackBoxWarningTitle=TITLE |blackBoxWarningBody=Condition Name: (Content) |offLabelAdultGuideSupport=There is limited information regarding Off-Label Guideline-Supported Use of Carbinoxamine in adult patients. |offLabelAdultNoGuideSupport=There is limited information regarding Off-Label Non–Guideline-Supported Use of Carbinoxamine in adult patients. |offLabelPedGuideSupport=There is limited information regarding Off-Label Guideline-Supported Use of Carbinoxamine in pediatric patients. |offLabelPedNoGuideSupport=There is limited information regarding Off-Label Non–Guideline-Supported Use of Carbinoxamine in pediatric patients. |alcohol=Alcohol-Carbinoxamine interaction has not been established. Talk to your doctor about the effects of taking alcohol with this medication. }}

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