Paromomycin sulfate: Difference between revisions

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__NOTOC__
{{DrugProjectFormSinglePage
{{Paromomycin sulfate}}
|authorTag=<!--Overview-->
{{CMG}}
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==Overview==
* Content
Paromomycin is an [[aminoglycoside]] antibiotic, first isolated from ''Streptomyces krestomuceticus'' in the 1950s.<ref name="Davidson2008">{{cite journal| author = Davidson R.N., den Boer M., Ritmeijer K. | year = 2008 | title = Paromomycin | journal = Transactions of the Royal Society of Tropical Medicine and Hygiene | volume = 103| issue = 7| pages = 653–60| doi = 10.1016/j.trstmh.2008.09.008| pmid = 18947845}}</ref> It was discovered by [[Parke Davis]] now [[Pfizer]] and introduced as ''Humatin'' in 1960.<ref>Page 1166. http://books.google.co.in/books?id=XCsJgUnclbcC&pg=PA1257&dq=Pharmaceutical+Manufacturing+Encyclopedia,+Volume+2&hl=en&sa=X&ei=9V7iT8mqJoOIrAfe4P2zAw&ved=0CDoQ6AEwAA#v=onepage&q=Pharmaceutical%20Manufacturing%20Encyclopedia%2C%20Volume%202&f=false</ref> It is also called monomycin and aminosidine.<ref name="Neal1994">{{cite journal |author= Neal R.A. ''et al''. |year=1994 |title=Aminosidine ointments for the treatment of experimental cutaneous leishmaniasis |journal=Transactions of the Royal Society of Tropical Medicine and Hygiene |volume=88 |issue=2 |pages=223–5 | doi=10.1016/0035-9203(94)90307-7 |pmid= 8036682 }}</ref>


==Category==
<!--Adult Indications and Dosage-->
Amebicide


==US Brand Names==
<!--FDA-Labeled Indications and Dosage (Adult)-->
PAROMOMYCIN SULFATE capsule<sup>®</sup>, HUMATIN<sup>®</sup> (''DISCONTINUED'')
|fdaLIADAdult======Condition1=====


==FDA Package Insert==
* Dosing Information
'''[[Paromomycin sulfate description|Description]]'''
'''| [[Paromomycin sulfate clinical pharmacology|Clinical Pharmacology]]'''
'''| [[Paromomycin sulfate indications and usage|Indications and Usage]]'''
'''| [[Paromomycin sulfate contraindications|Contraindications]]'''
'''| [[Paromomycin sulfate warnings and precautions|Warnings and Precautions]]'''
'''| [[Paromomycin sulfate adverse reactions|Adverse Reactions]]'''
'''| [[Paromomycin sulfate dosage and administration|Dosage and Administration]]'''
'''| [[Paromomycin sulfate how supplied|How Supplied]]'''
'''| [[Paromomycin sulfate labels and packages|Labels and Packages]]'''


==Mechanisms of Action==
:* Dosage
Paromomycin is a [[protein synthesis inhibitor]] in non-resistant cells by binding to [[16S ribosomal RNA|16S]] [[ribosomal RNA]].<ref>{{cite journal
| last = Vicens | first = Quentin | coauthors = Eric Westhof
| year = 2001 | month = August
| title = Crystal Structure of Paromomycin Docked into the Eubacterial Ribosomal Decoding A Site | journal = Structure
| volume = 9 | issue = 8 | pages = 647–658
| doi = 10.1016/S0969-2126(01)00629-3 | pmid = 11587639
| url = http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6VSR-43VBX2W-C&_user=10&_coverDate=08%2F31%2F2001&_rdoc=1&_fmt=&_orig=search&_sort=d&view=c&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=1b1e19d11ca34e14eca1603c2be009d5
| accessdate = 2007-02-10
}}</ref> This broad spectrum antibiotic soluble in water, is very similar in action to [[Neomycin]]. Antimicrobial activity of Paromomycin against [[Escherichia coli]] and [[Staphylococcus aureus]] has been shown.<ref>{{ cite web | title = Paromomycin | url = http://www.toku-e.com/Upload/Products/PDS/20120518007094.pdf | format = pdf | publisher = Toku-E | date = 2010-01-12 | accessdate = 2012-06-11 }}</ref>


==References==
=====Condition2=====
{{Reflist|2}}


[[Category:Antibiotics]]
* Dosing Information
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<!--FDA-Labeled Indications and Dosage (Pediatric)-->
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[[Category:Drug]]

Revision as of 19:41, 3 February 2015

Paromomycin sulfate
Black Box Warning
Adult Indications & Dosage
Pediatric Indications & Dosage
Contraindications
Warnings & Precautions
Adverse Reactions
Drug Interactions
Use in Specific Populations
Administration & Monitoring
Overdosage
Pharmacology
Clinical Studies
How Supplied
Images
Patient Counseling Information
Precautions with Alcohol
Brand Names
Look-Alike Names

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1];

Disclaimer

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Black Box Warning

ConditionName:
See full prescribing information for complete Boxed Warning.
ConditionName:
  • Content

Overview

Paromomycin sulfate is a {{{drugClass}}} that is FDA approved for the {{{indicationType}}} of {{{indication}}}. There is a Black Box Warning for this drug as shown here. Common adverse reactions include .

Adult Indications and Dosage

FDA-Labeled Indications and Dosage (Adult)

Condition1
  • Dosing Information
  • Dosage
Condition2
  • Dosing Information
  • Dosage
Condition3
  • Dosing Information
  • Dosage
Condition4
  • Dosing Information
  • Dosage

Off-Label Use and Dosage (Adult)

Guideline-Supported Use

Condition1
  • Developed by:
  • Class of Recommendation:
  • Strength of Evidence:
  • Dosing Information
  • Dosage
Condition2

There is limited information regarding Off-Label Guideline-Supported Use of Paromomycin sulfate in adult patients.

Non–Guideline-Supported Use

Condition1
  • Dosing Information
  • Dosage
Condition2

There is limited information regarding Off-Label Non–Guideline-Supported Use of Paromomycin sulfate in adult patients.

Pediatric Indications and Dosage

FDA-Labeled Indications and Dosage (Pediatric)

Condition1
  • Dosing Information
  • Dosage
Condition2

There is limited information regarding FDA-Labeled Use of Paromomycin sulfate in pediatric patients.

Off-Label Use and Dosage (Pediatric)

Guideline-Supported Use

Condition1
  • Developed by:
  • Class of Recommendation:
  • Strength of Evidence:
  • Dosing Information
  • Dosage
Condition2

There is limited information regarding Off-Label Guideline-Supported Use of Paromomycin sulfate in pediatric patients.

Non–Guideline-Supported Use

Condition1
  • Dosing Information
  • Dosage
Condition2

There is limited information regarding Off-Label Non–Guideline-Supported Use of Paromomycin sulfate in pediatric patients.

Contraindications

  • Condition1

Warnings

ConditionName:
See full prescribing information for complete Boxed Warning.
ConditionName:
  • Content
  • Description

Precautions

  • Description

Adverse Reactions

Clinical Trials Experience

There is limited information regarding Clinical Trial Experience of Paromomycin sulfate in the drug label.

Body as a Whole
Cardiovascular
Digestive
Endocrine
Hematologic and Lymphatic
Metabolic and Nutritional
Musculoskeletal
Neurologic
Respiratory
Skin and Hypersensitivy Reactions
Special Senses
Urogenital
Miscellaneous

Postmarketing Experience

There is limited information regarding Postmarketing Experience of Paromomycin sulfate in the drug label.

Body as a Whole
Cardiovascular
Digestive
Endocrine
Hematologic and Lymphatic
Metabolic and Nutritional
Musculoskeletal
Neurologic
Respiratory
Skin and Hypersensitivy Reactions
Special Senses
Urogenital
Miscellaneous

Drug Interactions

  • Drug
  • Description

Use in Specific Populations

Pregnancy

Pregnancy Category (FDA):

  • Pregnancy Category


Pregnancy Category (AUS):

  • Australian Drug Evaluation Committee (ADEC) Pregnancy Category

There is no Australian Drug Evaluation Committee (ADEC) guidance on usage of Paromomycin sulfate in women who are pregnant.

Labor and Delivery

There is no FDA guidance on use of Paromomycin sulfate during labor and delivery.

Nursing Mothers

There is no FDA guidance on the use of Paromomycin sulfate with respect to nursing mothers.

Pediatric Use

There is no FDA guidance on the use of Paromomycin sulfate with respect to pediatric patients.

Geriatic Use

There is no FDA guidance on the use of Paromomycin sulfate with respect to geriatric patients.

Gender

There is no FDA guidance on the use of Paromomycin sulfate with respect to specific gender populations.

Race

There is no FDA guidance on the use of Paromomycin sulfate with respect to specific racial populations.

Renal Impairment

There is no FDA guidance on the use of Paromomycin sulfate in patients with renal impairment.

Hepatic Impairment

There is no FDA guidance on the use of Paromomycin sulfate in patients with hepatic impairment.

Females of Reproductive Potential and Males

There is no FDA guidance on the use of Paromomycin sulfate in women of reproductive potentials and males.

Immunocompromised Patients

There is no FDA guidance one the use of Paromomycin sulfate in patients who are immunocompromised.

Administration and Monitoring

Administration

  • Oral
  • Intravenous

Monitoring

There is limited information regarding Monitoring of Paromomycin sulfate in the drug label.

  • Description

IV Compatibility

There is limited information regarding IV Compatibility of Paromomycin sulfate in the drug label.

Overdosage

Acute Overdose

Signs and Symptoms

  • Description

Management

  • Description

Chronic Overdose

There is limited information regarding Chronic Overdose of Paromomycin sulfate in the drug label.

Pharmacology

There is limited information regarding Paromomycin sulfate Pharmacology in the drug label.

Mechanism of Action

Structure

File:Paromomycin sulfate01.png
This image is provided by the National Library of Medicine.

Pharmacodynamics

There is limited information regarding Pharmacodynamics of Paromomycin sulfate in the drug label.

Pharmacokinetics

There is limited information regarding Pharmacokinetics of Paromomycin sulfate in the drug label.

Nonclinical Toxicology

There is limited information regarding Nonclinical Toxicology of Paromomycin sulfate in the drug label.

Clinical Studies

There is limited information regarding Clinical Studies of Paromomycin sulfate in the drug label.

How Supplied

Storage

There is limited information regarding Paromomycin sulfate Storage in the drug label.

Images

Drug Images

{{#ask: Page Name::Paromomycin sulfate |?Pill Name |?Drug Name |?Pill Ingred |?Pill Imprint |?Pill Dosage |?Pill Color |?Pill Shape |?Pill Size (mm) |?Pill Scoring |?NDC |?Drug Author |format=template |template=DrugPageImages |mainlabel=- |sort=Pill Name }}

Package and Label Display Panel

{{#ask: Label Page::Paromomycin sulfate |?Label Name |format=template |template=DrugLabelImages |mainlabel=- |sort=Label Page }}

Patient Counseling Information

There is limited information regarding Patient Counseling Information of Paromomycin sulfate in the drug label.

Precautions with Alcohol

  • Alcohol-Paromomycin sulfate interaction has not been established. Talk to your doctor about the effects of taking alcohol with this medication.

Brand Names

Look-Alike Drug Names

Drug Shortage Status

Price

References

The contents of this FDA label are provided by the National Library of Medicine.

  1. ↑ Empty citation (help)
  2. ↑ "http://www.ismp.org". External link in |title= (help)

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