Lomustine: Difference between revisions
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|hasBlackBoxWarning=Yes | |hasBlackBoxWarning=Yes | ||
|adverseReactions=<!--Black Box Warning--> | |adverseReactions=<!--Black Box Warning--> | ||
|blackBoxWarningTitle= | |blackBoxWarningTitle=WARNINGS | ||
|blackBoxWarningBody= | |blackBoxWarningBody=* Gleostine (lomustine) should be administered under the supervision of a qualified physician experienced in the use of cancer chemotherapeutic agents. | ||
* | * Bone marrow suppression, notably thrombocytopenia and leukopenia, which may contribute to bleeding and overwhelming infections in an already compromised patient, is the most common and severe of the toxic effects of Gleostine. | ||
* Since the major toxicity is delayed bone marrow suppression, blood counts should be monitored weekly for at least 6 weeks after a dose. At the recommended dosage, courses of Gleostine should not be given more frequently than every 6 weeks. | |||
* The bone marrow toxicity of Gleostine is cumulative and therefore dosage adjustment must be considered on the basis of nadir blood counts from prior dose. | |||
|fdaLIADAdult======Condition1===== | |fdaLIADAdult======Condition1===== | ||
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|administration=* Oral | |administration=* Oral | ||
|monitoring=There is limited information regarding <i>Monitoring</i> of {{PAGENAME}} in the drug label. | |monitoring=There is limited information regarding <i>Monitoring</i> of {{PAGENAME}} in the drug label. | ||
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|clinicalStudies=There is limited information regarding <i>Clinical Studies</i> of {{PAGENAME}} in the drug label. | |clinicalStudies=There is limited information regarding <i>Clinical Studies</i> of {{PAGENAME}} in the drug label. | ||
|howSupplied=* | |howSupplied=* | ||
|packLabel=<!--Patient Counseling Information--> | |packLabel=<!--Patient Counseling Information--> | ||
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<!--Brand Names--> | <!--Brand Names--> | ||
|brandNames=* | |brandNames=* GLEOSTINE | ||
|lookAlike=* A® — B®<ref name="www.ismp.org">{{Cite web | last = | first = | title = http://www.ismp.org | url = http://www.ismp.org | publisher = | date = }}</ref> | |lookAlike=* A® — B®<ref name="www.ismp.org">{{Cite web | last = | first = | title = http://www.ismp.org | url = http://www.ismp.org | publisher = | date = }}</ref> | ||
Revision as of 14:29, 13 February 2015
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Kiran Singh, M.D. [2]
Disclaimer
WikiDoc MAKES NO GUARANTEE OF VALIDITY. WikiDoc is not a professional health care provider, nor is it a suitable replacement for a licensed healthcare provider. WikiDoc is intended to be an educational tool, not a tool for any form of healthcare delivery. The educational content on WikiDoc drug pages is based upon the FDA package insert, National Library of Medicine content and practice guidelines / consensus statements. WikiDoc does not promote the administration of any medication or device that is not consistent with its labeling. Please read our full disclaimer here.
Black Box Warning
WARNINGS
See full prescribing information for complete Boxed Warning.
* Gleostine (lomustine) should be administered under the supervision of a qualified physician experienced in the use of cancer chemotherapeutic agents.
|
Overview
Lomustine is a {{{drugClass}}} that is FDA approved for the {{{indicationType}}} of {{{indication}}}. There is a Black Box Warning for this drug as shown here. Common adverse reactions include .
Adult Indications and Dosage
FDA-Labeled Indications and Dosage (Adult)
Condition1
- Dosing Information
- Dosage
Condition2
- Dosing Information
- Dosage
Condition3
- Dosing Information
- Dosage
Condition4
- Dosing Information
- Dosage
Off-Label Use and Dosage (Adult)
Guideline-Supported Use
Condition1
- Developed by:
- Class of Recommendation:
- Strength of Evidence:
- Dosing Information
- Dosage
Condition2
There is limited information regarding Off-Label Guideline-Supported Use of Lomustine in adult patients.
Non–Guideline-Supported Use
Condition1
- Dosing Information
- Dosage
Condition2
There is limited information regarding Off-Label Non–Guideline-Supported Use of Lomustine in adult patients.
Pediatric Indications and Dosage
FDA-Labeled Indications and Dosage (Pediatric)
Condition1
- Dosing Information
- Dosage
Condition2
There is limited information regarding FDA-Labeled Use of Lomustine in pediatric patients.
Off-Label Use and Dosage (Pediatric)
Guideline-Supported Use
Condition1
- Developed by:
- Class of Recommendation:
- Strength of Evidence:
- Dosing Information
- Dosage
Condition2
There is limited information regarding Off-Label Guideline-Supported Use of Lomustine in pediatric patients.
Non–Guideline-Supported Use
Condition1
- Dosing Information
- Dosage
Condition2
There is limited information regarding Off-Label Non–Guideline-Supported Use of Lomustine in pediatric patients.
Contraindications
- Condition1
Warnings
WARNINGS
See full prescribing information for complete Boxed Warning.
* Gleostine (lomustine) should be administered under the supervision of a qualified physician experienced in the use of cancer chemotherapeutic agents.
|
- Description
Precautions
- Description
Adverse Reactions
Clinical Trials Experience
There is limited information regarding Clinical Trial Experience of Lomustine in the drug label.
Body as a Whole
Cardiovascular
Digestive
Endocrine
Hematologic and Lymphatic
Metabolic and Nutritional
Musculoskeletal
Neurologic
Respiratory
Skin and Hypersensitivy Reactions
Special Senses
Urogenital
Miscellaneous
Postmarketing Experience
There is limited information regarding Postmarketing Experience of Lomustine in the drug label.
Body as a Whole
Cardiovascular
Digestive
Endocrine
Hematologic and Lymphatic
Metabolic and Nutritional
Musculoskeletal
Neurologic
Respiratory
Skin and Hypersensitivy Reactions
Special Senses
Urogenital
Miscellaneous
Drug Interactions
- Drug
- Description
Use in Specific Populations
Pregnancy
- Pregnancy Category
- Australian Drug Evaluation Committee (ADEC) Pregnancy Category
There is no Australian Drug Evaluation Committee (ADEC) guidance on usage of Lomustine in women who are pregnant.
Labor and Delivery
There is no FDA guidance on use of Lomustine during labor and delivery.
Nursing Mothers
There is no FDA guidance on the use of Lomustine with respect to nursing mothers.
Pediatric Use
There is no FDA guidance on the use of Lomustine with respect to pediatric patients.
Geriatic Use
There is no FDA guidance on the use of Lomustine with respect to geriatric patients.
Gender
There is no FDA guidance on the use of Lomustine with respect to specific gender populations.
Race
There is no FDA guidance on the use of Lomustine with respect to specific racial populations.
Renal Impairment
There is no FDA guidance on the use of Lomustine in patients with renal impairment.
Hepatic Impairment
There is no FDA guidance on the use of Lomustine in patients with hepatic impairment.
Females of Reproductive Potential and Males
There is no FDA guidance on the use of Lomustine in women of reproductive potentials and males.
Immunocompromised Patients
There is no FDA guidance one the use of Lomustine in patients who are immunocompromised.
Administration and Monitoring
Administration
- Oral
Monitoring
There is limited information regarding Monitoring of Lomustine in the drug label.
- Description
IV Compatibility
There is limited information regarding IV Compatibility of Lomustine in the drug label.
Overdosage
Acute Overdose
Signs and Symptoms
- Description
Management
- Description
Chronic Overdose
There is limited information regarding Chronic Overdose of Lomustine in the drug label.
Pharmacology
There is limited information regarding Lomustine Pharmacology in the drug label.
Mechanism of Action
Structure
Pharmacodynamics
There is limited information regarding Pharmacodynamics of Lomustine in the drug label.
Pharmacokinetics
There is limited information regarding Pharmacokinetics of Lomustine in the drug label.
Nonclinical Toxicology
There is limited information regarding Nonclinical Toxicology of Lomustine in the drug label.
Clinical Studies
There is limited information regarding Clinical Studies of Lomustine in the drug label.
How Supplied
Storage
There is limited information regarding Lomustine Storage in the drug label.
Images
Drug Images
{{#ask: Page Name::Lomustine |?Pill Name |?Drug Name |?Pill Ingred |?Pill Imprint |?Pill Dosage |?Pill Color |?Pill Shape |?Pill Size (mm) |?Pill Scoring |?NDC |?Drug Author |format=template |template=DrugPageImages |mainlabel=- |sort=Pill Name }}
Package and Label Display Panel
{{#ask: Label Page::Lomustine |?Label Name |format=template |template=DrugLabelImages |mainlabel=- |sort=Label Page }}
Patient Counseling Information
There is limited information regarding Patient Counseling Information of Lomustine in the drug label.
Precautions with Alcohol
- Alcohol-Lomustine interaction has not been established. Talk to your doctor about the effects of taking alcohol with this medication.
Brand Names
- GLEOSTINE
Look-Alike Drug Names
- A® — B®[1]
Drug Shortage Status
Price
References
The contents of this FDA label are provided by the National Library of Medicine.
- ↑ "http://www.ismp.org". External link in
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